General transcription and DNA repair factor IIH helicase subunit XPD

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TFIIH basal transcription factor complex helicase subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AX74_LEIMU

TriTrypDb:

LmxM.24.2280

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AX74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX74

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006289	nucleotide-excision repair	6	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000018	regulation of DNA recombination	6	1
GO:0000019	regulation of mitotic recombination	7	1
GO:0000717	nucleotide-excision repair, DNA duplex unwinding	9	1
GO:0006351	DNA-templated transcription	7	1
GO:0006366	transcription by RNA polymerase II	8	1
GO:0006996	organelle organization	4	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0032392	DNA geometric change	7	1
GO:0032508	DNA duplex unwinding	8	1
GO:0032774	RNA biosynthetic process	5	1
GO:0033683	obsolete nucleotide-excision repair, DNA incision	6	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0045911	positive regulation of DNA recombination	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045951	positive regulation of mitotic recombination	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051052	regulation of DNA metabolic process	5	1
GO:0051054	positive regulation of DNA metabolic process	6	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051276	chromosome organization	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071103	DNA conformation change	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0097659	nucleic acid-templated transcription	6	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	8
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003684	damaged DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.423
CLV_C14_Caspase3-7	242	246	PF00656	0.479
CLV_C14_Caspase3-7	539	543	PF00656	0.413
CLV_NRD_NRD_1	185	187	PF00675	0.213
CLV_NRD_NRD_1	486	488	PF00675	0.350
CLV_NRD_NRD_1	594	596	PF00675	0.223
CLV_NRD_NRD_1	67	69	PF00675	0.324
CLV_NRD_NRD_1	753	755	PF00675	0.511
CLV_NRD_NRD_1	803	805	PF00675	0.620
CLV_NRD_NRD_1	87	89	PF00675	0.124
CLV_PCSK_KEX2_1	29	31	PF00082	0.448
CLV_PCSK_KEX2_1	594	596	PF00082	0.223
CLV_PCSK_KEX2_1	67	69	PF00082	0.321
CLV_PCSK_KEX2_1	691	693	PF00082	0.213
CLV_PCSK_KEX2_1	753	755	PF00082	0.534
CLV_PCSK_KEX2_1	805	807	PF00082	0.598
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.448
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.336
CLV_PCSK_PC1ET2_1	691	693	PF00082	0.233
CLV_PCSK_PC1ET2_1	805	807	PF00082	0.598
CLV_PCSK_SKI1_1	135	139	PF00082	0.223
CLV_PCSK_SKI1_1	186	190	PF00082	0.223
CLV_PCSK_SKI1_1	212	216	PF00082	0.316
CLV_PCSK_SKI1_1	373	377	PF00082	0.228
CLV_PCSK_SKI1_1	569	573	PF00082	0.226
CLV_PCSK_SKI1_1	574	578	PF00082	0.199
CLV_PCSK_SKI1_1	692	696	PF00082	0.232
CLV_PCSK_SKI1_1	726	730	PF00082	0.356
CLV_PCSK_SKI1_1	88	92	PF00082	0.223
CLV_Separin_Metazoa	640	644	PF03568	0.413
DEG_APCC_DBOX_1	185	193	PF00400	0.479
DEG_Kelch_actinfilin_1	491	495	PF01344	0.340
DEG_Nend_UBRbox_1	1	4	PF02207	0.316
DEG_SCF_FBW7_1	471	478	PF00400	0.330
DOC_CDC14_PxL_1	629	637	PF14671	0.413
DOC_CKS1_1	297	302	PF01111	0.340
DOC_CYCLIN_RxL_1	102	110	PF00134	0.496
DOC_CYCLIN_RxL_1	370	378	PF00134	0.455
DOC_CYCLIN_RxL_1	466	474	PF00134	0.292
DOC_MAPK_DCC_7	186	194	PF00069	0.516
DOC_MAPK_DCC_7	487	495	PF00069	0.297
DOC_MAPK_gen_1	186	194	PF00069	0.423
DOC_MAPK_gen_1	353	362	PF00069	0.413
DOC_MAPK_gen_1	408	417	PF00069	0.330
DOC_MAPK_gen_1	487	495	PF00069	0.304
DOC_MAPK_gen_1	569	578	PF00069	0.516
DOC_MAPK_gen_1	610	619	PF00069	0.413
DOC_MAPK_gen_1	643	651	PF00069	0.479
DOC_MAPK_gen_1	678	687	PF00069	0.413
DOC_MAPK_HePTP_8	184	196	PF00069	0.479
DOC_MAPK_HePTP_8	677	689	PF00069	0.413
DOC_MAPK_MEF2A_6	186	194	PF00069	0.481
DOC_MAPK_MEF2A_6	34	42	PF00069	0.378
DOC_MAPK_MEF2A_6	48	57	PF00069	0.212
DOC_MAPK_MEF2A_6	645	653	PF00069	0.479
DOC_MAPK_MEF2A_6	680	689	PF00069	0.413
DOC_MIT_MIM_1	365	375	PF04212	0.479
DOC_PP1_RVXF_1	325	332	PF00149	0.423
DOC_PP1_RVXF_1	467	474	PF00149	0.301
DOC_PP1_RVXF_1	572	578	PF00149	0.413
DOC_PP2B_LxvP_1	158	161	PF13499	0.516
DOC_PP2B_LxvP_1	40	43	PF13499	0.307
DOC_PP4_FxxP_1	630	633	PF00568	0.413
DOC_PP4_FxxP_1	634	637	PF00568	0.413
DOC_USP7_MATH_1	205	209	PF00917	0.516
DOC_USP7_MATH_1	528	532	PF00917	0.369
DOC_USP7_UBL2_3	250	254	PF12436	0.358
DOC_WW_Pin1_4	296	301	PF00397	0.440
DOC_WW_Pin1_4	459	464	PF00397	0.297
DOC_WW_Pin1_4	471	476	PF00397	0.308
LIG_14-3-3_CanoR_1	135	140	PF00244	0.413
LIG_14-3-3_CanoR_1	338	344	PF00244	0.418
LIG_14-3-3_CanoR_1	366	375	PF00244	0.402
LIG_14-3-3_CanoR_1	450	455	PF00244	0.441
LIG_14-3-3_CanoR_1	497	504	PF00244	0.427
LIG_14-3-3_CanoR_1	667	676	PF00244	0.418
LIG_14-3-3_CanoR_1	678	687	PF00244	0.402
LIG_14-3-3_CanoR_1	757	765	PF00244	0.600
LIG_Actin_WH2_2	249	266	PF00022	0.415
LIG_Actin_WH2_2	429	447	PF00022	0.316
LIG_APCC_ABBA_1	1	6	PF00400	0.365
LIG_BRCT_BRCA1_1	477	481	PF00533	0.394
LIG_BRCT_BRCA1_1	562	566	PF00533	0.516
LIG_Clathr_ClatBox_1	575	579	PF01394	0.413
LIG_EH1_1	682	690	PF00400	0.413
LIG_eIF4E_1	387	393	PF01652	0.516
LIG_eIF4E_1	4	10	PF01652	0.395
LIG_eIF4E_1	553	559	PF01652	0.423
LIG_eIF4E_1	683	689	PF01652	0.423
LIG_FHA_1	217	223	PF00498	0.437
LIG_FHA_1	297	303	PF00498	0.417
LIG_FHA_1	330	336	PF00498	0.423
LIG_FHA_1	376	382	PF00498	0.434
LIG_FHA_1	433	439	PF00498	0.431
LIG_FHA_1	47	53	PF00498	0.287
LIG_FHA_1	472	478	PF00498	0.348
LIG_FHA_1	578	584	PF00498	0.421
LIG_FHA_1	72	78	PF00498	0.413
LIG_FHA_1	742	748	PF00498	0.460
LIG_FHA_2	240	246	PF00498	0.413
LIG_FHA_2	503	509	PF00498	0.477
LIG_FHA_2	537	543	PF00498	0.419
LIG_FHA_2	74	80	PF00498	0.430
LIG_FHA_2	783	789	PF00498	0.652
LIG_FHA_2	81	87	PF00498	0.452
LIG_IRF3_LxIS_1	651	656	PF10401	0.516
LIG_LIR_Apic_2	15	19	PF02991	0.305
LIG_LIR_Apic_2	406	412	PF02991	0.377
LIG_LIR_Gen_1	198	207	PF02991	0.413
LIG_LIR_Gen_1	273	283	PF02991	0.412
LIG_LIR_Gen_1	526	537	PF02991	0.290
LIG_LIR_Gen_1	549	559	PF02991	0.413
LIG_LIR_LC3C_4	6	11	PF02991	0.439
LIG_LIR_Nem_3	273	278	PF02991	0.412
LIG_LIR_Nem_3	363	368	PF02991	0.516
LIG_LIR_Nem_3	446	451	PF02991	0.303
LIG_LIR_Nem_3	465	470	PF02991	0.345
LIG_LIR_Nem_3	526	532	PF02991	0.297
LIG_LIR_Nem_3	657	663	PF02991	0.416
LIG_LYPXL_S_1	466	470	PF13949	0.295
LIG_LYPXL_SIV_4	181	189	PF13949	0.423
LIG_LYPXL_yS_3	467	470	PF13949	0.299
LIG_MYND_1	633	637	PF01753	0.413
LIG_NRBOX	371	377	PF00104	0.455
LIG_PCNA_PIPBox_1	87	96	PF02747	0.516
LIG_Pex14_2	630	634	PF04695	0.413
LIG_REV1ctd_RIR_1	726	734	PF16727	0.352
LIG_SH2_CRK	150	154	PF00017	0.503
LIG_SH2_CRK	275	279	PF00017	0.423
LIG_SH2_CRK	387	391	PF00017	0.466
LIG_SH2_CRK	397	401	PF00017	0.404
LIG_SH2_CRK	451	455	PF00017	0.299
LIG_SH2_NCK_1	409	413	PF00017	0.370
LIG_SH2_PTP2	16	19	PF00017	0.293
LIG_SH2_SRC	14	17	PF00017	0.316
LIG_SH2_SRC	59	62	PF00017	0.328
LIG_SH2_STAP1	14	18	PF00017	0.311
LIG_SH2_STAP1	150	154	PF00017	0.503
LIG_SH2_STAP1	275	279	PF00017	0.413
LIG_SH2_STAP1	529	533	PF00017	0.287
LIG_SH2_STAT3	18	21	PF00017	0.283
LIG_SH2_STAT5	16	19	PF00017	0.245
LIG_SH2_STAT5	183	186	PF00017	0.413
LIG_SH2_STAT5	199	202	PF00017	0.415
LIG_SH2_STAT5	24	27	PF00017	0.159
LIG_SH2_STAT5	343	346	PF00017	0.413
LIG_SH2_STAT5	367	370	PF00017	0.423
LIG_SH2_STAT5	397	400	PF00017	0.443
LIG_SH2_STAT5	4	7	PF00017	0.358
LIG_SH2_STAT5	404	407	PF00017	0.403
LIG_SH2_STAT5	59	62	PF00017	0.294
LIG_SH2_STAT5	72	75	PF00017	0.413
LIG_SH3_3	151	157	PF00018	0.406
LIG_SH3_3	294	300	PF00018	0.441
LIG_SH3_3	341	347	PF00018	0.413
LIG_SH3_3	420	426	PF00018	0.362
LIG_SH3_3	630	636	PF00018	0.413
LIG_SH3_3	7	13	PF00018	0.286
LIG_SH3_3	777	783	PF00018	0.632
LIG_SH3_3	793	799	PF00018	0.487
LIG_Sin3_3	521	528	PF02671	0.472
LIG_SUMO_SIM_anti_2	219	225	PF11976	0.437
LIG_SUMO_SIM_anti_2	49	54	PF11976	0.275
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.327
LIG_SUMO_SIM_par_1	217	225	PF11976	0.438
LIG_SUMO_SIM_par_1	48	54	PF11976	0.337
LIG_SUMO_SIM_par_1	491	496	PF11976	0.283
LIG_SUMO_SIM_par_1	685	690	PF11976	0.413
LIG_TRAF2_1	505	508	PF00917	0.483
LIG_TRAF2_1	76	79	PF00917	0.439
LIG_TRAF2_1	785	788	PF00917	0.577
LIG_UBA3_1	532	538	PF00899	0.263
LIG_UBA3_1	604	612	PF00899	0.423
LIG_UBA3_1	685	691	PF00899	0.516
LIG_WRC_WIRS_1	765	770	PF05994	0.498
MOD_CK1_1	120	126	PF00069	0.455
MOD_CK1_1	208	214	PF00069	0.482
MOD_CK1_1	498	504	PF00069	0.457
MOD_CK1_1	51	57	PF00069	0.361
MOD_CK1_1	748	754	PF00069	0.423
MOD_CK2_1	502	508	PF00069	0.496
MOD_CK2_1	524	530	PF00069	0.341
MOD_CK2_1	653	659	PF00069	0.479
MOD_CK2_1	73	79	PF00069	0.413
MOD_CK2_1	764	770	PF00069	0.623
MOD_CK2_1	782	788	PF00069	0.621
MOD_CK2_1	80	86	PF00069	0.413
MOD_GlcNHglycan	43	46	PF01048	0.322
MOD_GlcNHglycan	457	460	PF01048	0.285
MOD_GlcNHglycan	526	529	PF01048	0.321
MOD_GlcNHglycan	563	566	PF01048	0.223
MOD_GlcNHglycan	760	763	PF01048	0.501
MOD_GlcNHglycan	786	792	PF01048	0.648
MOD_GSK3_1	116	123	PF00069	0.438
MOD_GSK3_1	235	242	PF00069	0.413
MOD_GSK3_1	375	382	PF00069	0.403
MOD_GSK3_1	398	405	PF00069	0.425
MOD_GSK3_1	446	453	PF00069	0.307
MOD_GSK3_1	455	462	PF00069	0.293
MOD_GSK3_1	471	478	PF00069	0.359
MOD_GSK3_1	496	503	PF00069	0.502
MOD_GSK3_1	524	531	PF00069	0.452
MOD_GSK3_1	557	564	PF00069	0.340
MOD_GSK3_1	741	748	PF00069	0.390
MOD_GSK3_1	764	771	PF00069	0.521
MOD_GSK3_1	778	785	PF00069	0.746
MOD_LATS_1	364	370	PF00433	0.413
MOD_N-GLC_1	678	683	PF02516	0.222
MOD_N-GLC_1	711	716	PF02516	0.378
MOD_N-GLC_2	114	116	PF02516	0.213
MOD_NEK2_1	107	112	PF00069	0.437
MOD_NEK2_1	239	244	PF00069	0.455
MOD_NEK2_1	263	268	PF00069	0.413
MOD_NEK2_1	360	365	PF00069	0.472
MOD_NEK2_1	375	380	PF00069	0.358
MOD_NEK2_1	444	449	PF00069	0.421
MOD_NEK2_1	481	486	PF00069	0.332
MOD_NEK2_1	524	529	PF00069	0.386
MOD_NEK2_1	536	541	PF00069	0.369
MOD_NEK2_1	577	582	PF00069	0.423
MOD_NEK2_1	742	747	PF00069	0.382
MOD_NEK2_1	758	763	PF00069	0.429
MOD_NEK2_1	764	769	PF00069	0.590
MOD_NEK2_1	80	85	PF00069	0.423
MOD_PIKK_1	577	583	PF00454	0.413
MOD_PIKK_1	667	673	PF00454	0.413
MOD_PK_1	450	456	PF00069	0.309
MOD_PKA_1	243	249	PF00069	0.578
MOD_PKA_2	337	343	PF00069	0.418
MOD_PKA_2	444	450	PF00069	0.460
MOD_PKA_2	496	502	PF00069	0.393
MOD_PKA_2	756	762	PF00069	0.510
MOD_Plk_1	117	123	PF00069	0.463
MOD_Plk_1	216	222	PF00069	0.437
MOD_Plk_1	360	366	PF00069	0.464
MOD_Plk_1	438	444	PF00069	0.280
MOD_Plk_1	583	589	PF00069	0.438
MOD_Plk_1	714	720	PF00069	0.336
MOD_Plk_4	120	126	PF00069	0.463
MOD_Plk_4	149	155	PF00069	0.429
MOD_Plk_4	195	201	PF00069	0.413
MOD_Plk_4	216	222	PF00069	0.429
MOD_Plk_4	235	241	PF00069	0.341
MOD_Plk_4	346	352	PF00069	0.423
MOD_Plk_4	395	401	PF00069	0.453
MOD_Plk_4	51	57	PF00069	0.274
MOD_Plk_4	528	534	PF00069	0.382
MOD_Plk_4	742	748	PF00069	0.378
MOD_ProDKin_1	296	302	PF00069	0.440
MOD_ProDKin_1	459	465	PF00069	0.307
MOD_ProDKin_1	471	477	PF00069	0.304
MOD_SUMO_for_1	354	357	PF00179	0.455
MOD_SUMO_for_1	783	786	PF00179	0.692
MOD_SUMO_rev_2	166	173	PF00179	0.437
TRG_AP2beta_CARGO_1	657	667	PF09066	0.516
TRG_DiLeu_BaEn_1	235	240	PF01217	0.423
TRG_DiLeu_BaEn_1	274	279	PF01217	0.413
TRG_DiLeu_BaEn_1	292	297	PF01217	0.413
TRG_DiLeu_BaEn_1	86	91	PF01217	0.423
TRG_DiLeu_BaEn_2	409	415	PF01217	0.336
TRG_ENDOCYTIC_2	14	17	PF00928	0.316
TRG_ENDOCYTIC_2	150	153	PF00928	0.503
TRG_ENDOCYTIC_2	182	185	PF00928	0.437
TRG_ENDOCYTIC_2	199	202	PF00928	0.437
TRG_ENDOCYTIC_2	275	278	PF00928	0.413
TRG_ENDOCYTIC_2	387	390	PF00928	0.466
TRG_ENDOCYTIC_2	397	400	PF00928	0.404
TRG_ENDOCYTIC_2	451	454	PF00928	0.314
TRG_ENDOCYTIC_2	467	470	PF00928	0.389
TRG_ENDOCYTIC_2	529	532	PF00928	0.291
TRG_ENDOCYTIC_2	551	554	PF00928	0.413
TRG_ENDOCYTIC_2	683	686	PF00928	0.413
TRG_ENDOCYTIC_2	765	768	PF00928	0.540
TRG_ER_diArg_1	593	595	PF00400	0.423
TRG_ER_diArg_1	642	645	PF00400	0.419
TRG_ER_diArg_1	752	754	PF00400	0.521
TRG_NES_CRM1_1	427	439	PF08389	0.462
TRG_NES_CRM1_1	644	659	PF08389	0.413
TRG_NLS_MonoCore_2	803	808	PF00514	0.680
TRG_NLS_MonoExtC_3	803	808	PF00514	0.591
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.207
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.225
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.212
TRG_Pf-PMV_PEXEL_1	704	708	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K3	Leptomonas seymouri	24%	85%
A0A0N1PBH5	Leptomonas seymouri	90%	100%
A0A0S4KNN1	Bodo saltans	67%	100%
A0A1X0NWG0	Trypanosomatidae	74%	99%
A0A3R7REL5	Trypanosoma rangeli	75%	100%
A0A3S7WYU3	Leishmania donovani	97%	100%
A0A3S7X2X3	Leishmania donovani	24%	85%
A4HDT9	Leishmania braziliensis	95%	100%
A4HHR4	Leishmania braziliensis	24%	100%
A4I136	Leishmania infantum	97%	100%
A4I4X4	Leishmania infantum	24%	85%
A4K436	Bos taurus	24%	67%
A5DNW6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	22%	99%
A5DUW8	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	21%	91%
A6QLJ0	Bos taurus	44%	100%
A8MPP1	Homo sapiens	21%	90%
A8WS58	Caenorhabditis briggsae	24%	82%
B0W9F4	Culex quinquefasciatus	24%	83%
B3MSG8	Drosophila ananassae	24%	82%
B3NSW1	Drosophila erecta	24%	83%
B4L1Z2	Drosophila mojavensis	25%	80%
B4M891	Drosophila virilis	25%	81%
B4PZB4	Drosophila yakuba	24%	83%
C9ZKX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	84%
C9ZW71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	99%
E9AEC8	Leishmania major	25%	100%
E9ALF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	85%
F4HQE2	Arabidopsis thaliana	24%	78%
O08811	Mus musculus	44%	100%
P06839	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P0C928	Danio rerio	25%	69%
P18074	Homo sapiens	44%	100%
P26659	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
Q0VGM9	Mus musculus	23%	68%
Q16X92	Aedes aegypti	24%	80%
Q4QAA2	Leishmania major	96%	100%
Q55G81	Dictyostelium discoideum	40%	100%
Q5SXJ3	Mus musculus	23%	69%
Q60452	Cricetulus griseus	44%	100%
Q6AXC6	Mus musculus	21%	90%
Q6BZD9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	99%
Q6H1L8	Mus spretus	24%	68%
Q7QEI1	Anopheles gambiae	24%	82%
Q8W4M7	Arabidopsis thaliana	42%	100%
Q92771	Homo sapiens	21%	86%
Q93575	Caenorhabditis elegans	24%	82%
Q96FC9	Homo sapiens	21%	84%
Q9NZ71	Homo sapiens	24%	67%
V5B587	Trypanosoma cruzi	77%	100%