STOP axonemal protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX44_LEIMU

TriTrypDb:

LmxM.24.1980

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AX44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX44

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0034453	microtubule anchoring	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.552
CLV_NRD_NRD_1	129	131	PF00675	0.640
CLV_NRD_NRD_1	57	59	PF00675	0.593
CLV_PCSK_FUR_1	127	131	PF00082	0.668
CLV_PCSK_KEX2_1	129	131	PF00082	0.641
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.668
CLV_PCSK_SKI1_1	167	171	PF00082	0.642
CLV_Separin_Metazoa	151	155	PF03568	0.633
DOC_MAPK_MEF2A_6	248	256	PF00069	0.683
DOC_MAPK_MEF2A_6	27	35	PF00069	0.574
DOC_PP2B_LxvP_1	33	36	PF13499	0.595
DOC_USP7_MATH_1	92	96	PF00917	0.566
DOC_WW_Pin1_4	130	135	PF00397	0.388
LIG_14-3-3_CanoR_1	61	65	PF00244	0.664
LIG_BRCT_BRCA1_1	177	181	PF00533	0.647
LIG_EVH1_1	162	166	PF00568	0.629
LIG_EVH1_2	165	169	PF00568	0.573
LIG_FHA_2	40	46	PF00498	0.529
LIG_FHA_2	75	81	PF00498	0.576
LIG_LIR_Apic_2	222	228	PF02991	0.535
LIG_LIR_Apic_2	255	260	PF02991	0.596
LIG_LIR_Nem_3	178	184	PF02991	0.645
LIG_Pex14_1	121	125	PF04695	0.668
LIG_SH2_CRK	225	229	PF00017	0.570
LIG_SH2_CRK	257	261	PF00017	0.576
LIG_SH2_NCK_1	257	261	PF00017	0.594
LIG_SH2_STAP1	187	191	PF00017	0.493
LIG_SH2_STAT5	142	145	PF00017	0.697
LIG_SH2_STAT5	187	190	PF00017	0.487
LIG_SH2_STAT5	47	50	PF00017	0.542
LIG_SH3_3	133	139	PF00018	0.628
LIG_SH3_3	160	166	PF00018	0.559
LIG_SH3_3	239	245	PF00018	0.607
LIG_TRAF2_1	148	151	PF00917	0.578
LIG_TRAF2_1	77	80	PF00917	0.575
MOD_CDK_SPxxK_3	130	137	PF00069	0.392
MOD_CK1_1	6	12	PF00069	0.589
MOD_CK2_1	64	70	PF00069	0.624
MOD_CK2_1	74	80	PF00069	0.505
MOD_GlcNHglycan	200	203	PF01048	0.669
MOD_GlcNHglycan	221	224	PF01048	0.546
MOD_GlcNHglycan	260	263	PF01048	0.581
MOD_GSK3_1	138	145	PF00069	0.595
MOD_GSK3_1	171	178	PF00069	0.652
MOD_GSK3_1	60	67	PF00069	0.656
MOD_N-GLC_1	125	130	PF02516	0.671
MOD_N-GLC_1	185	190	PF02516	0.567
MOD_NEK2_1	108	113	PF00069	0.518
MOD_NEK2_1	175	180	PF00069	0.655
MOD_NEK2_1	198	203	PF00069	0.672
MOD_NEK2_1	217	222	PF00069	0.512
MOD_NEK2_1	74	79	PF00069	0.553
MOD_NEK2_2	60	65	PF00069	0.709
MOD_PKA_2	60	66	PF00069	0.640
MOD_Plk_1	171	177	PF00069	0.568
MOD_Plk_1	39	45	PF00069	0.528
MOD_Plk_4	138	144	PF00069	0.702
MOD_Plk_4	252	258	PF00069	0.600
MOD_Plk_4	60	66	PF00069	0.660
MOD_ProDKin_1	130	136	PF00069	0.525
TRG_DiLeu_BaEn_1	80	85	PF01217	0.673
TRG_NLS_MonoExtN_4	56	62	PF00514	0.624
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS5	Leptomonas seymouri	82%	99%
A0A0S4J038	Bodo saltans	39%	100%
A0A0S4J0F3	Bodo saltans	28%	100%
A0A0S4JWV5	Bodo saltans	33%	98%
A0A1X0NVY6	Trypanosomatidae	61%	100%
A0A3R7MY93	Trypanosoma rangeli	61%	100%
A0A3S7WYJ9	Leishmania donovani	96%	100%
A4HDR0	Leishmania braziliensis	92%	100%
A4I106	Leishmania infantum	96%	100%
C9ZWA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
Q4QAD2	Leishmania major	97%	100%
V5BF29	Trypanosoma cruzi	60%	89%