HSF_DOMAIN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX81_LEIMU

TriTrypDb:

LmxM.25.0050

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.524
CLV_NRD_NRD_1	57	59	PF00675	0.456
CLV_PCSK_KEX2_1	125	127	PF00082	0.556
CLV_PCSK_KEX2_1	160	162	PF00082	0.537
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.607
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.642
CLV_PCSK_SKI1_1	116	120	PF00082	0.578
DEG_APCC_DBOX_1	161	169	PF00400	0.615
DEG_Nend_UBRbox_2	1	3	PF02207	0.496
DEG_SCF_FBW7_1	118	123	PF00400	0.587
DOC_MAPK_gen_1	125	133	PF00069	0.558
DOC_MAPK_RevD_3	146	162	PF00069	0.423
DOC_PP1_RVXF_1	14	20	PF00149	0.462
DOC_PP2B_LxvP_1	148	151	PF13499	0.437
DOC_USP7_MATH_1	120	124	PF00917	0.661
DOC_USP7_MATH_1	132	136	PF00917	0.765
DOC_WW_Pin1_4	116	121	PF00397	0.593
DOC_WW_Pin1_4	124	129	PF00397	0.713
LIG_14-3-3_CanoR_1	113	119	PF00244	0.501
LIG_14-3-3_CanoR_1	136	144	PF00244	0.673
LIG_14-3-3_CanoR_1	78	87	PF00244	0.319
LIG_EVH1_1	148	152	PF00568	0.433
LIG_FHA_1	51	57	PF00498	0.443
LIG_FHA_1	74	80	PF00498	0.485
LIG_FHA_1	82	88	PF00498	0.563
LIG_FHA_2	138	144	PF00498	0.460
LIG_FHA_2	154	160	PF00498	0.534
LIG_LIR_Gen_1	21	30	PF02991	0.504
LIG_LIR_Gen_1	37	46	PF02991	0.425
LIG_LIR_Gen_1	5	14	PF02991	0.456
LIG_LIR_Nem_3	21	25	PF02991	0.393
LIG_LIR_Nem_3	37	41	PF02991	0.463
LIG_LIR_Nem_3	5	10	PF02991	0.452
LIG_LIR_Nem_3	61	65	PF02991	0.504
LIG_NRBOX	110	116	PF00104	0.423
LIG_OCRL_FandH_1	6	18	PF00620	0.457
LIG_Pex14_2	40	44	PF04695	0.317
LIG_REV1ctd_RIR_1	38	47	PF16727	0.327
LIG_SH2_STAP1	38	42	PF00017	0.419
LIG_SH3_3	146	152	PF00018	0.630
LIG_WW_3	136	140	PF00397	0.550
MOD_CDC14_SPxK_1	127	130	PF00782	0.479
MOD_CDK_SPxK_1	124	130	PF00069	0.474
MOD_CK1_1	5	11	PF00069	0.549
MOD_CK2_1	137	143	PF00069	0.555
MOD_DYRK1A_RPxSP_1	116	120	PF00069	0.617
MOD_GlcNHglycan	101	104	PF01048	0.458
MOD_GlcNHglycan	90	93	PF01048	0.538
MOD_GSK3_1	116	123	PF00069	0.560
MOD_GSK3_1	164	171	PF00069	0.688
MOD_NEK2_1	107	112	PF00069	0.478
MOD_NEK2_1	114	119	PF00069	0.466
MOD_NEK2_1	3	8	PF00069	0.350
MOD_NEK2_2	73	78	PF00069	0.518
MOD_Plk_2-3	23	29	PF00069	0.472
MOD_Plk_4	107	113	PF00069	0.479
MOD_Plk_4	153	159	PF00069	0.501
MOD_Plk_4	36	42	PF00069	0.514
MOD_ProDKin_1	116	122	PF00069	0.604
MOD_ProDKin_1	124	130	PF00069	0.715
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.489
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.440
TRG_ENDOCYTIC_2	38	41	PF00928	0.419
TRG_ENDOCYTIC_2	46	49	PF00928	0.270
TRG_ER_diArg_1	161	163	PF00400	0.651
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW6	Leptomonas seymouri	58%	98%
A0A0S4IX66	Bodo saltans	28%	99%
A0A3Q8ID49	Leishmania donovani	89%	100%
A4HDV2	Leishmania braziliensis	80%	100%
A4I147	Leishmania infantum	89%	100%
C9ZU45	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
Q4QA91	Leishmania major	89%	100%
V5D433	Trypanosoma cruzi	44%	98%