Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX65_LEIMU

TriTrypDb:

LmxM.24.2190

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005635	nuclear envelope	4	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1

Expansion

Sequence features

E9AX65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.438
CLV_NRD_NRD_1	123	125	PF00675	0.601
CLV_NRD_NRD_1	177	179	PF00675	0.630
CLV_PCSK_KEX2_1	123	125	PF00082	0.625
CLV_PCSK_KEX2_1	13	15	PF00082	0.528
CLV_PCSK_KEX2_1	177	179	PF00082	0.630
CLV_PCSK_KEX2_1	192	194	PF00082	0.649
CLV_PCSK_KEX2_1	50	52	PF00082	0.491
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.592
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.622
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.531
CLV_PCSK_PC7_1	46	52	PF00082	0.496
CLV_PCSK_SKI1_1	115	119	PF00082	0.631
CLV_PCSK_SKI1_1	167	171	PF00082	0.643
DEG_SCF_FBW7_1	21	27	PF00400	0.595
DEG_SPOP_SBC_1	109	113	PF00917	0.480
DOC_CKS1_1	185	190	PF01111	0.449
DOC_CKS1_1	21	26	PF01111	0.593
DOC_CYCLIN_RxL_1	56	66	PF00134	0.515
DOC_MAPK_gen_1	175	185	PF00069	0.379
DOC_MAPK_gen_1	65	74	PF00069	0.579
DOC_PP1_RVXF_1	178	185	PF00149	0.350
DOC_PP1_RVXF_1	57	64	PF00149	0.571
DOC_PP2B_LxvP_1	170	173	PF13499	0.441
DOC_USP7_MATH_1	110	114	PF00917	0.371
DOC_USP7_MATH_1	159	163	PF00917	0.413
DOC_USP7_MATH_1	214	218	PF00917	0.478
DOC_USP7_MATH_1	49	53	PF00917	0.691
DOC_WW_Pin1_4	184	189	PF00397	0.411
DOC_WW_Pin1_4	20	25	PF00397	0.734
DOC_WW_Pin1_4	222	227	PF00397	0.477
DOC_WW_Pin1_4	88	93	PF00397	0.672
LIG_14-3-3_CanoR_1	193	199	PF00244	0.442
LIG_14-3-3_CanoR_1	218	222	PF00244	0.397
LIG_APCC_ABBA_1	171	176	PF00400	0.304
LIG_BIR_II_1	1	5	PF00653	0.808
LIG_BRCT_BRCA1_1	140	144	PF00533	0.477
LIG_BRCT_BRCA1_1	156	160	PF00533	0.360
LIG_EH1_1	237	245	PF00400	0.439
LIG_FHA_1	218	224	PF00498	0.437
LIG_FHA_1	74	80	PF00498	0.451
LIG_FHA_2	135	141	PF00498	0.444
LIG_FHA_2	184	190	PF00498	0.394
LIG_GBD_Chelix_1	194	202	PF00786	0.545
LIG_GBD_Chelix_1	82	90	PF00786	0.317
LIG_LIR_Apic_2	93	98	PF02991	0.497
LIG_LIR_Gen_1	157	168	PF02991	0.362
LIG_LIR_Nem_3	157	163	PF02991	0.325
LIG_LIR_Nem_3	66	72	PF02991	0.566
LIG_NRBOX	85	91	PF00104	0.448
LIG_PDZ_Class_1	242	247	PF00595	0.486
LIG_SH2_CRK	95	99	PF00017	0.497
LIG_SH3_3	18	24	PF00018	0.618
LIG_SH3_3	182	188	PF00018	0.439
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.201
LIG_SUMO_SIM_par_1	152	157	PF11976	0.249
LIG_SUMO_SIM_par_1	219	225	PF11976	0.378
MOD_CDK_SPxxK_3	222	229	PF00069	0.431
MOD_CK1_1	122	128	PF00069	0.408
MOD_CK1_1	143	149	PF00069	0.418
MOD_CK1_1	208	214	PF00069	0.442
MOD_CK1_1	217	223	PF00069	0.393
MOD_CK1_1	225	231	PF00069	0.406
MOD_CK1_1	27	33	PF00069	0.725
MOD_CK1_1	9	15	PF00069	0.743
MOD_CK2_1	183	189	PF00069	0.394
MOD_CK2_1	194	200	PF00069	0.412
MOD_GlcNHglycan	127	130	PF01048	0.611
MOD_GlcNHglycan	148	151	PF01048	0.622
MOD_GlcNHglycan	156	159	PF01048	0.635
MOD_GlcNHglycan	207	210	PF01048	0.693
MOD_GlcNHglycan	43	46	PF01048	0.543
MOD_GlcNHglycan	6	9	PF01048	0.588
MOD_GlcNHglycan	92	95	PF01048	0.690
MOD_GSK3_1	134	141	PF00069	0.447
MOD_GSK3_1	2	9	PF00069	0.815
MOD_GSK3_1	20	27	PF00069	0.614
MOD_NEK2_1	232	237	PF00069	0.446
MOD_NEK2_1	63	68	PF00069	0.501
MOD_PIKK_1	143	149	PF00454	0.412
MOD_PIKK_1	39	45	PF00454	0.700
MOD_PKA_2	122	128	PF00069	0.387
MOD_PKA_2	176	182	PF00069	0.342
MOD_PKA_2	217	223	PF00069	0.403
MOD_PKA_2	27	33	PF00069	0.771
MOD_Plk_4	208	214	PF00069	0.451
MOD_Plk_4	217	223	PF00069	0.384
MOD_Plk_4	73	79	PF00069	0.360
MOD_ProDKin_1	184	190	PF00069	0.408
MOD_ProDKin_1	20	26	PF00069	0.736
MOD_ProDKin_1	222	228	PF00069	0.479
MOD_ProDKin_1	88	94	PF00069	0.677
MOD_SUMO_rev_2	42	52	PF00179	0.732
TRG_ER_diArg_1	14	17	PF00400	0.694
TRG_ER_diArg_1	177	180	PF00400	0.427
TRG_NLS_MonoExtN_4	10	17	PF00514	0.779
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II61	Leptomonas seymouri	52%	96%
A0A3Q8IC37	Leishmania donovani	89%	100%
A0A422MRD3	Trypanosoma rangeli	37%	100%
A4HDT0	Leishmania braziliensis	76%	100%
A4I128	Leishmania infantum	88%	100%
C9ZW81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	98%
Q4QAB1	Leishmania major	86%	100%