Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX87_LEIMU

TriTrypDb:

LmxM.25.0110

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	469	473	PF00656	0.508
CLV_NRD_NRD_1	189	191	PF00675	0.612
CLV_NRD_NRD_1	2	4	PF00675	0.593
CLV_NRD_NRD_1	305	307	PF00675	0.680
CLV_NRD_NRD_1	376	378	PF00675	0.522
CLV_NRD_NRD_1	67	69	PF00675	0.406
CLV_PCSK_KEX2_1	189	191	PF00082	0.612
CLV_PCSK_KEX2_1	2	4	PF00082	0.516
CLV_PCSK_KEX2_1	305	307	PF00082	0.675
CLV_PCSK_KEX2_1	376	378	PF00082	0.522
CLV_PCSK_KEX2_1	414	416	PF00082	0.364
CLV_PCSK_KEX2_1	67	69	PF00082	0.406
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.364
CLV_PCSK_SKI1_1	29	33	PF00082	0.418
CLV_PCSK_SKI1_1	34	38	PF00082	0.363
CLV_PCSK_SKI1_1	407	411	PF00082	0.535
CLV_Separin_Metazoa	260	264	PF03568	0.447
DEG_APCC_DBOX_1	97	105	PF00400	0.371
DEG_COP1_1	288	297	PF00400	0.556
DEG_Nend_UBRbox_1	1	4	PF02207	0.492
DOC_CKS1_1	227	232	PF01111	0.398
DOC_CKS1_1	334	339	PF01111	0.606
DOC_MAPK_gen_1	186	195	PF00069	0.609
DOC_MAPK_gen_1	414	422	PF00069	0.348
DOC_MAPK_gen_1	48	56	PF00069	0.404
DOC_MAPK_MEF2A_6	116	123	PF00069	0.543
DOC_MAPK_MEF2A_6	189	197	PF00069	0.520
DOC_MAPK_MEF2A_6	376	385	PF00069	0.449
DOC_MAPK_MEF2A_6	50	58	PF00069	0.318
DOC_PP4_FxxP_1	334	337	PF00568	0.490
DOC_PP4_FxxP_1	418	421	PF00568	0.373
DOC_USP7_MATH_1	180	184	PF00917	0.583
DOC_USP7_MATH_1	19	23	PF00917	0.461
DOC_USP7_MATH_1	221	225	PF00917	0.436
DOC_USP7_MATH_1	304	308	PF00917	0.578
DOC_USP7_MATH_1	361	365	PF00917	0.589
DOC_USP7_MATH_1	436	440	PF00917	0.507
DOC_USP7_MATH_1	468	472	PF00917	0.720
DOC_WW_Pin1_4	226	231	PF00397	0.432
DOC_WW_Pin1_4	333	338	PF00397	0.650
DOC_WW_Pin1_4	8	13	PF00397	0.390
LIG_14-3-3_CanoR_1	137	144	PF00244	0.381
LIG_14-3-3_CanoR_1	2	6	PF00244	0.473
LIG_14-3-3_CanoR_1	208	215	PF00244	0.548
LIG_14-3-3_CanoR_1	34	39	PF00244	0.385
LIG_14-3-3_CanoR_1	458	464	PF00244	0.534
LIG_14-3-3_CanoR_1	50	55	PF00244	0.261
LIG_APCC_ABBA_1	235	240	PF00400	0.415
LIG_BRCT_BRCA1_1	298	302	PF00533	0.489
LIG_BRCT_BRCA1_1	38	42	PF00533	0.371
LIG_Clathr_ClatBox_1	120	124	PF01394	0.378
LIG_deltaCOP1_diTrp_1	89	95	PF00928	0.348
LIG_DLG_GKlike_1	50	57	PF00625	0.389
LIG_FAT_LD_1	54	62	PF03623	0.473
LIG_FHA_1	159	165	PF00498	0.420
LIG_FHA_1	223	229	PF00498	0.462
LIG_FHA_1	341	347	PF00498	0.627
LIG_FHA_1	353	359	PF00498	0.441
LIG_FHA_1	404	410	PF00498	0.532
LIG_FHA_1	75	81	PF00498	0.533
LIG_FHA_2	42	48	PF00498	0.546
LIG_FHA_2	467	473	PF00498	0.595
LIG_FHA_2	50	56	PF00498	0.469
LIG_GBD_Chelix_1	101	109	PF00786	0.252
LIG_LIR_Gen_1	200	211	PF02991	0.524
LIG_LIR_Gen_1	39	47	PF02991	0.389
LIG_LIR_Gen_1	89	96	PF02991	0.402
LIG_LIR_Nem_3	200	206	PF02991	0.531
LIG_LIR_Nem_3	360	365	PF02991	0.412
LIG_LIR_Nem_3	39	45	PF02991	0.393
LIG_LIR_Nem_3	81	86	PF02991	0.407
LIG_LIR_Nem_3	89	93	PF02991	0.345
LIG_MYND_1	347	351	PF01753	0.459
LIG_NRBOX	100	106	PF00104	0.442
LIG_NRBOX	53	59	PF00104	0.389
LIG_Pex14_2	418	422	PF04695	0.367
LIG_SH2_CRK	30	34	PF00017	0.429
LIG_SH2_NCK_1	298	302	PF00017	0.478
LIG_SH2_STAP1	298	302	PF00017	0.478
LIG_SH2_STAP1	412	416	PF00017	0.367
LIG_SH2_STAP1	6	10	PF00017	0.343
LIG_SH2_STAT5	165	168	PF00017	0.377
LIG_SH2_STAT5	425	428	PF00017	0.334
LIG_SH2_STAT5	64	67	PF00017	0.491
LIG_SH3_1	236	242	PF00018	0.448
LIG_SH3_3	224	230	PF00018	0.402
LIG_SH3_3	236	242	PF00018	0.452
LIG_SH3_3	289	295	PF00018	0.486
LIG_SH3_3	348	354	PF00018	0.360
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.467
LIG_SUMO_SIM_anti_2	99	106	PF11976	0.414
LIG_SUMO_SIM_par_1	119	124	PF11976	0.496
LIG_SUMO_SIM_par_1	354	360	PF11976	0.476
LIG_SUMO_SIM_par_1	381	386	PF11976	0.395
LIG_SUMO_SIM_par_1	99	106	PF11976	0.399
LIG_TRAF2_1	399	402	PF00917	0.582
LIG_UBA3_1	120	126	PF00899	0.395
MOD_CK1_1	307	313	PF00069	0.605
MOD_CK1_1	41	47	PF00069	0.460
MOD_CK1_1	74	80	PF00069	0.431
MOD_CK2_1	250	256	PF00069	0.328
MOD_CK2_1	367	373	PF00069	0.533
MOD_CK2_1	436	442	PF00069	0.332
MOD_Cter_Amidation	65	68	PF01082	0.395
MOD_GlcNHglycan	105	108	PF01048	0.572
MOD_GlcNHglycan	182	185	PF01048	0.514
MOD_GlcNHglycan	209	212	PF01048	0.651
MOD_GlcNHglycan	299	302	PF01048	0.529
MOD_GlcNHglycan	324	327	PF01048	0.654
MOD_GlcNHglycan	359	362	PF01048	0.500
MOD_GlcNHglycan	370	373	PF01048	0.537
MOD_GlcNHglycan	429	432	PF01048	0.497
MOD_GlcNHglycan	61	64	PF01048	0.311
MOD_GSK3_1	132	139	PF00069	0.391
MOD_GSK3_1	222	229	PF00069	0.429
MOD_GSK3_1	34	41	PF00069	0.524
MOD_GSK3_1	357	364	PF00069	0.525
MOD_GSK3_1	459	466	PF00069	0.498
MOD_LATS_1	303	309	PF00433	0.593
MOD_N-GLC_2	392	394	PF02516	0.428
MOD_NEK2_1	1	6	PF00069	0.484
MOD_NEK2_1	105	110	PF00069	0.269
MOD_NEK2_1	20	25	PF00069	0.446
MOD_NEK2_1	36	41	PF00069	0.380
MOD_PIKK_1	307	313	PF00454	0.578
MOD_PIKK_1	74	80	PF00454	0.431
MOD_PKA_1	305	311	PF00069	0.618
MOD_PKA_2	1	7	PF00069	0.474
MOD_PKA_2	132	138	PF00069	0.386
MOD_PKA_2	207	213	PF00069	0.592
MOD_PKA_2	304	310	PF00069	0.639
MOD_PKA_2	340	346	PF00069	0.656
MOD_PKA_2	403	409	PF00069	0.469
MOD_PKA_2	443	449	PF00069	0.473
MOD_PKA_2	49	55	PF00069	0.405
MOD_Plk_1	201	207	PF00069	0.485
MOD_Plk_1	221	227	PF00069	0.276
MOD_Plk_1	383	389	PF00069	0.373
MOD_Plk_2-3	250	256	PF00069	0.278
MOD_Plk_4	222	228	PF00069	0.540
MOD_Plk_4	352	358	PF00069	0.335
MOD_Plk_4	443	449	PF00069	0.462
MOD_ProDKin_1	226	232	PF00069	0.432
MOD_ProDKin_1	333	339	PF00069	0.650
MOD_ProDKin_1	8	14	PF00069	0.390
MOD_SUMO_rev_2	89	96	PF00179	0.331
TRG_DiLeu_BaEn_1	100	105	PF01217	0.408
TRG_DiLeu_BaEn_1	443	448	PF01217	0.530
TRG_DiLeu_BaEn_2	221	227	PF01217	0.438
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.536
TRG_ENDOCYTIC_2	425	428	PF00928	0.334
TRG_ER_diArg_1	1	3	PF00400	0.532
TRG_ER_diArg_1	376	378	PF00400	0.668
TRG_NES_CRM1_1	78	92	PF08389	0.422
TRG_NES_CRM1_1	99	115	PF08389	0.257
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X3	Leptomonas seymouri	71%	100%
A0A0S4IT89	Bodo saltans	42%	82%
A0A1X0P4R6	Trypanosomatidae	58%	100%
A0A3Q8IN33	Leishmania donovani	92%	100%
A0A3R7MKC3	Trypanosoma rangeli	57%	100%
A4HDV8	Leishmania braziliensis	86%	100%
A4I153	Leishmania infantum	93%	100%
D0A5D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D0A5D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q4QA85	Leishmania major	92%	100%
V5BSX0	Trypanosoma cruzi	56%	100%