GP-PDE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glycerophosphoryl diester phosphodiesterase family, putative

Species:

Leishmania mexicana

UniProt:

E9AX62_LEIMU

TriTrypDb:

LmxM.24.2160

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX62

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0006066	alcohol metabolic process	3	1
GO:0006576	biogenic amine metabolic process	5	1
GO:0006580	ethanolamine metabolic process	5	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009308	amine metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034308	primary alcohol metabolic process	4	1
GO:0042439	ethanolamine-containing compound metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0070291	N-acylethanolamine metabolic process	5	1
GO:1901160	primary amino compound metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008081	phosphoric diester hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0008889	glycerophosphodiester phosphodiesterase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.333
CLV_NRD_NRD_1	186	188	PF00675	0.406
CLV_NRD_NRD_1	260	262	PF00675	0.336
CLV_NRD_NRD_1	325	327	PF00675	0.372
CLV_NRD_NRD_1	99	101	PF00675	0.363
CLV_PCSK_KEX2_1	149	151	PF00082	0.294
CLV_PCSK_KEX2_1	163	165	PF00082	0.224
CLV_PCSK_KEX2_1	191	193	PF00082	0.412
CLV_PCSK_KEX2_1	259	261	PF00082	0.354
CLV_PCSK_KEX2_1	327	329	PF00082	0.442
CLV_PCSK_KEX2_1	99	101	PF00082	0.279
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.392
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.400
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.481
CLV_PCSK_PC7_1	187	193	PF00082	0.319
CLV_PCSK_SKI1_1	146	150	PF00082	0.381
CLV_PCSK_SKI1_1	2	6	PF00082	0.414
CLV_PCSK_SKI1_1	261	265	PF00082	0.466
DEG_Nend_UBRbox_1	1	4	PF02207	0.432
DEG_SCF_FBW7_1	46	53	PF00400	0.390
DOC_CKS1_1	279	284	PF01111	0.516
DOC_MAPK_gen_1	187	195	PF00069	0.271
DOC_MAPK_gen_1	73	83	PF00069	0.271
DOC_MAPK_gen_1	99	106	PF00069	0.286
DOC_PP1_RVXF_1	28	34	PF00149	0.319
DOC_PP2B_LxvP_1	302	305	PF13499	0.334
DOC_USP7_MATH_1	60	64	PF00917	0.332
DOC_WW_Pin1_4	278	283	PF00397	0.490
DOC_WW_Pin1_4	46	51	PF00397	0.395
LIG_14-3-3_CanoR_1	110	115	PF00244	0.319
LIG_Actin_WH2_2	136	151	PF00022	0.406
LIG_Actin_WH2_2	7	22	PF00022	0.483
LIG_AP2alpha_1	83	87	PF02296	0.406
LIG_APCC_ABBA_1	80	85	PF00400	0.271
LIG_eIF4E_1	170	176	PF01652	0.390
LIG_FHA_1	117	123	PF00498	0.271
LIG_FHA_1	153	159	PF00498	0.383
LIG_FHA_1	171	177	PF00498	0.148
LIG_FHA_1	262	268	PF00498	0.338
LIG_FHA_1	96	102	PF00498	0.262
LIG_FHA_2	103	109	PF00498	0.339
LIG_FHA_2	124	130	PF00498	0.271
LIG_LIR_Gen_1	206	215	PF02991	0.491
LIG_LIR_Nem_3	160	165	PF02991	0.271
LIG_LIR_Nem_3	206	210	PF02991	0.484
LIG_LIR_Nem_3	293	299	PF02991	0.537
LIG_MYND_3	124	128	PF01753	0.262
LIG_Pex14_1	217	221	PF04695	0.347
LIG_Pex14_2	83	87	PF04695	0.406
LIG_SH2_NCK_1	59	63	PF00017	0.153
LIG_SH2_STAP1	199	203	PF00017	0.432
LIG_SH2_STAT5	152	155	PF00017	0.404
LIG_SH2_STAT5	18	21	PF00017	0.376
LIG_SH2_STAT5	270	273	PF00017	0.438
LIG_SH2_STAT5	280	283	PF00017	0.472
LIG_SH3_2	25	30	PF14604	0.332
LIG_SH3_3	119	125	PF00018	0.390
LIG_SH3_3	22	28	PF00018	0.330
LIG_SUMO_SIM_par_1	141	147	PF11976	0.271
LIG_TRAF2_1	126	129	PF00917	0.294
LIG_WRC_WIRS_1	175	180	PF05994	0.330
LIG_WW_1	305	308	PF00397	0.594
MOD_CDK_SPxxK_3	278	285	PF00069	0.490
MOD_CK1_1	177	183	PF00069	0.409
MOD_CK2_1	102	108	PF00069	0.330
MOD_CK2_1	123	129	PF00069	0.286
MOD_GlcNHglycan	179	182	PF01048	0.386
MOD_GlcNHglycan	62	65	PF01048	0.332
MOD_GSK3_1	112	119	PF00069	0.312
MOD_GSK3_1	148	155	PF00069	0.319
MOD_GSK3_1	170	177	PF00069	0.346
MOD_GSK3_1	46	53	PF00069	0.390
MOD_N-GLC_2	266	268	PF02516	0.447
MOD_NEK2_1	14	19	PF00069	0.406
MOD_NEK2_1	148	153	PF00069	0.319
MOD_NEK2_1	203	208	PF00069	0.471
MOD_NEK2_1	241	246	PF00069	0.299
MOD_NEK2_1	6	11	PF00069	0.373
MOD_PKA_2	72	78	PF00069	0.271
MOD_PKB_1	259	267	PF00069	0.468
MOD_Plk_1	102	108	PF00069	0.294
MOD_Plk_1	170	176	PF00069	0.271
MOD_Plk_1	50	56	PF00069	0.271
MOD_Plk_2-3	102	108	PF00069	0.330
MOD_Plk_4	102	108	PF00069	0.306
MOD_Plk_4	171	177	PF00069	0.272
MOD_Plk_4	242	248	PF00069	0.300
MOD_ProDKin_1	278	284	PF00069	0.483
MOD_ProDKin_1	46	52	PF00069	0.395
MOD_SUMO_rev_2	144	151	PF00179	0.406
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.447
TRG_ENDOCYTIC_2	296	299	PF00928	0.578
TRG_ENDOCYTIC_2	308	311	PF00928	0.520
TRG_ER_diArg_1	162	164	PF00400	0.339
TRG_ER_diArg_1	259	261	PF00400	0.358
TRG_ER_diArg_1	326	329	PF00400	0.430
TRG_ER_diArg_1	99	101	PF00400	0.362
TRG_NLS_MonoExtC_3	325	330	PF00514	0.392
TRG_NLS_MonoExtN_4	326	331	PF00514	0.341
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.271
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S0	Leptomonas seymouri	72%	100%
A0A0S4KJA2	Bodo saltans	50%	100%
A0A1X0NVZ2	Trypanosomatidae	54%	99%
A0A3Q8IGB4	Leishmania donovani	94%	100%
A0A422NWY6	Trypanosoma rangeli	54%	99%
A4HDS7	Leishmania braziliensis	79%	100%
A4I125	Leishmania infantum	94%	100%
C9ZW84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
Q3T0T0	Bos taurus	28%	100%
Q4QAB4	Leishmania major	92%	100%
Q9NZC3	Homo sapiens	26%	100%
V5B577	Trypanosoma cruzi	55%	96%