UBC core domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme, putative

Species:

Leishmania mexicana

UniProt:

E9AX60_LEIMU

TriTrypDb:

LmxM.24.2140

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX60

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.554
CLV_NRD_NRD_1	258	260	PF00675	0.423
CLV_NRD_NRD_1	26	28	PF00675	0.379
CLV_NRD_NRD_1	263	265	PF00675	0.372
CLV_PCSK_KEX2_1	197	199	PF00082	0.525
CLV_PCSK_KEX2_1	258	260	PF00082	0.423
CLV_PCSK_KEX2_1	26	28	PF00082	0.379
CLV_PCSK_KEX2_1	263	265	PF00082	0.372
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.503
CLV_PCSK_PC7_1	254	260	PF00082	0.544
CLV_PCSK_SKI1_1	197	201	PF00082	0.501
CLV_PCSK_SKI1_1	226	230	PF00082	0.315
CLV_PCSK_SKI1_1	264	268	PF00082	0.405
CLV_PCSK_SKI1_1	27	31	PF00082	0.433
CLV_PCSK_SKI1_1	317	321	PF00082	0.568
CLV_PCSK_SKI1_1	67	71	PF00082	0.452
DEG_APCC_DBOX_1	316	324	PF00400	0.484
DEG_SCF_FBW7_2	41	46	PF00400	0.547
DEG_SPOP_SBC_1	111	115	PF00917	0.221
DOC_CKS1_1	98	103	PF01111	0.594
DOC_CYCLIN_RxL_1	16	28	PF00134	0.379
DOC_CYCLIN_yCln2_LP_2	71	74	PF00134	0.349
DOC_MAPK_DCC_7	132	142	PF00069	0.393
DOC_MAPK_gen_1	197	203	PF00069	0.425
DOC_MAPK_gen_1	26	32	PF00069	0.485
DOC_MAPK_MEF2A_6	214	222	PF00069	0.456
DOC_PP1_RVXF_1	224	230	PF00149	0.330
DOC_PP2B_LxvP_1	70	73	PF13499	0.363
DOC_PP4_FxxP_1	135	138	PF00568	0.310
DOC_USP7_MATH_1	145	149	PF00917	0.300
DOC_USP7_MATH_1	190	194	PF00917	0.664
DOC_USP7_MATH_1	2	6	PF00917	0.557
DOC_USP7_MATH_2	231	237	PF00917	0.405
DOC_WW_Pin1_4	113	118	PF00397	0.305
DOC_WW_Pin1_4	179	184	PF00397	0.664
DOC_WW_Pin1_4	237	242	PF00397	0.416
DOC_WW_Pin1_4	39	44	PF00397	0.583
DOC_WW_Pin1_4	4	9	PF00397	0.570
DOC_WW_Pin1_4	81	86	PF00397	0.706
DOC_WW_Pin1_4	97	102	PF00397	0.456
LIG_14-3-3_CanoR_1	112	117	PF00244	0.239
LIG_14-3-3_CanoR_1	214	218	PF00244	0.351
LIG_14-3-3_CanoR_1	263	273	PF00244	0.427
LIG_Actin_WH2_2	52	69	PF00022	0.512
LIG_APCC_ABBA_1	200	205	PF00400	0.350
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_deltaCOP1_diTrp_1	233	238	PF00928	0.454
LIG_FHA_1	217	223	PF00498	0.475
LIG_FHA_1	265	271	PF00498	0.425
LIG_FHA_1	302	308	PF00498	0.615
LIG_FHA_1	314	320	PF00498	0.419
LIG_FHA_1	82	88	PF00498	0.542
LIG_FHA_2	40	46	PF00498	0.626
LIG_FHA_2	63	69	PF00498	0.319
LIG_LIR_Apic_2	236	241	PF02991	0.403
LIG_LIR_Gen_1	204	215	PF02991	0.430
LIG_LIR_Nem_3	102	108	PF02991	0.338
LIG_LIR_Nem_3	17	23	PF02991	0.428
LIG_LIR_Nem_3	204	210	PF02991	0.365
LIG_MYND_1	97	101	PF01753	0.462
LIG_Pex14_2	125	129	PF04695	0.363
LIG_Pex14_2	288	292	PF04695	0.543
LIG_SH2_NCK_1	207	211	PF00017	0.480
LIG_SH2_STAP1	315	319	PF00017	0.593
LIG_SH2_STAT5	126	129	PF00017	0.340
LIG_SH2_STAT5	18	21	PF00017	0.401
LIG_SH2_STAT5	24	27	PF00017	0.343
LIG_SH2_STAT5	279	282	PF00017	0.449
LIG_SH2_STAT5	315	318	PF00017	0.553
LIG_SH2_STAT5	76	79	PF00017	0.501
LIG_SH3_2	192	197	PF14604	0.415
LIG_SH3_3	124	130	PF00018	0.264
LIG_SH3_3	131	137	PF00018	0.352
LIG_SH3_3	189	195	PF00018	0.557
LIG_SH3_3	196	202	PF00018	0.447
LIG_SH3_4	274	281	PF00018	0.524
LIG_SUMO_SIM_anti_2	269	274	PF11976	0.523
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.399
LIG_SUMO_SIM_par_1	138	143	PF11976	0.312
LIG_SUMO_SIM_par_1	28	34	PF11976	0.494
LIG_TRAF2_1	202	205	PF00917	0.472
LIG_TRAF2_1	43	46	PF00917	0.605
LIG_WW_1	73	76	PF00397	0.503
MOD_CDC14_SPxK_1	182	185	PF00782	0.593
MOD_CDK_SPxK_1	179	185	PF00069	0.591
MOD_CDK_SPxxK_3	113	120	PF00069	0.300
MOD_CK1_1	113	119	PF00069	0.341
MOD_CK1_1	12	18	PF00069	0.522
MOD_CK1_1	171	177	PF00069	0.746
MOD_CK1_1	216	222	PF00069	0.478
MOD_CK1_1	237	243	PF00069	0.573
MOD_CK1_1	39	45	PF00069	0.680
MOD_CK1_1	4	10	PF00069	0.693
MOD_CK1_1	58	64	PF00069	0.403
MOD_CK2_1	39	45	PF00069	0.697
MOD_CK2_1	83	89	PF00069	0.471
MOD_GlcNHglycan	161	166	PF01048	0.655
MOD_GlcNHglycan	170	173	PF01048	0.704
MOD_GlcNHglycan	248	251	PF01048	0.648
MOD_GlcNHglycan	38	41	PF01048	0.564
MOD_GlcNHglycan	60	63	PF01048	0.613
MOD_GSK3_1	168	175	PF00069	0.707
MOD_GSK3_1	186	193	PF00069	0.643
MOD_GSK3_1	233	240	PF00069	0.464
MOD_GSK3_1	301	308	PF00069	0.736
MOD_GSK3_1	51	58	PF00069	0.734
MOD_GSK3_1	79	86	PF00069	0.634
MOD_LATS_1	110	116	PF00433	0.318
MOD_NEK2_1	1	6	PF00069	0.593
MOD_NEK2_1	19	24	PF00069	0.314
MOD_NEK2_1	213	218	PF00069	0.358
MOD_NEK2_1	30	35	PF00069	0.399
MOD_NEK2_1	303	308	PF00069	0.539
MOD_NEK2_2	62	67	PF00069	0.329
MOD_PIKK_1	264	270	PF00454	0.410
MOD_PK_1	51	57	PF00069	0.609
MOD_PKA_2	111	117	PF00069	0.305
MOD_PKA_2	213	219	PF00069	0.359
MOD_PKA_2	246	252	PF00069	0.551
MOD_PKA_2	262	268	PF00069	0.400
MOD_Plk_4	213	219	PF00069	0.359
MOD_ProDKin_1	113	119	PF00069	0.305
MOD_ProDKin_1	179	185	PF00069	0.665
MOD_ProDKin_1	237	243	PF00069	0.416
MOD_ProDKin_1	39	45	PF00069	0.585
MOD_ProDKin_1	4	10	PF00069	0.569
MOD_ProDKin_1	81	87	PF00069	0.709
MOD_ProDKin_1	97	103	PF00069	0.452
TRG_AP2beta_CARGO_1	17	27	PF09066	0.441
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.445
TRG_ENDOCYTIC_2	126	129	PF00928	0.334
TRG_ENDOCYTIC_2	207	210	PF00928	0.361
TRG_ER_diArg_1	25	27	PF00400	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S2	Leptomonas seymouri	52%	100%
A0A1X0NWL0	Trypanosomatidae	33%	100%
A0A3Q8ID23	Leishmania donovani	91%	100%
A0A3S5IS47	Trypanosoma rangeli	35%	100%
A4HDS5	Leishmania braziliensis	74%	98%
A4I123	Leishmania infantum	91%	100%
Q4QAB6	Leishmania major	90%	100%
V5BEA3	Trypanosoma cruzi	34%	100%