Putative poly(A)-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A)-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AX84_LEIMU

TriTrypDb:

LmxM.25.0080

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AX84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX84

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0005515	protein binding	2	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0031369	translation initiation factor binding	3	1
GO:0031370	eukaryotic initiation factor 4G binding	4	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.473
CLV_NRD_NRD_1	175	177	PF00675	0.448
CLV_NRD_NRD_1	379	381	PF00675	0.542
CLV_NRD_NRD_1	433	435	PF00675	0.599
CLV_NRD_NRD_1	93	95	PF00675	0.432
CLV_PCSK_KEX2_1	175	177	PF00082	0.506
CLV_PCSK_KEX2_1	379	381	PF00082	0.540
CLV_PCSK_KEX2_1	433	435	PF00082	0.599
CLV_PCSK_SKI1_1	129	133	PF00082	0.267
CLV_PCSK_SKI1_1	153	157	PF00082	0.260
CLV_PCSK_SKI1_1	193	197	PF00082	0.223
CLV_PCSK_SKI1_1	228	232	PF00082	0.297
CLV_PCSK_SKI1_1	258	262	PF00082	0.565
CLV_PCSK_SKI1_1	306	310	PF00082	0.299
CLV_PCSK_SKI1_1	358	362	PF00082	0.328
CLV_PCSK_SKI1_1	83	87	PF00082	0.435
CLV_Separin_Metazoa	445	449	PF03568	0.667
DOC_CKS1_1	58	63	PF01111	0.357
DOC_CYCLIN_RxL_1	490	500	PF00134	0.483
DOC_MAPK_MEF2A_6	504	512	PF00069	0.432
DOC_PP1_RVXF_1	81	87	PF00149	0.510
DOC_PP4_FxxP_1	58	61	PF00568	0.363
DOC_PP4_MxPP_1	389	392	PF00568	0.601
DOC_PP4_MxPP_1	408	411	PF00568	0.664
DOC_PP4_MxPP_1	412	415	PF00568	0.668
DOC_PP4_MxPP_1	447	450	PF00568	0.681
DOC_USP7_MATH_1	131	135	PF00917	0.523
DOC_USP7_MATH_1	183	187	PF00917	0.492
DOC_USP7_MATH_1	345	349	PF00917	0.513
DOC_USP7_MATH_1	35	39	PF00917	0.457
DOC_USP7_MATH_1	496	500	PF00917	0.499
DOC_WW_Pin1_4	475	480	PF00397	0.457
DOC_WW_Pin1_4	57	62	PF00397	0.357
DOC_WW_Pin1_4	74	79	PF00397	0.343
LIG_14-3-3_CanoR_1	124	132	PF00244	0.489
LIG_14-3-3_CanoR_1	339	349	PF00244	0.478
LIG_14-3-3_CanoR_1	402	412	PF00244	0.584
LIG_14-3-3_CanoR_1	452	456	PF00244	0.632
LIG_14-3-3_CanoR_1	7	11	PF00244	0.341
LIG_Actin_WH2_2	183	198	PF00022	0.164
LIG_Actin_WH2_2	293	308	PF00022	0.487
LIG_Clathr_ClatBox_1	231	235	PF01394	0.452
LIG_CtBP_PxDLS_1	418	422	PF00389	0.674
LIG_FHA_1	504	510	PF00498	0.432
LIG_FHA_2	196	202	PF00498	0.438
LIG_FHA_2	204	210	PF00498	0.431
LIG_FHA_2	58	64	PF00498	0.499
LIG_LIR_Gen_1	227	234	PF02991	0.518
LIG_LIR_Gen_1	488	497	PF02991	0.432
LIG_LIR_Gen_1	515	526	PF02991	0.499
LIG_LIR_Nem_3	138	144	PF02991	0.432
LIG_LIR_Nem_3	186	190	PF02991	0.365
LIG_LIR_Nem_3	209	214	PF02991	0.468
LIG_LIR_Nem_3	227	232	PF02991	0.457
LIG_LIR_Nem_3	307	312	PF02991	0.434
LIG_LIR_Nem_3	327	331	PF02991	0.417
LIG_LIR_Nem_3	488	494	PF02991	0.432
LIG_LIR_Nem_3	50	56	PF02991	0.432
LIG_LIR_Nem_3	515	521	PF02991	0.499
LIG_LIR_Nem_3	523	528	PF02991	0.499
LIG_NRBOX	485	491	PF00104	0.499
LIG_Pex14_2	225	229	PF04695	0.517
LIG_Pex14_2	396	400	PF04695	0.617
LIG_SH2_CRK	141	145	PF00017	0.455
LIG_SH2_CRK	453	457	PF00017	0.606
LIG_SH2_CRK	491	495	PF00017	0.457
LIG_SH2_CRK	53	57	PF00017	0.432
LIG_SH2_CRK	73	77	PF00017	0.340
LIG_SH2_GRB2like	284	287	PF00017	0.556
LIG_SH2_GRB2like	55	58	PF00017	0.432
LIG_SH2_SRC	284	287	PF00017	0.556
LIG_SH2_STAP1	491	495	PF00017	0.499
LIG_SH2_STAT3	362	365	PF00017	0.323
LIG_SH2_STAT3	460	463	PF00017	0.774
LIG_SH2_STAT5	11	14	PF00017	0.417
LIG_SH2_STAT5	191	194	PF00017	0.432
LIG_SH2_STAT5	292	295	PF00017	0.432
LIG_SH2_STAT5	362	365	PF00017	0.390
LIG_SH2_STAT5	453	456	PF00017	0.631
LIG_SH2_STAT5	473	476	PF00017	0.363
LIG_SH2_STAT5	485	488	PF00017	0.499
LIG_SH2_STAT5	55	58	PF00017	0.432
LIG_SH2_STAT5	73	76	PF00017	0.432
LIG_SH3_3	166	172	PF00018	0.512
LIG_SH3_3	398	404	PF00018	0.572
LIG_SH3_3	408	414	PF00018	0.542
LIG_SH3_3	433	439	PF00018	0.509
LIG_SH3_3	443	449	PF00018	0.587
LIG_Sin3_3	260	267	PF02671	0.332
LIG_TRAF2_1	233	236	PF00917	0.483
LIG_TRAF2_1	513	516	PF00917	0.499
LIG_TRAF2_2	462	467	PF00917	0.614
LIG_TYR_ITIM	489	494	PF00017	0.499
LIG_TYR_ITIM	51	56	PF00017	0.432
LIG_TYR_ITIM	71	76	PF00017	0.340
LIG_WRC_WIRS_1	208	213	PF05994	0.395
MOD_CDK_SPxK_1	74	80	PF00069	0.357
MOD_CK1_1	250	256	PF00069	0.631
MOD_CK1_1	475	481	PF00069	0.493
MOD_CK2_1	195	201	PF00069	0.414
MOD_CK2_1	203	209	PF00069	0.401
MOD_CK2_1	266	272	PF00069	0.558
MOD_CK2_1	361	367	PF00069	0.447
MOD_CK2_1	510	516	PF00069	0.499
MOD_GlcNHglycan	133	136	PF01048	0.252
MOD_GlcNHglycan	251	255	PF01048	0.534
MOD_GlcNHglycan	342	345	PF01048	0.290
MOD_GlcNHglycan	427	430	PF01048	0.641
MOD_GlcNHglycan	95	98	PF01048	0.511
MOD_GSK3_1	131	138	PF00069	0.523
MOD_GSK3_1	203	210	PF00069	0.485
MOD_GSK3_1	213	220	PF00069	0.421
MOD_GSK3_1	350	357	PF00069	0.456
MOD_N-GLC_1	247	252	PF02516	0.299
MOD_N-GLC_1	324	329	PF02516	0.287
MOD_N-GLC_1	71	76	PF02516	0.232
MOD_NEK2_1	158	163	PF00069	0.483
MOD_NEK2_1	195	200	PF00069	0.357
MOD_NEK2_1	29	34	PF00069	0.439
MOD_NEK2_1	354	359	PF00069	0.459
MOD_NEK2_1	361	366	PF00069	0.353
MOD_NEK2_1	489	494	PF00069	0.499
MOD_NEK2_1	497	502	PF00069	0.499
MOD_NEK2_1	71	76	PF00069	0.487
MOD_NEK2_2	183	188	PF00069	0.470
MOD_NEK2_2	324	329	PF00069	0.452
MOD_NEK2_2	35	40	PF00069	0.443
MOD_OFUCOSY	122	128	PF10250	0.299
MOD_PIKK_1	361	367	PF00454	0.348
MOD_PIKK_1	44	50	PF00454	0.432
MOD_PIKK_1	451	457	PF00454	0.634
MOD_PKA_2	451	457	PF00069	0.705
MOD_PKA_2	6	12	PF00069	0.355
MOD_PKA_2	93	99	PF00069	0.506
MOD_Plk_2-3	298	304	PF00069	0.499
MOD_Plk_4	213	219	PF00069	0.472
MOD_Plk_4	279	285	PF00069	0.551
MOD_Plk_4	6	12	PF00069	0.351
MOD_ProDKin_1	475	481	PF00069	0.457
MOD_ProDKin_1	57	63	PF00069	0.357
MOD_ProDKin_1	74	80	PF00069	0.343
MOD_SUMO_rev_2	201	207	PF00179	0.459
MOD_SUMO_rev_2	271	280	PF00179	0.515
MOD_SUMO_rev_2	364	371	PF00179	0.474
TRG_DiLeu_BaEn_3	515	521	PF01217	0.452
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.571
TRG_ENDOCYTIC_2	141	144	PF00928	0.455
TRG_ENDOCYTIC_2	491	494	PF00928	0.457
TRG_ENDOCYTIC_2	53	56	PF00928	0.432
TRG_ENDOCYTIC_2	73	76	PF00928	0.340
TRG_ER_diArg_1	174	176	PF00400	0.497
TRG_ER_diArg_1	371	374	PF00400	0.538
TRG_ER_diArg_1	432	434	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	493	498	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y8	Leptomonas seymouri	39%	96%
A0A0N1I0F0	Leptomonas seymouri	76%	99%
A0A0S4IKZ4	Bodo saltans	34%	95%
A0A0S4JPT3	Bodo saltans	47%	96%
A0A1X0P4T3	Trypanosomatidae	35%	97%
A0A1X0P4V5	Trypanosomatidae	45%	95%
A0A1X0P525	Trypanosomatidae	36%	99%
A0A3Q8IF40	Leishmania donovani	93%	100%
A0A3Q8IGR8	Leishmania donovani	38%	97%
A0A3Q8IMW2	Leishmania donovani	35%	93%
A0A3R7NAH9	Trypanosoma rangeli	38%	100%
A0A422NK82	Trypanosoma rangeli	36%	99%
A1D4K4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	35%	72%
A2Q848	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	74%
A3LXL0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	35%	86%
A4HDV5	Leishmania braziliensis	83%	100%
A4HN85	Leishmania braziliensis	36%	99%
A4HNG6	Leishmania braziliensis	35%	100%
A4I150	Leishmania infantum	93%	100%
A4IBV3	Leishmania infantum	35%	93%
A4IC57	Leishmania infantum	38%	97%
A4QUF0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	36%	71%
A5DM21	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	36%	86%
A5DW14	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	35%	82%
C9ZYE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
C9ZYQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
E9AFP0	Leishmania major	37%	100%
E9AFX7	Leishmania major	34%	99%
E9B6U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B730	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
F1QB54	Danio rerio	42%	86%
F4HT49	Arabidopsis thaliana	37%	100%
O04319	Arabidopsis thaliana	37%	100%
O22173	Arabidopsis thaliana	38%	82%
O60176	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
O64380	Arabidopsis thaliana	37%	82%
P04147	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	94%
P09405	Mus musculus	22%	77%
P0CB38	Homo sapiens	39%	100%
P0CP46	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	35%	81%
P0CP47	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	35%	81%
P11940	Homo sapiens	36%	86%
P19338	Homo sapiens	23%	77%
P20397	Xenopus laevis	22%	84%
P20965	Xenopus laevis	42%	86%
P21187	Drosophila melanogaster	43%	86%
P29341	Mus musculus	36%	86%
P31209	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	83%
P42731	Arabidopsis thaliana	38%	86%
P60047	Gorilla gorilla gorilla	33%	100%
P60048	Hylobates lar	33%	100%
P60049	Pan troglodytes	33%	100%
P60050	Pongo pygmaeus	33%	100%
P61286	Bos taurus	36%	86%
Q05196	Arabidopsis thaliana	34%	80%
Q0CR95	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	35%	72%
Q0U1G2	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	35%	73%
Q13310	Homo sapiens	39%	84%
Q1DXH0	Coccidioides immitis (strain RS)	33%	71%
Q1ZXC2	Dictyostelium discoideum	33%	67%
Q2GSX8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	35%	69%
Q4P8R9	Ustilago maydis (strain 521 / FGSC 9021)	35%	84%
Q4QA88	Leishmania major	92%	100%
Q4R4J7	Macaca fascicularis	23%	77%
Q4VXU2	Homo sapiens	41%	89%
Q4WK03	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	35%	72%
Q54BM2	Dictyostelium discoideum	34%	96%
Q5AI15	Candida albicans (strain SC5314 / ATCC MYA-2876)	35%	86%
Q5B630	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	74%
Q5R8F7	Pongo abelii	36%	86%
Q5RF26	Pongo abelii	23%	76%
Q6BI95	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	36%	87%
Q6CDH3	Yarrowia lipolytica (strain CLIB 122 / E 150)	37%	86%
Q6CSV3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	36%	92%
Q6DEY7	Xenopus tropicalis	40%	86%
Q6FKG4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	94%
Q6GR16	Xenopus laevis	40%	86%
Q6IP09	Xenopus laevis	36%	86%
Q74ZS6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	93%
Q7JGR2	Macaca mulatta	33%	100%
Q7S6N6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	35%	71%
Q8SR30	Encephalitozoon cuniculi (strain GB-M1)	32%	100%
Q96DU9	Homo sapiens	33%	100%
Q98SP8	Xenopus laevis	40%	86%
Q9EPH8	Rattus norvegicus	36%	86%
Q9FXA2	Arabidopsis thaliana	40%	81%
Q9H361	Homo sapiens	34%	86%
Q9ZQA8	Arabidopsis thaliana	34%	89%
V5BYR2	Trypanosoma cruzi	36%	96%
V5DUJ1	Trypanosoma cruzi	36%	99%