CID domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX56_LEIMU

TriTrypDb:

LmxM.24.2100

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.563
CLV_NRD_NRD_1	292	294	PF00675	0.636
CLV_NRD_NRD_1	297	299	PF00675	0.633
CLV_NRD_NRD_1	65	67	PF00675	0.429
CLV_PCSK_KEX2_1	290	292	PF00082	0.646
CLV_PCSK_KEX2_1	296	298	PF00082	0.628
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.718
CLV_PCSK_PC7_1	292	298	PF00082	0.628
CLV_PCSK_SKI1_1	203	207	PF00082	0.657
CLV_PCSK_SKI1_1	66	70	PF00082	0.442
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.363
DOC_MAPK_DCC_7	277	286	PF00069	0.705
DOC_MAPK_gen_1	277	286	PF00069	0.705
DOC_MAPK_MEF2A_6	277	286	PF00069	0.705
DOC_MAPK_MEF2A_6	92	101	PF00069	0.396
DOC_PP2B_LxvP_1	101	104	PF13499	0.432
DOC_PP2B_LxvP_1	284	287	PF13499	0.710
DOC_USP7_MATH_1	152	156	PF00917	0.562
DOC_USP7_MATH_1	168	172	PF00917	0.642
DOC_USP7_MATH_1	201	205	PF00917	0.628
DOC_USP7_MATH_1	247	251	PF00917	0.779
DOC_USP7_MATH_1	3	7	PF00917	0.379
DOC_WW_Pin1_4	13	18	PF00397	0.643
DOC_WW_Pin1_4	176	181	PF00397	0.570
DOC_WW_Pin1_4	224	229	PF00397	0.753
DOC_WW_Pin1_4	266	271	PF00397	0.734
LIG_14-3-3_CanoR_1	122	127	PF00244	0.625
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BIR_III_2	76	80	PF00653	0.264
LIG_Clathr_ClatBox_1	126	130	PF01394	0.539
LIG_eIF4E_1	85	91	PF01652	0.360
LIG_FHA_1	24	30	PF00498	0.551
LIG_LIR_Apic_2	233	239	PF02991	0.719
LIG_LIR_Gen_1	135	144	PF02991	0.489
LIG_LIR_Gen_1	188	196	PF02991	0.469
LIG_LIR_Gen_1	60	70	PF02991	0.413
LIG_LIR_Nem_3	135	139	PF02991	0.395
LIG_LIR_Nem_3	188	193	PF02991	0.465
LIG_LIR_Nem_3	60	65	PF02991	0.382
LIG_LIR_Nem_3	82	87	PF02991	0.426
LIG_NRBOX	160	166	PF00104	0.606
LIG_PALB2_WD40_1	124	132	PF16756	0.536
LIG_PTAP_UEV_1	227	232	PF05743	0.591
LIG_SH2_CRK	145	149	PF00017	0.523
LIG_SH2_CRK	236	240	PF00017	0.759
LIG_SH2_CRK	31	35	PF00017	0.533
LIG_SH2_NCK_1	236	240	PF00017	0.585
LIG_SH2_STAP1	25	29	PF00017	0.579
LIG_SH2_STAT3	109	112	PF00017	0.426
LIG_SH2_STAT5	109	112	PF00017	0.405
LIG_SH2_STAT5	25	28	PF00017	0.575
LIG_SH2_STAT5	268	271	PF00017	0.647
LIG_SH2_STAT5	85	88	PF00017	0.353
LIG_SH3_3	14	20	PF00018	0.671
LIG_SH3_3	225	231	PF00018	0.792
LIG_SH3_3	94	100	PF00018	0.391
LIG_TYR_ITIM	29	34	PF00017	0.527
MOD_CDK_SPK_2	13	18	PF00069	0.704
MOD_CK1_1	224	230	PF00069	0.764
MOD_CK1_1	256	262	PF00069	0.719
MOD_CK1_1	58	64	PF00069	0.504
MOD_CK2_1	154	160	PF00069	0.481
MOD_Cter_Amidation	294	297	PF01082	0.758
MOD_GlcNHglycan	1	4	PF01048	0.463
MOD_GlcNHglycan	145	148	PF01048	0.466
MOD_GlcNHglycan	156	159	PF01048	0.431
MOD_GlcNHglycan	21	24	PF01048	0.372
MOD_GlcNHglycan	228	231	PF01048	0.696
MOD_GlcNHglycan	255	258	PF01048	0.720
MOD_GlcNHglycan	5	8	PF01048	0.617
MOD_GlcNHglycan	57	60	PF01048	0.451
MOD_GSK3_1	19	26	PF00069	0.560
MOD_GSK3_1	222	229	PF00069	0.741
MOD_GSK3_1	243	250	PF00069	0.675
MOD_N-GLC_1	222	227	PF02516	0.682
MOD_N-GLC_1	79	84	PF02516	0.451
MOD_NEK2_1	107	112	PF00069	0.512
MOD_NEK2_2	201	206	PF00069	0.685
MOD_PIKK_1	256	262	PF00454	0.780
MOD_Plk_1	107	113	PF00069	0.515
MOD_Plk_1	168	174	PF00069	0.599
MOD_Plk_1	79	85	PF00069	0.487
MOD_Plk_4	122	128	PF00069	0.550
MOD_Plk_4	201	207	PF00069	0.651
MOD_ProDKin_1	13	19	PF00069	0.637
MOD_ProDKin_1	176	182	PF00069	0.564
MOD_ProDKin_1	224	230	PF00069	0.752
MOD_ProDKin_1	266	272	PF00069	0.734
TRG_DiLeu_BaEn_1	160	165	PF01217	0.606
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.449
TRG_ENDOCYTIC_2	145	148	PF00928	0.512
TRG_ENDOCYTIC_2	31	34	PF00928	0.525
TRG_ER_diArg_1	291	293	PF00400	0.636
TRG_ER_diArg_1	296	298	PF00400	0.629
TRG_NES_CRM1_1	124	137	PF08389	0.549
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R9	Leptomonas seymouri	67%	99%
A0A0S4IT31	Bodo saltans	27%	100%
A0A1X0NWE2	Trypanosomatidae	38%	100%
A0A3R7MR43	Trypanosoma rangeli	39%	100%
A0A3S7WYL9	Leishmania donovani	93%	99%
A4HDS1	Leishmania braziliensis	85%	100%
A4I119	Leishmania infantum	92%	99%
C9ZW91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4QAC0	Leishmania major	92%	100%
V5AV25	Trypanosoma cruzi	39%	99%