Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX92_LEIMU

TriTrypDb:

LmxM.25.0160

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.601
CLV_NRD_NRD_1	154	156	PF00675	0.626
CLV_NRD_NRD_1	179	181	PF00675	0.552
CLV_NRD_NRD_1	187	189	PF00675	0.558
CLV_NRD_NRD_1	39	41	PF00675	0.586
CLV_PCSK_FUR_1	37	41	PF00082	0.598
CLV_PCSK_KEX2_1	154	156	PF00082	0.626
CLV_PCSK_KEX2_1	186	188	PF00082	0.560
CLV_PCSK_KEX2_1	39	41	PF00082	0.586
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.578
CLV_PCSK_SKI1_1	133	137	PF00082	0.483
CLV_PCSK_SKI1_1	154	158	PF00082	0.627
CLV_PCSK_SKI1_1	198	202	PF00082	0.480
CLV_PCSK_SKI1_1	82	86	PF00082	0.511
CLV_Separin_Metazoa	34	38	PF03568	0.587
DOC_CYCLIN_RxL_1	195	202	PF00134	0.462
DOC_MAPK_gen_1	133	141	PF00069	0.488
DOC_MAPK_MEF2A_6	51	58	PF00069	0.531
DOC_USP7_MATH_1	172	176	PF00917	0.598
DOC_USP7_MATH_1	192	196	PF00917	0.267
DOC_USP7_MATH_1	41	45	PF00917	0.649
DOC_USP7_MATH_1	54	58	PF00917	0.534
DOC_WW_Pin1_4	108	113	PF00397	0.543
DOC_WW_Pin1_4	205	210	PF00397	0.686
LIG_14-3-3_CanoR_1	166	173	PF00244	0.425
LIG_14-3-3_CanoR_1	203	209	PF00244	0.589
LIG_14-3-3_CanoR_1	40	46	PF00244	0.590
LIG_Actin_WH2_2	24	41	PF00022	0.558
LIG_BIR_II_1	1	5	PF00653	0.523
LIG_BIR_III_3	1	5	PF00653	0.612
LIG_Clathr_ClatBox_1	9	13	PF01394	0.482
LIG_FHA_1	118	124	PF00498	0.536
LIG_FHA_1	25	31	PF00498	0.277
LIG_FHA_1	5	11	PF00498	0.500
LIG_FHA_1	65	71	PF00498	0.638
LIG_FHA_2	174	180	PF00498	0.424
LIG_FHA_2	58	64	PF00498	0.578
LIG_LIR_Gen_1	179	189	PF02991	0.562
LIG_LIR_Gen_1	83	93	PF02991	0.488
LIG_LIR_LC3C_4	137	141	PF02991	0.513
LIG_LIR_Nem_3	179	185	PF02991	0.538
LIG_LIR_Nem_3	83	88	PF02991	0.490
LIG_NRBOX	87	93	PF00104	0.423
LIG_RPA_C_Fungi	35	47	PF08784	0.541
LIG_SH2_SRC	189	192	PF00017	0.517
LIG_SH2_STAP1	144	148	PF00017	0.426
LIG_SH2_STAP1	189	193	PF00017	0.515
LIG_SH3_3	208	214	PF00018	0.689
LIG_SUMO_SIM_anti_2	27	34	PF11976	0.313
LIG_SUMO_SIM_par_1	6	13	PF11976	0.542
LIG_TRAF2_1	60	63	PF00917	0.716
MOD_CDK_SPK_2	108	113	PF00069	0.540
MOD_CK1_1	57	63	PF00069	0.479
MOD_CK1_1	64	70	PF00069	0.457
MOD_CK2_1	173	179	PF00069	0.565
MOD_CK2_1	57	63	PF00069	0.602
MOD_GlcNHglycan	170	173	PF01048	0.417
MOD_GlcNHglycan	62	67	PF01048	0.752
MOD_GlcNHglycan	73	78	PF01048	0.645
MOD_GSK3_1	168	175	PF00069	0.411
MOD_GSK3_1	205	212	PF00069	0.494
MOD_GSK3_1	4	11	PF00069	0.535
MOD_GSK3_1	57	64	PF00069	0.594
MOD_N-GLC_1	41	46	PF02516	0.560
MOD_NEK2_1	173	178	PF00069	0.425
MOD_NEK2_1	61	66	PF00069	0.537
MOD_PIKK_1	192	198	PF00454	0.406
MOD_PIKK_1	22	28	PF00454	0.608
MOD_PKA_2	165	171	PF00069	0.598
MOD_Plk_1	117	123	PF00069	0.559
MOD_Plk_1	41	47	PF00069	0.651
MOD_Plk_4	173	179	PF00069	0.425
MOD_Plk_4	4	10	PF00069	0.591
MOD_Plk_4	41	47	PF00069	0.640
MOD_ProDKin_1	108	114	PF00069	0.545
MOD_ProDKin_1	205	211	PF00069	0.690
MOD_SUMO_rev_2	175	183	PF00179	0.592
TRG_DiLeu_BaEn_4	130	136	PF01217	0.585
TRG_ENDOCYTIC_2	182	185	PF00928	0.587
TRG_ER_diArg_1	153	155	PF00400	0.630
TRG_ER_diArg_1	187	189	PF00400	0.617
TRG_ER_diArg_1	36	39	PF00400	0.559
TRG_ER_diArg_1	98	101	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM96	Leptomonas seymouri	45%	96%
A0A1X0P602	Trypanosomatidae	35%	69%
A0A3Q8ID59	Leishmania donovani	88%	100%
A0A422NF37	Trypanosoma rangeli	32%	69%
A4HDW3	Leishmania braziliensis	75%	100%
A4I158	Leishmania infantum	89%	100%
D0A5E3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	68%
Q4QA80	Leishmania major	85%	100%
V5BXK9	Trypanosoma cruzi	32%	69%