Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX45_LEIMU

TriTrypDb:

LmxM.24.1990

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.519
CLV_C14_Caspase3-7	236	240	PF00656	0.459
CLV_C14_Caspase3-7	256	260	PF00656	0.606
CLV_NRD_NRD_1	107	109	PF00675	0.356
CLV_NRD_NRD_1	120	122	PF00675	0.471
CLV_NRD_NRD_1	37	39	PF00675	0.474
CLV_NRD_NRD_1	79	81	PF00675	0.480
CLV_NRD_NRD_1	88	90	PF00675	0.463
CLV_NRD_NRD_1	96	98	PF00675	0.560
CLV_PCSK_KEX2_1	107	109	PF00082	0.356
CLV_PCSK_KEX2_1	37	39	PF00082	0.428
CLV_PCSK_KEX2_1	79	81	PF00082	0.437
CLV_PCSK_KEX2_1	88	90	PF00082	0.459
CLV_PCSK_KEX2_1	95	97	PF00082	0.532
CLV_PCSK_SKI1_1	170	174	PF00082	0.654
CLV_PCSK_SKI1_1	340	344	PF00082	0.534
CLV_PCSK_SKI1_1	79	83	PF00082	0.587
CLV_PCSK_SKI1_1	89	93	PF00082	0.436
CLV_PCSK_SKI1_1	97	101	PF00082	0.449
DOC_MAPK_MEF2A_6	302	309	PF00069	0.590
DOC_PP1_RVXF_1	338	344	PF00149	0.338
DOC_PP1_RVXF_1	5	11	PF00149	0.604
DOC_PP2B_LxvP_1	332	335	PF13499	0.531
DOC_USP7_MATH_1	138	142	PF00917	0.525
DOC_USP7_MATH_1	230	234	PF00917	0.551
DOC_USP7_MATH_1	246	250	PF00917	0.547
DOC_USP7_MATH_1	322	326	PF00917	0.460
LIG_14-3-3_CanoR_1	213	220	PF00244	0.542
LIG_14-3-3_CanoR_1	221	226	PF00244	0.453
LIG_14-3-3_CanoR_1	254	258	PF00244	0.585
LIG_14-3-3_CanoR_1	320	328	PF00244	0.454
LIG_14-3-3_CanoR_1	37	41	PF00244	0.326
LIG_14-3-3_CanoR_1	95	100	PF00244	0.544
LIG_BIR_III_4	247	251	PF00653	0.614
LIG_FHA_2	234	240	PF00498	0.449
LIG_FHA_2	331	337	PF00498	0.472
LIG_FHA_2	98	104	PF00498	0.518
LIG_LIR_Gen_1	261	271	PF02991	0.478
LIG_LIR_Nem_3	51	57	PF02991	0.531
LIG_Pex14_1	180	184	PF04695	0.700
LIG_SH2_CRK	3	7	PF00017	0.529
LIG_SH2_GRB2like	16	19	PF00017	0.570
LIG_SH2_NCK_1	57	61	PF00017	0.400
LIG_SH2_SRC	123	126	PF00017	0.523
LIG_SH2_STAP1	16	20	PF00017	0.563
LIG_SH2_STAT5	11	14	PF00017	0.494
LIG_SH2_STAT5	157	160	PF00017	0.478
LIG_SH2_STAT5	205	208	PF00017	0.561
LIG_SH3_1	165	171	PF00018	0.506
LIG_SH3_3	165	171	PF00018	0.559
LIG_SH3_3	206	212	PF00018	0.604
LIG_SH3_3	316	322	PF00018	0.634
LIG_TRAF2_1	42	45	PF00917	0.416
LIG_WW_3	210	214	PF00397	0.394
LIG_WW_3	320	324	PF00397	0.470
MOD_CK1_1	106	112	PF00069	0.540
MOD_CK1_1	183	189	PF00069	0.613
MOD_CK1_1	233	239	PF00069	0.438
MOD_CK1_1	277	283	PF00069	0.557
MOD_CK1_1	297	303	PF00069	0.384
MOD_CK2_1	211	217	PF00069	0.512
MOD_CK2_1	280	286	PF00069	0.532
MOD_CK2_1	330	336	PF00069	0.501
MOD_CK2_1	97	103	PF00069	0.585
MOD_GlcNHglycan	129	132	PF01048	0.608
MOD_GlcNHglycan	140	143	PF01048	0.599
MOD_GlcNHglycan	20	23	PF01048	0.362
MOD_GlcNHglycan	213	216	PF01048	0.593
MOD_GlcNHglycan	247	251	PF01048	0.756
MOD_GlcNHglycan	40	43	PF01048	0.301
MOD_GSK3_1	14	21	PF00069	0.345
MOD_GSK3_1	277	284	PF00069	0.578
MOD_GSK3_1	294	301	PF00069	0.547
MOD_GSK3_1	322	329	PF00069	0.714
MOD_GSK3_1	91	98	PF00069	0.699
MOD_LATS_1	36	42	PF00433	0.324
MOD_N-GLC_1	330	335	PF02516	0.576
MOD_NEK2_1	127	132	PF00069	0.660
MOD_NEK2_1	173	178	PF00069	0.664
MOD_NEK2_1	294	299	PF00069	0.659
MOD_NEK2_1	346	351	PF00069	0.640
MOD_PIKK_1	233	239	PF00454	0.505
MOD_PK_1	30	36	PF00069	0.524
MOD_PKA_1	95	101	PF00069	0.684
MOD_PKA_2	106	112	PF00069	0.467
MOD_PKA_2	253	259	PF00069	0.790
MOD_PKA_2	322	328	PF00069	0.573
MOD_PKA_2	36	42	PF00069	0.372
MOD_PKA_2	95	101	PF00069	0.696
MOD_PKB_1	95	103	PF00069	0.546
MOD_Plk_1	230	236	PF00069	0.565
MOD_Plk_1	330	336	PF00069	0.482
MOD_Plk_2-3	330	336	PF00069	0.583
MOD_Plk_4	274	280	PF00069	0.560
MOD_SUMO_for_1	81	84	PF00179	0.467
MOD_SUMO_rev_2	141	148	PF00179	0.499
TRG_DiLeu_BaEn_4	71	77	PF01217	0.510
TRG_ENDOCYTIC_2	16	19	PF00928	0.549
TRG_ER_diArg_1	107	110	PF00400	0.362
TRG_ER_diArg_1	79	81	PF00400	0.502
TRG_ER_diArg_1	87	89	PF00400	0.483
TRG_ER_diArg_1	95	97	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P5	Leptomonas seymouri	54%	100%
A0A3Q8ID13	Leishmania donovani	87%	100%
A0A422NWQ4	Trypanosoma rangeli	33%	100%
A4HDR1	Leishmania braziliensis	73%	99%
A4I107	Leishmania infantum	89%	100%
C9ZWA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4QAD1	Leishmania major	91%	100%
V5BJJ9	Trypanosoma cruzi	35%	100%