Cleavage and polyadenylation specificity factor subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cleavage and polyadenylation specificity factor, putative

Species:

Leishmania mexicana

UniProt:

E9AX93_LEIMU

TriTrypDb:

LmxM.25.0170

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	11
GO:0005849	mRNA cleavage factor complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0140513	nuclear protein-containing complex	2	11
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX93

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006378	mRNA polyadenylation	7	11
GO:0006379	mRNA cleavage	7	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0031123	RNA 3'-end processing	7	11
GO:0031124	mRNA 3'-end processing	8	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043631	RNA polyadenylation	6	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	11
GO:0090501	RNA phosphodiester bond hydrolysis	6	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	8	1
GO:0008334	histone mRNA metabolic process	7	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.460
CLV_NRD_NRD_1	392	394	PF00675	0.419
CLV_NRD_NRD_1	416	418	PF00675	0.456
CLV_NRD_NRD_1	582	584	PF00675	0.367
CLV_NRD_NRD_1	679	681	PF00675	0.335
CLV_NRD_NRD_1	716	718	PF00675	0.336
CLV_NRD_NRD_1	758	760	PF00675	0.313
CLV_NRD_NRD_1	789	791	PF00675	0.249
CLV_NRD_NRD_1	811	813	PF00675	0.270
CLV_PCSK_KEX2_1	307	309	PF00082	0.406
CLV_PCSK_KEX2_1	392	394	PF00082	0.394
CLV_PCSK_KEX2_1	415	417	PF00082	0.460
CLV_PCSK_KEX2_1	438	440	PF00082	0.643
CLV_PCSK_KEX2_1	522	524	PF00082	0.645
CLV_PCSK_KEX2_1	542	544	PF00082	0.411
CLV_PCSK_KEX2_1	582	584	PF00082	0.451
CLV_PCSK_KEX2_1	679	681	PF00082	0.267
CLV_PCSK_KEX2_1	715	717	PF00082	0.270
CLV_PCSK_KEX2_1	758	760	PF00082	0.471
CLV_PCSK_KEX2_1	811	813	PF00082	0.381
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.406
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.486
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.506
CLV_PCSK_PC1ET2_1	542	544	PF00082	0.411
CLV_PCSK_SKI1_1	221	225	PF00082	0.437
CLV_PCSK_SKI1_1	230	234	PF00082	0.368
CLV_PCSK_SKI1_1	276	280	PF00082	0.417
CLV_PCSK_SKI1_1	307	311	PF00082	0.441
CLV_PCSK_SKI1_1	34	38	PF00082	0.227
CLV_PCSK_SKI1_1	485	489	PF00082	0.770
CLV_PCSK_SKI1_1	585	589	PF00082	0.425
CLV_PCSK_SKI1_1	601	605	PF00082	0.213
CLV_PCSK_SKI1_1	625	629	PF00082	0.349
CLV_PCSK_SKI1_1	635	639	PF00082	0.338
DEG_APCC_DBOX_1	584	592	PF00400	0.443
DEG_Nend_Nbox_1	1	3	PF02207	0.439
DEG_SPOP_SBC_1	643	647	PF00917	0.329
DOC_ANK_TNKS_1	789	796	PF00023	0.381
DOC_CKS1_1	802	807	PF01111	0.381
DOC_CYCLIN_RxL_1	224	235	PF00134	0.402
DOC_CYCLIN_RxL_1	499	511	PF00134	0.582
DOC_CYCLIN_yCln2_LP_2	494	500	PF00134	0.546
DOC_MAPK_gen_1	483	492	PF00069	0.571
DOC_MAPK_gen_1	572	580	PF00069	0.520
DOC_MAPK_gen_1	582	588	PF00069	0.401
DOC_MAPK_gen_1	776	783	PF00069	0.381
DOC_MAPK_HePTP_8	252	264	PF00069	0.405
DOC_MAPK_MEF2A_6	241	250	PF00069	0.316
DOC_MAPK_MEF2A_6	255	264	PF00069	0.262
DOC_MAPK_MEF2A_6	485	494	PF00069	0.602
DOC_MAPK_MEF2A_6	572	580	PF00069	0.479
DOC_MAPK_MEF2A_6	776	783	PF00069	0.267
DOC_MAPK_RevD_3	778	791	PF00069	0.381
DOC_PP1_RVXF_1	32	38	PF00149	0.509
DOC_PP1_RVXF_1	501	508	PF00149	0.548
DOC_PP2B_LxvP_1	492	495	PF13499	0.546
DOC_PP2B_PxIxI_1	327	333	PF00149	0.425
DOC_PP4_FxxP_1	182	185	PF00568	0.427
DOC_PP4_FxxP_1	198	201	PF00568	0.329
DOC_USP7_MATH_1	730	734	PF00917	0.308
DOC_USP7_UBL2_3	146	150	PF12436	0.509
DOC_USP7_UBL2_3	230	234	PF12436	0.395
DOC_USP7_UBL2_3	601	605	PF12436	0.456
DOC_WW_Pin1_4	16	21	PF00397	0.470
DOC_WW_Pin1_4	64	69	PF00397	0.427
DOC_WW_Pin1_4	801	806	PF00397	0.259
DOC_WW_Pin1_4	81	86	PF00397	0.427
LIG_14-3-3_CanoR_1	3	11	PF00244	0.311
LIG_14-3-3_CanoR_1	547	554	PF00244	0.556
LIG_14-3-3_CanoR_1	585	595	PF00244	0.333
LIG_14-3-3_CanoR_1	715	723	PF00244	0.313
LIG_14-3-3_CanoR_1	811	815	PF00244	0.291
LIG_Actin_WH2_2	225	243	PF00022	0.346
LIG_Actin_WH2_2	663	681	PF00022	0.313
LIG_Actin_WH2_2	748	763	PF00022	0.277
LIG_Actin_WH2_2	795	813	PF00022	0.267
LIG_APCC_ABBA_1	780	785	PF00400	0.381
LIG_BIR_III_2	551	555	PF00653	0.675
LIG_BIR_III_4	473	477	PF00653	0.496
LIG_BRCT_BRCA1_1	113	117	PF00533	0.470
LIG_BRCT_BRCA1_1	210	214	PF00533	0.432
LIG_BRCT_BRCA1_1	336	340	PF00533	0.440
LIG_BRCT_BRCA1_1	640	644	PF00533	0.428
LIG_BRCT_BRCA1_1	7	11	PF00533	0.346
LIG_BRCT_BRCA1_1	746	750	PF00533	0.381
LIG_Clathr_ClatBox_1	27	31	PF01394	0.427
LIG_Clathr_ClatBox_1	780	784	PF01394	0.329
LIG_CtBP_PxDLS_1	652	656	PF00389	0.400
LIG_deltaCOP1_diTrp_1	38	45	PF00928	0.427
LIG_eIF4E_1	176	182	PF01652	0.427
LIG_FHA_1	114	120	PF00498	0.424
LIG_FHA_1	124	130	PF00498	0.427
LIG_FHA_1	201	207	PF00498	0.351
LIG_FHA_1	293	299	PF00498	0.339
LIG_FHA_1	45	51	PF00498	0.509
LIG_FHA_1	487	493	PF00498	0.569
LIG_FHA_1	511	517	PF00498	0.562
LIG_FHA_1	525	531	PF00498	0.575
LIG_FHA_1	687	693	PF00498	0.353
LIG_FHA_1	794	800	PF00498	0.381
LIG_FHA_1	802	808	PF00498	0.381
LIG_FHA_1	93	99	PF00498	0.450
LIG_FHA_2	116	122	PF00498	0.548
LIG_FHA_2	291	297	PF00498	0.362
LIG_FHA_2	736	742	PF00498	0.306
LIG_GBD_Chelix_1	670	678	PF00786	0.381
LIG_KLC1_Yacidic_2	402	407	PF13176	0.541
LIG_LIR_Apic_2	106	112	PF02991	0.460
LIG_LIR_Apic_2	179	185	PF02991	0.427
LIG_LIR_Apic_2	525	531	PF02991	0.462
LIG_LIR_Gen_1	130	139	PF02991	0.414
LIG_LIR_Gen_1	300	309	PF02991	0.415
LIG_LIR_Gen_1	402	412	PF02991	0.427
LIG_LIR_Gen_1	423	432	PF02991	0.652
LIG_LIR_Gen_1	768	779	PF02991	0.381
LIG_LIR_Gen_1	8	15	PF02991	0.356
LIG_LIR_Nem_3	130	136	PF02991	0.414
LIG_LIR_Nem_3	231	236	PF02991	0.313
LIG_LIR_Nem_3	273	278	PF02991	0.337
LIG_LIR_Nem_3	300	304	PF02991	0.511
LIG_LIR_Nem_3	402	408	PF02991	0.422
LIG_LIR_Nem_3	423	428	PF02991	0.641
LIG_LIR_Nem_3	506	510	PF02991	0.625
LIG_LIR_Nem_3	768	774	PF02991	0.381
LIG_LIR_Nem_3	8	14	PF02991	0.338
LIG_LIR_Nem_3	813	818	PF02991	0.268
LIG_Pex14_1	172	176	PF04695	0.414
LIG_Pex14_1	41	45	PF04695	0.427
LIG_Pex14_2	37	41	PF04695	0.509
LIG_Pex14_2	45	49	PF04695	0.509
LIG_Rb_pABgroove_1	31	39	PF01858	0.509
LIG_RPA_C_Fungi	350	362	PF08784	0.492
LIG_SH2_CRK	109	113	PF00017	0.381
LIG_SH2_CRK	24	28	PF00017	0.385
LIG_SH2_CRK	275	279	PF00017	0.307
LIG_SH2_CRK	528	532	PF00017	0.462
LIG_SH2_NCK_1	723	727	PF00017	0.269
LIG_SH2_PTP2	405	408	PF00017	0.488
LIG_SH2_SRC	109	112	PF00017	0.381
LIG_SH2_STAP1	170	174	PF00017	0.313
LIG_SH2_STAP1	225	229	PF00017	0.357
LIG_SH2_STAP1	24	28	PF00017	0.395
LIG_SH2_STAP1	660	664	PF00017	0.424
LIG_SH2_STAP1	818	822	PF00017	0.533
LIG_SH2_STAT3	225	228	PF00017	0.369
LIG_SH2_STAT3	662	665	PF00017	0.416
LIG_SH2_STAT5	183	186	PF00017	0.275
LIG_SH2_STAT5	26	29	PF00017	0.327
LIG_SH2_STAT5	301	304	PF00017	0.410
LIG_SH2_STAT5	349	352	PF00017	0.370
LIG_SH2_STAT5	405	408	PF00017	0.488
LIG_SH2_STAT5	56	59	PF00017	0.205
LIG_SH3_1	52	58	PF00018	0.269
LIG_SH3_3	17	23	PF00018	0.386
LIG_SH3_3	243	249	PF00018	0.286
LIG_SH3_3	364	370	PF00018	0.373
LIG_SH3_3	490	496	PF00018	0.697
LIG_SH3_3	52	58	PF00018	0.269
LIG_SUMO_SIM_anti_2	359	366	PF11976	0.410
LIG_SUMO_SIM_par_1	26	31	PF11976	0.248
LIG_SUMO_SIM_par_1	359	366	PF11976	0.414
LIG_SUMO_SIM_par_1	651	657	PF11976	0.522
LIG_SUMO_SIM_par_1	778	785	PF11976	0.327
LIG_SUMO_SIM_par_1	794	801	PF11976	0.327
LIG_TRAF2_1	318	321	PF00917	0.344
LIG_TRAF2_1	397	400	PF00917	0.528
LIG_TRAF2_1	533	536	PF00917	0.602
LIG_TRAF2_1	764	767	PF00917	0.458
LIG_TRFH_1	193	197	PF08558	0.338
LIG_WRC_WIRS_1	104	109	PF05994	0.313
LIG_WRC_WIRS_1	133	138	PF05994	0.327
LIG_WW_2	367	370	PF00397	0.514
MOD_CK1_1	135	141	PF00069	0.313
MOD_CK1_1	394	400	PF00069	0.559
MOD_CK1_1	5	11	PF00069	0.292
MOD_CK1_1	514	520	PF00069	0.562
MOD_CK1_1	571	577	PF00069	0.487
MOD_CK1_1	589	595	PF00069	0.433
MOD_CK1_1	645	651	PF00069	0.448
MOD_CK1_1	686	692	PF00069	0.289
MOD_CK1_1	724	730	PF00069	0.268
MOD_CK1_1	801	807	PF00069	0.277
MOD_CK1_1	81	87	PF00069	0.426
MOD_CK2_1	10	16	PF00069	0.461
MOD_CK2_1	135	141	PF00069	0.381
MOD_CK2_1	290	296	PF00069	0.350
MOD_CK2_1	315	321	PF00069	0.322
MOD_CK2_1	394	400	PF00069	0.519
MOD_CK2_1	530	536	PF00069	0.538
MOD_CK2_1	685	691	PF00069	0.359
MOD_CK2_1	735	741	PF00069	0.306
MOD_CK2_1	761	767	PF00069	0.458
MOD_GlcNHglycan	317	320	PF01048	0.466
MOD_GlcNHglycan	342	345	PF01048	0.320
MOD_GlcNHglycan	396	399	PF01048	0.450
MOD_GlcNHglycan	4	7	PF01048	0.308
MOD_GlcNHglycan	422	425	PF01048	0.546
MOD_GlcNHglycan	516	519	PF01048	0.466
MOD_GlcNHglycan	590	594	PF01048	0.344
MOD_GlcNHglycan	619	622	PF01048	0.452
MOD_GlcNHglycan	648	651	PF01048	0.382
MOD_GlcNHglycan	698	702	PF01048	0.436
MOD_GlcNHglycan	746	749	PF01048	0.381
MOD_GlcNHglycan	767	770	PF01048	0.323
MOD_GSK3_1	111	118	PF00069	0.201
MOD_GSK3_1	121	128	PF00069	0.289
MOD_GSK3_1	185	192	PF00069	0.248
MOD_GSK3_1	330	337	PF00069	0.442
MOD_GSK3_1	479	486	PF00069	0.557
MOD_GSK3_1	499	506	PF00069	0.648
MOD_GSK3_1	5	12	PF00069	0.290
MOD_GSK3_1	510	517	PF00069	0.668
MOD_GSK3_1	599	606	PF00069	0.354
MOD_GSK3_1	638	645	PF00069	0.580
MOD_GSK3_1	64	71	PF00069	0.327
MOD_GSK3_1	654	661	PF00069	0.417
MOD_GSK3_1	666	673	PF00069	0.352
MOD_GSK3_1	681	688	PF00069	0.169
MOD_GSK3_1	726	733	PF00069	0.363
MOD_GSK3_1	761	768	PF00069	0.381
MOD_GSK3_1	793	800	PF00069	0.259
MOD_GSK3_1	99	106	PF00069	0.313
MOD_LATS_1	501	507	PF00433	0.595
MOD_N-GLC_1	219	224	PF02516	0.506
MOD_NEK2_1	2	7	PF00069	0.354
MOD_NEK2_1	208	213	PF00069	0.353
MOD_NEK2_1	214	219	PF00069	0.401
MOD_NEK2_1	236	241	PF00069	0.393
MOD_NEK2_1	388	393	PF00069	0.384
MOD_NEK2_1	45	50	PF00069	0.327
MOD_NEK2_1	510	515	PF00069	0.562
MOD_NEK2_1	644	649	PF00069	0.447
MOD_NEK2_1	666	671	PF00069	0.286
MOD_NEK2_1	760	765	PF00069	0.291
MOD_NEK2_1	78	83	PF00069	0.458
MOD_NEK2_1	810	815	PF00069	0.313
MOD_NEK2_2	145	150	PF00069	0.269
MOD_NEK2_2	170	175	PF00069	0.300
MOD_NEK2_2	185	190	PF00069	0.212
MOD_PIKK_1	730	736	PF00454	0.375
MOD_PIKK_1	816	822	PF00454	0.409
MOD_PKA_1	715	721	PF00069	0.381
MOD_PKA_2	2	8	PF00069	0.340
MOD_PKA_2	391	397	PF00069	0.455
MOD_PKA_2	617	623	PF00069	0.367
MOD_PKA_2	681	687	PF00069	0.335
MOD_PKA_2	715	721	PF00069	0.381
MOD_PKA_2	760	766	PF00069	0.303
MOD_PKA_2	810	816	PF00069	0.291
MOD_PKB_1	759	767	PF00069	0.381
MOD_Plk_1	185	191	PF00069	0.252
MOD_Plk_1	45	51	PF00069	0.297
MOD_Plk_1	524	530	PF00069	0.462
MOD_Plk_1	666	672	PF00069	0.381
MOD_Plk_2-3	334	340	PF00069	0.323
MOD_Plk_4	10	16	PF00069	0.323
MOD_Plk_4	128	134	PF00069	0.464
MOD_Plk_4	228	234	PF00069	0.424
MOD_Plk_4	45	51	PF00069	0.291
MOD_Plk_4	599	605	PF00069	0.409
MOD_Plk_4	746	752	PF00069	0.327
MOD_Plk_4	84	90	PF00069	0.381
MOD_Plk_4	99	105	PF00069	0.381
MOD_ProDKin_1	16	22	PF00069	0.462
MOD_ProDKin_1	64	70	PF00069	0.267
MOD_ProDKin_1	801	807	PF00069	0.259
MOD_ProDKin_1	81	87	PF00069	0.267
MOD_SUMO_for_1	223	226	PF00179	0.278
MOD_SUMO_for_1	437	440	PF00179	0.603
MOD_SUMO_rev_2	300	309	PF00179	0.567
TRG_DiLeu_BaEn_4	535	541	PF01217	0.620
TRG_DiLeu_BaLyEn_6	776	781	PF01217	0.381
TRG_ENDOCYTIC_2	133	136	PF00928	0.267
TRG_ENDOCYTIC_2	24	27	PF00928	0.396
TRG_ENDOCYTIC_2	275	278	PF00928	0.312
TRG_ENDOCYTIC_2	301	304	PF00928	0.410
TRG_ENDOCYTIC_2	405	408	PF00928	0.428
TRG_ENDOCYTIC_2	771	774	PF00928	0.381
TRG_ER_diArg_1	392	395	PF00400	0.428
TRG_ER_diArg_1	415	417	PF00400	0.531
TRG_ER_diArg_1	582	585	PF00400	0.454
TRG_ER_diArg_1	678	680	PF00400	0.291
TRG_ER_diArg_1	715	717	PF00400	0.295
TRG_ER_diArg_1	757	759	PF00400	0.427
TRG_ER_diArg_1	810	812	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.248
TRG_Pf-PMV_PEXEL_1	417	422	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	758	762	PF00026	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP3	Leptomonas seymouri	75%	99%
A0A0S4JJR9	Bodo saltans	30%	87%
A0A1X0P5N3	Trypanosomatidae	50%	100%
A0A3Q8IBL1	Leishmania donovani	95%	100%
A0A422NF58	Trypanosoma rangeli	51%	100%
A4HDW4	Leishmania braziliensis	89%	100%
A4I159	Leishmania infantum	95%	100%
A8XUS3	Caenorhabditis briggsae	22%	98%
D0A5E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
O17403	Caenorhabditis elegans	22%	98%
Q4QA79	Leishmania major	96%	100%
Q652P4	Oryza sativa subsp. japonica	22%	100%
Q9LKF9	Arabidopsis thaliana	23%	100%