LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AXA1_LEIMU
TriTrypDb:
LmxM.25.0250
Length:
877

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXA1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXA1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 428 432 PF00656 0.520
CLV_C14_Caspase3-7 43 47 PF00656 0.486
CLV_C14_Caspase3-7 513 517 PF00656 0.356
CLV_C14_Caspase3-7 697 701 PF00656 0.587
CLV_NRD_NRD_1 49 51 PF00675 0.397
CLV_NRD_NRD_1 650 652 PF00675 0.468
CLV_NRD_NRD_1 870 872 PF00675 0.670
CLV_NRD_NRD_1 97 99 PF00675 0.582
CLV_PCSK_KEX2_1 650 652 PF00082 0.468
CLV_PCSK_KEX2_1 869 871 PF00082 0.677
CLV_PCSK_KEX2_1 97 99 PF00082 0.582
CLV_PCSK_SKI1_1 19 23 PF00082 0.554
CLV_PCSK_SKI1_1 229 233 PF00082 0.566
CLV_PCSK_SKI1_1 264 268 PF00082 0.252
CLV_PCSK_SKI1_1 570 574 PF00082 0.469
CLV_PCSK_SKI1_1 696 700 PF00082 0.508
CLV_PCSK_SKI1_1 748 752 PF00082 0.584
CLV_PCSK_SKI1_1 763 767 PF00082 0.574
CLV_Separin_Metazoa 760 764 PF03568 0.553
DEG_APCC_DBOX_1 586 594 PF00400 0.502
DEG_APCC_DBOX_1 695 703 PF00400 0.522
DEG_APCC_DBOX_1 708 716 PF00400 0.550
DEG_Nend_Nbox_1 1 3 PF02207 0.344
DEG_SCF_FBW7_1 398 405 PF00400 0.510
DEG_SPOP_SBC_1 57 61 PF00917 0.338
DOC_CDC14_PxL_1 862 870 PF14671 0.622
DOC_CKS1_1 399 404 PF01111 0.665
DOC_CKS1_1 77 82 PF01111 0.487
DOC_CKS1_1 872 877 PF01111 0.639
DOC_CYCLIN_RxL_1 619 631 PF00134 0.475
DOC_CYCLIN_yCln2_LP_2 262 268 PF00134 0.324
DOC_MAPK_gen_1 495 503 PF00069 0.375
DOC_MAPK_gen_1 584 592 PF00069 0.536
DOC_MAPK_gen_1 620 628 PF00069 0.482
DOC_PP4_FxxP_1 418 421 PF00568 0.544
DOC_USP7_MATH_1 237 241 PF00917 0.423
DOC_USP7_MATH_1 359 363 PF00917 0.664
DOC_USP7_MATH_1 388 392 PF00917 0.590
DOC_USP7_MATH_1 422 426 PF00917 0.631
DOC_USP7_MATH_1 517 521 PF00917 0.523
DOC_USP7_MATH_1 542 546 PF00917 0.514
DOC_USP7_MATH_1 550 554 PF00917 0.493
DOC_USP7_MATH_1 560 564 PF00917 0.558
DOC_USP7_MATH_1 572 576 PF00917 0.478
DOC_USP7_MATH_1 670 674 PF00917 0.567
DOC_USP7_MATH_1 701 705 PF00917 0.420
DOC_USP7_UBL2_3 643 647 PF12436 0.543
DOC_WW_Pin1_4 246 251 PF00397 0.410
DOC_WW_Pin1_4 277 282 PF00397 0.420
DOC_WW_Pin1_4 398 403 PF00397 0.625
DOC_WW_Pin1_4 417 422 PF00397 0.490
DOC_WW_Pin1_4 76 81 PF00397 0.422
DOC_WW_Pin1_4 780 785 PF00397 0.646
DOC_WW_Pin1_4 799 804 PF00397 0.628
DOC_WW_Pin1_4 834 839 PF00397 0.611
DOC_WW_Pin1_4 871 876 PF00397 0.639
LIG_14-3-3_CanoR_1 187 195 PF00244 0.488
LIG_14-3-3_CanoR_1 229 238 PF00244 0.465
LIG_14-3-3_CanoR_1 28 33 PF00244 0.459
LIG_14-3-3_CanoR_1 305 314 PF00244 0.379
LIG_14-3-3_CanoR_1 408 416 PF00244 0.593
LIG_14-3-3_CanoR_1 48 54 PF00244 0.267
LIG_14-3-3_CanoR_1 519 523 PF00244 0.445
LIG_14-3-3_CanoR_1 539 548 PF00244 0.383
LIG_14-3-3_CanoR_1 584 593 PF00244 0.609
LIG_14-3-3_CanoR_1 687 695 PF00244 0.457
LIG_14-3-3_CanoR_1 82 90 PF00244 0.440
LIG_14-3-3_CanoR_1 843 850 PF00244 0.664
LIG_14-3-3_CanoR_1 97 102 PF00244 0.471
LIG_Actin_WH2_2 480 497 PF00022 0.554
LIG_BRCT_BRCA1_1 200 204 PF00533 0.403
LIG_BRCT_BRCA1_1 208 212 PF00533 0.490
LIG_BRCT_BRCA1_1 367 371 PF00533 0.503
LIG_BRCT_BRCA1_1 390 394 PF00533 0.657
LIG_BRCT_BRCA1_1 813 817 PF00533 0.633
LIG_CaM_IQ_9 20 36 PF13499 0.314
LIG_FHA_1 255 261 PF00498 0.418
LIG_FHA_1 327 333 PF00498 0.599
LIG_FHA_1 469 475 PF00498 0.519
LIG_FHA_1 599 605 PF00498 0.667
LIG_FHA_1 705 711 PF00498 0.538
LIG_FHA_1 813 819 PF00498 0.638
LIG_FHA_2 129 135 PF00498 0.487
LIG_FHA_2 153 159 PF00498 0.443
LIG_FHA_2 163 169 PF00498 0.447
LIG_FHA_2 221 227 PF00498 0.428
LIG_FHA_2 290 296 PF00498 0.388
LIG_FHA_2 38 44 PF00498 0.424
LIG_FHA_2 438 444 PF00498 0.618
LIG_FHA_2 495 501 PF00498 0.468
LIG_FHA_2 674 680 PF00498 0.666
LIG_FHA_2 687 693 PF00498 0.439
LIG_FHA_2 98 104 PF00498 0.454
LIG_GBD_Chelix_1 582 590 PF00786 0.448
LIG_HCF-1_HBM_1 618 621 PF13415 0.514
LIG_Integrin_RGD_1 578 580 PF01839 0.415
LIG_LIR_Apic_2 443 448 PF02991 0.565
LIG_LIR_Gen_1 162 172 PF02991 0.404
LIG_LIR_Gen_1 189 200 PF02991 0.389
LIG_LIR_Gen_1 216 227 PF02991 0.363
LIG_LIR_Gen_1 63 74 PF02991 0.421
LIG_LIR_Nem_3 14 20 PF02991 0.475
LIG_LIR_Nem_3 162 167 PF02991 0.404
LIG_LIR_Nem_3 169 175 PF02991 0.390
LIG_LIR_Nem_3 178 184 PF02991 0.394
LIG_LIR_Nem_3 189 195 PF02991 0.289
LIG_LIR_Nem_3 216 222 PF02991 0.380
LIG_LIR_Nem_3 23 29 PF02991 0.433
LIG_LIR_Nem_3 278 282 PF02991 0.375
LIG_LIR_Nem_3 470 475 PF02991 0.497
LIG_LIR_Nem_3 52 58 PF02991 0.408
LIG_LIR_Nem_3 63 69 PF02991 0.332
LIG_LIR_Nem_3 837 842 PF02991 0.581
LIG_LIR_Nem_3 849 853 PF02991 0.601
LIG_NRBOX 258 264 PF00104 0.397
LIG_Pex14_1 275 279 PF04695 0.328
LIG_Pex14_2 202 206 PF04695 0.397
LIG_Pex14_2 293 297 PF04695 0.386
LIG_REV1ctd_RIR_1 369 377 PF16727 0.517
LIG_RPA_C_Fungi 230 242 PF08784 0.454
LIG_RPA_C_Fungi 645 657 PF08784 0.527
LIG_SH2_CRK 17 21 PF00017 0.436
LIG_SH2_CRK 445 449 PF00017 0.564
LIG_SH2_CRK 472 476 PF00017 0.488
LIG_SH2_CRK 66 70 PF00017 0.413
LIG_SH2_NCK_1 445 449 PF00017 0.564
LIG_SH2_PTP2 172 175 PF00017 0.349
LIG_SH2_SRC 522 525 PF00017 0.359
LIG_SH2_STAP1 307 311 PF00017 0.364
LIG_SH2_STAP1 522 526 PF00017 0.534
LIG_SH2_STAP1 66 70 PF00017 0.467
LIG_SH2_STAP1 743 747 PF00017 0.485
LIG_SH2_STAT3 743 746 PF00017 0.542
LIG_SH2_STAT5 172 175 PF00017 0.412
LIG_SH2_STAT5 261 264 PF00017 0.438
LIG_SH2_STAT5 30 33 PF00017 0.354
LIG_SH3_1 869 875 PF00018 0.688
LIG_SH3_2 838 843 PF14604 0.532
LIG_SH3_3 114 120 PF00018 0.490
LIG_SH3_3 341 347 PF00018 0.509
LIG_SH3_3 396 402 PF00018 0.676
LIG_SH3_3 418 424 PF00018 0.629
LIG_SH3_3 447 453 PF00018 0.506
LIG_SH3_3 66 72 PF00018 0.396
LIG_SH3_3 74 80 PF00018 0.369
LIG_SH3_3 765 771 PF00018 0.600
LIG_SH3_3 835 841 PF00018 0.530
LIG_SH3_3 869 875 PF00018 0.688
LIG_SUMO_SIM_anti_2 280 286 PF11976 0.455
LIG_SUMO_SIM_anti_2 308 315 PF11976 0.450
LIG_SUMO_SIM_anti_2 38 43 PF11976 0.412
LIG_SUMO_SIM_anti_2 588 594 PF11976 0.508
LIG_SUMO_SIM_par_1 280 286 PF11976 0.455
LIG_SUMO_SIM_par_1 40 46 PF11976 0.473
LIG_SUMO_SIM_par_1 624 629 PF11976 0.526
LIG_SUMO_SIM_par_1 86 91 PF11976 0.365
LIG_TRAF2_1 292 295 PF00917 0.459
LIG_TRAF2_1 458 461 PF00917 0.630
LIG_TRAF2_1 563 566 PF00917 0.744
LIG_TRAF2_1 676 679 PF00917 0.508
LIG_TRAF2_1 849 852 PF00917 0.540
LIG_TRFH_1 261 265 PF08558 0.338
LIG_UBA3_1 259 264 PF00899 0.424
LIG_WRC_WIRS_1 199 204 PF05994 0.325
LIG_WRC_WIRS_1 219 224 PF05994 0.215
LIG_WRC_WIRS_1 276 281 PF05994 0.417
LIG_WW_3 802 806 PF00397 0.663
MOD_CDK_SPxK_1 76 82 PF00069 0.480
MOD_CDK_SPxK_1 799 805 PF00069 0.664
MOD_CK1_1 11 17 PF00069 0.591
MOD_CK1_1 128 134 PF00069 0.435
MOD_CK1_1 177 183 PF00069 0.466
MOD_CK1_1 280 286 PF00069 0.402
MOD_CK1_1 426 432 PF00069 0.740
MOD_CK1_1 543 549 PF00069 0.499
MOD_CK1_1 553 559 PF00069 0.532
MOD_CK1_1 60 66 PF00069 0.494
MOD_CK1_1 673 679 PF00069 0.511
MOD_CK1_1 704 710 PF00069 0.489
MOD_CK1_1 752 758 PF00069 0.519
MOD_CK1_1 825 831 PF00069 0.651
MOD_CK1_1 846 852 PF00069 0.646
MOD_CK2_1 152 158 PF00069 0.453
MOD_CK2_1 162 168 PF00069 0.454
MOD_CK2_1 220 226 PF00069 0.414
MOD_CK2_1 280 286 PF00069 0.452
MOD_CK2_1 289 295 PF00069 0.413
MOD_CK2_1 560 566 PF00069 0.562
MOD_CK2_1 671 677 PF00069 0.637
MOD_CK2_1 686 692 PF00069 0.406
MOD_CK2_1 846 852 PF00069 0.551
MOD_DYRK1A_RPxSP_1 871 875 PF00069 0.638
MOD_GlcNHglycan 12 16 PF01048 0.476
MOD_GlcNHglycan 127 130 PF01048 0.431
MOD_GlcNHglycan 239 242 PF01048 0.427
MOD_GlcNHglycan 321 324 PF01048 0.574
MOD_GlcNHglycan 379 382 PF01048 0.647
MOD_GlcNHglycan 390 393 PF01048 0.695
MOD_GlcNHglycan 411 414 PF01048 0.690
MOD_GlcNHglycan 460 465 PF01048 0.528
MOD_GlcNHglycan 552 555 PF01048 0.544
MOD_GlcNHglycan 673 676 PF01048 0.525
MOD_GlcNHglycan 822 827 PF01048 0.723
MOD_GlcNHglycan 845 848 PF01048 0.772
MOD_GlcNHglycan 93 96 PF01048 0.504
MOD_GSK3_1 121 128 PF00069 0.452
MOD_GSK3_1 246 253 PF00069 0.419
MOD_GSK3_1 28 35 PF00069 0.568
MOD_GSK3_1 355 362 PF00069 0.581
MOD_GSK3_1 373 380 PF00069 0.656
MOD_GSK3_1 398 405 PF00069 0.701
MOD_GSK3_1 407 414 PF00069 0.646
MOD_GSK3_1 422 429 PF00069 0.574
MOD_GSK3_1 456 463 PF00069 0.599
MOD_GSK3_1 56 63 PF00069 0.401
MOD_GSK3_1 735 742 PF00069 0.604
MOD_GSK3_1 776 783 PF00069 0.679
MOD_N-GLC_1 134 139 PF02516 0.475
MOD_N-GLC_1 213 218 PF02516 0.369
MOD_N-GLC_1 314 319 PF02516 0.525
MOD_NEK2_1 109 114 PF00069 0.448
MOD_NEK2_1 20 25 PF00069 0.360
MOD_NEK2_1 206 211 PF00069 0.424
MOD_NEK2_1 231 236 PF00069 0.437
MOD_NEK2_1 254 259 PF00069 0.382
MOD_NEK2_1 306 311 PF00069 0.417
MOD_NEK2_1 314 319 PF00069 0.557
MOD_NEK2_1 355 360 PF00069 0.537
MOD_NEK2_1 371 376 PF00069 0.752
MOD_NEK2_1 409 414 PF00069 0.592
MOD_NEK2_1 58 63 PF00069 0.527
MOD_NEK2_1 73 78 PF00069 0.319
MOD_NEK2_1 735 740 PF00069 0.544
MOD_NEK2_1 798 803 PF00069 0.754
MOD_PIKK_1 20 26 PF00454 0.420
MOD_PIKK_1 365 371 PF00454 0.753
MOD_PIKK_1 402 408 PF00454 0.635
MOD_PIKK_1 572 578 PF00454 0.602
MOD_PIKK_1 60 66 PF00454 0.412
MOD_PIKK_1 704 710 PF00454 0.509
MOD_PIKK_1 81 87 PF00454 0.465
MOD_PKA_1 505 511 PF00069 0.436
MOD_PKA_1 97 103 PF00069 0.458
MOD_PKA_2 186 192 PF00069 0.496
MOD_PKA_2 364 370 PF00069 0.573
MOD_PKA_2 407 413 PF00069 0.651
MOD_PKA_2 49 55 PF00069 0.446
MOD_PKA_2 494 500 PF00069 0.511
MOD_PKA_2 518 524 PF00069 0.502
MOD_PKA_2 670 676 PF00069 0.480
MOD_PKA_2 686 692 PF00069 0.497
MOD_PKA_2 81 87 PF00069 0.465
MOD_PKA_2 97 103 PF00069 0.488
MOD_PKB_1 363 371 PF00069 0.501
MOD_Plk_1 134 140 PF00069 0.455
MOD_Plk_1 177 183 PF00069 0.469
MOD_Plk_1 213 219 PF00069 0.364
MOD_Plk_1 35 41 PF00069 0.450
MOD_Plk_1 543 549 PF00069 0.489
MOD_Plk_1 775 781 PF00069 0.636
MOD_Plk_2-3 134 140 PF00069 0.506
MOD_Plk_2-3 152 158 PF00069 0.566
MOD_Plk_2-3 289 295 PF00069 0.463
MOD_Plk_2-3 510 516 PF00069 0.539
MOD_Plk_2-3 686 692 PF00069 0.512
MOD_Plk_4 152 158 PF00069 0.508
MOD_Plk_4 28 34 PF00069 0.391
MOD_Plk_4 280 286 PF00069 0.498
MOD_Plk_4 314 320 PF00069 0.474
MOD_Plk_4 543 549 PF00069 0.437
MOD_Plk_4 73 79 PF00069 0.435
MOD_Plk_4 97 103 PF00069 0.442
MOD_ProDKin_1 246 252 PF00069 0.404
MOD_ProDKin_1 277 283 PF00069 0.426
MOD_ProDKin_1 398 404 PF00069 0.625
MOD_ProDKin_1 417 423 PF00069 0.489
MOD_ProDKin_1 76 82 PF00069 0.430
MOD_ProDKin_1 780 786 PF00069 0.645
MOD_ProDKin_1 799 805 PF00069 0.630
MOD_ProDKin_1 834 840 PF00069 0.612
MOD_ProDKin_1 871 877 PF00069 0.641
MOD_SUMO_for_1 750 753 PF00179 0.503
MOD_SUMO_rev_2 744 752 PF00179 0.500
TRG_DiLeu_BaEn_1 599 604 PF01217 0.528
TRG_DiLeu_BaEn_2 678 684 PF01217 0.517
TRG_DiLeu_BaLyEn_6 69 74 PF01217 0.429
TRG_ENDOCYTIC_2 17 20 PF00928 0.490
TRG_ENDOCYTIC_2 172 175 PF00928 0.376
TRG_ENDOCYTIC_2 29 32 PF00928 0.360
TRG_ENDOCYTIC_2 472 475 PF00928 0.488
TRG_ENDOCYTIC_2 55 58 PF00928 0.450
TRG_ENDOCYTIC_2 66 69 PF00928 0.333
TRG_ER_diArg_1 361 364 PF00400 0.634
TRG_ER_diArg_1 536 539 PF00400 0.424
TRG_ER_diArg_1 621 624 PF00400 0.478
TRG_ER_diArg_1 693 696 PF00400 0.503
TRG_ER_diArg_1 709 712 PF00400 0.452
TRG_ER_diArg_1 842 845 PF00400 0.709
TRG_ER_diArg_1 868 871 PF00400 0.676
TRG_NLS_MonoExtC_3 504 509 PF00514 0.438
TRG_NLS_MonoExtN_4 502 509 PF00514 0.444
TRG_Pf-PMV_PEXEL_1 509 514 PF00026 0.495
TRG_Pf-PMV_PEXEL_1 584 589 PF00026 0.510
TRG_Pf-PMV_PEXEL_1 624 629 PF00026 0.507
TRG_Pf-PMV_PEXEL_1 748 753 PF00026 0.545

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDP5 Leptomonas seymouri 48% 97%
A0A3Q8IN51 Leishmania donovani 89% 100%
A0A3R7KB27 Trypanosoma rangeli 30% 96%
A4HDX2 Leishmania braziliensis 73% 100%
A4I167 Leishmania infantum 88% 100%
Q4QA71 Leishmania major 86% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS