Mediator of RNA polymerase II transcription subunit 13

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX39_LEIMU

TriTrypDb:

LmxM.24.1930

Length:

694

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX39

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019751	polyol metabolic process	4	7
GO:0032957	inositol trisphosphate metabolic process	5	7
GO:0043647	inositol phosphate metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044281	small molecule metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901615	organic hydroxy compound metabolic process	3	7
GO:0005975	carbohydrate metabolic process	3	1
GO:0006020	inositol metabolic process	4	1
GO:0016310	phosphorylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0046835	carbohydrate phosphorylation	4	1
GO:0052746	obsolete inositol phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0000287	magnesium ion binding	5	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0047325	inositol tetrakisphosphate 1-kinase activity	6	7
GO:0051765	inositol tetrakisphosphate kinase activity	5	7
GO:0051766	inositol trisphosphate kinase activity	5	7
GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity	6	7
GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity	6	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.519
CLV_NRD_NRD_1	221	223	PF00675	0.424
CLV_NRD_NRD_1	226	228	PF00675	0.432
CLV_NRD_NRD_1	547	549	PF00675	0.470
CLV_NRD_NRD_1	594	596	PF00675	0.632
CLV_NRD_NRD_1	689	691	PF00675	0.584
CLV_NRD_NRD_1	96	98	PF00675	0.630
CLV_PCSK_FUR_1	224	228	PF00082	0.433
CLV_PCSK_FUR_1	94	98	PF00082	0.672
CLV_PCSK_KEX2_1	219	221	PF00082	0.445
CLV_PCSK_KEX2_1	226	228	PF00082	0.431
CLV_PCSK_KEX2_1	688	690	PF00082	0.654
CLV_PCSK_KEX2_1	96	98	PF00082	0.625
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.481
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.654
CLV_PCSK_PC7_1	222	228	PF00082	0.455
CLV_PCSK_SKI1_1	143	147	PF00082	0.391
CLV_PCSK_SKI1_1	18	22	PF00082	0.443
CLV_PCSK_SKI1_1	198	202	PF00082	0.361
CLV_PCSK_SKI1_1	216	220	PF00082	0.554
CLV_PCSK_SKI1_1	245	249	PF00082	0.343
CLV_PCSK_SKI1_1	351	355	PF00082	0.429
CLV_PCSK_SKI1_1	360	364	PF00082	0.286
CLV_PCSK_SKI1_1	419	423	PF00082	0.454
CLV_Separin_Metazoa	470	474	PF03568	0.516
DEG_APCC_DBOX_1	226	234	PF00400	0.577
DEG_APCC_DBOX_1	244	252	PF00400	0.270
DEG_APCC_DBOX_1	359	367	PF00400	0.316
DEG_Nend_UBRbox_3	1	3	PF02207	0.658
DEG_SCF_FBW7_1	505	511	PF00400	0.373
DEG_SPOP_SBC_1	439	443	PF00917	0.567
DOC_CKS1_1	202	207	PF01111	0.448
DOC_CKS1_1	505	510	PF01111	0.368
DOC_CKS1_1	605	610	PF01111	0.441
DOC_MAPK_gen_1	141	148	PF00069	0.405
DOC_MAPK_gen_1	224	233	PF00069	0.416
DOC_MAPK_MEF2A_6	141	148	PF00069	0.405
DOC_MAPK_MEF2A_6	387	394	PF00069	0.370
DOC_MAPK_NFAT4_5	141	149	PF00069	0.413
DOC_PP2B_LxvP_1	106	109	PF13499	0.488
DOC_PP4_FxxP_1	202	205	PF00568	0.399
DOC_PP4_FxxP_1	502	505	PF00568	0.389
DOC_PP4_MxPP_1	10	13	PF00568	0.492
DOC_USP7_MATH_1	109	113	PF00917	0.586
DOC_USP7_MATH_1	322	326	PF00917	0.436
DOC_USP7_MATH_1	342	346	PF00917	0.448
DOC_USP7_MATH_1	390	394	PF00917	0.392
DOC_USP7_MATH_1	424	428	PF00917	0.464
DOC_USP7_MATH_1	439	443	PF00917	0.637
DOC_USP7_MATH_1	488	492	PF00917	0.390
DOC_USP7_MATH_1	575	579	PF00917	0.605
DOC_USP7_MATH_1	600	604	PF00917	0.587
DOC_USP7_MATH_1	661	665	PF00917	0.461
DOC_USP7_MATH_1	71	75	PF00917	0.494
DOC_USP7_UBL2_3	165	169	PF12436	0.481
DOC_WW_Pin1_4	120	125	PF00397	0.378
DOC_WW_Pin1_4	172	177	PF00397	0.615
DOC_WW_Pin1_4	201	206	PF00397	0.389
DOC_WW_Pin1_4	289	294	PF00397	0.418
DOC_WW_Pin1_4	4	9	PF00397	0.657
DOC_WW_Pin1_4	450	455	PF00397	0.586
DOC_WW_Pin1_4	464	469	PF00397	0.559
DOC_WW_Pin1_4	504	509	PF00397	0.372
DOC_WW_Pin1_4	604	609	PF00397	0.720
DOC_WW_Pin1_4	624	629	PF00397	0.280
LIG_14-3-3_CanoR_1	100	109	PF00244	0.641
LIG_14-3-3_CanoR_1	111	121	PF00244	0.490
LIG_14-3-3_CanoR_1	18	23	PF00244	0.446
LIG_14-3-3_CanoR_1	3	8	PF00244	0.566
LIG_14-3-3_CanoR_1	403	408	PF00244	0.493
LIG_14-3-3_CanoR_1	473	482	PF00244	0.581
LIG_14-3-3_CanoR_1	577	584	PF00244	0.562
LIG_14-3-3_CanoR_1	614	621	PF00244	0.571
LIG_14-3-3_CanoR_1	689	694	PF00244	0.621
LIG_BRCT_BRCA1_1	609	613	PF00533	0.524
LIG_BRCT_BRCA1_1	615	619	PF00533	0.427
LIG_Clathr_ClatBox_1	230	234	PF01394	0.369
LIG_deltaCOP1_diTrp_1	497	502	PF00928	0.395
LIG_FHA_1	100	106	PF00498	0.658
LIG_FHA_1	17	23	PF00498	0.396
LIG_FHA_1	324	330	PF00498	0.495
LIG_FHA_1	389	395	PF00498	0.369
LIG_FHA_1	457	463	PF00498	0.534
LIG_FHA_1	625	631	PF00498	0.395
LIG_FHA_2	298	304	PF00498	0.601
LIG_FHA_2	310	316	PF00498	0.403
LIG_FHA_2	404	410	PF00498	0.469
LIG_FHA_2	473	479	PF00498	0.670
LIG_LIR_Apic_2	201	205	PF02991	0.394
LIG_LIR_Apic_2	268	274	PF02991	0.373
LIG_LIR_Gen_1	298	307	PF02991	0.473
LIG_LIR_Gen_1	34	41	PF02991	0.415
LIG_LIR_Gen_1	497	505	PF02991	0.387
LIG_LIR_Gen_1	507	517	PF02991	0.383
LIG_LIR_Nem_3	34	38	PF02991	0.414
LIG_LIR_Nem_3	497	502	PF02991	0.395
LIG_LIR_Nem_3	507	513	PF02991	0.377
LIG_LIR_Nem_3	561	567	PF02991	0.529
LIG_NRBOX	247	253	PF00104	0.359
LIG_PTB_Apo_2	124	131	PF02174	0.359
LIG_PTB_Phospho_1	131	137	PF10480	0.279
LIG_SH2_CRK	369	373	PF00017	0.391
LIG_SH2_CRK	510	514	PF00017	0.426
LIG_SH2_CRK	646	650	PF00017	0.425
LIG_SH2_NCK_1	510	514	PF00017	0.411
LIG_SH2_SRC	367	370	PF00017	0.340
LIG_SH2_STAT3	137	140	PF00017	0.377
LIG_SH2_STAT5	367	370	PF00017	0.340
LIG_SH2_STAT5	378	381	PF00017	0.336
LIG_SH2_STAT5	397	400	PF00017	0.417
LIG_SH2_STAT5	510	513	PF00017	0.412
LIG_SH2_STAT5	541	544	PF00017	0.543
LIG_SH2_STAT5	642	645	PF00017	0.385
LIG_SH3_2	468	473	PF14604	0.513
LIG_SH3_3	118	124	PF00018	0.384
LIG_SH3_3	229	235	PF00018	0.427
LIG_SH3_3	341	347	PF00018	0.413
LIG_SH3_3	448	454	PF00018	0.711
LIG_SH3_3	459	465	PF00018	0.650
LIG_SH3_3	479	485	PF00018	0.536
LIG_SH3_3	502	508	PF00018	0.389
LIG_SH3_3	533	539	PF00018	0.325
LIG_SH3_3	6	12	PF00018	0.674
LIG_SH3_3	602	608	PF00018	0.564
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.425
LIG_SUMO_SIM_anti_2	391	396	PF11976	0.392
LIG_SUMO_SIM_anti_2	534	539	PF11976	0.326
LIG_SUMO_SIM_par_1	228	234	PF11976	0.387
LIG_SUMO_SIM_par_1	409	416	PF11976	0.343
LIG_SUMO_SIM_par_1	627	633	PF11976	0.352
LIG_SUMO_SIM_par_1	634	639	PF11976	0.366
LIG_SUMO_SIM_par_1	658	664	PF11976	0.373
LIG_TRAF2_1	301	304	PF00917	0.505
LIG_TRAF2_1	77	80	PF00917	0.627
LIG_TYR_ITIM	562	567	PF00017	0.524
LIG_UBA3_1	230	238	PF00899	0.280
LIG_UBA3_1	656	663	PF00899	0.431
LIG_WRC_WIRS_1	199	204	PF05994	0.376
LIG_WRC_WIRS_1	296	301	PF05994	0.450
LIG_WW_3	470	474	PF00397	0.516
MOD_CAAXbox	691	694	PF01239	0.648
MOD_CK1_1	112	118	PF00069	0.522
MOD_CK1_1	123	129	PF00069	0.309
MOD_CK1_1	289	295	PF00069	0.478
MOD_CK1_1	298	304	PF00069	0.443
MOD_CK1_1	382	388	PF00069	0.434
MOD_CK1_1	4	10	PF00069	0.718
MOD_CK1_1	427	433	PF00069	0.565
MOD_CK1_1	438	444	PF00069	0.660
MOD_CK1_1	476	482	PF00069	0.634
MOD_CK1_1	578	584	PF00069	0.646
MOD_CK1_1	95	101	PF00069	0.688
MOD_CK2_1	111	117	PF00069	0.589
MOD_CK2_1	297	303	PF00069	0.584
MOD_CK2_1	309	315	PF00069	0.448
MOD_CK2_1	464	470	PF00069	0.666
MOD_CK2_1	472	478	PF00069	0.609
MOD_GlcNHglycan	14	17	PF01048	0.529
MOD_GlcNHglycan	158	161	PF01048	0.688
MOD_GlcNHglycan	288	291	PF01048	0.573
MOD_GlcNHglycan	3	6	PF01048	0.660
MOD_GlcNHglycan	422	425	PF01048	0.450
MOD_GlcNHglycan	437	440	PF01048	0.687
MOD_GlcNHglycan	478	481	PF01048	0.780
MOD_GlcNHglycan	519	523	PF01048	0.403
MOD_GlcNHglycan	55	58	PF01048	0.440
MOD_GlcNHglycan	622	625	PF01048	0.471
MOD_GlcNHglycan	65	69	PF01048	0.566
MOD_GlcNHglycan	83	86	PF01048	0.673
MOD_GSK3_1	109	116	PF00069	0.624
MOD_GSK3_1	12	19	PF00069	0.506
MOD_GSK3_1	152	159	PF00069	0.544
MOD_GSK3_1	282	289	PF00069	0.567
MOD_GSK3_1	399	406	PF00069	0.489
MOD_GSK3_1	4	11	PF00069	0.600
MOD_GSK3_1	420	427	PF00069	0.467
MOD_GSK3_1	435	442	PF00069	0.612
MOD_GSK3_1	472	479	PF00069	0.638
MOD_GSK3_1	504	511	PF00069	0.374
MOD_GSK3_1	554	561	PF00069	0.481
MOD_GSK3_1	600	607	PF00069	0.594
MOD_GSK3_1	620	627	PF00069	0.573
MOD_GSK3_1	88	95	PF00069	0.630
MOD_GSK3_1	96	103	PF00069	0.605
MOD_LATS_1	401	407	PF00433	0.530
MOD_N-GLC_1	1	6	PF02516	0.671
MOD_N-GLC_1	285	290	PF02516	0.532
MOD_N-GLC_1	309	314	PF02516	0.555
MOD_NEK2_1	1	6	PF00069	0.668
MOD_NEK2_1	24	29	PF00069	0.417
MOD_NEK2_1	241	246	PF00069	0.363
MOD_NEK2_1	630	635	PF00069	0.356
MOD_NEK2_2	661	666	PF00069	0.396
MOD_PIKK_1	181	187	PF00454	0.558
MOD_PIKK_1	413	419	PF00454	0.410
MOD_PIKK_1	430	436	PF00454	0.581
MOD_PIKK_1	607	613	PF00454	0.443
MOD_PKA_1	220	226	PF00069	0.499
MOD_PKA_1	96	102	PF00069	0.617
MOD_PKA_2	112	118	PF00069	0.490
MOD_PKA_2	220	226	PF00069	0.499
MOD_PKA_2	402	408	PF00069	0.512
MOD_PKA_2	472	478	PF00069	0.555
MOD_PKA_2	576	582	PF00069	0.522
MOD_PKA_2	613	619	PF00069	0.533
MOD_PKA_2	95	101	PF00069	0.634
MOD_PKB_1	111	119	PF00069	0.481
MOD_PKB_1	94	102	PF00069	0.758
MOD_Plk_1	342	348	PF00069	0.523
MOD_Plk_2-3	478	484	PF00069	0.475
MOD_Plk_4	390	396	PF00069	0.395
MOD_Plk_4	457	463	PF00069	0.501
MOD_Plk_4	488	494	PF00069	0.380
MOD_Plk_4	526	532	PF00069	0.423
MOD_ProDKin_1	120	126	PF00069	0.369
MOD_ProDKin_1	172	178	PF00069	0.615
MOD_ProDKin_1	201	207	PF00069	0.381
MOD_ProDKin_1	289	295	PF00069	0.419
MOD_ProDKin_1	4	10	PF00069	0.657
MOD_ProDKin_1	450	456	PF00069	0.587
MOD_ProDKin_1	464	470	PF00069	0.562
MOD_ProDKin_1	504	510	PF00069	0.370
MOD_ProDKin_1	604	610	PF00069	0.717
MOD_ProDKin_1	624	630	PF00069	0.273
MOD_SUMO_rev_2	149	155	PF00179	0.516
MOD_SUMO_rev_2	166	170	PF00179	0.518
TRG_DiLeu_BaEn_1	237	242	PF01217	0.383
TRG_DiLeu_BaEn_2	356	362	PF01217	0.367
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.379
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.420
TRG_DiLeu_BaLyEn_6	625	630	PF01217	0.279
TRG_ENDOCYTIC_2	510	513	PF00928	0.427
TRG_ENDOCYTIC_2	564	567	PF00928	0.552
TRG_ENDOCYTIC_2	646	649	PF00928	0.420
TRG_ER_diArg_1	110	113	PF00400	0.477
TRG_ER_diArg_1	141	144	PF00400	0.406
TRG_ER_diArg_1	220	222	PF00400	0.410
TRG_ER_diArg_1	224	227	PF00400	0.451
TRG_ER_diArg_1	94	97	PF00400	0.628
TRG_NES_CRM1_1	658	669	PF08389	0.466
TRG_NLS_MonoCore_2	218	223	PF00514	0.311
TRG_NLS_MonoCore_2	686	691	PF00514	0.606
TRG_NLS_MonoExtN_4	216	223	PF00514	0.311
TRG_NLS_MonoExtN_4	687	692	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV4	Leptomonas seymouri	49%	100%
A0A3S5H7D6	Leishmania donovani	87%	97%
A4HDQ5	Leishmania braziliensis	66%	98%
A4I101	Leishmania infantum	87%	98%
Q4QAD7	Leishmania major	86%	100%