PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX66_LEIMU

TriTrypDb:

LmxM.24.2200

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.497
CLV_NRD_NRD_1	209	211	PF00675	0.552
CLV_PCSK_KEX2_1	209	211	PF00082	0.469
CLV_PCSK_KEX2_1	239	241	PF00082	0.567
CLV_PCSK_KEX2_1	86	88	PF00082	0.325
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.528
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.412
CLV_PCSK_SKI1_1	122	126	PF00082	0.416
CLV_PCSK_SKI1_1	219	223	PF00082	0.646
CLV_PCSK_SKI1_1	83	87	PF00082	0.406
DOC_AGCK_PIF_1	161	166	PF00069	0.360
DOC_CYCLIN_RxL_1	216	226	PF00134	0.686
DOC_PP1_RVXF_1	217	224	PF00149	0.376
DOC_PP2B_LxvP_1	241	244	PF13499	0.745
DOC_PP4_FxxP_1	217	220	PF00568	0.456
DOC_USP7_MATH_1	231	235	PF00917	0.584
DOC_USP7_MATH_1	3	7	PF00917	0.441
LIG_Clathr_ClatBox_1	201	205	PF01394	0.165
LIG_eIF4E_1	164	170	PF01652	0.360
LIG_FHA_1	121	127	PF00498	0.395
LIG_FHA_1	165	171	PF00498	0.304
LIG_FHA_1	61	67	PF00498	0.308
LIG_LIR_Apic_2	216	220	PF02991	0.369
LIG_LIR_Gen_1	114	125	PF02991	0.335
LIG_LIR_Gen_1	165	172	PF02991	0.305
LIG_LIR_Gen_1	60	70	PF02991	0.331
LIG_LIR_Nem_3	114	120	PF02991	0.300
LIG_LIR_Nem_3	165	169	PF02991	0.305
LIG_LIR_Nem_3	60	65	PF02991	0.321
LIG_Pex14_1	18	22	PF04695	0.407
LIG_SH2_NCK_1	110	114	PF00017	0.250
LIG_SH2_SRC	110	113	PF00017	0.250
LIG_SH2_STAP1	166	170	PF00017	0.320
LIG_SH2_STAP1	181	185	PF00017	0.347
LIG_SH2_STAT3	26	29	PF00017	0.363
LIG_SH2_STAT5	164	167	PF00017	0.308
LIG_SH3_3	157	163	PF00018	0.336
LIG_SUMO_SIM_par_1	200	206	PF11976	0.412
LIG_TRAF2_1	137	140	PF00917	0.412
LIG_TRAF2_1	50	53	PF00917	0.412
LIG_WRC_WIRS_1	117	122	PF05994	0.393
MOD_CK1_1	188	194	PF00069	0.165
MOD_CK1_1	60	66	PF00069	0.397
MOD_Cter_Amidation	207	210	PF01082	0.406
MOD_GlcNHglycan	140	143	PF01048	0.438
MOD_GlcNHglycan	229	232	PF01048	0.558
MOD_GlcNHglycan	5	8	PF01048	0.522
MOD_GSK3_1	116	123	PF00069	0.371
MOD_GSK3_1	227	234	PF00069	0.623
MOD_N-GLC_1	57	62	PF02516	0.360
MOD_NEK2_1	120	125	PF00069	0.412
MOD_NEK2_1	185	190	PF00069	0.241
MOD_NEK2_1	235	240	PF00069	0.783
MOD_NEK2_1	32	37	PF00069	0.468
MOD_NEK2_1	46	51	PF00069	0.302
MOD_NEK2_1	57	62	PF00069	0.279
MOD_PIKK_1	194	200	PF00454	0.412
MOD_PKB_1	136	144	PF00069	0.281
MOD_Plk_1	57	63	PF00069	0.352
MOD_Plk_4	120	126	PF00069	0.441
MOD_SUMO_for_1	85	88	PF00179	0.412
MOD_SUMO_rev_2	31	37	PF00179	0.269
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.487
TRG_ENDOCYTIC_2	110	113	PF00928	0.408
TRG_ENDOCYTIC_2	166	169	PF00928	0.325
TRG_ER_diArg_1	135	138	PF00400	0.412
TRG_NES_CRM1_1	114	127	PF08389	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTQ2	Leptomonas seymouri	74%	99%
A0A0N1I1J7	Leptomonas seymouri	26%	88%
A0A0S4KKY6	Bodo saltans	54%	100%
A0A1X0NXK5	Trypanosomatidae	59%	100%
A0A1X0P0D8	Trypanosomatidae	24%	78%
A0A3Q8IF22	Leishmania donovani	93%	100%
A0A3Q8IJ22	Leishmania donovani	22%	88%
A0A3R7KPI7	Trypanosoma rangeli	26%	88%
A4HDT1	Leishmania braziliensis	85%	100%
A4I129	Leishmania infantum	93%	100%
A4IDQ9	Leishmania infantum	22%	88%
C9ZW80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9ATR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
Q4QAB0	Leishmania major	93%	100%
V5DLI8	Trypanosoma cruzi	25%	81%