RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXA5_LEIMU

TriTrypDb:

LmxM.25.0290

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXA5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.499
CLV_C14_Caspase3-7	418	422	PF00656	0.306
CLV_NRD_NRD_1	235	237	PF00675	0.594
CLV_NRD_NRD_1	369	371	PF00675	0.578
CLV_NRD_NRD_1	495	497	PF00675	0.656
CLV_NRD_NRD_1	69	71	PF00675	0.320
CLV_PCSK_KEX2_1	235	237	PF00082	0.594
CLV_PCSK_KEX2_1	369	371	PF00082	0.578
CLV_PCSK_KEX2_1	495	497	PF00082	0.656
CLV_PCSK_SKI1_1	370	374	PF00082	0.577
CLV_PCSK_SKI1_1	70	74	PF00082	0.296
DEG_SPOP_SBC_1	57	61	PF00917	0.432
DOC_CKS1_1	475	480	PF01111	0.574
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	487	493	PF00134	0.617
DOC_CYCLIN_yCln2_LP_2	533	539	PF00134	0.627
DOC_MAPK_gen_1	401	410	PF00069	0.455
DOC_MAPK_MEF2A_6	540	548	PF00069	0.565
DOC_PP1_RVXF_1	154	161	PF00149	0.385
DOC_PP1_RVXF_1	338	345	PF00149	0.287
DOC_PP2B_LxvP_1	152	155	PF13499	0.390
DOC_PP2B_LxvP_1	189	192	PF13499	0.627
DOC_PP2B_LxvP_1	256	259	PF13499	0.607
DOC_PP2B_LxvP_1	487	490	PF13499	0.617
DOC_PP2B_LxvP_1	533	536	PF13499	0.681
DOC_PP4_FxxP_1	82	85	PF00568	0.422
DOC_USP7_MATH_1	227	231	PF00917	0.621
DOC_USP7_MATH_1	273	277	PF00917	0.669
DOC_USP7_MATH_1	287	291	PF00917	0.591
DOC_USP7_MATH_1	387	391	PF00917	0.418
DOC_USP7_MATH_1	499	503	PF00917	0.825
DOC_USP7_MATH_1	550	554	PF00917	0.695
DOC_USP7_MATH_1	9	13	PF00917	0.558
DOC_WW_Pin1_4	107	112	PF00397	0.476
DOC_WW_Pin1_4	12	17	PF00397	0.497
DOC_WW_Pin1_4	240	245	PF00397	0.613
DOC_WW_Pin1_4	276	281	PF00397	0.693
DOC_WW_Pin1_4	348	353	PF00397	0.397
DOC_WW_Pin1_4	431	436	PF00397	0.671
DOC_WW_Pin1_4	474	479	PF00397	0.573
DOC_WW_Pin1_4	508	513	PF00397	0.607
DOC_WW_Pin1_4	522	527	PF00397	0.667
DOC_WW_Pin1_4	571	576	PF00397	0.805
LIG_14-3-3_CanoR_1	264	273	PF00244	0.629
LIG_14-3-3_CanoR_1	451	457	PF00244	0.715
LIG_14-3-3_CanoR_1	582	588	PF00244	0.651
LIG_APCC_ABBAyCdc20_2	163	169	PF00400	0.412
LIG_deltaCOP1_diTrp_1	320	329	PF00928	0.502
LIG_EVH1_1	189	193	PF00568	0.629
LIG_EVH1_2	352	356	PF00568	0.449
LIG_FHA_1	13	19	PF00498	0.392
LIG_FHA_1	372	378	PF00498	0.466
LIG_FHA_1	389	395	PF00498	0.329
LIG_FHA_1	85	91	PF00498	0.468
LIG_FHA_1	93	99	PF00498	0.416
LIG_FHA_2	107	113	PF00498	0.397
LIG_FHA_2	308	314	PF00498	0.526
LIG_FHA_2	58	64	PF00498	0.453
LIG_Integrin_isoDGR_2	138	140	PF01839	0.412
LIG_LIR_Apic_2	250	254	PF02991	0.612
LIG_LIR_Apic_2	29	34	PF02991	0.402
LIG_LIR_Apic_2	320	325	PF02991	0.418
LIG_LIR_Apic_2	428	433	PF02991	0.625
LIG_LIR_Gen_1	119	129	PF02991	0.402
LIG_LIR_Gen_1	15	25	PF02991	0.367
LIG_LIR_Gen_1	178	189	PF02991	0.644
LIG_LIR_Gen_1	95	105	PF02991	0.368
LIG_LIR_Nem_3	119	124	PF02991	0.406
LIG_LIR_Nem_3	15	20	PF02991	0.361
LIG_LIR_Nem_3	178	184	PF02991	0.637
LIG_LIR_Nem_3	304	308	PF02991	0.381
LIG_LIR_Nem_3	95	100	PF02991	0.371
LIG_MYND_1	187	191	PF01753	0.644
LIG_MYND_1	214	218	PF01753	0.618
LIG_PROFILIN_1	190	196	PF00235	0.480
LIG_PROFILIN_1	209	215	PF00235	0.567
LIG_PROFILIN_1	459	465	PF00235	0.627
LIG_PTB_Apo_2	323	330	PF02174	0.442
LIG_PTB_Apo_2	72	79	PF02174	0.467
LIG_PTB_Phospho_1	72	78	PF10480	0.466
LIG_REV1ctd_RIR_1	79	84	PF16727	0.390
LIG_SH2_CRK	181	185	PF00017	0.609
LIG_SH2_CRK	251	255	PF00017	0.688
LIG_SH2_CRK	31	35	PF00017	0.363
LIG_SH2_CRK	358	362	PF00017	0.371
LIG_SH2_CRK	509	513	PF00017	0.513
LIG_SH2_GRB2like	19	22	PF00017	0.395
LIG_SH2_NCK_1	509	513	PF00017	0.513
LIG_SH2_NCK_1	91	95	PF00017	0.399
LIG_SH2_PTP2	97	100	PF00017	0.352
LIG_SH2_SRC	19	22	PF00017	0.395
LIG_SH2_STAP1	358	362	PF00017	0.371
LIG_SH2_STAT3	161	164	PF00017	0.511
LIG_SH2_STAT5	101	104	PF00017	0.408
LIG_SH2_STAT5	117	120	PF00017	0.397
LIG_SH2_STAT5	167	170	PF00017	0.378
LIG_SH2_STAT5	19	22	PF00017	0.395
LIG_SH2_STAT5	308	311	PF00017	0.418
LIG_SH2_STAT5	322	325	PF00017	0.405
LIG_SH2_STAT5	38	41	PF00017	0.518
LIG_SH2_STAT5	430	433	PF00017	0.637
LIG_SH2_STAT5	97	100	PF00017	0.388
LIG_SH3_1	251	257	PF00018	0.607
LIG_SH3_1	458	464	PF00018	0.682
LIG_SH3_2	193	198	PF14604	0.623
LIG_SH3_3	184	190	PF00018	0.574
LIG_SH3_3	191	197	PF00018	0.554
LIG_SH3_3	205	211	PF00018	0.662
LIG_SH3_3	212	218	PF00018	0.565
LIG_SH3_3	219	225	PF00018	0.571
LIG_SH3_3	251	257	PF00018	0.607
LIG_SH3_3	429	435	PF00018	0.637
LIG_SH3_3	453	459	PF00018	0.675
LIG_SH3_3	475	481	PF00018	0.787
LIG_SH3_3	572	578	PF00018	0.713
LIG_SH3_CIN85_PxpxPR_1	193	198	PF14604	0.532
LIG_Sin3_3	543	550	PF02671	0.503
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.389
LIG_SUMO_SIM_par_1	415	422	PF11976	0.362
LIG_TYR_ITSM	93	100	PF00017	0.404
LIG_WRC_WIRS_1	118	123	PF05994	0.381
LIG_WW_2	214	217	PF00397	0.613
LIG_WW_3	195	199	PF00397	0.598
MOD_CK1_1	10	16	PF00069	0.555
MOD_CK1_1	276	282	PF00069	0.555
MOD_CK1_1	351	357	PF00069	0.491
MOD_CK1_1	390	396	PF00069	0.454
MOD_CK1_1	502	508	PF00069	0.788
MOD_CK1_1	518	524	PF00069	0.622
MOD_CK1_1	525	531	PF00069	0.697
MOD_CK1_1	573	579	PF00069	0.636
MOD_CK1_1	583	589	PF00069	0.653
MOD_CK2_1	106	112	PF00069	0.390
MOD_CK2_1	168	174	PF00069	0.426
MOD_CK2_1	332	338	PF00069	0.434
MOD_CK2_1	58	64	PF00069	0.447
MOD_GlcNHglycan	484	487	PF01048	0.615
MOD_GlcNHglycan	504	507	PF01048	0.595
MOD_GlcNHglycan	517	520	PF01048	0.782
MOD_GlcNHglycan	537	540	PF01048	0.610
MOD_GlcNHglycan	60	63	PF01048	0.462
MOD_GlcNHglycan	7	10	PF01048	0.703
MOD_GSK3_1	1	8	PF00069	0.596
MOD_GSK3_1	267	274	PF00069	0.684
MOD_GSK3_1	347	354	PF00069	0.524
MOD_GSK3_1	518	525	PF00069	0.689
MOD_GSK3_1	559	566	PF00069	0.679
MOD_GSK3_1	569	576	PF00069	0.607
MOD_GSK3_1	86	93	PF00069	0.445
MOD_N-GLC_1	107	112	PF02516	0.395
MOD_N-GLC_1	499	504	PF02516	0.823
MOD_N-GLC_1	564	569	PF02516	0.724
MOD_NEK2_1	265	270	PF00069	0.709
MOD_NEK2_1	281	286	PF00069	0.663
MOD_NEK2_1	347	352	PF00069	0.459
MOD_NEK2_1	419	424	PF00069	0.497
MOD_NEK2_1	65	70	PF00069	0.293
MOD_NEK2_1	90	95	PF00069	0.432
MOD_NEK2_2	287	292	PF00069	0.628
MOD_NEK2_2	527	532	PF00069	0.573
MOD_PIKK_1	258	264	PF00454	0.634
MOD_PKA_2	227	233	PF00069	0.616
MOD_PKB_1	407	415	PF00069	0.449
MOD_Plk_4	227	233	PF00069	0.605
MOD_Plk_4	301	307	PF00069	0.392
MOD_Plk_4	351	357	PF00069	0.456
MOD_Plk_4	583	589	PF00069	0.573
MOD_Plk_4	86	92	PF00069	0.426
MOD_ProDKin_1	107	113	PF00069	0.475
MOD_ProDKin_1	12	18	PF00069	0.483
MOD_ProDKin_1	240	246	PF00069	0.615
MOD_ProDKin_1	276	282	PF00069	0.692
MOD_ProDKin_1	348	354	PF00069	0.391
MOD_ProDKin_1	431	437	PF00069	0.670
MOD_ProDKin_1	474	480	PF00069	0.572
MOD_ProDKin_1	508	514	PF00069	0.612
MOD_ProDKin_1	522	528	PF00069	0.669
MOD_ProDKin_1	571	577	PF00069	0.802
TRG_ENDOCYTIC_2	167	170	PF00928	0.378
TRG_ENDOCYTIC_2	181	184	PF00928	0.661
TRG_ENDOCYTIC_2	358	361	PF00928	0.362
TRG_ENDOCYTIC_2	36	39	PF00928	0.463
TRG_ENDOCYTIC_2	78	81	PF00928	0.367
TRG_ENDOCYTIC_2	97	100	PF00928	0.352
TRG_ER_diArg_1	235	237	PF00400	0.594
TRG_ER_diArg_1	407	410	PF00400	0.451
TRG_ER_diArg_1	443	446	PF00400	0.624
TRG_NES_CRM1_1	112	126	PF08389	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM94	Leptomonas seymouri	54%	94%
A0A3S7WYR7	Leishmania donovani	94%	100%
A4HDX6	Leishmania braziliensis	82%	100%
A4I171	Leishmania infantum	94%	100%
Q4QA67	Leishmania major	93%	99%