Hypothetical predicted multi-pass transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Heme Response-1 protein, putative

Species:

Leishmania mexicana

UniProt:

E9AX69_LEIMU

TriTrypDb:

LmxM.24.2230

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AX69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.462
CLV_NRD_NRD_1	8	10	PF00675	0.455
CLV_PCSK_FUR_1	6	10	PF00082	0.476
CLV_PCSK_KEX2_1	7	9	PF00082	0.479
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.479
CLV_PCSK_SKI1_1	101	105	PF00082	0.670
CLV_PCSK_SKI1_1	55	59	PF00082	0.430
DEG_APCC_KENBOX_2	170	174	PF00400	0.625
DEG_Nend_UBRbox_3	1	3	PF02207	0.709
DOC_CKS1_1	59	64	PF01111	0.666
DOC_MAPK_gen_1	6	15	PF00069	0.606
DOC_MAPK_MEF2A_6	126	135	PF00069	0.389
DOC_MAPK_MEF2A_6	8	17	PF00069	0.577
DOC_PP2B_LxvP_1	69	72	PF13499	0.516
DOC_USP7_MATH_1	167	171	PF00917	0.557
DOC_WW_Pin1_4	58	63	PF00397	0.586
LIG_14-3-3_CanoR_1	106	115	PF00244	0.405
LIG_14-3-3_CanoR_1	6	12	PF00244	0.635
LIG_Actin_WH2_2	41	57	PF00022	0.446
LIG_EH1_1	44	52	PF00400	0.434
LIG_eIF4E_1	18	24	PF01652	0.327
LIG_eIF4E_1	25	31	PF01652	0.389
LIG_eIF4E_1	64	70	PF01652	0.532
LIG_EVH1_2	71	75	PF00568	0.697
LIG_FHA_1	130	136	PF00498	0.419
LIG_FHA_1	8	14	PF00498	0.637
LIG_FHA_1	80	86	PF00498	0.447
LIG_FHA_2	140	146	PF00498	0.695
LIG_GBD_Chelix_1	15	23	PF00786	0.402
LIG_GBD_Chelix_1	46	54	PF00786	0.434
LIG_LIR_Gen_1	74	83	PF02991	0.684
LIG_LIR_Nem_3	61	67	PF02991	0.735
LIG_LIR_Nem_3	74	78	PF02991	0.701
LIG_PCNA_PIPBox_1	63	72	PF02747	0.529
LIG_PCNA_yPIPBox_3	63	77	PF02747	0.523
LIG_Pex14_1	14	18	PF04695	0.480
LIG_SH2_STAT5	114	117	PF00017	0.355
LIG_SH2_STAT5	129	132	PF00017	0.314
LIG_SH2_STAT5	18	21	PF00017	0.356
LIG_SH2_STAT5	25	28	PF00017	0.353
LIG_SH3_3	128	134	PF00018	0.426
LIG_TRAF2_1	142	145	PF00917	0.651
LIG_TRFH_1	67	71	PF08558	0.525
LIG_WRC_WIRS_1	80	85	PF05994	0.447
MOD_CDK_SPxxK_3	58	65	PF00069	0.644
MOD_CK2_1	139	145	PF00069	0.681
MOD_GlcNHglycan	155	158	PF01048	0.543
MOD_GlcNHglycan	161	164	PF01048	0.548
MOD_GlcNHglycan	26	29	PF01048	0.470
MOD_GSK3_1	125	132	PF00069	0.412
MOD_NEK2_1	153	158	PF00069	0.732
MOD_NEK2_2	79	84	PF00069	0.447
MOD_PKA_1	7	13	PF00069	0.624
MOD_PKA_2	105	111	PF00069	0.481
MOD_PKA_2	159	165	PF00069	0.609
MOD_PKA_2	7	13	PF00069	0.632
MOD_Plk_1	139	145	PF00069	0.699
MOD_Plk_4	79	85	PF00069	0.392
MOD_ProDKin_1	58	64	PF00069	0.587
TRG_DiLeu_BaEn_1	144	149	PF01217	0.699
TRG_ENDOCYTIC_2	18	21	PF00928	0.355
TRG_ENDOCYTIC_2	67	70	PF00928	0.674
TRG_ENDOCYTIC_2	80	83	PF00928	0.408
TRG_ER_diArg_1	6	9	PF00400	0.599
TRG_NLS_MonoExtN_4	6	11	PF00514	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C1	Leptomonas seymouri	64%	100%
A0A0S4IMU6	Bodo saltans	31%	78%
A0A1X0NWM1	Trypanosomatidae	34%	100%
A0A3R7LPV2	Trypanosoma rangeli	32%	100%
A0A3S7WYQ2	Leishmania donovani	93%	100%
A4HDT4	Leishmania braziliensis	68%	100%
A4I132	Leishmania infantum	93%	100%
C9ZW76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4QAA7	Leishmania major	92%	100%