Bola-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Bola-like protein

Gene product:

BolA-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9AX50_LEIMU

TriTrypDb:

LmxM.24.2040

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX50

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:0106035	protein maturation by [4Fe-4S] cluster transfer	6	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_Nbox_1	1	3	PF02207	0.475
DOC_CDC14_PxL_1	2	10	PF14671	0.516
DOC_USP7_MATH_1	29	33	PF00917	0.402
DOC_WW_Pin1_4	49	54	PF00397	0.464
LIG_Actin_WH2_2	14	30	PF00022	0.403
LIG_BRCT_BRCA1_1	51	55	PF00533	0.422
LIG_FHA_2	11	17	PF00498	0.346
LIG_LIR_Nem_3	44	48	PF02991	0.422
LIG_SH2_NCK_1	12	16	PF00017	0.405
LIG_SH2_STAT5	12	15	PF00017	0.404
LIG_SUMO_SIM_par_1	34	39	PF11976	0.368
MOD_GlcNHglycan	37	41	PF01048	0.333
MOD_GlcNHglycan	73	78	PF01048	0.243
MOD_NEK2_2	29	34	PF00069	0.364
MOD_NEK2_2	41	46	PF00069	0.408
MOD_Plk_1	73	79	PF00069	0.464
MOD_Plk_4	41	47	PF00069	0.422
MOD_Plk_4	56	62	PF00069	0.524
MOD_ProDKin_1	49	55	PF00069	0.464
MOD_SUMO_for_1	19	22	PF00179	0.403
MOD_SUMO_for_1	71	74	PF00179	0.404
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX7	Leptomonas seymouri	85%	100%
A0A0S4IUF9	Bodo saltans	49%	97%
A0A3Q8IC84	Leishmania donovani	97%	100%
A4HDR6	Leishmania braziliensis	92%	100%
A4I112	Leishmania infantum	97%	100%
C9ZW98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
O14280	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
P39724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	75%
P53082	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	73%
Q3SZ84	Bos taurus	36%	80%
Q4QAC6	Leishmania major	94%	100%
Q53S33	Homo sapiens	37%	82%
Q8CEI1	Mus musculus	35%	80%
Q9FIC3	Arabidopsis thaliana	42%	95%
Q9USK1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	76%