RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXB1_LEIMU

TriTrypDb:

LmxM.25.0340

Length:

660

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXB1

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	349	353	PF00656	0.646
CLV_NRD_NRD_1	259	261	PF00675	0.502
CLV_NRD_NRD_1	389	391	PF00675	0.607
CLV_NRD_NRD_1	466	468	PF00675	0.530
CLV_NRD_NRD_1	479	481	PF00675	0.605
CLV_NRD_NRD_1	61	63	PF00675	0.334
CLV_PCSK_KEX2_1	381	383	PF00082	0.722
CLV_PCSK_KEX2_1	466	468	PF00082	0.530
CLV_PCSK_KEX2_1	479	481	PF00082	0.605
CLV_PCSK_KEX2_1	61	63	PF00082	0.334
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.727
CLV_PCSK_PC7_1	462	468	PF00082	0.349
CLV_PCSK_PC7_1	57	63	PF00082	0.333
CLV_PCSK_SKI1_1	187	191	PF00082	0.279
CLV_PCSK_SKI1_1	61	65	PF00082	0.330
CLV_PCSK_SKI1_1	630	634	PF00082	0.282
CLV_Separin_Metazoa	54	58	PF03568	0.340
DEG_APCC_DBOX_1	60	68	PF00400	0.336
DEG_SPOP_SBC_1	490	494	PF00917	0.521
DOC_ANK_TNKS_1	450	457	PF00023	0.341
DOC_CDC14_PxL_1	148	156	PF14671	0.549
DOC_CYCLIN_RxL_1	184	194	PF00134	0.274
DOC_CYCLIN_yCln2_LP_2	202	208	PF00134	0.345
DOC_MAPK_gen_1	466	473	PF00069	0.574
DOC_MAPK_gen_1	61	67	PF00069	0.332
DOC_MAPK_MEF2A_6	596	605	PF00069	0.452
DOC_PP1_RVXF_1	185	192	PF00149	0.269
DOC_PP1_RVXF_1	227	233	PF00149	0.426
DOC_PP1_RVXF_1	425	432	PF00149	0.346
DOC_PP2B_LxvP_1	116	119	PF13499	0.305
DOC_PP2B_LxvP_1	206	209	PF13499	0.341
DOC_USP7_MATH_1	212	216	PF00917	0.313
DOC_USP7_MATH_1	338	342	PF00917	0.545
DOC_USP7_MATH_1	4	8	PF00917	0.485
DOC_USP7_MATH_1	436	440	PF00917	0.329
DOC_USP7_MATH_1	495	499	PF00917	0.681
DOC_USP7_MATH_1	586	590	PF00917	0.477
DOC_USP7_UBL2_3	146	150	PF12436	0.548
DOC_WW_Pin1_4	491	496	PF00397	0.612
LIG_14-3-3_CanoR_1	105	113	PF00244	0.353
LIG_14-3-3_CanoR_1	187	192	PF00244	0.391
LIG_14-3-3_CanoR_1	19	27	PF00244	0.423
LIG_14-3-3_CanoR_1	260	264	PF00244	0.499
LIG_14-3-3_CanoR_1	312	317	PF00244	0.556
LIG_14-3-3_CanoR_1	406	415	PF00244	0.606
LIG_14-3-3_CanoR_1	466	473	PF00244	0.535
LIG_14-3-3_CanoR_1	479	486	PF00244	0.757
LIG_14-3-3_CanoR_1	489	495	PF00244	0.714
LIG_14-3-3_CanoR_1	57	65	PF00244	0.310
LIG_14-3-3_CanoR_1	580	588	PF00244	0.476
LIG_14-3-3_CanoR_1	590	598	PF00244	0.356
LIG_14-3-3_CanoR_1	78	84	PF00244	0.437
LIG_BRCT_BRCA1_1	144	148	PF00533	0.372
LIG_BRCT_BRCA1_1	261	265	PF00533	0.507
LIG_BRCT_BRCA1_1	409	413	PF00533	0.514
LIG_BRCT_BRCA1_2	144	150	PF00533	0.380
LIG_Clathr_ClatBox_1	64	68	PF01394	0.342
LIG_deltaCOP1_diTrp_1	75	83	PF00928	0.361
LIG_FHA_1	113	119	PF00498	0.445
LIG_FHA_1	220	226	PF00498	0.339
LIG_FHA_1	28	34	PF00498	0.387
LIG_FHA_1	403	409	PF00498	0.535
LIG_FHA_1	416	422	PF00498	0.326
LIG_FHA_1	491	497	PF00498	0.598
LIG_FHA_1	530	536	PF00498	0.579
LIG_FHA_1	580	586	PF00498	0.452
LIG_FHA_1	79	85	PF00498	0.339
LIG_FHA_2	569	575	PF00498	0.346
LIG_FHA_2	604	610	PF00498	0.476
LIG_LIR_Gen_1	320	330	PF02991	0.654
LIG_LIR_Gen_1	355	361	PF02991	0.493
LIG_LIR_Gen_1	50	60	PF02991	0.349
LIG_LIR_Gen_1	79	88	PF02991	0.375
LIG_LIR_Gen_1	98	107	PF02991	0.351
LIG_LIR_Nem_3	145	151	PF02991	0.494
LIG_LIR_Nem_3	320	326	PF02991	0.702
LIG_LIR_Nem_3	355	359	PF02991	0.494
LIG_LIR_Nem_3	50	55	PF02991	0.365
LIG_LIR_Nem_3	609	615	PF02991	0.285
LIG_LIR_Nem_3	75	80	PF02991	0.407
LIG_LIR_Nem_3	98	102	PF02991	0.360
LIG_MYND_1	152	156	PF01753	0.381
LIG_MYND_1	515	519	PF01753	0.653
LIG_MYND_3	151	155	PF01753	0.507
LIG_MYND_3	157	161	PF01753	0.440
LIG_Pex14_2	292	296	PF04695	0.448
LIG_Pex14_2	413	417	PF04695	0.423
LIG_REV1ctd_RIR_1	272	282	PF16727	0.258
LIG_SH2_CRK	356	360	PF00017	0.493
LIG_SH2_GRB2like	237	240	PF00017	0.540
LIG_SH2_NCK_1	356	360	PF00017	0.493
LIG_SH2_PTP2	52	55	PF00017	0.345
LIG_SH2_SRC	52	55	PF00017	0.345
LIG_SH2_STAP1	162	166	PF00017	0.328
LIG_SH2_STAP1	80	84	PF00017	0.333
LIG_SH2_STAT3	276	279	PF00017	0.331
LIG_SH2_STAT3	644	647	PF00017	0.408
LIG_SH2_STAT5	124	127	PF00017	0.400
LIG_SH2_STAT5	213	216	PF00017	0.391
LIG_SH2_STAT5	361	364	PF00017	0.651
LIG_SH2_STAT5	52	55	PF00017	0.374
LIG_SH2_STAT5	58	61	PF00017	0.377
LIG_SH2_STAT5	80	83	PF00017	0.338
LIG_SH2_STAT5	99	102	PF00017	0.353
LIG_SH3_1	381	387	PF00018	0.667
LIG_SH3_1	509	515	PF00018	0.654
LIG_SH3_3	381	387	PF00018	0.548
LIG_SH3_3	397	403	PF00018	0.596
LIG_SH3_3	509	515	PF00018	0.654
LIG_SH3_3	645	651	PF00018	0.381
LIG_SH3_4	146	153	PF00018	0.546
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.277
LIG_SUMO_SIM_par_1	177	183	PF11976	0.277
LIG_SUMO_SIM_par_1	526	534	PF11976	0.592
LIG_TRAF2_1	606	609	PF00917	0.462
LIG_TYR_ITIM	354	359	PF00017	0.493
LIG_WRC_WIRS_1	414	419	PF05994	0.416
LIG_WRC_WIRS_1	80	85	PF05994	0.419
MOD_CDK_SPxK_1	491	497	PF00069	0.521
MOD_CK1_1	219	225	PF00069	0.340
MOD_CK1_1	259	265	PF00069	0.562
MOD_CK1_1	317	323	PF00069	0.465
MOD_CK1_1	332	338	PF00069	0.579
MOD_CK1_1	365	371	PF00069	0.545
MOD_CK1_1	499	505	PF00069	0.635
MOD_CK1_1	589	595	PF00069	0.313
MOD_CK1_1	7	13	PF00069	0.583
MOD_CK2_1	177	183	PF00069	0.436
MOD_CK2_1	431	437	PF00069	0.305
MOD_CK2_1	603	609	PF00069	0.487
MOD_GlcNHglycan	107	110	PF01048	0.380
MOD_GlcNHglycan	214	217	PF01048	0.471
MOD_GlcNHglycan	305	308	PF01048	0.466
MOD_GlcNHglycan	338	341	PF01048	0.509
MOD_GlcNHglycan	392	395	PF01048	0.556
MOD_GlcNHglycan	409	412	PF01048	0.505
MOD_GlcNHglycan	480	483	PF01048	0.705
MOD_GlcNHglycan	6	9	PF01048	0.658
MOD_GSK3_1	187	194	PF00069	0.562
MOD_GSK3_1	212	219	PF00069	0.359
MOD_GSK3_1	255	262	PF00069	0.417
MOD_GSK3_1	314	321	PF00069	0.564
MOD_GSK3_1	328	335	PF00069	0.550
MOD_GSK3_1	338	345	PF00069	0.613
MOD_GSK3_1	348	355	PF00069	0.634
MOD_GSK3_1	361	368	PF00069	0.567
MOD_GSK3_1	390	397	PF00069	0.643
MOD_GSK3_1	413	420	PF00069	0.422
MOD_GSK3_1	454	461	PF00069	0.424
MOD_GSK3_1	491	498	PF00069	0.674
MOD_GSK3_1	653	660	PF00069	0.480
MOD_GSK3_1	91	98	PF00069	0.415
MOD_N-GLC_1	352	357	PF02516	0.594
MOD_N-GLC_1	394	399	PF02516	0.672
MOD_N-GLC_1	630	635	PF02516	0.250
MOD_NEK2_1	111	116	PF00069	0.353
MOD_NEK2_1	125	130	PF00069	0.373
MOD_NEK2_1	191	196	PF00069	0.562
MOD_NEK2_1	27	32	PF00069	0.485
MOD_NEK2_1	305	310	PF00069	0.462
MOD_NEK2_1	326	331	PF00069	0.662
MOD_NEK2_1	33	38	PF00069	0.412
MOD_NEK2_1	413	418	PF00069	0.357
MOD_NEK2_1	56	61	PF00069	0.330
MOD_PIKK_1	130	136	PF00454	0.470
MOD_PIKK_1	244	250	PF00454	0.430
MOD_PIKK_1	332	338	PF00454	0.590
MOD_PIKK_1	466	472	PF00454	0.563
MOD_PIKK_1	653	659	PF00454	0.603
MOD_PK_1	312	318	PF00069	0.580
MOD_PKA_1	390	396	PF00069	0.524
MOD_PKA_1	466	472	PF00069	0.563
MOD_PKA_2	259	265	PF00069	0.445
MOD_PKA_2	466	472	PF00069	0.530
MOD_PKA_2	478	484	PF00069	0.748
MOD_PKA_2	56	62	PF00069	0.267
MOD_PKA_2	579	585	PF00069	0.451
MOD_PKA_2	589	595	PF00069	0.334
MOD_PKB_1	310	318	PF00069	0.472
MOD_Plk_1	14	20	PF00069	0.484
MOD_Plk_1	318	324	PF00069	0.639
MOD_Plk_1	352	358	PF00069	0.540
MOD_Plk_1	436	442	PF00069	0.541
MOD_Plk_1	630	636	PF00069	0.331
MOD_Plk_2-3	177	183	PF00069	0.436
MOD_Plk_4	338	344	PF00069	0.507
MOD_Plk_4	513	519	PF00069	0.538
MOD_Plk_4	79	85	PF00069	0.489
MOD_Plk_4	95	101	PF00069	0.262
MOD_ProDKin_1	491	497	PF00069	0.614
MOD_SUMO_for_1	65	68	PF00179	0.347
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.469
TRG_ENDOCYTIC_2	356	359	PF00928	0.494
TRG_ENDOCYTIC_2	52	55	PF00928	0.345
TRG_ENDOCYTIC_2	80	83	PF00928	0.374
TRG_ENDOCYTIC_2	99	102	PF00928	0.353
TRG_ER_diArg_1	309	312	PF00400	0.408
TRG_ER_diArg_1	459	462	PF00400	0.478
TRG_ER_diArg_1	465	467	PF00400	0.444
TRG_ER_diArg_1	61	63	PF00400	0.334
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D4	Leptomonas seymouri	50%	93%
Q4QA61	Leishmania major	83%	100%