Cullin-like protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cullin-like protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AX75_LEIMU

TriTrypDb:

LmxM.24.2290

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0005737	cytoplasm	2	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9AX75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX75

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12
GO:0016567	protein ubiquitination	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070647	protein modification by small protein conjugation or removal	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0019899	enzyme binding	3	12
GO:0031625	ubiquitin protein ligase binding	5	12
GO:0044389	ubiquitin-like protein ligase binding	4	12
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.330
CLV_MEL_PAP_1	706	712	PF00089	0.251
CLV_NRD_NRD_1	241	243	PF00675	0.343
CLV_NRD_NRD_1	267	269	PF00675	0.364
CLV_NRD_NRD_1	298	300	PF00675	0.250
CLV_NRD_NRD_1	623	625	PF00675	0.314
CLV_NRD_NRD_1	648	650	PF00675	0.422
CLV_NRD_NRD_1	674	676	PF00675	0.230
CLV_NRD_NRD_1	690	692	PF00675	0.206
CLV_NRD_NRD_1	726	728	PF00675	0.213
CLV_NRD_NRD_1	9	11	PF00675	0.371
CLV_PCSK_FUR_1	646	650	PF00082	0.438
CLV_PCSK_KEX2_1	206	208	PF00082	0.366
CLV_PCSK_KEX2_1	241	243	PF00082	0.349
CLV_PCSK_KEX2_1	267	269	PF00082	0.296
CLV_PCSK_KEX2_1	298	300	PF00082	0.250
CLV_PCSK_KEX2_1	648	650	PF00082	0.521
CLV_PCSK_KEX2_1	690	692	PF00082	0.228
CLV_PCSK_KEX2_1	726	728	PF00082	0.301
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.366
CLV_PCSK_PC7_1	237	243	PF00082	0.257
CLV_PCSK_SKI1_1	151	155	PF00082	0.316
CLV_PCSK_SKI1_1	156	160	PF00082	0.313
CLV_PCSK_SKI1_1	251	255	PF00082	0.285
CLV_PCSK_SKI1_1	444	448	PF00082	0.228
CLV_PCSK_SKI1_1	550	554	PF00082	0.220
CLV_PCSK_SKI1_1	6	10	PF00082	0.400
CLV_PCSK_SKI1_1	620	624	PF00082	0.278
CLV_PCSK_SKI1_1	628	632	PF00082	0.331
CLV_PCSK_SKI1_1	685	689	PF00082	0.211
CLV_PCSK_SKI1_1	715	719	PF00082	0.244
CLV_Separin_Metazoa	537	541	PF03568	0.457
DEG_APCC_DBOX_1	5	13	PF00400	0.505
DEG_MDM2_SWIB_1	212	219	PF02201	0.426
DEG_Nend_Nbox_1	1	3	PF02207	0.407
DEG_SPOP_SBC_1	379	383	PF00917	0.455
DOC_CKS1_1	592	597	PF01111	0.457
DOC_CYCLIN_RxL_1	151	161	PF00134	0.515
DOC_MAPK_gen_1	298	305	PF00069	0.451
DOC_MAPK_gen_1	497	504	PF00069	0.401
DOC_MAPK_gen_1	568	575	PF00069	0.501
DOC_MAPK_MEF2A_6	497	504	PF00069	0.448
DOC_MAPK_MEF2A_6	519	528	PF00069	0.472
DOC_MAPK_MEF2A_6	709	716	PF00069	0.524
DOC_PP1_RVXF_1	548	555	PF00149	0.411
DOC_PP4_FxxP_1	197	200	PF00568	0.424
DOC_USP7_MATH_1	379	383	PF00917	0.531
DOC_USP7_MATH_1	545	549	PF00917	0.469
DOC_USP7_MATH_1	657	661	PF00917	0.561
DOC_USP7_UBL2_3	104	108	PF12436	0.421
DOC_USP7_UBL2_3	156	160	PF12436	0.514
DOC_WW_Pin1_4	260	265	PF00397	0.478
DOC_WW_Pin1_4	270	275	PF00397	0.530
DOC_WW_Pin1_4	587	592	PF00397	0.464
DOC_WW_Pin1_4	708	713	PF00397	0.478
LIG_14-3-3_CanoR_1	151	159	PF00244	0.381
LIG_14-3-3_CanoR_1	165	174	PF00244	0.461
LIG_14-3-3_CanoR_1	242	252	PF00244	0.443
LIG_14-3-3_CanoR_1	28	34	PF00244	0.339
LIG_14-3-3_CanoR_1	419	425	PF00244	0.459
LIG_14-3-3_CanoR_1	432	441	PF00244	0.437
LIG_14-3-3_CanoR_1	49	57	PF00244	0.464
LIG_14-3-3_CanoR_1	519	527	PF00244	0.435
LIG_14-3-3_CanoR_1	550	555	PF00244	0.421
LIG_14-3-3_CanoR_1	601	607	PF00244	0.495
LIG_14-3-3_CanoR_1	658	662	PF00244	0.550
LIG_14-3-3_CanoR_1	690	694	PF00244	0.435
LIG_APCC_ABBA_1	135	140	PF00400	0.429
LIG_APCC_ABBA_1	198	203	PF00400	0.478
LIG_APCC_ABBA_1	391	396	PF00400	0.478
LIG_APCC_Cbox_2	431	437	PF00515	0.514
LIG_BRCT_BRCA1_1	352	356	PF00533	0.453
LIG_BRCT_BRCA1_1	485	489	PF00533	0.478
LIG_BRCT_BRCA1_1	706	710	PF00533	0.435
LIG_Clathr_ClatBox_1	630	634	PF01394	0.457
LIG_Clathr_ClatBox_1	65	69	PF01394	0.453
LIG_CtBP_PxDLS_1	653	657	PF00389	0.548
LIG_deltaCOP1_diTrp_1	482	489	PF00928	0.549
LIG_EH1_1	503	511	PF00400	0.514
LIG_eIF4E_1	60	66	PF01652	0.435
LIG_eIF4E_2	612	618	PF01652	0.426
LIG_FHA_1	152	158	PF00498	0.420
LIG_FHA_1	187	193	PF00498	0.514
LIG_FHA_1	471	477	PF00498	0.448
LIG_FHA_1	501	507	PF00498	0.507
LIG_FHA_1	73	79	PF00498	0.416
LIG_FHA_2	203	209	PF00498	0.498
LIG_FHA_2	244	250	PF00498	0.500
LIG_FHA_2	252	258	PF00498	0.473
LIG_FHA_2	426	432	PF00498	0.469
LIG_FHA_2	434	440	PF00498	0.416
LIG_FHA_2	636	642	PF00498	0.457
LIG_GBD_Chelix_1	149	157	PF00786	0.314
LIG_Integrin_RGD_1	162	164	PF01839	0.140
LIG_LIR_Apic_2	195	200	PF02991	0.426
LIG_LIR_Gen_1	15	23	PF02991	0.371
LIG_LIR_Gen_1	208	213	PF02991	0.495
LIG_LIR_Gen_1	215	224	PF02991	0.500
LIG_LIR_Gen_1	605	614	PF02991	0.457
LIG_LIR_Gen_1	69	78	PF02991	0.424
LIG_LIR_Gen_1	91	99	PF02991	0.501
LIG_LIR_Nem_3	113	117	PF02991	0.371
LIG_LIR_Nem_3	118	124	PF02991	0.324
LIG_LIR_Nem_3	15	19	PF02991	0.362
LIG_LIR_Nem_3	208	212	PF02991	0.471
LIG_LIR_Nem_3	215	219	PF02991	0.481
LIG_LIR_Nem_3	24	30	PF02991	0.424
LIG_LIR_Nem_3	346	351	PF02991	0.442
LIG_LIR_Nem_3	399	404	PF02991	0.462
LIG_LIR_Nem_3	54	60	PF02991	0.418
LIG_LIR_Nem_3	605	609	PF02991	0.457
LIG_LIR_Nem_3	64	70	PF02991	0.402
LIG_LIR_Nem_3	91	96	PF02991	0.455
LIG_LIR_Nem_3	98	103	PF02991	0.421
LIG_LYPXL_S_1	347	351	PF13949	0.314
LIG_LYPXL_yS_3	348	351	PF13949	0.514
LIG_PCNA_yPIPBox_3	71	82	PF02747	0.411
LIG_PDZ_Class_2	739	744	PF00595	0.339
LIG_Pex14_1	397	401	PF04695	0.514
LIG_Pex14_2	212	216	PF04695	0.524
LIG_Pex14_2	356	360	PF04695	0.514
LIG_PTB_Apo_2	290	297	PF02174	0.457
LIG_PTB_Apo_2	400	407	PF02174	0.457
LIG_REV1ctd_RIR_1	293	303	PF16727	0.514
LIG_SH2_CRK	103	107	PF00017	0.421
LIG_SH2_CRK	40	44	PF00017	0.411
LIG_SH2_CRK	740	744	PF00017	0.437
LIG_SH2_GRB2like	401	404	PF00017	0.514
LIG_SH2_NCK_1	40	44	PF00017	0.411
LIG_SH2_SRC	612	615	PF00017	0.426
LIG_SH2_STAP1	209	213	PF00017	0.519
LIG_SH2_STAT3	404	407	PF00017	0.340
LIG_SH2_STAT5	116	119	PF00017	0.411
LIG_SH2_STAT5	121	124	PF00017	0.411
LIG_SH2_STAT5	193	196	PF00017	0.419
LIG_SH2_STAT5	201	204	PF00017	0.400
LIG_SH2_STAT5	243	246	PF00017	0.411
LIG_SH2_STAT5	337	340	PF00017	0.532
LIG_SH2_STAT5	401	404	PF00017	0.439
LIG_SH2_STAT5	426	429	PF00017	0.421
LIG_SH2_STAT5	44	47	PF00017	0.433
LIG_SH2_STAT5	543	546	PF00017	0.421
LIG_SH2_STAT5	612	615	PF00017	0.457
LIG_SH2_STAT5	729	732	PF00017	0.435
LIG_SH2_STAT5	77	80	PF00017	0.471
LIG_SH3_3	258	264	PF00018	0.514
LIG_SH3_3	268	274	PF00018	0.514
LIG_SH3_3	524	530	PF00018	0.508
LIG_SH3_3	589	595	PF00018	0.457
LIG_SH3_4	127	134	PF00018	0.435
LIG_SUMO_SIM_anti_2	300	307	PF11976	0.513
LIG_SUMO_SIM_anti_2	331	336	PF11976	0.521
LIG_SUMO_SIM_anti_2	505	510	PF11976	0.464
LIG_SUMO_SIM_par_1	95	101	PF11976	0.514
LIG_TRAF2_1	88	91	PF00917	0.501
LIG_TRAF2_2	595	600	PF00917	0.457
LIG_UBA3_1	305	312	PF00899	0.514
LIG_WRC_WIRS_1	111	116	PF05994	0.478
LIG_WRC_WIRS_1	30	35	PF05994	0.528
MOD_CDK_SPxxK_3	260	267	PF00069	0.514
MOD_CDK_SPxxK_3	708	715	PF00069	0.451
MOD_CK1_1	126	132	PF00069	0.453
MOD_CK1_1	263	269	PF00069	0.435
MOD_CK1_1	294	300	PF00069	0.442
MOD_CK1_1	382	388	PF00069	0.487
MOD_CK1_1	518	524	PF00069	0.546
MOD_CK1_1	708	714	PF00069	0.498
MOD_CK1_1	85	91	PF00069	0.526
MOD_CK2_1	243	249	PF00069	0.478
MOD_CK2_1	251	257	PF00069	0.463
MOD_CK2_1	280	286	PF00069	0.519
MOD_CK2_1	294	300	PF00069	0.454
MOD_CK2_1	382	388	PF00069	0.378
MOD_CK2_1	433	439	PF00069	0.516
MOD_CK2_1	556	562	PF00069	0.496
MOD_CK2_1	657	663	PF00069	0.588
MOD_CK2_1	85	91	PF00069	0.461
MOD_Cter_Amidation	688	691	PF01082	0.314
MOD_GlcNHglycan	274	277	PF01048	0.261
MOD_GlcNHglycan	300	303	PF01048	0.300
MOD_GlcNHglycan	384	387	PF01048	0.301
MOD_GlcNHglycan	413	416	PF01048	0.318
MOD_GlcNHglycan	53	56	PF01048	0.195
MOD_GlcNHglycan	547	550	PF01048	0.262
MOD_GlcNHglycan	559	562	PF01048	0.232
MOD_GlcNHglycan	625	628	PF01048	0.327
MOD_GlcNHglycan	83	87	PF01048	0.317
MOD_GSK3_1	188	195	PF00069	0.514
MOD_GSK3_1	231	238	PF00069	0.521
MOD_GSK3_1	294	301	PF00069	0.510
MOD_GSK3_1	378	385	PF00069	0.464
MOD_GSK3_1	45	52	PF00069	0.449
MOD_GSK3_1	552	559	PF00069	0.447
MOD_GSK3_1	587	594	PF00069	0.466
MOD_GSK3_1	616	623	PF00069	0.498
MOD_GSK3_1	657	664	PF00069	0.541
MOD_GSK3_1	704	711	PF00069	0.432
MOD_N-GLC_1	49	54	PF02516	0.296
MOD_N-GLC_1	587	592	PF02516	0.261
MOD_NEK2_1	180	185	PF00069	0.430
MOD_NEK2_1	202	207	PF00069	0.473
MOD_NEK2_1	291	296	PF00069	0.548
MOD_NEK2_1	358	363	PF00069	0.469
MOD_NEK2_1	433	438	PF00069	0.500
MOD_NEK2_1	563	568	PF00069	0.545
MOD_NEK2_1	616	621	PF00069	0.473
MOD_NEK2_1	73	78	PF00069	0.462
MOD_PIKK_1	151	157	PF00454	0.436
MOD_PIKK_1	186	192	PF00454	0.514
MOD_PIKK_1	243	249	PF00454	0.426
MOD_PIKK_1	568	574	PF00454	0.514
MOD_PKA_1	298	304	PF00069	0.514
MOD_PKA_1	450	456	PF00069	0.524
MOD_PKA_1	568	574	PF00069	0.514
MOD_PKA_2	298	304	PF00069	0.479
MOD_PKA_2	48	54	PF00069	0.421
MOD_PKA_2	518	524	PF00069	0.514
MOD_PKA_2	623	629	PF00069	0.478
MOD_PKA_2	657	663	PF00069	0.547
MOD_PKA_2	689	695	PF00069	0.514
MOD_PKB_1	618	626	PF00069	0.457
MOD_PKB_1	80	88	PF00069	0.457
MOD_Plk_1	235	241	PF00069	0.458
MOD_Plk_1	328	334	PF00069	0.517
MOD_Plk_1	358	364	PF00069	0.497
MOD_Plk_1	635	641	PF00069	0.548
MOD_Plk_2-3	328	334	PF00069	0.489
MOD_Plk_2-3	635	641	PF00069	0.514
MOD_Plk_4	133	139	PF00069	0.446
MOD_Plk_4	188	194	PF00069	0.504
MOD_Plk_4	291	297	PF00069	0.504
MOD_Plk_4	39	45	PF00069	0.421
MOD_Plk_4	475	481	PF00069	0.475
MOD_Plk_4	73	79	PF00069	0.496
MOD_ProDKin_1	260	266	PF00069	0.478
MOD_ProDKin_1	270	276	PF00069	0.530
MOD_ProDKin_1	587	593	PF00069	0.464
MOD_ProDKin_1	708	714	PF00069	0.478
MOD_SUMO_for_1	310	313	PF00179	0.552
MOD_SUMO_for_1	325	328	PF00179	0.468
MOD_SUMO_rev_2	164	174	PF00179	0.426
MOD_SUMO_rev_2	668	678	PF00179	0.408
MOD_SUMO_rev_2	707	717	PF00179	0.415
TRG_DiLeu_BaEn_1	505	510	PF01217	0.457
TRG_DiLeu_BaEn_2	428	434	PF01217	0.514
TRG_DiLeu_BaLyEn_6	612	617	PF01217	0.435
TRG_ENDOCYTIC_2	103	106	PF00928	0.411
TRG_ENDOCYTIC_2	120	123	PF00928	0.411
TRG_ENDOCYTIC_2	209	212	PF00928	0.467
TRG_ENDOCYTIC_2	30	33	PF00928	0.431
TRG_ENDOCYTIC_2	348	351	PF00928	0.478
TRG_ENDOCYTIC_2	40	43	PF00928	0.380
TRG_ENDOCYTIC_2	70	73	PF00928	0.418
TRG_ENDOCYTIC_2	740	743	PF00928	0.420
TRG_ENDOCYTIC_2	81	84	PF00928	0.430
TRG_ER_diArg_1	241	243	PF00400	0.513
TRG_ER_diArg_1	281	284	PF00400	0.441
TRG_ER_diArg_1	464	467	PF00400	0.528
TRG_ER_diArg_1	617	620	PF00400	0.514
TRG_ER_diArg_1	646	649	PF00400	0.574
TRG_ER_diArg_1	725	727	PF00400	0.503
TRG_NLS_MonoExtC_3	9	15	PF00514	0.418
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.192
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.226
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.253
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I048	Leptomonas seymouri	81%	100%
A0A0N1I9C6	Leptomonas seymouri	20%	100%
A0A0S4J5R6	Bodo saltans	24%	90%
A0A0S4KHD2	Bodo saltans	22%	100%
A0A0S4KHS5	Bodo saltans	33%	100%
A0A1X0NXD6	Trypanosomatidae	45%	100%
A0A3Q8IF31	Leishmania donovani	96%	100%
A0A3R7K785	Trypanosoma rangeli	46%	100%
A0A3R7K7T8	Trypanosoma rangeli	23%	92%
A2A432	Mus musculus	24%	77%
A4HDU0	Leishmania braziliensis	91%	100%
A4I137	Leishmania infantum	95%	100%
A4IHP4	Xenopus tropicalis	26%	97%
B5DF89	Rattus norvegicus	26%	97%
C9ZW70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A3I2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
O13790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	97%
O14122	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
O60999	Dictyostelium discoideum	25%	97%
P0CH31	Arabidopsis thaliana	25%	100%
Q09760	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	95%
Q12018	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	91%
Q13616	Homo sapiens	25%	96%
Q13617	Homo sapiens	23%	100%
Q13618	Homo sapiens	26%	97%
Q13619	Homo sapiens	25%	98%
Q13620	Homo sapiens	25%	81%
Q17389	Caenorhabditis elegans	25%	95%
Q17390	Caenorhabditis elegans	22%	94%
Q17391	Caenorhabditis elegans	26%	96%
Q21346	Caenorhabditis elegans	25%	100%
Q23639	Caenorhabditis elegans	23%	97%
Q24311	Drosophila melanogaster	24%	96%
Q29425	Oryctolagus cuniculus	22%	95%
Q3TCH7	Mus musculus	24%	98%
Q4QAA1	Leishmania major	96%	100%
Q54CS2	Dictyostelium discoideum	23%	93%
Q54NZ5	Dictyostelium discoideum	23%	97%
Q54XF7	Dictyostelium discoideum	22%	99%
Q5R4G6	Pongo abelii	25%	96%
Q5RB36	Pongo abelii	22%	95%
Q5RCF3	Pongo abelii	23%	100%
Q5ZC88	Oryza sativa subsp. japonica	26%	100%
Q6DE95	Xenopus laevis	26%	97%
Q6GPF3	Xenopus laevis	26%	97%
Q8LGH4	Arabidopsis thaliana	24%	94%
Q93034	Homo sapiens	22%	95%
Q94AH6	Arabidopsis thaliana	27%	100%
Q9C9L0	Arabidopsis thaliana	24%	100%
Q9D4H8	Mus musculus	23%	100%
Q9D5V5	Mus musculus	22%	95%
Q9JJ31	Rattus norvegicus	22%	95%
Q9JLV5	Mus musculus	26%	97%
Q9SRZ0	Arabidopsis thaliana	26%	100%
Q9WTX6	Mus musculus	25%	96%
Q9XZJ3	Dictyostelium discoideum	22%	96%
Q9ZVH4	Arabidopsis thaliana	25%	100%
V5APS6	Trypanosoma cruzi	45%	100%