ATPase_AAA_core domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX68_LEIMU

TriTrypDb:

LmxM.24.2220

Length:

396

Annotations

LeishMANIAdb annotations

Probably a secreted protein, similarly to its distant eukaryotic torsin homologs, involved in secretory processes. Also similar to bacterial ClpB ATPases, with chaperoning function.. Might be associated to known or unknown protein secretion pathways.. Localization: Endosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 9
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX68

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016462	pyrophosphatase activity	5	17
GO:0016787	hydrolase activity	2	17
GO:0016817	hydrolase activity, acting on acid anhydrides	3	17
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	17
GO:0016887	ATP hydrolysis activity	7	17
GO:0017076	purine nucleotide binding	4	17
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	368	370	PF00675	0.245
CLV_NRD_NRD_1	47	49	PF00675	0.621
CLV_PCSK_FUR_1	80	84	PF00082	0.484
CLV_PCSK_KEX2_1	368	370	PF00082	0.245
CLV_PCSK_KEX2_1	82	84	PF00082	0.474
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.529
CLV_PCSK_SKI1_1	242	246	PF00082	0.381
CLV_PCSK_SKI1_1	316	320	PF00082	0.345
CLV_PCSK_SKI1_1	51	55	PF00082	0.470
DEG_APCC_DBOX_1	102	110	PF00400	0.241
DOC_CYCLIN_RxL_1	238	246	PF00134	0.505
DOC_CYCLIN_RxL_1	313	322	PF00134	0.460
DOC_CYCLIN_RxL_1	48	60	PF00134	0.217
DOC_MAPK_DCC_7	168	176	PF00069	0.243
DOC_MAPK_gen_1	125	134	PF00069	0.349
DOC_MAPK_gen_1	368	374	PF00069	0.437
DOC_MAPK_gen_1	48	58	PF00069	0.275
DOC_MAPK_MEF2A_6	127	136	PF00069	0.352
DOC_MAPK_MEF2A_6	168	176	PF00069	0.369
DOC_MAPK_MEF2A_6	268	277	PF00069	0.478
DOC_PP1_RVXF_1	323	330	PF00149	0.556
DOC_PP1_RVXF_1	4	11	PF00149	0.341
DOC_PP2B_LxvP_1	18	21	PF13499	0.400
DOC_PP4_FxxP_1	23	26	PF00568	0.313
DOC_USP7_MATH_1	143	147	PF00917	0.383
DOC_USP7_MATH_1	218	222	PF00917	0.355
DOC_USP7_MATH_1	38	42	PF00917	0.336
DOC_WW_Pin1_4	202	207	PF00397	0.332
DOC_WW_Pin1_4	67	72	PF00397	0.264
LIG_14-3-3_CanoR_1	210	215	PF00244	0.311
LIG_14-3-3_CanoR_1	240	245	PF00244	0.559
LIG_14-3-3_CanoR_1	248	258	PF00244	0.517
LIG_14-3-3_CanoR_1	368	373	PF00244	0.447
LIG_14-3-3_CanoR_1	90	95	PF00244	0.364
LIG_Actin_WH2_2	54	69	PF00022	0.268
LIG_APCC_ABBA_1	187	192	PF00400	0.354
LIG_APCC_ABBAyCdc20_2	369	375	PF00400	0.430
LIG_CtBP_PxDLS_1	274	278	PF00389	0.458
LIG_FHA_1	142	148	PF00498	0.337
LIG_FHA_1	149	155	PF00498	0.253
LIG_FHA_1	3	9	PF00498	0.469
LIG_FHA_1	313	319	PF00498	0.587
LIG_FHA_1	352	358	PF00498	0.621
LIG_FHA_1	369	375	PF00498	0.568
LIG_FHA_2	155	161	PF00498	0.317
LIG_FHA_2	192	198	PF00498	0.390
LIG_FHA_2	277	283	PF00498	0.464
LIG_Integrin_isoDGR_2	323	325	PF01839	0.261
LIG_IRF3_LxIS_1	270	276	PF10401	0.559
LIG_IRF3_LxIS_1	298	304	PF10401	0.425
LIG_KLC1_Yacidic_2	355	360	PF13176	0.504
LIG_LIR_Apic_2	25	31	PF02991	0.431
LIG_LIR_Gen_1	252	263	PF02991	0.532
LIG_LIR_Gen_1	355	366	PF02991	0.640
LIG_LIR_Nem_3	252	258	PF02991	0.482
LIG_LIR_Nem_3	269	275	PF02991	0.440
LIG_LIR_Nem_3	355	361	PF02991	0.652
LIG_LIR_Nem_3	70	76	PF02991	0.343
LIG_NRBOX	14	20	PF00104	0.324
LIG_NRBOX	334	340	PF00104	0.477
LIG_SH2_PTP2	28	31	PF00017	0.287
LIG_SH2_SRC	358	361	PF00017	0.680
LIG_SH2_SRC	84	87	PF00017	0.234
LIG_SH2_STAP1	259	263	PF00017	0.592
LIG_SH2_STAT5	28	31	PF00017	0.287
LIG_SH2_STAT5	346	349	PF00017	0.567
LIG_SH2_STAT5	358	361	PF00017	0.567
LIG_SH2_STAT5	76	79	PF00017	0.294
LIG_SH2_STAT5	84	87	PF00017	0.297
LIG_SH3_1	268	274	PF00018	0.522
LIG_SH3_1	62	68	PF00018	0.259
LIG_SH3_3	106	112	PF00018	0.249
LIG_SH3_3	200	206	PF00018	0.279
LIG_SH3_3	212	218	PF00018	0.298
LIG_SH3_3	268	274	PF00018	0.496
LIG_SH3_3	62	68	PF00018	0.382
LIG_SUMO_SIM_par_1	149	155	PF11976	0.270
LIG_SUMO_SIM_par_1	224	232	PF11976	0.220
LIG_SUMO_SIM_par_1	273	279	PF11976	0.571
LIG_UBA3_1	131	139	PF00899	0.223
MOD_CDK_SPxxK_3	67	74	PF00069	0.258
MOD_CK1_1	155	161	PF00069	0.284
MOD_CK1_1	276	282	PF00069	0.493
MOD_CK2_1	160	166	PF00069	0.305
MOD_CK2_1	191	197	PF00069	0.364
MOD_CK2_1	210	216	PF00069	0.214
MOD_CK2_1	240	246	PF00069	0.529
MOD_CK2_1	94	100	PF00069	0.403
MOD_DYRK1A_RPxSP_1	202	206	PF00069	0.252
MOD_GlcNHglycan	154	157	PF01048	0.450
MOD_GlcNHglycan	293	296	PF01048	0.340
MOD_GlcNHglycan	348	351	PF01048	0.529
MOD_GlcNHglycan	393	396	PF01048	0.389
MOD_GlcNHglycan	62	65	PF01048	0.647
MOD_GSK3_1	143	150	PF00069	0.313
MOD_GSK3_1	192	199	PF00069	0.351
MOD_GSK3_1	236	243	PF00069	0.530
MOD_GSK3_1	262	269	PF00069	0.482
MOD_GSK3_1	384	391	PF00069	0.631
MOD_GSK3_1	90	97	PF00069	0.414
MOD_N-GLC_1	344	349	PF02516	0.475
MOD_NEK2_1	152	157	PF00069	0.252
MOD_NEK2_1	57	62	PF00069	0.324
MOD_OFUCOSY	140	145	PF10250	0.586
MOD_PK_1	90	96	PF00069	0.400
MOD_PKA_1	368	374	PF00069	0.437
MOD_PKA_2	209	215	PF00069	0.317
MOD_PKA_2	368	374	PF00069	0.455
MOD_PKB_1	238	246	PF00069	0.544
MOD_Plk_1	148	154	PF00069	0.270
MOD_Plk_1	191	197	PF00069	0.323
MOD_Plk_1	49	55	PF00069	0.384
MOD_Plk_2-3	160	166	PF00069	0.323
MOD_Plk_2-3	192	198	PF00069	0.377
MOD_Plk_4	148	154	PF00069	0.262
MOD_Plk_4	240	246	PF00069	0.592
MOD_Plk_4	368	374	PF00069	0.525
MOD_Plk_4	94	100	PF00069	0.383
MOD_ProDKin_1	202	208	PF00069	0.330
MOD_ProDKin_1	67	73	PF00069	0.254
TRG_DiLeu_BaEn_2	245	251	PF01217	0.592
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.261
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.227
TRG_ENDOCYTIC_2	159	162	PF00928	0.346
TRG_ENDOCYTIC_2	358	361	PF00928	0.593
TRG_ER_diArg_1	101	104	PF00400	0.312
TRG_ER_diArg_1	367	369	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R1	Leptomonas seymouri	59%	100%
A0A0N1PFB4	Leptomonas seymouri	35%	80%
A0A0S4KNW8	Bodo saltans	39%	100%
A0A1X0NMJ2	Trypanosomatidae	35%	90%
A0A1X0NW12	Trypanosomatidae	44%	100%
A0A3Q8ID18	Leishmania donovani	94%	100%
A0A3R7RCD3	Trypanosoma rangeli	35%	89%
A0A422N6P1	Trypanosoma rangeli	47%	100%
A4H5R3	Leishmania braziliensis	30%	71%
A4I131	Leishmania infantum	94%	100%
C9ZW77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D0A9G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	92%
Q4QAA8	Leishmania major	93%	100%
V5B582	Trypanosoma cruzi	49%	100%
V5B864	Trypanosoma cruzi	35%	88%