Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP76

Species:

Leishmania mexicana

UniProt:

E9AX43_LEIMU

TriTrypDb:

LmxM.24.1970

Length:

758

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0044612	nuclear pore linkers	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AX43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX43

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.400
CLV_C14_Caspase3-7	276	280	PF00656	0.512
CLV_C14_Caspase3-7	572	576	PF00656	0.514
CLV_C14_Caspase3-7	592	596	PF00656	0.371
CLV_NRD_NRD_1	116	118	PF00675	0.479
CLV_NRD_NRD_1	180	182	PF00675	0.526
CLV_NRD_NRD_1	44	46	PF00675	0.444
CLV_NRD_NRD_1	528	530	PF00675	0.478
CLV_NRD_NRD_1	676	678	PF00675	0.431
CLV_NRD_NRD_1	687	689	PF00675	0.541
CLV_NRD_NRD_1	697	699	PF00675	0.415
CLV_NRD_NRD_1	731	733	PF00675	0.593
CLV_NRD_NRD_1	744	746	PF00675	0.490
CLV_PCSK_FUR_1	695	699	PF00082	0.448
CLV_PCSK_KEX2_1	116	118	PF00082	0.479
CLV_PCSK_KEX2_1	180	182	PF00082	0.516
CLV_PCSK_KEX2_1	229	231	PF00082	0.494
CLV_PCSK_KEX2_1	527	529	PF00082	0.484
CLV_PCSK_KEX2_1	676	678	PF00082	0.431
CLV_PCSK_KEX2_1	687	689	PF00082	0.480
CLV_PCSK_KEX2_1	695	697	PF00082	0.396
CLV_PCSK_KEX2_1	731	733	PF00082	0.590
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.476
CLV_PCSK_PC7_1	524	530	PF00082	0.410
CLV_PCSK_SKI1_1	108	112	PF00082	0.424
CLV_PCSK_SKI1_1	181	185	PF00082	0.487
CLV_PCSK_SKI1_1	19	23	PF00082	0.501
CLV_PCSK_SKI1_1	229	233	PF00082	0.695
CLV_PCSK_SKI1_1	613	617	PF00082	0.382
CLV_PCSK_SKI1_1	745	749	PF00082	0.432
DEG_APCC_DBOX_1	180	188	PF00400	0.422
DEG_APCC_DBOX_1	655	663	PF00400	0.439
DEG_COP1_1	583	591	PF00400	0.440
DEG_Nend_UBRbox_1	1	4	PF02207	0.455
DEG_ODPH_VHL_1	486	499	PF01847	0.477
DOC_MAPK_gen_1	116	124	PF00069	0.463
DOC_MAPK_gen_1	545	554	PF00069	0.620
DOC_MAPK_MEF2A_6	463	472	PF00069	0.511
DOC_MAPK_MEF2A_6	600	608	PF00069	0.424
DOC_PP1_RVXF_1	106	112	PF00149	0.430
DOC_PP2B_LxvP_1	134	137	PF13499	0.486
DOC_PP2B_LxvP_1	567	570	PF13499	0.421
DOC_USP7_MATH_1	201	205	PF00917	0.804
DOC_USP7_MATH_1	277	281	PF00917	0.555
DOC_USP7_MATH_1	299	303	PF00917	0.703
DOC_USP7_MATH_1	338	342	PF00917	0.465
DOC_USP7_MATH_1	446	450	PF00917	0.459
DOC_USP7_MATH_1	482	486	PF00917	0.623
DOC_USP7_MATH_1	489	493	PF00917	0.530
DOC_USP7_MATH_1	51	55	PF00917	0.535
DOC_USP7_MATH_1	589	593	PF00917	0.620
DOC_USP7_MATH_1	665	669	PF00917	0.507
DOC_USP7_MATH_1	72	76	PF00917	0.568
DOC_USP7_MATH_1	89	93	PF00917	0.590
DOC_WW_Pin1_4	100	105	PF00397	0.487
DOC_WW_Pin1_4	199	204	PF00397	0.759
DOC_WW_Pin1_4	211	216	PF00397	0.610
DOC_WW_Pin1_4	280	285	PF00397	0.774
DOC_WW_Pin1_4	30	35	PF00397	0.531
DOC_WW_Pin1_4	314	319	PF00397	0.699
DOC_WW_Pin1_4	339	344	PF00397	0.366
DOC_WW_Pin1_4	464	469	PF00397	0.603
DOC_WW_Pin1_4	557	562	PF00397	0.495
DOC_WW_Pin1_4	90	95	PF00397	0.597
LIG_14-3-3_CanoR_1	483	487	PF00244	0.563
LIG_14-3-3_CanoR_1	702	707	PF00244	0.523
LIG_14-3-3_CanoR_1	71	81	PF00244	0.448
LIG_14-3-3_CanoR_1	97	104	PF00244	0.358
LIG_Actin_WH2_2	169	187	PF00022	0.475
LIG_Actin_WH2_2	599	615	PF00022	0.469
LIG_Actin_WH2_2	644	662	PF00022	0.425
LIG_BIR_III_2	558	562	PF00653	0.489
LIG_BRCT_BRCA1_1	227	231	PF00533	0.578
LIG_BRCT_BRCA1_1	28	32	PF00533	0.490
LIG_FHA_1	16	22	PF00498	0.453
LIG_FHA_1	217	223	PF00498	0.496
LIG_FHA_1	238	244	PF00498	0.764
LIG_FHA_1	251	257	PF00498	0.713
LIG_FHA_1	323	329	PF00498	0.608
LIG_FHA_1	340	346	PF00498	0.533
LIG_FHA_1	429	435	PF00498	0.417
LIG_FHA_1	45	51	PF00498	0.579
LIG_FHA_1	471	477	PF00498	0.461
LIG_FHA_1	492	498	PF00498	0.470
LIG_FHA_1	581	587	PF00498	0.369
LIG_FHA_1	603	609	PF00498	0.298
LIG_FHA_1	632	638	PF00498	0.598
LIG_FHA_1	669	675	PF00498	0.409
LIG_FHA_1	74	80	PF00498	0.744
LIG_FHA_2	161	167	PF00498	0.402
LIG_FHA_2	218	224	PF00498	0.680
LIG_FHA_2	250	256	PF00498	0.600
LIG_FHA_2	274	280	PF00498	0.580
LIG_FHA_2	379	385	PF00498	0.601
LIG_GBD_Chelix_1	608	616	PF00786	0.451
LIG_IRF3_LxIS_1	153	159	PF10401	0.365
LIG_LIR_Apic_2	332	337	PF02991	0.403
LIG_LIR_Gen_1	142	153	PF02991	0.524
LIG_LIR_Gen_1	400	409	PF02991	0.485
LIG_LIR_Nem_3	142	148	PF02991	0.434
LIG_LIR_Nem_3	168	174	PF02991	0.469
LIG_LIR_Nem_3	228	234	PF02991	0.663
LIG_LIR_Nem_3	400	405	PF02991	0.462
LIG_LIR_Nem_3	719	723	PF02991	0.440
LIG_PCNA_yPIPBox_3	636	648	PF02747	0.546
LIG_PCNA_yPIPBox_3	738	748	PF02747	0.462
LIG_Pex14_2	28	32	PF04695	0.490
LIG_Pex14_2	518	522	PF04695	0.407
LIG_PTB_Apo_2	8	15	PF02174	0.383
LIG_RPA_C_Fungi	692	704	PF08784	0.378
LIG_SH2_CRK	334	338	PF00017	0.461
LIG_SH2_CRK	402	406	PF00017	0.455
LIG_SH2_NCK_1	334	338	PF00017	0.461
LIG_SH2_SRC	65	68	PF00017	0.585
LIG_SH2_STAP1	356	360	PF00017	0.451
LIG_SH2_STAP1	65	69	PF00017	0.598
LIG_SH2_STAT5	120	123	PF00017	0.341
LIG_SH2_STAT5	171	174	PF00017	0.485
LIG_SH3_3	171	177	PF00018	0.512
LIG_SH3_3	200	206	PF00018	0.708
LIG_SH3_3	312	318	PF00018	0.825
LIG_SH3_3	36	42	PF00018	0.567
LIG_SH3_3	390	396	PF00018	0.445
LIG_SH3_3	445	451	PF00018	0.449
LIG_SH3_3	462	468	PF00018	0.603
LIG_SH3_3	485	491	PF00018	0.579
LIG_SH3_3	534	540	PF00018	0.359
LIG_SH3_3	558	564	PF00018	0.420
LIG_SH3_3	583	589	PF00018	0.315
LIG_SUMO_SIM_anti_2	325	332	PF11976	0.562
LIG_SUMO_SIM_anti_2	583	590	PF11976	0.431
LIG_SUMO_SIM_par_1	120	125	PF11976	0.336
LIG_SUMO_SIM_par_1	319	326	PF11976	0.529
LIG_SUMO_SIM_par_1	344	352	PF11976	0.408
LIG_SUMO_SIM_par_1	395	400	PF11976	0.481
LIG_SUMO_SIM_par_1	583	590	PF11976	0.381
LIG_SUMO_SIM_par_1	602	607	PF11976	0.497
LIG_TRAF2_1	381	384	PF00917	0.622
LIG_TRFH_1	334	338	PF08558	0.461
MOD_CDC14_SPxK_1	214	217	PF00782	0.611
MOD_CDK_SPK_2	314	319	PF00069	0.664
MOD_CDK_SPxK_1	211	217	PF00069	0.611
MOD_CDK_SPxxK_3	90	97	PF00069	0.558
MOD_CK1_1	202	208	PF00069	0.645
MOD_CK1_1	280	286	PF00069	0.651
MOD_CK1_1	30	36	PF00069	0.440
MOD_CK1_1	44	50	PF00069	0.326
MOD_CK1_1	54	60	PF00069	0.613
MOD_CK1_1	560	566	PF00069	0.354
MOD_CK1_1	628	634	PF00069	0.494
MOD_CK1_1	668	674	PF00069	0.527
MOD_CK2_1	217	223	PF00069	0.548
MOD_CK2_1	249	255	PF00069	0.725
MOD_CK2_1	299	305	PF00069	0.697
MOD_CK2_1	30	36	PF00069	0.586
MOD_CK2_1	378	384	PF00069	0.664
MOD_CK2_1	593	599	PF00069	0.400
MOD_CMANNOS	532	535	PF00535	0.379
MOD_GlcNHglycan	123	127	PF01048	0.286
MOD_GlcNHglycan	158	161	PF01048	0.429
MOD_GlcNHglycan	279	282	PF01048	0.757
MOD_GlcNHglycan	301	304	PF01048	0.802
MOD_GlcNHglycan	351	354	PF01048	0.431
MOD_GlcNHglycan	405	408	PF01048	0.472
MOD_GlcNHglycan	476	479	PF01048	0.565
MOD_GlcNHglycan	509	512	PF01048	0.467
MOD_GlcNHglycan	613	616	PF01048	0.459
MOD_GlcNHglycan	627	630	PF01048	0.602
MOD_GlcNHglycan	666	670	PF01048	0.518
MOD_GlcNHglycan	67	70	PF01048	0.631
MOD_GlcNHglycan	681	684	PF01048	0.361
MOD_GlcNHglycan	87	90	PF01048	0.744
MOD_GlcNHglycan	98	101	PF01048	0.548
MOD_GSK3_1	15	22	PF00069	0.400
MOD_GSK3_1	156	163	PF00069	0.494
MOD_GSK3_1	201	208	PF00069	0.802
MOD_GSK3_1	26	33	PF00069	0.387
MOD_GSK3_1	271	278	PF00069	0.687
MOD_GSK3_1	310	317	PF00069	0.645
MOD_GSK3_1	367	374	PF00069	0.654
MOD_GSK3_1	403	410	PF00069	0.483
MOD_GSK3_1	464	471	PF00069	0.463
MOD_GSK3_1	489	496	PF00069	0.458
MOD_GSK3_1	553	560	PF00069	0.575
MOD_GSK3_1	570	577	PF00069	0.506
MOD_GSK3_1	589	596	PF00069	0.536
MOD_GSK3_1	85	92	PF00069	0.510
MOD_GSK3_1	96	103	PF00069	0.426
MOD_N-GLC_1	468	473	PF02516	0.466
MOD_N-GLC_2	504	506	PF02516	0.417
MOD_NEK2_1	216	221	PF00069	0.490
MOD_NEK2_1	26	31	PF00069	0.379
MOD_NEK2_1	347	352	PF00069	0.411
MOD_NEK2_1	435	440	PF00069	0.366
MOD_NEK2_1	474	479	PF00069	0.473
MOD_NEK2_1	493	498	PF00069	0.401
MOD_NEK2_1	499	504	PF00069	0.467
MOD_NEK2_1	604	609	PF00069	0.457
MOD_NEK2_1	96	101	PF00069	0.452
MOD_NEK2_2	160	165	PF00069	0.404
MOD_PIKK_1	323	329	PF00454	0.601
MOD_PIKK_1	499	505	PF00454	0.473
MOD_PK_1	574	580	PF00069	0.460
MOD_PKA_2	216	222	PF00069	0.632
MOD_PKA_2	44	50	PF00069	0.557
MOD_PKA_2	482	488	PF00069	0.645
MOD_PKA_2	96	102	PF00069	0.390
MOD_Plk_1	122	128	PF00069	0.539
MOD_Plk_1	160	166	PF00069	0.408
MOD_Plk_1	167	173	PF00069	0.390
MOD_Plk_1	188	194	PF00069	0.509
MOD_Plk_1	468	474	PF00069	0.373
MOD_Plk_1	574	580	PF00069	0.445
MOD_Plk_1	589	595	PF00069	0.383
MOD_Plk_1	60	66	PF00069	0.457
MOD_Plk_1	631	637	PF00069	0.502
MOD_Plk_2-3	590	596	PF00069	0.505
MOD_Plk_4	160	166	PF00069	0.377
MOD_Plk_4	167	173	PF00069	0.447
MOD_ProDKin_1	100	106	PF00069	0.484
MOD_ProDKin_1	199	205	PF00069	0.763
MOD_ProDKin_1	211	217	PF00069	0.611
MOD_ProDKin_1	280	286	PF00069	0.776
MOD_ProDKin_1	30	36	PF00069	0.532
MOD_ProDKin_1	314	320	PF00069	0.699
MOD_ProDKin_1	339	345	PF00069	0.359
MOD_ProDKin_1	464	470	PF00069	0.594
MOD_ProDKin_1	557	563	PF00069	0.496
MOD_ProDKin_1	90	96	PF00069	0.586
TRG_DiLeu_BaEn_1	400	405	PF01217	0.482
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.535
TRG_ENDOCYTIC_2	171	174	PF00928	0.563
TRG_ENDOCYTIC_2	402	405	PF00928	0.488
TRG_ER_diArg_1	115	117	PF00400	0.469
TRG_ER_diArg_1	180	182	PF00400	0.581
TRG_ER_diArg_1	379	382	PF00400	0.660
TRG_ER_diArg_1	455	458	PF00400	0.538
TRG_ER_diArg_1	527	529	PF00400	0.484
TRG_ER_diArg_1	635	638	PF00400	0.407
TRG_ER_diArg_1	675	677	PF00400	0.609
TRG_ER_diArg_1	695	698	PF00400	0.503
TRG_NLS_MonoExtN_4	42	49	PF00514	0.516
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	676	680	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIR5	Leptomonas seymouri	47%	94%
A0A1X0NVW3	Trypanosomatidae	27%	98%
A0A3Q8ICZ9	Leishmania donovani	90%	100%
A0A3R7NQB0	Trypanosoma rangeli	29%	100%
A4HDQ9	Leishmania braziliensis	70%	100%
A4I105	Leishmania infantum	90%	100%
C9ZWA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4QAD3	Leishmania major	89%	99%