Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX41_LEIMU

TriTrypDb:

LmxM.24.1950

Length:

791

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

E9AX41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.694
CLV_C14_Caspase3-7	163	167	PF00656	0.511
CLV_C14_Caspase3-7	294	298	PF00656	0.723
CLV_C14_Caspase3-7	36	40	PF00656	0.731
CLV_C14_Caspase3-7	461	465	PF00656	0.611
CLV_C14_Caspase3-7	552	556	PF00656	0.685
CLV_MEL_PAP_1	499	505	PF00089	0.684
CLV_NRD_NRD_1	182	184	PF00675	0.452
CLV_NRD_NRD_1	185	187	PF00675	0.454
CLV_NRD_NRD_1	501	503	PF00675	0.631
CLV_NRD_NRD_1	547	549	PF00675	0.569
CLV_NRD_NRD_1	589	591	PF00675	0.706
CLV_NRD_NRD_1	634	636	PF00675	0.716
CLV_NRD_NRD_1	698	700	PF00675	0.660
CLV_PCSK_FUR_1	183	187	PF00082	0.524
CLV_PCSK_FUR_1	545	549	PF00082	0.539
CLV_PCSK_KEX2_1	184	186	PF00082	0.457
CLV_PCSK_KEX2_1	501	503	PF00082	0.603
CLV_PCSK_KEX2_1	547	549	PF00082	0.485
CLV_PCSK_KEX2_1	589	591	PF00082	0.708
CLV_PCSK_KEX2_1	634	636	PF00082	0.716
CLV_PCSK_KEX2_1	698	700	PF00082	0.660
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.567
CLV_PCSK_SKI1_1	177	181	PF00082	0.403
CLV_PCSK_SKI1_1	186	190	PF00082	0.412
CLV_PCSK_SKI1_1	354	358	PF00082	0.641
CLV_PCSK_SKI1_1	59	63	PF00082	0.693
CLV_PCSK_SKI1_1	706	710	PF00082	0.517
CLV_PCSK_SKI1_1	783	787	PF00082	0.723
CLV_Separin_Metazoa	695	699	PF03568	0.611
DEG_Nend_UBRbox_1	1	4	PF02207	0.595
DEG_SCF_TRCP1_1	267	273	PF00400	0.415
DEG_SPOP_SBC_1	612	616	PF00917	0.586
DEG_SPOP_SBC_1	642	646	PF00917	0.756
DOC_ANK_TNKS_1	589	596	PF00023	0.536
DOC_CDC14_PxL_1	62	70	PF14671	0.691
DOC_CDC14_PxL_1	90	98	PF14671	0.530
DOC_MAPK_gen_1	183	189	PF00069	0.494
DOC_MAPK_gen_1	245	252	PF00069	0.489
DOC_MAPK_gen_1	452	460	PF00069	0.585
DOC_MAPK_MEF2A_6	25	34	PF00069	0.594
DOC_MAPK_MEF2A_6	354	363	PF00069	0.545
DOC_MAPK_MEF2A_6	452	460	PF00069	0.577
DOC_PP2B_LxvP_1	655	658	PF13499	0.725
DOC_PP4_FxxP_1	290	293	PF00568	0.588
DOC_PP4_FxxP_1	343	346	PF00568	0.457
DOC_USP7_MATH_1	311	315	PF00917	0.634
DOC_USP7_MATH_1	397	401	PF00917	0.737
DOC_USP7_MATH_1	610	614	PF00917	0.680
DOC_USP7_MATH_1	643	647	PF00917	0.674
DOC_USP7_MATH_1	658	662	PF00917	0.589
DOC_USP7_MATH_1	678	682	PF00917	0.407
DOC_USP7_MATH_1	773	777	PF00917	0.569
DOC_USP7_MATH_2	677	683	PF00917	0.658
DOC_WW_Pin1_4	393	398	PF00397	0.768
DOC_WW_Pin1_4	45	50	PF00397	0.748
DOC_WW_Pin1_4	479	484	PF00397	0.683
DOC_WW_Pin1_4	673	678	PF00397	0.669
LIG_14-3-3_CanoR_1	2	10	PF00244	0.582
LIG_14-3-3_CanoR_1	291	297	PF00244	0.710
LIG_14-3-3_CanoR_1	501	509	PF00244	0.698
LIG_14-3-3_CanoR_1	551	560	PF00244	0.689
LIG_14-3-3_CanoR_1	698	702	PF00244	0.475
LIG_Actin_WH2_2	536	553	PF00022	0.509
LIG_Actin_WH2_2	757	774	PF00022	0.407
LIG_Actin_WH2_2	83	99	PF00022	0.472
LIG_APCC_ABBA_1	762	767	PF00400	0.606
LIG_BIR_III_2	213	217	PF00653	0.603
LIG_BRCT_BRCA1_1	339	343	PF00533	0.461
LIG_Clathr_ClatBox_1	209	213	PF01394	0.577
LIG_CtBP_PxDLS_1	741	745	PF00389	0.567
LIG_deltaCOP1_diTrp_1	756	765	PF00928	0.608
LIG_FHA_1	120	126	PF00498	0.582
LIG_FHA_1	2	8	PF00498	0.631
LIG_FHA_1	304	310	PF00498	0.614
LIG_FHA_1	365	371	PF00498	0.652
LIG_FHA_1	471	477	PF00498	0.729
LIG_FHA_1	520	526	PF00498	0.646
LIG_FHA_2	138	144	PF00498	0.746
LIG_FHA_2	34	40	PF00498	0.639
LIG_FHA_2	401	407	PF00498	0.623
LIG_FHA_2	431	437	PF00498	0.560
LIG_LIR_Apic_2	340	346	PF02991	0.460
LIG_LIR_Gen_1	661	670	PF02991	0.672
LIG_LIR_Gen_1	755	765	PF02991	0.534
LIG_LIR_Nem_3	661	667	PF02991	0.622
LIG_LIR_Nem_3	746	750	PF02991	0.562
LIG_LIR_Nem_3	755	761	PF02991	0.541
LIG_LIR_Nem_3	767	771	PF02991	0.428
LIG_MYND_3	156	160	PF01753	0.573
LIG_MYND_3	203	207	PF01753	0.522
LIG_Pex14_1	598	602	PF04695	0.599
LIG_SH2_CRK	492	496	PF00017	0.495
LIG_SH2_CRK	664	668	PF00017	0.622
LIG_SH2_PTP2	457	460	PF00017	0.609
LIG_SH2_SRC	726	729	PF00017	0.612
LIG_SH2_STAT5	124	127	PF00017	0.583
LIG_SH2_STAT5	380	383	PF00017	0.697
LIG_SH2_STAT5	457	460	PF00017	0.532
LIG_SH2_STAT5	726	729	PF00017	0.537
LIG_SH2_STAT5	750	753	PF00017	0.640
LIG_SH2_STAT5	80	83	PF00017	0.476
LIG_SH3_3	46	52	PF00018	0.749
LIG_SH3_3	604	610	PF00018	0.778
LIG_SH3_3	733	739	PF00018	0.652
LIG_SUMO_SIM_anti_2	366	372	PF11976	0.650
LIG_SUMO_SIM_par_1	160	166	PF11976	0.515
LIG_SUMO_SIM_par_1	207	213	PF11976	0.565
LIG_TYR_ITIM	490	495	PF00017	0.614
LIG_UBA3_1	178	184	PF00899	0.448
MOD_CK1_1	257	263	PF00069	0.679
MOD_CK1_1	338	344	PF00069	0.674
MOD_CK1_1	400	406	PF00069	0.651
MOD_CK1_1	519	525	PF00069	0.647
MOD_CK1_1	565	571	PF00069	0.783
MOD_CK1_1	613	619	PF00069	0.659
MOD_CK1_1	641	647	PF00069	0.532
MOD_CK1_1	682	688	PF00069	0.538
MOD_CK1_1	729	735	PF00069	0.618
MOD_CK2_1	143	149	PF00069	0.713
MOD_CK2_1	16	22	PF00069	0.679
MOD_CK2_1	322	328	PF00069	0.698
MOD_CK2_1	430	436	PF00069	0.558
MOD_CK2_1	642	648	PF00069	0.697
MOD_CK2_1	673	679	PF00069	0.728
MOD_GlcNHglycan	117	120	PF01048	0.517
MOD_GlcNHglycan	145	148	PF01048	0.746
MOD_GlcNHglycan	173	176	PF01048	0.472
MOD_GlcNHglycan	256	259	PF01048	0.639
MOD_GlcNHglycan	267	270	PF01048	0.682
MOD_GlcNHglycan	324	327	PF01048	0.656
MOD_GlcNHglycan	337	340	PF01048	0.703
MOD_GlcNHglycan	399	402	PF01048	0.698
MOD_GlcNHglycan	4	7	PF01048	0.580
MOD_GlcNHglycan	560	563	PF01048	0.766
MOD_GlcNHglycan	564	567	PF01048	0.744
MOD_GlcNHglycan	638	643	PF01048	0.633
MOD_GlcNHglycan	681	684	PF01048	0.669
MOD_GSK3_1	115	122	PF00069	0.547
MOD_GSK3_1	137	144	PF00069	0.735
MOD_GSK3_1	311	318	PF00069	0.625
MOD_GSK3_1	335	342	PF00069	0.724
MOD_GSK3_1	35	42	PF00069	0.582
MOD_GSK3_1	392	399	PF00069	0.699
MOD_GSK3_1	430	437	PF00069	0.579
MOD_GSK3_1	497	504	PF00069	0.575
MOD_GSK3_1	558	565	PF00069	0.570
MOD_GSK3_1	598	605	PF00069	0.664
MOD_GSK3_1	610	617	PF00069	0.660
MOD_GSK3_1	638	645	PF00069	0.592
MOD_GSK3_1	669	676	PF00069	0.685
MOD_GSK3_1	678	685	PF00069	0.615
MOD_GSK3_1	72	79	PF00069	0.556
MOD_GSK3_1	748	755	PF00069	0.450
MOD_LATS_1	549	555	PF00433	0.461
MOD_N-GLC_2	310	312	PF02516	0.689
MOD_N-GLC_2	67	69	PF02516	0.655
MOD_NEK2_1	1	6	PF00069	0.594
MOD_NEK2_1	141	146	PF00069	0.671
MOD_NEK2_1	317	322	PF00069	0.628
MOD_NEK2_1	435	440	PF00069	0.525
MOD_NEK2_1	503	508	PF00069	0.697
MOD_NEK2_1	74	79	PF00069	0.508
MOD_PIKK_1	297	303	PF00454	0.720
MOD_PIKK_1	436	442	PF00454	0.624
MOD_PIKK_1	568	574	PF00454	0.767
MOD_PIKK_1	74	80	PF00454	0.600
MOD_PKA_1	501	507	PF00069	0.694
MOD_PKA_2	1	7	PF00069	0.631
MOD_PKA_2	240	246	PF00069	0.599
MOD_PKA_2	501	507	PF00069	0.694
MOD_PKA_2	550	556	PF00069	0.706
MOD_PKA_2	562	568	PF00069	0.691
MOD_PKA_2	697	703	PF00069	0.542
MOD_Plk_4	380	386	PF00069	0.703
MOD_Plk_4	669	675	PF00069	0.639
MOD_Plk_4	740	746	PF00069	0.635
MOD_Plk_4	757	763	PF00069	0.315
MOD_Plk_4	76	82	PF00069	0.559
MOD_ProDKin_1	393	399	PF00069	0.767
MOD_ProDKin_1	45	51	PF00069	0.740
MOD_ProDKin_1	479	485	PF00069	0.678
MOD_ProDKin_1	673	679	PF00069	0.670
TRG_DiLeu_BaEn_1	781	786	PF01217	0.653
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.443
TRG_ENDOCYTIC_2	235	238	PF00928	0.560
TRG_ENDOCYTIC_2	457	460	PF00928	0.536
TRG_ENDOCYTIC_2	491	494	PF00928	0.477
TRG_ENDOCYTIC_2	664	667	PF00928	0.624
TRG_ER_diArg_1	182	185	PF00400	0.440
TRG_ER_diArg_1	451	454	PF00400	0.516
TRG_ER_diArg_1	501	503	PF00400	0.599
TRG_ER_diArg_1	545	548	PF00400	0.591
TRG_ER_diArg_1	588	590	PF00400	0.713
TRG_ER_diArg_1	633	635	PF00400	0.714
TRG_ER_diArg_1	697	699	PF00400	0.642
TRG_ER_diArg_1	714	717	PF00400	0.375
TRG_ER_diArg_1	769	772	PF00400	0.580
TRG_NLS_MonoCore_2	182	187	PF00514	0.492
TRG_NLS_MonoExtN_4	183	188	PF00514	0.503
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	699	704	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	783	788	PF00026	0.727

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1U0	Leptomonas seymouri	44%	100%
A0A1X0NVW0	Trypanosomatidae	24%	100%
A0A3S7WYK4	Leishmania donovani	93%	100%
A0A422NX08	Trypanosoma rangeli	24%	100%
A4HDQ7	Leishmania braziliensis	78%	100%
A4I103	Leishmania infantum	92%	100%
Q4QAD5	Leishmania major	92%	99%
V5BAG5	Trypanosoma cruzi	23%	100%