PCIF1_WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphorylated CTD interacting factor 1 WW domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AX46_LEIMU

TriTrypDb:

LmxM.24.2000

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX46

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	11
GO:0001098	basal transcription machinery binding	3	11
GO:0001099	basal RNA polymerase II transcription machinery binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0008174	mRNA methyltransferase activity	5	11
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0019899	enzyme binding	3	11
GO:0043175	RNA polymerase core enzyme binding	5	11
GO:0070063	RNA polymerase binding	4	11
GO:0099122	RNA polymerase II C-terminal domain binding	6	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.464
CLV_C14_Caspase3-7	5	9	PF00656	0.704
CLV_NRD_NRD_1	206	208	PF00675	0.482
CLV_NRD_NRD_1	238	240	PF00675	0.495
CLV_NRD_NRD_1	33	35	PF00675	0.364
CLV_NRD_NRD_1	491	493	PF00675	0.469
CLV_NRD_NRD_1	54	56	PF00675	0.541
CLV_NRD_NRD_1	573	575	PF00675	0.294
CLV_PCSK_FUR_1	204	208	PF00082	0.538
CLV_PCSK_KEX2_1	179	181	PF00082	0.425
CLV_PCSK_KEX2_1	2	4	PF00082	0.580
CLV_PCSK_KEX2_1	206	208	PF00082	0.482
CLV_PCSK_KEX2_1	238	240	PF00082	0.495
CLV_PCSK_KEX2_1	33	35	PF00082	0.364
CLV_PCSK_KEX2_1	491	493	PF00082	0.574
CLV_PCSK_KEX2_1	573	575	PF00082	0.508
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.420
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.580
CLV_PCSK_SKI1_1	21	25	PF00082	0.319
CLV_PCSK_SKI1_1	276	280	PF00082	0.522
CLV_PCSK_SKI1_1	291	295	PF00082	0.222
CLV_PCSK_SKI1_1	34	38	PF00082	0.350
CLV_PCSK_SKI1_1	402	406	PF00082	0.339
CLV_PCSK_SKI1_1	429	433	PF00082	0.405
CLV_PCSK_SKI1_1	460	464	PF00082	0.472
CLV_PCSK_SKI1_1	518	522	PF00082	0.655
CLV_PCSK_SKI1_1	573	577	PF00082	0.564
CLV_PCSK_SKI1_1	67	71	PF00082	0.345
DEG_APCC_DBOX_1	33	41	PF00400	0.410
DEG_Nend_UBRbox_1	1	4	PF02207	0.581
DEG_SPOP_SBC_1	431	435	PF00917	0.407
DOC_CKS1_1	214	219	PF01111	0.580
DOC_CYCLIN_RxL_1	455	466	PF00134	0.421
DOC_MAPK_gen_1	241	250	PF00069	0.288
DOC_MAPK_JIP1_4	402	408	PF00069	0.337
DOC_MAPK_MEF2A_6	241	250	PF00069	0.378
DOC_MAPK_MEF2A_6	402	410	PF00069	0.342
DOC_PP1_RVXF_1	282	289	PF00149	0.270
DOC_PP1_RVXF_1	45	52	PF00149	0.550
DOC_PP2B_LxvP_1	408	411	PF13499	0.380
DOC_PP2B_LxvP_1	446	449	PF13499	0.354
DOC_PP4_FxxP_1	347	350	PF00568	0.173
DOC_USP7_MATH_1	122	126	PF00917	0.686
DOC_USP7_MATH_1	227	231	PF00917	0.481
DOC_USP7_MATH_1	304	308	PF00917	0.313
DOC_USP7_MATH_1	351	355	PF00917	0.479
DOC_USP7_MATH_1	431	435	PF00917	0.522
DOC_USP7_MATH_1	523	527	PF00917	0.558
DOC_USP7_MATH_1	575	579	PF00917	0.472
DOC_WW_Pin1_4	193	198	PF00397	0.451
DOC_WW_Pin1_4	213	218	PF00397	0.317
DOC_WW_Pin1_4	330	335	PF00397	0.279
DOC_WW_Pin1_4	474	479	PF00397	0.701
DOC_WW_Pin1_4	566	571	PF00397	0.505
DOC_WW_Pin1_4	583	588	PF00397	0.601
LIG_14-3-3_CanoR_1	291	296	PF00244	0.328
LIG_Clathr_ClatBox_1	405	409	PF01394	0.332
LIG_deltaCOP1_diTrp_1	527	536	PF00928	0.426
LIG_FHA_1	196	202	PF00498	0.399
LIG_FHA_1	292	298	PF00498	0.259
LIG_FHA_1	303	309	PF00498	0.279
LIG_FHA_1	405	411	PF00498	0.348
LIG_FHA_1	464	470	PF00498	0.664
LIG_FHA_1	556	562	PF00498	0.396
LIG_FHA_2	141	147	PF00498	0.436
LIG_FHA_2	554	560	PF00498	0.421
LIG_LIR_Apic_2	346	350	PF02991	0.173
LIG_LIR_Apic_2	498	503	PF02991	0.513
LIG_LIR_Apic_2	577	583	PF02991	0.582
LIG_LIR_Gen_1	249	260	PF02991	0.468
LIG_LIR_Gen_1	418	428	PF02991	0.362
LIG_LIR_Gen_1	443	450	PF02991	0.331
LIG_LIR_Gen_1	526	537	PF02991	0.433
LIG_LIR_Nem_3	374	380	PF02991	0.297
LIG_LIR_Nem_3	418	424	PF02991	0.358
LIG_LIR_Nem_3	443	447	PF02991	0.312
LIG_LIR_Nem_3	526	532	PF02991	0.414
LIG_LIR_Nem_3	538	544	PF02991	0.401
LIG_LIR_Nem_3	577	582	PF02991	0.585
LIG_NRBOX	415	421	PF00104	0.469
LIG_PCNA_yPIPBox_3	55	69	PF02747	0.364
LIG_Pex14_2	366	370	PF04695	0.279
LIG_Pex14_2	532	536	PF04695	0.409
LIG_SH2_NCK_1	160	164	PF00017	0.367
LIG_SH2_PTP2	444	447	PF00017	0.314
LIG_SH2_PTP2	580	583	PF00017	0.442
LIG_SH2_STAP1	144	148	PF00017	0.391
LIG_SH2_STAP1	160	164	PF00017	0.399
LIG_SH2_STAP1	412	416	PF00017	0.244
LIG_SH2_STAT3	144	147	PF00017	0.398
LIG_SH2_STAT5	365	368	PF00017	0.239
LIG_SH2_STAT5	376	379	PF00017	0.279
LIG_SH2_STAT5	444	447	PF00017	0.318
LIG_SH2_STAT5	543	546	PF00017	0.369
LIG_SH2_STAT5	580	583	PF00017	0.490
LIG_SH3_3	228	234	PF00018	0.412
LIG_SH3_3	245	251	PF00018	0.376
LIG_SH3_3	393	399	PF00018	0.532
LIG_SH3_3	73	79	PF00018	0.466
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.390
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.322
LIG_SUMO_SIM_par_1	402	407	PF11976	0.338
LIG_TYR_ITIM	442	447	PF00017	0.390
LIG_WRC_WIRS_1	576	581	PF05994	0.459
MOD_CDK_SPxxK_3	566	573	PF00069	0.493
MOD_CDK_SPxxK_3	583	590	PF00069	0.424
MOD_CK1_1	153	159	PF00069	0.476
MOD_CK1_1	266	272	PF00069	0.500
MOD_CK1_1	379	385	PF00069	0.283
MOD_CK1_1	430	436	PF00069	0.492
MOD_CK1_1	472	478	PF00069	0.688
MOD_CK1_1	89	95	PF00069	0.626
MOD_CK2_1	140	146	PF00069	0.560
MOD_CK2_1	502	508	PF00069	0.530
MOD_CK2_1	553	559	PF00069	0.429
MOD_GlcNHglycan	107	110	PF01048	0.440
MOD_GlcNHglycan	125	128	PF01048	0.520
MOD_GlcNHglycan	132	135	PF01048	0.768
MOD_GlcNHglycan	161	164	PF01048	0.512
MOD_GlcNHglycan	279	282	PF01048	0.498
MOD_GlcNHglycan	300	303	PF01048	0.371
MOD_GlcNHglycan	367	370	PF01048	0.279
MOD_GlcNHglycan	381	384	PF01048	0.297
MOD_GlcNHglycan	429	432	PF01048	0.567
MOD_GlcNHglycan	478	481	PF01048	0.629
MOD_GlcNHglycan	93	96	PF01048	0.713
MOD_GSK3_1	123	130	PF00069	0.687
MOD_GSK3_1	298	305	PF00069	0.173
MOD_GSK3_1	427	434	PF00069	0.430
MOD_GSK3_1	463	470	PF00069	0.590
MOD_GSK3_1	472	479	PF00069	0.674
MOD_GSK3_1	86	93	PF00069	0.564
MOD_N-GLC_1	156	161	PF02516	0.515
MOD_N-GLC_1	173	178	PF02516	0.377
MOD_NEK2_1	1	6	PF00069	0.694
MOD_NEK2_1	463	468	PF00069	0.551
MOD_NEK2_1	544	549	PF00069	0.484
MOD_NEK2_2	575	580	PF00069	0.474
MOD_PIKK_1	195	201	PF00454	0.411
MOD_PIKK_1	68	74	PF00454	0.387
MOD_PIKK_1	86	92	PF00454	0.534
MOD_PK_1	150	156	PF00069	0.401
MOD_PKA_1	2	8	PF00069	0.709
MOD_PKA_2	2	8	PF00069	0.709
MOD_Plk_1	150	156	PF00069	0.374
MOD_Plk_1	173	179	PF00069	0.568
MOD_Plk_1	227	233	PF00069	0.418
MOD_Plk_2-3	140	146	PF00069	0.579
MOD_Plk_4	291	297	PF00069	0.337
MOD_Plk_4	525	531	PF00069	0.354
MOD_Plk_4	575	581	PF00069	0.434
MOD_ProDKin_1	193	199	PF00069	0.453
MOD_ProDKin_1	213	219	PF00069	0.307
MOD_ProDKin_1	330	336	PF00069	0.279
MOD_ProDKin_1	474	480	PF00069	0.697
MOD_ProDKin_1	566	572	PF00069	0.493
MOD_ProDKin_1	583	589	PF00069	0.601
MOD_SUMO_for_1	456	459	PF00179	0.464
MOD_SUMO_rev_2	394	404	PF00179	0.393
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.469
TRG_ENDOCYTIC_2	262	265	PF00928	0.372
TRG_ENDOCYTIC_2	325	328	PF00928	0.279
TRG_ENDOCYTIC_2	338	341	PF00928	0.279
TRG_ENDOCYTIC_2	444	447	PF00928	0.314
TRG_ENDOCYTIC_2	541	544	PF00928	0.372
TRG_ER_diArg_1	203	206	PF00400	0.510
TRG_ER_diArg_1	237	239	PF00400	0.461
TRG_ER_diArg_1	32	34	PF00400	0.353
TRG_ER_diArg_1	572	574	PF00400	0.291
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II31	Leptomonas seymouri	63%	98%
A0A1X0NXA7	Trypanosomatidae	45%	100%
A0A3Q8IBG9	Leishmania donovani	93%	100%
A0A422NWV1	Trypanosoma rangeli	47%	100%
A4HDR2	Leishmania braziliensis	82%	100%
A4I108	Leishmania infantum	93%	100%
C9ZWA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4QAD0	Leishmania major	92%	100%
V5BAG8	Trypanosoma cruzi	46%	100%