TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dual specificity phosphatase, catalytic domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AX99_LEIMU

TriTrypDb:

LmxM.25.0230

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AX99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX99

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016311	dephosphorylation	5	12
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0016310	phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	8	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	187	189	PF00675	0.331
CLV_NRD_NRD_1	227	229	PF00675	0.383
CLV_NRD_NRD_1	45	47	PF00675	0.502
CLV_PCSK_KEX2_1	219	221	PF00082	0.287
CLV_PCSK_KEX2_1	269	271	PF00082	0.393
CLV_PCSK_KEX2_1	44	46	PF00082	0.473
CLV_PCSK_KEX2_1	55	57	PF00082	0.520
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.287
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.393
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.599
CLV_PCSK_SKI1_1	294	298	PF00082	0.663
CLV_PCSK_SKI1_1	55	59	PF00082	0.576
CLV_PCSK_SKI1_1	9	13	PF00082	0.439
DEG_Nend_UBRbox_3	1	3	PF02207	0.624
DOC_CYCLIN_RxL_1	289	299	PF00134	0.477
DOC_MAPK_gen_1	226	234	PF00069	0.318
DOC_MAPK_MEF2A_6	155	163	PF00069	0.320
DOC_USP7_MATH_1	275	279	PF00917	0.325
DOC_WW_Pin1_4	273	278	PF00397	0.279
LIG_14-3-3_CanoR_1	155	160	PF00244	0.477
LIG_14-3-3_CanoR_1	228	233	PF00244	0.411
LIG_14-3-3_CanoR_1	45	51	PF00244	0.523
LIG_BRCT_BRCA1_1	7	11	PF00533	0.646
LIG_eIF4E_1	93	99	PF01652	0.391
LIG_FHA_1	113	119	PF00498	0.520
LIG_FHA_1	122	128	PF00498	0.272
LIG_FHA_1	156	162	PF00498	0.412
LIG_FHA_1	229	235	PF00498	0.360
LIG_FHA_1	69	75	PF00498	0.722
LIG_FHA_2	10	16	PF00498	0.599
LIG_FHA_2	31	37	PF00498	0.516
LIG_FHA_2	47	53	PF00498	0.510
LIG_FHA_2	70	76	PF00498	0.658
LIG_LIR_Gen_1	196	203	PF02991	0.331
LIG_LIR_Nem_3	184	190	PF02991	0.314
LIG_LIR_Nem_3	196	200	PF02991	0.286
LIG_Pex14_2	282	286	PF04695	0.350
LIG_SH2_STAT5	106	109	PF00017	0.490
LIG_SH2_STAT5	233	236	PF00017	0.266
LIG_SH2_STAT5	250	253	PF00017	0.266
LIG_SH2_STAT5	93	96	PF00017	0.374
LIG_SUMO_SIM_anti_2	261	267	PF11976	0.276
LIG_TRAF2_1	12	15	PF00917	0.583
LIG_TRAF2_1	4	7	PF00917	0.702
LIG_TRAF2_1	73	76	PF00917	0.694
LIG_TYR_ITIM	195	200	PF00017	0.281
LIG_WRC_WIRS_1	47	52	PF05994	0.418
MOD_CDK_SPxxK_3	273	280	PF00069	0.337
MOD_CK2_1	255	261	PF00069	0.265
MOD_CK2_1	28	34	PF00069	0.473
MOD_CK2_1	46	52	PF00069	0.417
MOD_CK2_1	69	75	PF00069	0.705
MOD_CK2_1	9	15	PF00069	0.606
MOD_Cter_Amidation	53	56	PF01082	0.402
MOD_GlcNHglycan	140	143	PF01048	0.433
MOD_GlcNHglycan	2	5	PF01048	0.707
MOD_GlcNHglycan	81	84	PF01048	0.584
MOD_GSK3_1	108	115	PF00069	0.486
MOD_GSK3_1	133	140	PF00069	0.439
MOD_GSK3_1	240	247	PF00069	0.393
MOD_GSK3_1	292	299	PF00069	0.377
MOD_GSK3_1	5	12	PF00069	0.599
MOD_GSK3_1	77	84	PF00069	0.635
MOD_GSK3_1	94	101	PF00069	0.325
MOD_N-GLC_1	155	160	PF02516	0.353
MOD_NEK2_1	202	207	PF00069	0.415
MOD_NEK2_1	290	295	PF00069	0.380
MOD_NEK2_1	296	301	PF00069	0.462
MOD_NEK2_1	94	99	PF00069	0.411
MOD_OFUCOSY	249	254	PF10250	0.387
MOD_PIKK_1	133	139	PF00454	0.454
MOD_PIKK_1	143	149	PF00454	0.429
MOD_PIKK_1	275	281	PF00454	0.298
MOD_PIKK_1	38	44	PF00454	0.565
MOD_PIKK_1	9	15	PF00454	0.482
MOD_PKA_1	228	234	PF00069	0.411
MOD_PKA_2	108	114	PF00069	0.507
MOD_PKB_1	44	52	PF00069	0.312
MOD_Plk_1	14	20	PF00069	0.586
MOD_Plk_1	155	161	PF00069	0.348
MOD_Plk_1	38	44	PF00069	0.456
MOD_Plk_4	228	234	PF00069	0.411
MOD_Plk_4	46	52	PF00069	0.463
MOD_Plk_4	94	100	PF00069	0.385
MOD_ProDKin_1	273	279	PF00069	0.279
MOD_SUMO_rev_2	222	231	PF00179	0.210
MOD_SUMO_rev_2	52	57	PF00179	0.629
TRG_DiLeu_BaEn_1	186	191	PF01217	0.331
TRG_DiLeu_BaEn_1	261	266	PF01217	0.276
TRG_DiLeu_BaEn_1	53	58	PF01217	0.597
TRG_DiLeu_BaEn_4	14	20	PF01217	0.568
TRG_DiLeu_LyEn_5	53	58	PF01217	0.455
TRG_ENDOCYTIC_2	197	200	PF00928	0.281
TRG_ENDOCYTIC_2	47	50	PF00928	0.361
TRG_ER_diArg_1	43	46	PF00400	0.445
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A1	Leptomonas seymouri	66%	100%
A0A0S4JDL0	Bodo saltans	47%	87%
A0A1X0P5C5	Trypanosomatidae	50%	100%
A0A3Q8IF49	Leishmania donovani	94%	100%
A0A3R7ME04	Trypanosoma rangeli	53%	100%
A4HDX0	Leishmania braziliensis	83%	100%
A4I165	Leishmania infantum	94%	100%
D0A5F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
Q4QA73	Leishmania major	92%	100%
V5B7P3	Trypanosoma cruzi	53%	96%