SPRY domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXB0_LEIMU

TriTrypDb:

LmxM.25.0330

Length:

686

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AXB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXB0

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	3
GO:0006518	peptide metabolic process	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009059	macromolecule biosynthetic process	4	3
GO:0009987	cellular process	1	3
GO:0019538	protein metabolic process	3	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	3
GO:0043043	peptide biosynthetic process	5	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043603	amide metabolic process	3	3
GO:0043604	amide biosynthetic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3
GO:0044271	cellular nitrogen compound biosynthetic process	4	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901566	organonitrogen compound biosynthetic process	4	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	3
GO:0005198	structural molecule activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.630
CLV_C14_Caspase3-7	502	506	PF00656	0.617
CLV_NRD_NRD_1	346	348	PF00675	0.755
CLV_NRD_NRD_1	364	366	PF00675	0.652
CLV_NRD_NRD_1	423	425	PF00675	0.778
CLV_NRD_NRD_1	457	459	PF00675	0.827
CLV_NRD_NRD_1	562	564	PF00675	0.813
CLV_NRD_NRD_1	574	576	PF00675	0.526
CLV_PCSK_FUR_1	560	564	PF00082	0.817
CLV_PCSK_FUR_1	572	576	PF00082	0.549
CLV_PCSK_KEX2_1	248	250	PF00082	0.859
CLV_PCSK_KEX2_1	333	335	PF00082	0.822
CLV_PCSK_KEX2_1	346	348	PF00082	0.713
CLV_PCSK_KEX2_1	423	425	PF00082	0.778
CLV_PCSK_KEX2_1	457	459	PF00082	0.827
CLV_PCSK_KEX2_1	562	564	PF00082	0.813
CLV_PCSK_KEX2_1	572	574	PF00082	0.607
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.859
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.758
CLV_PCSK_PC7_1	342	348	PF00082	0.749
CLV_PCSK_PC7_1	419	425	PF00082	0.766
CLV_PCSK_SKI1_1	119	123	PF00082	0.694
CLV_PCSK_SKI1_1	129	133	PF00082	0.578
CLV_PCSK_SKI1_1	586	590	PF00082	0.606
DEG_Nend_Nbox_1	1	3	PF02207	0.777
DEG_SCF_FBW7_2	300	306	PF00400	0.775
DEG_SPOP_SBC_1	152	156	PF00917	0.719
DEG_SPOP_SBC_1	325	329	PF00917	0.666
DOC_CKS1_1	300	305	PF01111	0.771
DOC_CKS1_1	427	432	PF01111	0.813
DOC_CKS1_1	434	439	PF01111	0.707
DOC_CYCLIN_yCln2_LP_2	525	531	PF00134	0.602
DOC_MAPK_DCC_7	662	672	PF00069	0.530
DOC_MAPK_gen_1	127	134	PF00069	0.702
DOC_MAPK_gen_1	572	581	PF00069	0.588
DOC_MAPK_MEF2A_6	572	581	PF00069	0.588
DOC_PP1_RVXF_1	476	483	PF00149	0.644
DOC_PP2B_LxvP_1	525	528	PF13499	0.631
DOC_SPAK_OSR1_1	227	231	PF12202	0.542
DOC_USP7_MATH_1	103	107	PF00917	0.649
DOC_USP7_MATH_1	152	156	PF00917	0.719
DOC_USP7_MATH_1	186	190	PF00917	0.544
DOC_USP7_MATH_1	22	26	PF00917	0.790
DOC_USP7_MATH_1	261	265	PF00917	0.709
DOC_USP7_MATH_1	285	289	PF00917	0.783
DOC_USP7_MATH_1	293	297	PF00917	0.661
DOC_USP7_MATH_1	325	329	PF00917	0.668
DOC_USP7_MATH_1	336	340	PF00917	0.637
DOC_USP7_MATH_1	411	415	PF00917	0.687
DOC_USP7_MATH_1	439	443	PF00917	0.662
DOC_USP7_MATH_1	555	559	PF00917	0.516
DOC_USP7_MATH_1	66	70	PF00917	0.638
DOC_USP7_MATH_1	77	81	PF00917	0.819
DOC_WW_Pin1_4	148	153	PF00397	0.690
DOC_WW_Pin1_4	213	218	PF00397	0.826
DOC_WW_Pin1_4	259	264	PF00397	0.822
DOC_WW_Pin1_4	279	284	PF00397	0.573
DOC_WW_Pin1_4	287	292	PF00397	0.754
DOC_WW_Pin1_4	294	299	PF00397	0.663
DOC_WW_Pin1_4	31	36	PF00397	0.670
DOC_WW_Pin1_4	326	331	PF00397	0.861
DOC_WW_Pin1_4	341	346	PF00397	0.620
DOC_WW_Pin1_4	360	365	PF00397	0.587
DOC_WW_Pin1_4	426	431	PF00397	0.807
DOC_WW_Pin1_4	433	438	PF00397	0.709
DOC_WW_Pin1_4	441	446	PF00397	0.816
DOC_WW_Pin1_4	47	52	PF00397	0.524
DOC_WW_Pin1_4	547	552	PF00397	0.627
LIG_14-3-3_CanoR_1	159	165	PF00244	0.776
LIG_14-3-3_CanoR_1	204	209	PF00244	0.860
LIG_14-3-3_CanoR_1	365	374	PF00244	0.798
LIG_14-3-3_CanoR_1	424	430	PF00244	0.746
LIG_14-3-3_CanoR_1	556	560	PF00244	0.563
LIG_14-3-3_CanoR_1	84	94	PF00244	0.542
LIG_BIR_III_4	238	242	PF00653	0.657
LIG_BRCT_BRCA1_1	39	43	PF00533	0.626
LIG_CSL_BTD_1	162	165	PF09270	0.522
LIG_FHA_1	404	410	PF00498	0.765
LIG_FHA_1	427	433	PF00498	0.669
LIG_FHA_1	448	454	PF00498	0.787
LIG_FHA_1	48	54	PF00498	0.757
LIG_FHA_1	502	508	PF00498	0.482
LIG_FHA_1	601	607	PF00498	0.480
LIG_FHA_2	321	327	PF00498	0.574
LIG_FHA_2	506	512	PF00498	0.405
LIG_IBAR_NPY_1	90	92	PF08397	0.836
LIG_KLC1_Yacidic_2	644	648	PF13176	0.530
LIG_LIR_Apic_2	462	468	PF02991	0.630
LIG_LIR_Apic_2	619	625	PF02991	0.530
LIG_LIR_Apic_2	96	100	PF02991	0.818
LIG_LIR_Gen_1	193	203	PF02991	0.629
LIG_LIR_Gen_1	538	546	PF02991	0.570
LIG_LIR_Nem_3	193	199	PF02991	0.629
LIG_LIR_Nem_3	538	544	PF02991	0.578
LIG_LIR_Nem_3	585	591	PF02991	0.605
LIG_LYPXL_SIV_4	195	203	PF13949	0.551
LIG_MYND_1	430	434	PF01753	0.613
LIG_Pex14_2	544	548	PF04695	0.574
LIG_SH2_CRK	54	58	PF00017	0.813
LIG_SH2_CRK	622	626	PF00017	0.530
LIG_SH2_NCK_1	196	200	PF00017	0.630
LIG_SH2_SRC	196	199	PF00017	0.634
LIG_SH2_SRC	465	468	PF00017	0.706
LIG_SH2_SRC	626	629	PF00017	0.530
LIG_SH2_SRC	646	649	PF00017	0.530
LIG_SH2_STAT5	229	232	PF00017	0.755
LIG_SH2_STAT5	497	500	PF00017	0.367
LIG_SH2_STAT5	541	544	PF00017	0.393
LIG_SH2_STAT5	600	603	PF00017	0.434
LIG_SH2_STAT5	646	649	PF00017	0.530
LIG_SH2_STAT5	72	75	PF00017	0.766
LIG_SH2_STAT5	92	95	PF00017	0.512
LIG_SH3_1	342	348	PF00018	0.840
LIG_SH3_1	361	367	PF00018	0.573
LIG_SH3_1	622	628	PF00018	0.530
LIG_SH3_2	300	305	PF14604	0.771
LIG_SH3_3	18	24	PF00018	0.531
LIG_SH3_3	188	194	PF00018	0.568
LIG_SH3_3	208	214	PF00018	0.814
LIG_SH3_3	257	263	PF00018	0.693
LIG_SH3_3	297	303	PF00018	0.750
LIG_SH3_3	342	348	PF00018	0.840
LIG_SH3_3	361	367	PF00018	0.573
LIG_SH3_3	431	437	PF00018	0.786
LIG_SH3_3	622	628	PF00018	0.530
LIG_SH3_3	65	71	PF00018	0.557
LIG_SH3_3	663	669	PF00018	0.530
LIG_SH3_3	97	103	PF00018	0.635
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.506
LIG_SUMO_SIM_anti_2	504	511	PF11976	0.639
LIG_SUMO_SIM_par_1	668	674	PF11976	0.530
LIG_SxIP_EBH_1	19	33	PF03271	0.831
LIG_TRAF2_1	354	357	PF00917	0.571
LIG_WRC_WIRS_1	541	546	PF05994	0.342
MOD_CDC14_SPxK_1	292	295	PF00782	0.868
MOD_CDC14_SPxK_1	331	334	PF00782	0.867
MOD_CDC14_SPxK_1	34	37	PF00782	0.814
MOD_CDC14_SPxK_1	363	366	PF00782	0.777
MOD_CDK_SPK_2	328	333	PF00069	0.741
MOD_CDK_SPK_2	341	346	PF00069	0.618
MOD_CDK_SPK_2	360	365	PF00069	0.653
MOD_CDK_SPxK_1	289	295	PF00069	0.870
MOD_CDK_SPxK_1	299	305	PF00069	0.686
MOD_CDK_SPxK_1	31	37	PF00069	0.818
MOD_CDK_SPxK_1	328	334	PF00069	0.862
MOD_CDK_SPxK_1	341	347	PF00069	0.655
MOD_CDK_SPxK_1	360	366	PF00069	0.655
MOD_CDK_SPxxK_3	326	333	PF00069	0.743
MOD_CDK_SPxxK_3	441	448	PF00069	0.761
MOD_CK1_1	151	157	PF00069	0.792
MOD_CK1_1	184	190	PF00069	0.769
MOD_CK1_1	215	221	PF00069	0.820
MOD_CK1_1	264	270	PF00069	0.699
MOD_CK1_1	279	285	PF00069	0.684
MOD_CK1_1	328	334	PF00069	0.669
MOD_CK1_1	360	366	PF00069	0.859
MOD_CK1_1	403	409	PF00069	0.682
MOD_CK1_1	461	467	PF00069	0.807
MOD_CK1_1	55	61	PF00069	0.806
MOD_CK1_1	550	556	PF00069	0.580
MOD_CK1_1	611	617	PF00069	0.664
MOD_CK1_1	75	81	PF00069	0.507
MOD_CK2_1	120	126	PF00069	0.638
MOD_CK2_1	309	315	PF00069	0.815
MOD_CK2_1	320	326	PF00069	0.647
MOD_CK2_1	41	47	PF00069	0.832
MOD_CK2_1	505	511	PF00069	0.403
MOD_CK2_1	77	83	PF00069	0.549
MOD_Cter_Amidation	570	573	PF01082	0.496
MOD_GlcNHglycan	105	108	PF01048	0.834
MOD_GlcNHglycan	112	115	PF01048	0.645
MOD_GlcNHglycan	155	158	PF01048	0.803
MOD_GlcNHglycan	160	163	PF01048	0.742
MOD_GlcNHglycan	188	191	PF01048	0.618
MOD_GlcNHglycan	220	223	PF01048	0.854
MOD_GlcNHglycan	238	242	PF01048	0.534
MOD_GlcNHglycan	24	27	PF01048	0.635
MOD_GlcNHglycan	267	270	PF01048	0.681
MOD_GlcNHglycan	277	281	PF01048	0.762
MOD_GlcNHglycan	315	319	PF01048	0.819
MOD_GlcNHglycan	368	371	PF01048	0.814
MOD_GlcNHglycan	38	42	PF01048	0.605
MOD_GlcNHglycan	486	489	PF01048	0.483
MOD_GlcNHglycan	492	495	PF01048	0.447
MOD_GlcNHglycan	54	57	PF01048	0.547
MOD_GlcNHglycan	59	62	PF01048	0.718
MOD_GlcNHglycan	614	617	PF01048	0.532
MOD_GlcNHglycan	64	67	PF01048	0.628
MOD_GlcNHglycan	673	676	PF01048	0.436
MOD_GlcNHglycan	74	77	PF01048	0.497
MOD_GSK3_1	103	110	PF00069	0.555
MOD_GSK3_1	148	155	PF00069	0.774
MOD_GSK3_1	181	188	PF00069	0.758
MOD_GSK3_1	261	268	PF00069	0.768
MOD_GSK3_1	285	292	PF00069	0.862
MOD_GSK3_1	310	317	PF00069	0.823
MOD_GSK3_1	320	327	PF00069	0.663
MOD_GSK3_1	37	44	PF00069	0.558
MOD_GSK3_1	501	508	PF00069	0.469
MOD_GSK3_1	582	589	PF00069	0.586
MOD_GSK3_1	608	615	PF00069	0.622
MOD_GSK3_1	62	69	PF00069	0.647
MOD_GSK3_1	71	78	PF00069	0.632
MOD_NEK2_1	265	270	PF00069	0.574
MOD_NEK2_1	409	414	PF00069	0.777
MOD_NEK2_1	535	540	PF00069	0.600
MOD_NEK2_1	57	62	PF00069	0.804
MOD_NEK2_1	599	604	PF00069	0.576
MOD_NEK2_1	610	615	PF00069	0.563
MOD_NEK2_2	555	560	PF00069	0.518
MOD_PIKK_1	285	291	PF00454	0.745
MOD_PKA_2	158	164	PF00069	0.776
MOD_PKA_2	230	236	PF00069	0.536
MOD_PKA_2	425	431	PF00069	0.804
MOD_PKA_2	447	453	PF00069	0.756
MOD_PKA_2	555	561	PF00069	0.635
MOD_Plk_1	37	43	PF00069	0.758
MOD_Plk_2-3	505	511	PF00069	0.425
MOD_Plk_4	505	511	PF00069	0.425
MOD_ProDKin_1	148	154	PF00069	0.694
MOD_ProDKin_1	213	219	PF00069	0.824
MOD_ProDKin_1	259	265	PF00069	0.828
MOD_ProDKin_1	279	285	PF00069	0.572
MOD_ProDKin_1	287	293	PF00069	0.750
MOD_ProDKin_1	294	300	PF00069	0.656
MOD_ProDKin_1	31	37	PF00069	0.671
MOD_ProDKin_1	326	332	PF00069	0.858
MOD_ProDKin_1	341	347	PF00069	0.622
MOD_ProDKin_1	360	366	PF00069	0.585
MOD_ProDKin_1	426	432	PF00069	0.811
MOD_ProDKin_1	433	439	PF00069	0.710
MOD_ProDKin_1	441	447	PF00069	0.817
MOD_ProDKin_1	47	53	PF00069	0.525
MOD_ProDKin_1	547	553	PF00069	0.642
TRG_DiLeu_BaEn_2	593	599	PF01217	0.604
TRG_ENDOCYTIC_2	196	199	PF00928	0.634
TRG_ENDOCYTIC_2	54	57	PF00928	0.815
TRG_ENDOCYTIC_2	541	544	PF00928	0.393
TRG_ER_diArg_1	143	146	PF00400	0.718
TRG_ER_diArg_1	345	347	PF00400	0.678
TRG_ER_diArg_1	423	425	PF00400	0.778
TRG_ER_diArg_1	456	458	PF00400	0.829
TRG_ER_diArg_1	559	562	PF00400	0.810
TRG_ER_diArg_1	572	575	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYR3	Leishmania donovani	86%	100%
A4HDY0	Leishmania braziliensis	70%	100%
A4I176	Leishmania infantum	85%	100%
Q4QA62	Leishmania major	83%	100%