Putative tubulin folding cofactor D

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin folding cofactor D, putative

Species:

Leishmania mexicana

UniProt:

E9AX48_LEIMU

TriTrypDb:

LmxM.24.2020

Length:

1422

Annotations

LeishMANIAdb annotations

A conserved helical solenoid protein, related to animal tubulin-specific chaperone D. No TM segment can be discerned.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006457	protein folding	2	12
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	12
GO:0007023	post-chaperonin tubulin folding pathway	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12

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Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008047	enzyme activator activity	3	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0030234	enzyme regulator activity	2	12
GO:0030695	GTPase regulator activity	4	12
GO:0048487	beta-tubulin binding	5	12
GO:0060589	nucleoside-triphosphatase regulator activity	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1356	1360	PF00656	0.609
CLV_C14_Caspase3-7	279	283	PF00656	0.297
CLV_C14_Caspase3-7	311	315	PF00656	0.274
CLV_C14_Caspase3-7	36	40	PF00656	0.688
CLV_C14_Caspase3-7	6	10	PF00656	0.504
CLV_C14_Caspase3-7	693	697	PF00656	0.318
CLV_C14_Caspase3-7	926	930	PF00656	0.428
CLV_C14_Caspase3-7	963	967	PF00656	0.343
CLV_NRD_NRD_1	1122	1124	PF00675	0.506
CLV_NRD_NRD_1	1187	1189	PF00675	0.535

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P4	Leptomonas seymouri	67%	100%
A0A0S4IU88	Bodo saltans	38%	100%
A0A1X0NW58	Trypanosomatidae	43%	100%
A0A3Q8IC26	Leishmania donovani	90%	98%
A0A3R7KUD9	Trypanosoma rangeli	44%	100%
A4HDR4	Leishmania braziliensis	81%	100%
A4I110	Leishmania infantum	91%	98%
C9ZW99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q28205	Bos taurus	30%	100%
Q4QAC8	Leishmania major	90%	100%

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