Dynactin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AX76_LEIMU

TriTrypDb:

LmxM.24.2300

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	138	142	PF00082	0.703
CLV_PCSK_SKI1_1	169	173	PF00082	0.633
DEG_APCC_DBOX_1	137	145	PF00400	0.695
DEG_APCC_DBOX_1	168	176	PF00400	0.691
DEG_Nend_UBRbox_2	1	3	PF02207	0.782
DOC_MIT_MIM_1	97	105	PF04212	0.624
DOC_USP7_MATH_1	143	147	PF00917	0.574
DOC_USP7_MATH_1	20	24	PF00917	0.732
DOC_USP7_MATH_1	215	219	PF00917	0.403
DOC_USP7_MATH_1	25	29	PF00917	0.664
DOC_USP7_MATH_1	49	53	PF00917	0.706
DOC_USP7_MATH_1	66	70	PF00917	0.491
DOC_USP7_UBL2_3	107	111	PF12436	0.702
LIG_14-3-3_CanoR_1	101	106	PF00244	0.614
LIG_14-3-3_CanoR_1	160	165	PF00244	0.423
LIG_14-3-3_CanoR_1	211	219	PF00244	0.640
LIG_Actin_WH2_2	141	157	PF00022	0.673
LIG_Actin_WH2_2	56	74	PF00022	0.690
LIG_BRCT_BRCA1_1	51	55	PF00533	0.437
LIG_Clathr_ClatBox_1	102	106	PF01394	0.397
LIG_Clathr_ClatBox_1	123	127	PF01394	0.662
LIG_DLG_GKlike_1	101	109	PF00625	0.615
LIG_FHA_1	149	155	PF00498	0.532
LIG_FHA_1	229	235	PF00498	0.449
LIG_FHA_2	117	123	PF00498	0.671
LIG_FHA_2	154	160	PF00498	0.432
LIG_FHA_2	199	205	PF00498	0.478
LIG_LIR_Gen_1	146	154	PF02991	0.572
LIG_LIR_Gen_1	2	11	PF02991	0.711
LIG_LIR_Gen_1	218	227	PF02991	0.496
LIG_LIR_Nem_3	146	150	PF02991	0.572
LIG_LIR_Nem_3	2	7	PF02991	0.696
LIG_LIR_Nem_3	218	223	PF02991	0.464
LIG_NRBOX	108	114	PF00104	0.577
LIG_SH2_GRB2like	33	36	PF00017	0.714
LIG_SH2_NCK_1	33	37	PF00017	0.634
LIG_SH2_NCK_1	4	8	PF00017	0.688
LIG_SH2_NCK_1	48	52	PF00017	0.456
LIG_SH2_SRC	33	36	PF00017	0.714
LIG_SH2_STAP1	33	37	PF00017	0.604
LIG_SH2_STAP1	4	8	PF00017	0.766
LIG_SH2_STAT5	39	42	PF00017	0.655
LIG_SUMO_SIM_par_1	100	106	PF11976	0.403
LIG_SUMO_SIM_par_1	121	127	PF11976	0.668
LIG_TRAF2_1	119	122	PF00917	0.653
LIG_TRAF2_1	201	204	PF00917	0.506
LIG_UBA3_1	98	107	PF00899	0.406
LIG_WRC_WIRS_1	144	149	PF05994	0.587
MOD_CK1_1	131	137	PF00069	0.570
MOD_CK1_1	146	152	PF00069	0.449
MOD_CK1_1	27	33	PF00069	0.611
MOD_CK1_1	92	98	PF00069	0.704
MOD_CK2_1	116	122	PF00069	0.705
MOD_CK2_1	153	159	PF00069	0.373
MOD_CK2_1	197	203	PF00069	0.543
MOD_CK2_1	215	221	PF00069	0.361
MOD_GlcNHglycan	113	116	PF01048	0.391
MOD_GlcNHglycan	133	136	PF01048	0.698
MOD_GlcNHglycan	138	141	PF01048	0.621
MOD_GlcNHglycan	212	215	PF01048	0.555
MOD_GlcNHglycan	22	25	PF01048	0.685
MOD_GlcNHglycan	27	30	PF01048	0.674
MOD_GlcNHglycan	94	97	PF01048	0.605
MOD_GSK3_1	20	27	PF00069	0.742
MOD_GSK3_1	47	54	PF00069	0.616
MOD_GSK3_1	88	95	PF00069	0.714
MOD_GSK3_1	97	104	PF00069	0.591
MOD_N-GLC_1	128	133	PF02516	0.728
MOD_NEK2_1	13	18	PF00069	0.677
MOD_NEK2_1	153	158	PF00069	0.539
MOD_NEK2_1	187	192	PF00069	0.478
MOD_NEK2_1	209	214	PF00069	0.658
MOD_NEK2_2	215	220	PF00069	0.519
MOD_PK_1	3	9	PF00069	0.689
MOD_PKA_1	197	203	PF00069	0.364
MOD_PKA_2	20	26	PF00069	0.660
MOD_PKA_2	210	216	PF00069	0.647
MOD_Plk_1	105	111	PF00069	0.694
MOD_Plk_1	128	134	PF00069	0.640
MOD_Plk_1	66	72	PF00069	0.642
MOD_Plk_2-3	122	128	PF00069	0.662
MOD_Plk_4	143	149	PF00069	0.593
MOD_Plk_4	215	221	PF00069	0.416
MOD_Plk_4	66	72	PF00069	0.713
MOD_SUMO_rev_2	190	200	PF00179	0.635
TRG_DiLeu_BaEn_4	121	127	PF01217	0.661
TRG_ENDOCYTIC_2	4	7	PF00928	0.756
TRG_ER_diArg_1	80	83	PF00400	0.586
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C0	Leptomonas seymouri	26%	100%
A0A3S7WYM3	Leishmania donovani	82%	100%
A4HDU1	Leishmania braziliensis	62%	100%
A4I138	Leishmania infantum	81%	100%
Q4QAA0	Leishmania major	82%	100%