Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX91_LEIMU

TriTrypDb:

LmxM.25.0150

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.468
CLV_C14_Caspase3-7	371	375	PF00656	0.516
CLV_NRD_NRD_1	100	102	PF00675	0.585
CLV_NRD_NRD_1	492	494	PF00675	0.427
CLV_NRD_NRD_1	517	519	PF00675	0.403
CLV_NRD_NRD_1	97	99	PF00675	0.564
CLV_PCSK_FUR_1	98	102	PF00082	0.622
CLV_PCSK_KEX2_1	492	494	PF00082	0.424
CLV_PCSK_KEX2_1	517	519	PF00082	0.403
CLV_PCSK_KEX2_1	99	101	PF00082	0.599
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.648
CLV_PCSK_SKI1_1	100	104	PF00082	0.657
CLV_PCSK_SKI1_1	186	190	PF00082	0.709
CLV_PCSK_SKI1_1	450	454	PF00082	0.443
CLV_PCSK_SKI1_1	502	506	PF00082	0.439
CLV_PCSK_SKI1_1	554	558	PF00082	0.432
CLV_PCSK_SKI1_1	565	569	PF00082	0.609
CLV_Separin_Metazoa	200	204	PF03568	0.440
CLV_Separin_Metazoa	559	563	PF03568	0.300
DEG_APCC_DBOX_1	185	193	PF00400	0.499
DEG_APCC_DBOX_1	553	561	PF00400	0.536
DEG_Nend_UBRbox_2	1	3	PF02207	0.505
DOC_CDC14_PxL_1	165	173	PF14671	0.385
DOC_CYCLIN_RxL_1	447	457	PF00134	0.632
DOC_CYCLIN_RxL_1	499	508	PF00134	0.628
DOC_CYCLIN_RxL_1	97	106	PF00134	0.461
DOC_MAPK_gen_1	196	204	PF00069	0.449
DOC_MAPK_gen_1	517	527	PF00069	0.590
DOC_MAPK_MEF2A_6	518	527	PF00069	0.619
DOC_MAPK_MEF2A_6	684	692	PF00069	0.510
DOC_MAPK_MEF2A_6	86	93	PF00069	0.418
DOC_MAPK_NFAT4_5	86	94	PF00069	0.210
DOC_MAPK_RevD_3	87	100	PF00069	0.374
DOC_PP1_RVXF_1	448	455	PF00149	0.625
DOC_PP2B_LxvP_1	239	242	PF13499	0.459
DOC_PP4_FxxP_1	389	392	PF00568	0.489
DOC_PP4_FxxP_1	608	611	PF00568	0.324
DOC_SPAK_OSR1_1	203	207	PF12202	0.240
DOC_USP7_MATH_1	235	239	PF00917	0.570
DOC_USP7_MATH_1	414	418	PF00917	0.475
DOC_USP7_MATH_1	473	477	PF00917	0.660
DOC_USP7_MATH_1	548	552	PF00917	0.344
DOC_USP7_MATH_1	566	570	PF00917	0.392
DOC_USP7_MATH_1	581	585	PF00917	0.452
DOC_USP7_MATH_1	636	640	PF00917	0.508
DOC_USP7_MATH_1	675	679	PF00917	0.401
DOC_USP7_MATH_1	75	79	PF00917	0.370
DOC_USP7_MATH_2	385	391	PF00917	0.557
DOC_WW_Pin1_4	381	386	PF00397	0.536
DOC_WW_Pin1_4	577	582	PF00397	0.511
DOC_WW_Pin1_4	631	636	PF00397	0.476
DOC_WW_Pin1_4	690	695	PF00397	0.426
DOC_WW_Pin1_4	70	75	PF00397	0.437
LIG_14-3-3_CanoR_1	101	111	PF00244	0.529
LIG_14-3-3_CanoR_1	122	128	PF00244	0.410
LIG_14-3-3_CanoR_1	246	256	PF00244	0.528
LIG_14-3-3_CanoR_1	407	416	PF00244	0.558
LIG_14-3-3_CanoR_1	440	449	PF00244	0.703
LIG_14-3-3_CanoR_1	518	524	PF00244	0.583
LIG_14-3-3_CanoR_1	565	574	PF00244	0.465
LIG_14-3-3_CanoR_1	577	581	PF00244	0.315
LIG_14-3-3_CanoR_1	630	638	PF00244	0.465
LIG_14-3-3_CanoR_1	666	671	PF00244	0.446
LIG_Actin_WH2_2	135	151	PF00022	0.495
LIG_Actin_WH2_2	424	442	PF00022	0.406
LIG_APCC_ABBA_1	89	94	PF00400	0.420
LIG_BIR_III_2	150	154	PF00653	0.482
LIG_BRCT_BRCA1_1	107	111	PF00533	0.462
LIG_BRCT_BRCA1_1	313	317	PF00533	0.526
LIG_Clathr_ClatBox_1	367	371	PF01394	0.573
LIG_deltaCOP1_diTrp_1	31	40	PF00928	0.375
LIG_FHA_1	129	135	PF00498	0.451
LIG_FHA_1	248	254	PF00498	0.549
LIG_FHA_1	291	297	PF00498	0.438
LIG_FHA_1	332	338	PF00498	0.467
LIG_FHA_1	520	526	PF00498	0.581
LIG_FHA_2	209	215	PF00498	0.469
LIG_FHA_2	280	286	PF00498	0.571
LIG_FHA_2	674	680	PF00498	0.486
LIG_FHA_2	691	697	PF00498	0.459
LIG_GBD_Chelix_1	523	531	PF00786	0.409
LIG_GBD_Chelix_1	655	663	PF00786	0.429
LIG_LIR_Apic_2	387	392	PF02991	0.488
LIG_LIR_Apic_2	605	611	PF02991	0.336
LIG_LIR_Gen_1	108	119	PF02991	0.465
LIG_LIR_Gen_1	31	40	PF02991	0.459
LIG_LIR_Gen_1	363	373	PF02991	0.357
LIG_LIR_Gen_1	433	442	PF02991	0.323
LIG_LIR_Gen_1	491	501	PF02991	0.565
LIG_LIR_Gen_1	78	88	PF02991	0.360
LIG_LIR_LC3C_4	610	614	PF02991	0.396
LIG_LIR_Nem_3	108	114	PF02991	0.482
LIG_LIR_Nem_3	31	35	PF02991	0.443
LIG_LIR_Nem_3	363	368	PF02991	0.353
LIG_LIR_Nem_3	387	391	PF02991	0.429
LIG_LIR_Nem_3	433	438	PF02991	0.323
LIG_LIR_Nem_3	491	497	PF02991	0.572
LIG_LIR_Nem_3	78	83	PF02991	0.335
LIG_LIR_Nem_3	85	91	PF02991	0.330
LIG_LYPXL_yS_3	549	552	PF13949	0.444
LIG_MYND_3	22	26	PF01753	0.408
LIG_NRBOX	448	454	PF00104	0.651
LIG_NRBOX	556	562	PF00104	0.448
LIG_PCNA_PIPBox_1	591	600	PF02747	0.225
LIG_Pex14_1	256	260	PF04695	0.494
LIG_Pex14_2	137	141	PF04695	0.276
LIG_PTAP_UEV_1	165	170	PF05743	0.448
LIG_PTAP_UEV_1	265	270	PF05743	0.458
LIG_Rb_LxCxE_1	466	480	PF01857	0.630
LIG_SH2_CRK	227	231	PF00017	0.456
LIG_SH2_PTP2	435	438	PF00017	0.194
LIG_SH2_PTP2	80	83	PF00017	0.348
LIG_SH2_STAP1	420	424	PF00017	0.490
LIG_SH2_STAP1	494	498	PF00017	0.608
LIG_SH2_STAT5	388	391	PF00017	0.456
LIG_SH2_STAT5	435	438	PF00017	0.427
LIG_SH2_STAT5	465	468	PF00017	0.668
LIG_SH2_STAT5	80	83	PF00017	0.313
LIG_SH2_STAT5	88	91	PF00017	0.315
LIG_SH3_3	163	169	PF00018	0.543
LIG_SH3_3	263	269	PF00018	0.539
LIG_SH3_3	64	70	PF00018	0.467
LIG_SH3_4	180	187	PF00018	0.491
LIG_Sin3_3	219	226	PF02671	0.427
LIG_SUMO_SIM_anti_2	503	508	PF11976	0.428
LIG_SUMO_SIM_anti_2	610	616	PF11976	0.267
LIG_SUMO_SIM_par_1	366	371	PF11976	0.565
LIG_SUMO_SIM_par_1	398	404	PF11976	0.445
LIG_SUMO_SIM_par_1	503	508	PF11976	0.545
LIG_SUMO_SIM_par_1	521	526	PF11976	0.566
LIG_SUMO_SIM_par_1	62	68	PF11976	0.432
LIG_SUMO_SIM_par_1	693	699	PF11976	0.437
MOD_CK1_1	105	111	PF00069	0.637
MOD_CK1_1	311	317	PF00069	0.634
MOD_CK1_1	325	331	PF00069	0.640
MOD_CK1_1	423	429	PF00069	0.354
MOD_CK1_1	488	494	PF00069	0.600
MOD_CK1_1	602	608	PF00069	0.541
MOD_CK1_1	63	69	PF00069	0.503
MOD_CK1_1	631	637	PF00069	0.589
MOD_CK1_1	673	679	PF00069	0.460
MOD_CK2_1	209	215	PF00069	0.652
MOD_CK2_1	288	294	PF00069	0.598
MOD_CK2_1	381	387	PF00069	0.667
MOD_CK2_1	673	679	PF00069	0.561
MOD_GlcNHglycan	166	169	PF01048	0.641
MOD_GlcNHglycan	266	269	PF01048	0.597
MOD_GlcNHglycan	324	327	PF01048	0.503
MOD_GlcNHglycan	35	38	PF01048	0.504
MOD_GlcNHglycan	422	425	PF01048	0.416
MOD_GlcNHglycan	443	446	PF01048	0.611
MOD_GlcNHglycan	459	462	PF01048	0.405
MOD_GlcNHglycan	46	49	PF01048	0.396
MOD_GlcNHglycan	479	482	PF01048	0.420
MOD_GlcNHglycan	507	510	PF01048	0.489
MOD_GlcNHglycan	602	605	PF01048	0.552
MOD_GlcNHglycan	638	641	PF01048	0.643
MOD_GlcNHglycan	672	675	PF01048	0.413
MOD_GSK3_1	105	112	PF00069	0.689
MOD_GSK3_1	226	233	PF00069	0.526
MOD_GSK3_1	245	252	PF00069	0.719
MOD_GSK3_1	264	271	PF00069	0.483
MOD_GSK3_1	346	353	PF00069	0.684
MOD_GSK3_1	414	421	PF00069	0.649
MOD_GSK3_1	42	49	PF00069	0.586
MOD_GSK3_1	473	480	PF00069	0.568
MOD_GSK3_1	568	575	PF00069	0.449
MOD_GSK3_1	577	584	PF00069	0.597
MOD_GSK3_1	59	66	PF00069	0.456
MOD_GSK3_1	596	603	PF00069	0.304
MOD_GSK3_1	666	673	PF00069	0.413
MOD_NEK2_1	208	213	PF00069	0.543
MOD_NEK2_1	245	250	PF00069	0.730
MOD_NEK2_1	288	293	PF00069	0.604
MOD_NEK2_1	322	327	PF00069	0.595
MOD_NEK2_1	418	423	PF00069	0.579
MOD_NEK2_1	44	49	PF00069	0.641
MOD_NEK2_1	505	510	PF00069	0.460
MOD_NEK2_1	519	524	PF00069	0.484
MOD_NEK2_1	539	544	PF00069	0.252
MOD_NEK2_1	60	65	PF00069	0.505
MOD_NEK2_1	670	675	PF00069	0.324
MOD_NEK2_1	698	703	PF00069	0.463
MOD_NEK2_2	485	490	PF00069	0.462
MOD_NEK2_2	75	80	PF00069	0.453
MOD_PIKK_1	596	602	PF00454	0.552
MOD_PIKK_1	621	627	PF00454	0.460
MOD_PK_1	644	650	PF00069	0.499
MOD_PKA_2	156	162	PF00069	0.734
MOD_PKA_2	209	215	PF00069	0.497
MOD_PKA_2	245	251	PF00069	0.762
MOD_PKA_2	311	317	PF00069	0.530
MOD_PKA_2	341	347	PF00069	0.748
MOD_PKA_2	52	58	PF00069	0.634
MOD_PKA_2	576	582	PF00069	0.375
MOD_PKA_2	629	635	PF00069	0.561
MOD_Plk_1	532	538	PF00069	0.485
MOD_Plk_1	644	650	PF00069	0.556
MOD_Plk_1	688	694	PF00069	0.619
MOD_Plk_4	423	429	PF00069	0.354
MOD_Plk_4	539	545	PF00069	0.341
MOD_Plk_4	581	587	PF00069	0.467
MOD_Plk_4	60	66	PF00069	0.466
MOD_Plk_4	75	81	PF00069	0.322
MOD_ProDKin_1	381	387	PF00069	0.688
MOD_ProDKin_1	577	583	PF00069	0.643
MOD_ProDKin_1	631	637	PF00069	0.607
MOD_ProDKin_1	690	696	PF00069	0.526
MOD_ProDKin_1	70	76	PF00069	0.543
MOD_SUMO_for_1	567	570	PF00179	0.456
MOD_SUMO_rev_2	172	181	PF00179	0.722
TRG_DiLeu_BaEn_1	363	368	PF01217	0.723
TRG_DiLeu_BaEn_3	199	205	PF01217	0.265
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.621
TRG_ENDOCYTIC_2	227	230	PF00928	0.572
TRG_ENDOCYTIC_2	32	35	PF00928	0.474
TRG_ENDOCYTIC_2	388	391	PF00928	0.566
TRG_ENDOCYTIC_2	435	438	PF00928	0.194
TRG_ENDOCYTIC_2	494	497	PF00928	0.516
TRG_ENDOCYTIC_2	549	552	PF00928	0.397
TRG_ENDOCYTIC_2	80	83	PF00928	0.376
TRG_ENDOCYTIC_2	88	91	PF00928	0.379
TRG_ER_diArg_1	195	198	PF00400	0.496
TRG_ER_diArg_1	256	259	PF00400	0.749
TRG_ER_diArg_1	492	494	PF00400	0.582
TRG_ER_diArg_1	517	519	PF00400	0.590
TRG_ER_diArg_1	534	537	PF00400	0.319
TRG_ER_diArg_1	665	668	PF00400	0.519
TRG_ER_diArg_1	98	101	PF00400	0.495
TRG_NES_CRM1_1	610	622	PF08389	0.503
TRG_NLS_MonoExtN_4	98	103	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	657	661	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAE2	Leptomonas seymouri	39%	85%
A0A1X0P4U7	Trypanosomatidae	23%	98%
A0A3Q8ID38	Leishmania donovani	86%	100%
A0A422NF62	Trypanosoma rangeli	23%	99%
A4HDW2	Leishmania braziliensis	71%	100%
A4I157	Leishmania infantum	86%	100%
D0A5E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	97%
Q4QA81	Leishmania major	86%	100%