t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qc-SNARE protein, putative

Species:

Leishmania mexicana

UniProt:

E9AX85_LEIMU

TriTrypDb:

LmxM.25.0090

Length:

120

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AX85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX85

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0008104	protein localization	4	8
GO:0009987	cellular process	1	8
GO:0015031	protein transport	4	8
GO:0033036	macromolecule localization	2	8
GO:0045184	establishment of protein localization	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0051641	cellular localization	2	8
GO:0070727	cellular macromolecule localization	3	8
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	118	120	PF00082	0.596
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.596
CLV_PCSK_SKI1_1	10	14	PF00082	0.492
DEG_Nend_UBRbox_3	1	3	PF02207	0.705
DOC_USP7_MATH_1	39	43	PF00917	0.622
DOC_USP7_MATH_1	82	86	PF00917	0.633
DOC_USP7_UBL2_3	66	70	PF12436	0.573
LIG_Actin_WH2_2	102	120	PF00022	0.385
LIG_FHA_1	112	118	PF00498	0.306
LIG_LIR_Gen_1	19	29	PF02991	0.670
LIG_LIR_Nem_3	98	104	PF02991	0.282
LIG_PCNA_PIPBox_1	47	56	PF02747	0.636
LIG_RPA_C_Fungi	71	83	PF08784	0.568
LIG_SH2_NCK_1	97	101	PF00017	0.220
LIG_SH2_STAP1	113	117	PF00017	0.378
LIG_SH2_STAP1	97	101	PF00017	0.419
LIG_SH2_STAT5	110	113	PF00017	0.337
LIG_SH2_STAT5	97	100	PF00017	0.403
LIG_SH3_3	12	18	PF00018	0.496
LIG_UBA3_1	64	70	PF00899	0.598
MOD_CK1_1	42	48	PF00069	0.439
MOD_CK1_1	81	87	PF00069	0.553
MOD_GlcNHglycan	80	83	PF01048	0.572
MOD_GSK3_1	1	8	PF00069	0.595
MOD_GSK3_1	78	85	PF00069	0.568
MOD_NEK2_1	1	6	PF00069	0.562
MOD_NEK2_1	111	116	PF00069	0.271
MOD_NEK2_1	40	45	PF00069	0.434
MOD_NEK2_2	82	87	PF00069	0.554
MOD_Plk_4	1	7	PF00069	0.527
MOD_Plk_4	111	117	PF00069	0.262
MOD_Plk_4	85	91	PF00069	0.505
TRG_DiLeu_BaEn_1	60	65	PF01217	0.558
TRG_ENDOCYTIC_2	113	116	PF00928	0.308
TRG_ENDOCYTIC_2	22	25	PF00928	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I772	Leptomonas seymouri	69%	98%
A0A0S4IMR3	Bodo saltans	34%	82%
A0A1X0P4K2	Trypanosomatidae	42%	99%
A0A3S7WYP8	Leishmania donovani	90%	100%
A0A422NF19	Trypanosoma rangeli	42%	100%
A4HDV6	Leishmania braziliensis	79%	100%
A4I151	Leishmania infantum	90%	100%
D0A5D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q3MHP8	Bos taurus	32%	100%
Q4QA87	Leishmania major	92%	100%
Q5RBX2	Pongo abelii	32%	100%
Q9NYM9	Homo sapiens	32%	100%