Pre-mRNA-splicing factor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA-splicing factor of RES complex, putative

Species:

Leishmania mexicana

UniProt:

E9AXA0_LEIMU

TriTrypDb:

LmxM.25.0240

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.373
CLV_C14_Caspase3-7	82	86	PF00656	0.601
CLV_C14_Caspase3-7	93	97	PF00656	0.460
CLV_NRD_NRD_1	159	161	PF00675	0.300
CLV_NRD_NRD_1	9	11	PF00675	0.578
CLV_PCSK_KEX2_1	115	117	PF00082	0.378
CLV_PCSK_KEX2_1	7	9	PF00082	0.580
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.378
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.580
CLV_PCSK_SKI1_1	115	119	PF00082	0.426
DEG_SPOP_SBC_1	23	27	PF00917	0.426
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.410
DOC_PP2B_LxvP_1	126	129	PF13499	0.412
DOC_USP7_MATH_1	151	155	PF00917	0.525
DOC_USP7_MATH_1	22	26	PF00917	0.529
DOC_WW_Pin1_4	24	29	PF00397	0.515
LIG_14-3-3_CanoR_1	116	125	PF00244	0.381
LIG_14-3-3_CanoR_1	137	144	PF00244	0.508
LIG_14-3-3_CanoR_1	160	164	PF00244	0.478
LIG_14-3-3_CanoR_1	24	28	PF00244	0.535
LIG_14-3-3_CanoR_1	81	87	PF00244	0.563
LIG_APCC_ABBAyCdc20_2	99	105	PF00400	0.564
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_FHA_1	138	144	PF00498	0.458
LIG_FHA_1	24	30	PF00498	0.472
LIG_FHA_1	38	44	PF00498	0.539
LIG_FHA_2	43	49	PF00498	0.674
LIG_FHA_2	67	73	PF00498	0.687
LIG_LIR_Gen_1	17	28	PF02991	0.559
LIG_LIR_Nem_3	113	117	PF02991	0.674
LIG_LIR_Nem_3	17	23	PF02991	0.577
LIG_PTB_Apo_2	121	128	PF02174	0.441
LIG_SH2_CRK	114	118	PF00017	0.448
LIG_SH2_GRB2like	163	166	PF00017	0.484
LIG_SH2_PTP2	20	23	PF00017	0.575
LIG_SH2_STAT5	132	135	PF00017	0.421
LIG_SH2_STAT5	20	23	PF00017	0.651
LIG_SH3_3	61	67	PF00018	0.520
LIG_UBA3_1	126	135	PF00899	0.479
MOD_CK2_1	66	72	PF00069	0.671
MOD_DYRK1A_RPxSP_1	24	28	PF00069	0.459
MOD_GlcNHglycan	1	4	PF01048	0.772
MOD_GlcNHglycan	118	121	PF01048	0.508
MOD_GlcNHglycan	92	95	PF01048	0.575
MOD_GSK3_1	55	62	PF00069	0.632
MOD_NEK2_1	59	64	PF00069	0.637
MOD_NEK2_1	79	84	PF00069	0.516
MOD_OFUCOSY	134	139	PF10250	0.462
MOD_PIKK_1	142	148	PF00454	0.586
MOD_PKA_2	159	165	PF00069	0.437
MOD_PKA_2	23	29	PF00069	0.541
MOD_PKA_2	80	86	PF00069	0.609
MOD_PKB_1	8	16	PF00069	0.566
MOD_Plk_2-3	42	48	PF00069	0.690
MOD_ProDKin_1	24	30	PF00069	0.512
MOD_SUMO_rev_2	105	110	PF00179	0.449
MOD_SUMO_rev_2	154	162	PF00179	0.277
TRG_DiLeu_BaEn_1	113	118	PF01217	0.474
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.506
TRG_DiLeu_LyEn_5	113	118	PF01217	0.375
TRG_ENDOCYTIC_2	114	117	PF00928	0.475
TRG_ENDOCYTIC_2	147	150	PF00928	0.383
TRG_ENDOCYTIC_2	20	23	PF00928	0.575
TRG_ER_diArg_1	179	182	PF00400	0.469
TRG_ER_diArg_1	8	10	PF00400	0.578
TRG_NES_CRM1_1	121	131	PF08389	0.438
TRG_NLS_MonoCore_2	6	11	PF00514	0.576
TRG_NLS_MonoExtC_3	6	12	PF00514	0.574
TRG_NLS_MonoExtN_4	5	11	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X4	Leptomonas seymouri	46%	96%
A0A3Q8ICC4	Leishmania donovani	83%	100%
A4HDX1	Leishmania braziliensis	68%	100%
A4I166	Leishmania infantum	82%	100%
Q4QA72	Leishmania major	87%	100%