RUN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX98_LEIMU

TriTrypDb:

LmxM.25.0220

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.543
CLV_C14_Caspase3-7	507	511	PF00656	0.501
CLV_C14_Caspase3-7	514	518	PF00656	0.432
CLV_NRD_NRD_1	142	144	PF00675	0.663
CLV_NRD_NRD_1	237	239	PF00675	0.553
CLV_NRD_NRD_1	253	255	PF00675	0.557
CLV_NRD_NRD_1	475	477	PF00675	0.459
CLV_PCSK_FUR_1	237	241	PF00082	0.557
CLV_PCSK_KEX2_1	237	239	PF00082	0.553
CLV_PCSK_KEX2_1	262	264	PF00082	0.616
CLV_PCSK_KEX2_1	313	315	PF00082	0.493
CLV_PCSK_KEX2_1	447	449	PF00082	0.522
CLV_PCSK_KEX2_1	475	477	PF00082	0.470
CLV_PCSK_KEX2_1	629	631	PF00082	0.634
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.558
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.727
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.493
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.522
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.634
CLV_PCSK_SKI1_1	360	364	PF00082	0.432
CLV_PCSK_SKI1_1	447	451	PF00082	0.502
CLV_PCSK_SKI1_1	55	59	PF00082	0.406
CLV_PCSK_SKI1_1	64	68	PF00082	0.411
CLV_PCSK_SKI1_1	77	81	PF00082	0.436
DEG_APCC_DBOX_1	237	245	PF00400	0.564
DEG_APCC_DBOX_1	54	62	PF00400	0.503
DEG_APCC_DBOX_1	76	84	PF00400	0.403
DOC_CYCLIN_RxL_1	444	454	PF00134	0.563
DOC_MAPK_gen_1	143	153	PF00069	0.664
DOC_MAPK_gen_1	313	321	PF00069	0.452
DOC_MAPK_gen_1	634	643	PF00069	0.663
DOC_MAPK_MEF2A_6	104	111	PF00069	0.443
DOC_MAPK_MEF2A_6	314	323	PF00069	0.439
DOC_MAPK_MEF2A_6	564	572	PF00069	0.533
DOC_PP4_FxxP_1	559	562	PF00568	0.554
DOC_PP4_FxxP_1	609	612	PF00568	0.580
DOC_USP7_MATH_1	127	131	PF00917	0.691
DOC_USP7_MATH_1	213	217	PF00917	0.527
DOC_USP7_MATH_1	281	285	PF00917	0.695
DOC_USP7_MATH_1	289	293	PF00917	0.572
DOC_USP7_MATH_1	516	520	PF00917	0.504
DOC_USP7_MATH_1	90	94	PF00917	0.543
DOC_USP7_UBL2_3	134	138	PF12436	0.718
DOC_WW_Pin1_4	364	369	PF00397	0.537
LIG_14-3-3_CanoR_1	146	154	PF00244	0.679
LIG_14-3-3_CanoR_1	343	348	PF00244	0.467
LIG_14-3-3_CanoR_1	418	427	PF00244	0.405
LIG_14-3-3_CanoR_1	448	453	PF00244	0.505
LIG_14-3-3_CanoR_1	550	558	PF00244	0.507
LIG_14-3-3_CanoR_1	569	573	PF00244	0.578
LIG_14-3-3_CanoR_1	634	639	PF00244	0.671
LIG_14-3-3_CanoR_1	91	99	PF00244	0.555
LIG_Actin_RPEL_3	526	545	PF02755	0.517
LIG_AP_GAE_1	596	602	PF02883	0.614
LIG_APCC_ABBA_1	524	529	PF00400	0.506
LIG_BIR_II_1	1	5	PF00653	0.481
LIG_BIR_III_4	432	436	PF00653	0.564
LIG_BRCT_BRCA1_1	107	111	PF00533	0.546
LIG_BRCT_BRCA1_1	366	370	PF00533	0.522
LIG_deltaCOP1_diTrp_1	94	99	PF00928	0.455
LIG_FHA_1	164	170	PF00498	0.634
LIG_FHA_1	367	373	PF00498	0.430
LIG_FHA_1	401	407	PF00498	0.329
LIG_FHA_1	420	426	PF00498	0.403
LIG_FHA_1	550	556	PF00498	0.553
LIG_FHA_1	626	632	PF00498	0.608
LIG_FHA_2	512	518	PF00498	0.540
LIG_FHA_2	652	658	PF00498	0.599
LIG_FHA_2	90	96	PF00498	0.571
LIG_LIR_Apic_2	608	612	PF02991	0.608
LIG_LIR_Gen_1	295	303	PF02991	0.499
LIG_LIR_Gen_1	361	370	PF02991	0.408
LIG_LIR_Gen_1	656	665	PF02991	0.709
LIG_LIR_Gen_1	93	103	PF02991	0.441
LIG_LIR_Nem_3	290	296	PF02991	0.572
LIG_LIR_Nem_3	355	359	PF02991	0.440
LIG_LIR_Nem_3	361	365	PF02991	0.412
LIG_LIR_Nem_3	367	373	PF02991	0.414
LIG_LIR_Nem_3	391	397	PF02991	0.489
LIG_LIR_Nem_3	482	488	PF02991	0.477
LIG_LIR_Nem_3	575	579	PF02991	0.440
LIG_LIR_Nem_3	656	662	PF02991	0.687
LIG_LIR_Nem_3	93	99	PF02991	0.452
LIG_Pex14_2	620	624	PF04695	0.624
LIG_SH2_SRC	198	201	PF00017	0.620
LIG_SH2_SRC	233	236	PF00017	0.645
LIG_SH2_STAP1	154	158	PF00017	0.390
LIG_SH3_3	197	203	PF00018	0.622
LIG_SH3_3	552	558	PF00018	0.506
LIG_SH3_3	559	565	PF00018	0.536
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.422
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.414
LIG_SUMO_SIM_anti_2	98	106	PF11976	0.420
LIG_SUMO_SIM_par_1	448	454	PF11976	0.576
LIG_SUMO_SIM_par_1	611	618	PF11976	0.582
LIG_TRAF2_1	248	251	PF00917	0.635
LIG_UBA3_1	119	128	PF00899	0.585
LIG_WW_3	561	565	PF00397	0.546
MOD_CDK_SPxxK_3	364	371	PF00069	0.561
MOD_CK1_1	105	111	PF00069	0.547
MOD_CK1_1	14	20	PF00069	0.613
MOD_CK1_1	193	199	PF00069	0.740
MOD_CK1_1	342	348	PF00069	0.557
MOD_CK1_1	618	624	PF00069	0.706
MOD_CK2_1	245	251	PF00069	0.680
MOD_CK2_1	448	454	PF00069	0.551
MOD_CK2_1	590	596	PF00069	0.602
MOD_CK2_1	597	603	PF00069	0.605
MOD_CK2_1	651	657	PF00069	0.622
MOD_CK2_1	89	95	PF00069	0.584
MOD_GlcNHglycan	129	132	PF01048	0.735
MOD_GlcNHglycan	172	176	PF01048	0.624
MOD_GlcNHglycan	214	218	PF01048	0.732
MOD_GlcNHglycan	276	279	PF01048	0.784
MOD_GlcNHglycan	283	286	PF01048	0.664
MOD_GlcNHglycan	49	52	PF01048	0.582
MOD_GlcNHglycan	669	672	PF01048	0.735
MOD_GSK3_1	107	114	PF00069	0.470
MOD_GSK3_1	11	18	PF00069	0.558
MOD_GSK3_1	145	152	PF00069	0.674
MOD_GSK3_1	158	165	PF00069	0.586
MOD_GSK3_1	190	197	PF00069	0.765
MOD_GSK3_1	270	277	PF00069	0.783
MOD_GSK3_1	339	346	PF00069	0.437
MOD_GSK3_1	43	50	PF00069	0.524
MOD_GSK3_1	649	656	PF00069	0.673
MOD_GSK3_1	663	670	PF00069	0.607
MOD_GSK3_1	98	105	PF00069	0.500
MOD_N-GLC_1	681	686	PF02516	0.742
MOD_NEK2_1	1	6	PF00069	0.462
MOD_NEK2_1	102	107	PF00069	0.422
MOD_NEK2_1	111	116	PF00069	0.420
MOD_NEK2_1	158	163	PF00069	0.616
MOD_NEK2_1	190	195	PF00069	0.655
MOD_NEK2_1	43	48	PF00069	0.468
MOD_NEK2_1	479	484	PF00069	0.508
MOD_PIKK_1	185	191	PF00454	0.640
MOD_PIKK_1	649	655	PF00454	0.616
MOD_PKA_2	145	151	PF00069	0.662
MOD_PKA_2	158	164	PF00069	0.547
MOD_PKA_2	342	348	PF00069	0.436
MOD_PKA_2	381	387	PF00069	0.576
MOD_PKA_2	549	555	PF00069	0.495
MOD_PKA_2	568	574	PF00069	0.534
MOD_PKA_2	625	631	PF00069	0.605
MOD_PKA_2	90	96	PF00069	0.570
MOD_PKB_1	263	271	PF00069	0.734
MOD_PKB_1	476	484	PF00069	0.592
MOD_Plk_1	390	396	PF00069	0.603
MOD_Plk_1	43	49	PF00069	0.548
MOD_Plk_1	516	522	PF00069	0.496
MOD_Plk_2-3	590	596	PF00069	0.607
MOD_Plk_2-3	597	603	PF00069	0.596
MOD_Plk_4	111	117	PF00069	0.384
MOD_Plk_4	149	155	PF00069	0.408
MOD_Plk_4	615	621	PF00069	0.638
MOD_Plk_4	98	104	PF00069	0.464
MOD_ProDKin_1	364	370	PF00069	0.531
MOD_SUMO_rev_2	125	130	PF00179	0.675
MOD_SUMO_rev_2	172	180	PF00179	0.733
MOD_SUMO_rev_2	625	631	PF00179	0.605
TRG_DiLeu_BaEn_1	336	341	PF01217	0.418
TRG_DiLeu_BaEn_2	574	580	PF01217	0.456
TRG_DiLeu_BaEn_2	94	100	PF01217	0.544
TRG_ENDOCYTIC_2	293	296	PF00928	0.591
TRG_ENDOCYTIC_2	576	579	PF00928	0.441
TRG_ENDOCYTIC_2	659	662	PF00928	0.690
TRG_ER_diArg_1	237	240	PF00400	0.554
TRG_ER_diArg_1	406	409	PF00400	0.400
TRG_ER_diArg_1	474	476	PF00400	0.444
TRG_ER_diArg_1	708	711	PF00400	0.777
TRG_NES_CRM1_1	113	126	PF08389	0.602
TRG_NLS_MonoExtC_3	237	242	PF00514	0.559
TRG_NLS_MonoExtC_3	261	267	PF00514	0.737
TRG_NLS_MonoExtN_4	237	242	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I765	Leptomonas seymouri	82%	100%
A0A0S4JHQ3	Bodo saltans	41%	82%
A0A1X0P4I5	Trypanosomatidae	60%	100%
A0A3S7WYX6	Leishmania donovani	95%	100%
A0A422NF47	Trypanosoma rangeli	59%	100%
A4HDW9	Leishmania braziliensis	88%	100%
A4I164	Leishmania infantum	95%	100%
D0A5F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
Q4QA74	Leishmania major	94%	100%
V5DPB1	Trypanosoma cruzi	59%	100%