Vps54_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function N-terminal domain (DUF2450)/Protein of unknown function C-terminus (DUF2451), putative

Species:

Leishmania mexicana

UniProt:

E9AX63_LEIMU

TriTrypDb:

LmxM.24.2170

Length:

1012

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	11
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	11
GO:1990745	EARP complex	2	11

Expansion

Sequence features

E9AX63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX63

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0009987	cellular process	1	11
GO:0016192	vesicle-mediated transport	4	11
GO:0016197	endosomal transport	4	11
GO:0016482	cytosolic transport	4	11
GO:0032456	endocytic recycling	5	11
GO:0042147	retrograde transport, endosome to Golgi	5	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0051668	localization within membrane	3	11
GO:0098876	vesicle-mediated transport to the plasma membrane	4	11

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.354
CLV_C14_Caspase3-7	174	178	PF00656	0.416
CLV_C14_Caspase3-7	598	602	PF00656	0.610
CLV_C14_Caspase3-7	680	684	PF00656	0.368
CLV_NRD_NRD_1	156	158	PF00675	0.351
CLV_NRD_NRD_1	193	195	PF00675	0.319
CLV_NRD_NRD_1	23	25	PF00675	0.545
CLV_NRD_NRD_1	419	421	PF00675	0.543
CLV_NRD_NRD_1	54	56	PF00675	0.556
CLV_NRD_NRD_1	873	875	PF00675	0.513
CLV_PCSK_KEX2_1	155	157	PF00082	0.290
CLV_PCSK_KEX2_1	232	234	PF00082	0.379
CLV_PCSK_KEX2_1	253	255	PF00082	0.554
CLV_PCSK_KEX2_1	536	538	PF00082	0.413
CLV_PCSK_KEX2_1	54	56	PF00082	0.533
CLV_PCSK_KEX2_1	873	875	PF00082	0.397
CLV_PCSK_KEX2_1	908	910	PF00082	0.558
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.279
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.379
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.554
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.298
CLV_PCSK_PC1ET2_1	908	910	PF00082	0.558
CLV_PCSK_SKI1_1	100	104	PF00082	0.345
CLV_PCSK_SKI1_1	156	160	PF00082	0.277
CLV_PCSK_SKI1_1	27	31	PF00082	0.561
CLV_PCSK_SKI1_1	285	289	PF00082	0.496
CLV_PCSK_SKI1_1	309	313	PF00082	0.412
CLV_PCSK_SKI1_1	342	346	PF00082	0.493
CLV_PCSK_SKI1_1	479	483	PF00082	0.420
CLV_PCSK_SKI1_1	526	530	PF00082	0.400
CLV_PCSK_SKI1_1	533	537	PF00082	0.387
CLV_PCSK_SKI1_1	54	58	PF00082	0.533
CLV_PCSK_SKI1_1	889	893	PF00082	0.347
CLV_PCSK_SKI1_1	946	950	PF00082	0.417
CLV_PCSK_SKI1_1	997	1001	PF00082	0.425
DEG_APCC_DBOX_1	232	240	PF00400	0.320
DEG_APCC_KENBOX_2	212	216	PF00400	0.427
DEG_COP1_1	936	943	PF00400	0.414
DEG_Nend_UBRbox_2	1	3	PF02207	0.554
DEG_SCF_FBW7_2	876	883	PF00400	0.441
DEG_SPOP_SBC_1	569	573	PF00917	0.590
DEG_SPOP_SBC_1	636	640	PF00917	0.490
DOC_ANK_TNKS_1	132	139	PF00023	0.416
DOC_CKS1_1	490	495	PF01111	0.488
DOC_CKS1_1	725	730	PF01111	0.574
DOC_CKS1_1	877	882	PF01111	0.435
DOC_MAPK_FxFP_2	749	752	PF00069	0.448
DOC_MAPK_gen_1	232	239	PF00069	0.320
DOC_MAPK_gen_1	848	856	PF00069	0.522
DOC_MAPK_gen_1	907	915	PF00069	0.457
DOC_MAPK_JIP1_4	985	991	PF00069	0.502
DOC_MAPK_MEF2A_6	446	454	PF00069	0.467
DOC_PP1_RVXF_1	887	893	PF00149	0.406
DOC_PP4_FxxP_1	303	306	PF00568	0.509
DOC_PP4_FxxP_1	490	493	PF00568	0.417
DOC_PP4_FxxP_1	749	752	PF00568	0.564
DOC_USP7_MATH_1	199	203	PF00917	0.488
DOC_USP7_MATH_1	569	573	PF00917	0.590
DOC_USP7_MATH_1	778	782	PF00917	0.337
DOC_USP7_MATH_1	836	840	PF00917	0.520
DOC_USP7_MATH_1	881	885	PF00917	0.463
DOC_USP7_UBL2_3	13	17	PF12436	0.604
DOC_USP7_UBL2_3	27	31	PF12436	0.518
DOC_USP7_UBL2_3	529	533	PF12436	0.541
DOC_USP7_UBL2_3	842	846	PF12436	0.440
DOC_USP7_UBL2_3	904	908	PF12436	0.456
DOC_USP7_UBL2_3	97	101	PF12436	0.330
DOC_WW_Pin1_4	399	404	PF00397	0.580
DOC_WW_Pin1_4	489	494	PF00397	0.501
DOC_WW_Pin1_4	507	512	PF00397	0.474
DOC_WW_Pin1_4	521	526	PF00397	0.475
DOC_WW_Pin1_4	724	729	PF00397	0.557
DOC_WW_Pin1_4	794	799	PF00397	0.495
DOC_WW_Pin1_4	876	881	PF00397	0.453
LIG_14-3-3_CanoR_1	24	30	PF00244	0.606
LIG_14-3-3_CanoR_1	398	404	PF00244	0.523
LIG_14-3-3_CanoR_1	909	916	PF00244	0.500
LIG_Actin_WH2_2	26	41	PF00022	0.628
LIG_Actin_WH2_2	833	850	PF00022	0.517
LIG_APCC_ABBA_1	391	396	PF00400	0.498
LIG_BRCT_BRCA1_1	759	763	PF00533	0.622
LIG_BRCT_BRCA1_1	783	787	PF00533	0.371
LIG_BRCT_BRCA1_1	910	914	PF00533	0.406
LIG_EH_1	557	561	PF12763	0.404
LIG_EH1_1	450	458	PF00400	0.330
LIG_EH1_1	970	978	PF00400	0.228
LIG_eIF4E_1	971	977	PF01652	0.421
LIG_FHA_1	167	173	PF00498	0.400
LIG_FHA_1	217	223	PF00498	0.288
LIG_FHA_1	24	30	PF00498	0.517
LIG_FHA_1	286	292	PF00498	0.466
LIG_FHA_1	294	300	PF00498	0.377
LIG_FHA_1	3	9	PF00498	0.648
LIG_FHA_1	322	328	PF00498	0.447
LIG_FHA_1	407	413	PF00498	0.266
LIG_FHA_1	42	48	PF00498	0.419
LIG_FHA_1	429	435	PF00498	0.409
LIG_FHA_1	476	482	PF00498	0.417
LIG_FHA_1	569	575	PF00498	0.450
LIG_FHA_1	621	627	PF00498	0.548
LIG_FHA_1	877	883	PF00498	0.460
LIG_FHA_2	121	127	PF00498	0.344
LIG_FHA_2	180	186	PF00498	0.320
LIG_FHA_2	603	609	PF00498	0.592
LIG_FHA_2	678	684	PF00498	0.360
LIG_FHA_2	725	731	PF00498	0.616
LIG_GBD_Chelix_1	426	434	PF00786	0.408
LIG_LIR_Apic_2	300	306	PF02991	0.523
LIG_LIR_Apic_2	747	752	PF02991	0.584
LIG_LIR_Gen_1	367	376	PF02991	0.485
LIG_LIR_Gen_1	382	391	PF02991	0.214
LIG_LIR_Gen_1	557	568	PF02991	0.320
LIG_LIR_Gen_1	683	693	PF02991	0.434
LIG_LIR_Gen_1	901	910	PF02991	0.405
LIG_LIR_Nem_3	276	280	PF02991	0.414
LIG_LIR_Nem_3	367	371	PF02991	0.506
LIG_LIR_Nem_3	382	386	PF02991	0.221
LIG_LIR_Nem_3	401	407	PF02991	0.450
LIG_LIR_Nem_3	458	464	PF02991	0.457
LIG_LIR_Nem_3	557	563	PF02991	0.302
LIG_LIR_Nem_3	577	583	PF02991	0.480
LIG_LIR_Nem_3	683	688	PF02991	0.413
LIG_LIR_Nem_3	748	754	PF02991	0.605
LIG_LIR_Nem_3	901	905	PF02991	0.390
LIG_NRBOX	990	996	PF00104	0.404
LIG_PCNA_yPIPBox_3	926	935	PF02747	0.419
LIG_PDZ_Class_2	1007	1012	PF00595	0.536
LIG_Pex14_2	580	584	PF04695	0.500
LIG_REV1ctd_RIR_1	100	108	PF16727	0.345
LIG_REV1ctd_RIR_1	54	64	PF16727	0.655
LIG_SH2_CRK	387	391	PF00017	0.466
LIG_SH2_CRK	404	408	PF00017	0.297
LIG_SH2_CRK	902	906	PF00017	0.393
LIG_SH2_NCK_1	679	683	PF00017	0.357
LIG_SH2_SRC	107	110	PF00017	0.368
LIG_SH2_SRC	385	388	PF00017	0.466
LIG_SH2_STAP1	387	391	PF00017	0.459
LIG_SH2_STAP1	789	793	PF00017	0.449
LIG_SH2_STAT3	538	541	PF00017	0.552
LIG_SH2_STAT3	859	862	PF00017	0.439
LIG_SH2_STAT5	122	125	PF00017	0.427
LIG_SH2_STAT5	268	271	PF00017	0.541
LIG_SH2_STAT5	368	371	PF00017	0.510
LIG_SH2_STAT5	385	388	PF00017	0.448
LIG_SH2_STAT5	414	417	PF00017	0.505
LIG_SH2_STAT5	538	541	PF00017	0.426
LIG_SH2_STAT5	677	680	PF00017	0.340
LIG_SH2_STAT5	726	729	PF00017	0.500
LIG_SH2_STAT5	859	862	PF00017	0.381
LIG_SH2_STAT5	943	946	PF00017	0.383
LIG_SH2_STAT5	972	975	PF00017	0.274
LIG_SH3_3	505	511	PF00018	0.482
LIG_SH3_3	519	525	PF00018	0.418
LIG_SH3_3	627	633	PF00018	0.521
LIG_SH3_3	654	660	PF00018	0.482
LIG_SH3_3	795	801	PF00018	0.421
LIG_SH3_3	872	878	PF00018	0.512
LIG_SH3_3	935	941	PF00018	0.456
LIG_SUMO_SIM_anti_2	202	208	PF11976	0.442
LIG_SUMO_SIM_anti_2	428	436	PF11976	0.392
LIG_SUMO_SIM_anti_2	781	787	PF11976	0.341
LIG_SUMO_SIM_par_1	430	436	PF11976	0.442
LIG_SUMO_SIM_par_1	616	623	PF11976	0.503
LIG_TRAF2_1	84	87	PF00917	0.613
LIG_UBA3_1	236	244	PF00899	0.276
LIG_UBA3_1	976	985	PF00899	0.466
LIG_UBA3_1	995	1000	PF00899	0.370
LIG_WRC_WIRS_1	528	533	PF05994	0.527
LIG_WRC_WIRS_1	682	687	PF05994	0.494
MOD_CDK_SPK_2	489	494	PF00069	0.497
MOD_CDK_SPK_2	521	526	PF00069	0.502
MOD_CDK_SPK_2	724	729	PF00069	0.552
MOD_CK1_1	164	170	PF00069	0.409
MOD_CK1_1	455	461	PF00069	0.457
MOD_CK1_1	510	516	PF00069	0.549
MOD_CK1_1	599	605	PF00069	0.543
MOD_CK1_1	635	641	PF00069	0.398
MOD_CK1_1	684	690	PF00069	0.529
MOD_CK1_1	736	742	PF00069	0.472
MOD_CK1_1	781	787	PF00069	0.341
MOD_CK1_1	903	909	PF00069	0.498
MOD_CK2_1	120	126	PF00069	0.351
MOD_CK2_1	164	170	PF00069	0.353
MOD_CK2_1	340	346	PF00069	0.382
MOD_CK2_1	539	545	PF00069	0.550
MOD_CK2_1	608	614	PF00069	0.629
MOD_CK2_1	80	86	PF00069	0.628
MOD_Cter_Amidation	230	233	PF01082	0.416
MOD_Cter_Amidation	418	421	PF01082	0.436
MOD_GlcNHglycan	166	169	PF01048	0.427
MOD_GlcNHglycan	241	244	PF01048	0.410
MOD_GlcNHglycan	41	44	PF01048	0.644
MOD_GlcNHglycan	435	438	PF01048	0.441
MOD_GlcNHglycan	598	601	PF01048	0.735
MOD_GlcNHglycan	639	642	PF01048	0.407
MOD_GlcNHglycan	699	703	PF01048	0.439
MOD_GlcNHglycan	735	738	PF01048	0.538
MOD_GlcNHglycan	764	767	PF01048	0.598
MOD_GlcNHglycan	848	851	PF01048	0.393
MOD_GSK3_1	175	182	PF00069	0.385
MOD_GSK3_1	293	300	PF00069	0.409
MOD_GSK3_1	345	352	PF00069	0.481
MOD_GSK3_1	428	435	PF00069	0.459
MOD_GSK3_1	540	547	PF00069	0.484
MOD_GSK3_1	570	577	PF00069	0.497
MOD_GSK3_1	616	623	PF00069	0.665
MOD_GSK3_1	632	639	PF00069	0.500
MOD_GSK3_1	677	684	PF00069	0.417
MOD_GSK3_1	757	764	PF00069	0.533
MOD_GSK3_1	76	83	PF00069	0.613
MOD_GSK3_1	836	843	PF00069	0.383
MOD_LATS_1	731	737	PF00433	0.418
MOD_N-GLC_1	175	180	PF02516	0.424
MOD_N-GLC_1	744	749	PF02516	0.629
MOD_N-GLC_1	773	778	PF02516	0.475
MOD_NEK2_1	179	184	PF00069	0.301
MOD_NEK2_1	239	244	PF00069	0.379
MOD_NEK2_1	260	265	PF00069	0.527
MOD_NEK2_1	327	332	PF00069	0.424
MOD_NEK2_1	340	345	PF00069	0.320
MOD_NEK2_1	386	391	PF00069	0.347
MOD_NEK2_1	574	579	PF00069	0.469
MOD_NEK2_1	637	642	PF00069	0.390
MOD_NEK2_1	855	860	PF00069	0.498
MOD_NEK2_1	863	868	PF00069	0.502
MOD_NEK2_1	933	938	PF00069	0.488
MOD_NEK2_2	559	564	PF00069	0.315
MOD_NEK2_2	881	886	PF00069	0.480
MOD_OFUCOSY	320	325	PF10250	0.481
MOD_PIKK_1	199	205	PF00454	0.448
MOD_PIKK_1	231	237	PF00454	0.379
MOD_PIKK_1	312	318	PF00454	0.505
MOD_PIKK_1	319	325	PF00454	0.517
MOD_PIKK_1	406	412	PF00454	0.436
MOD_PIKK_1	473	479	PF00454	0.413
MOD_PIKK_1	574	580	PF00454	0.541
MOD_PK_1	25	31	PF00069	0.671
MOD_PK_1	438	444	PF00069	0.508
MOD_PKA_1	285	291	PF00069	0.545
MOD_PKA_1	908	914	PF00069	0.426
MOD_PKA_2	193	199	PF00069	0.383
MOD_PKA_2	23	29	PF00069	0.603
MOD_PKA_2	397	403	PF00069	0.551
MOD_PKA_2	757	763	PF00069	0.585
MOD_PKA_2	908	914	PF00069	0.515
MOD_Plk_1	103	109	PF00069	0.328
MOD_Plk_1	175	181	PF00069	0.435
MOD_Plk_1	216	222	PF00069	0.314
MOD_Plk_1	260	266	PF00069	0.496
MOD_Plk_1	345	351	PF00069	0.403
MOD_Plk_1	569	575	PF00069	0.497
MOD_Plk_1	744	750	PF00069	0.517
MOD_Plk_1	773	779	PF00069	0.538
MOD_Plk_1	789	795	PF00069	0.328
MOD_Plk_4	161	167	PF00069	0.360
MOD_Plk_4	175	181	PF00069	0.469
MOD_Plk_4	25	31	PF00069	0.628
MOD_Plk_4	327	333	PF00069	0.392
MOD_Plk_4	345	351	PF00069	0.505
MOD_Plk_4	386	392	PF00069	0.475
MOD_Plk_4	428	434	PF00069	0.493
MOD_Plk_4	452	458	PF00069	0.331
MOD_Plk_4	527	533	PF00069	0.523
MOD_Plk_4	570	576	PF00069	0.577
MOD_Plk_4	632	638	PF00069	0.422
MOD_Plk_4	677	683	PF00069	0.367
MOD_Plk_4	778	784	PF00069	0.357
MOD_Plk_4	804	810	PF00069	0.433
MOD_Plk_4	855	861	PF00069	0.416
MOD_Plk_4	881	887	PF00069	0.432
MOD_Plk_4	928	934	PF00069	0.487
MOD_ProDKin_1	399	405	PF00069	0.572
MOD_ProDKin_1	489	495	PF00069	0.496
MOD_ProDKin_1	507	513	PF00069	0.477
MOD_ProDKin_1	521	527	PF00069	0.474
MOD_ProDKin_1	724	730	PF00069	0.571
MOD_ProDKin_1	794	800	PF00069	0.495
MOD_ProDKin_1	876	882	PF00069	0.444
MOD_SUMO_for_1	350	353	PF00179	0.423
MOD_SUMO_rev_2	134	140	PF00179	0.387
MOD_SUMO_rev_2	183	189	PF00179	0.427
MOD_SUMO_rev_2	96	103	PF00179	0.310
TRG_DiLeu_BaEn_2	246	252	PF01217	0.503
TRG_DiLeu_BaEn_2	496	502	PF01217	0.500
TRG_DiLeu_BaEn_4	671	677	PF01217	0.399
TRG_DiLeu_BaLyEn_6	795	800	PF01217	0.389
TRG_DiLeu_BaLyEn_6	886	891	PF01217	0.444
TRG_ENDOCYTIC_2	255	258	PF00928	0.292
TRG_ENDOCYTIC_2	368	371	PF00928	0.521
TRG_ENDOCYTIC_2	387	390	PF00928	0.476
TRG_ENDOCYTIC_2	404	407	PF00928	0.306
TRG_ENDOCYTIC_2	679	682	PF00928	0.454
TRG_ENDOCYTIC_2	902	905	PF00928	0.390
TRG_ENDOCYTIC_2	971	974	PF00928	0.480
TRG_ER_diArg_1	156	158	PF00400	0.355
TRG_ER_diArg_1	53	55	PF00400	0.565
TRG_ER_diArg_1	811	814	PF00400	0.462
TRG_ER_diArg_1	873	875	PF00400	0.513
TRG_NES_CRM1_1	170	185	PF08389	0.416
TRG_NES_CRM1_1	912	926	PF08389	0.415
TRG_NLS_MonoExtC_3	906	912	PF00514	0.460
TRG_NLS_MonoExtN_4	904	911	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	813	817	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	868	872	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	997	1002	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIU4	Leptomonas seymouri	76%	100%
A0A0S4KHU7	Bodo saltans	33%	100%
A0A1X0NVY5	Trypanosomatidae	45%	100%
A0A3S7WYM4	Leishmania donovani	94%	100%
A0A422NWJ9	Trypanosoma rangeli	45%	100%
A4HDS8	Leishmania braziliensis	85%	100%
A4I126	Leishmania infantum	94%	100%
Q4QAB3	Leishmania major	94%	100%
V5D5L5	Trypanosoma cruzi	46%	100%