Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX38_LEIMU

TriTrypDb:

LmxM.24.1920

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	237	243	PF00089	0.298
CLV_NRD_NRD_1	224	226	PF00675	0.619
CLV_NRD_NRD_1	281	283	PF00675	0.534
CLV_NRD_NRD_1	453	455	PF00675	0.502
CLV_NRD_NRD_1	510	512	PF00675	0.552
CLV_PCSK_FUR_1	508	512	PF00082	0.613
CLV_PCSK_KEX2_1	281	283	PF00082	0.538
CLV_PCSK_KEX2_1	453	455	PF00082	0.505
CLV_PCSK_KEX2_1	510	512	PF00082	0.556
CLV_PCSK_PC7_1	277	283	PF00082	0.584
CLV_PCSK_PC7_1	506	512	PF00082	0.602
CLV_PCSK_SKI1_1	21	25	PF00082	0.719
CLV_PCSK_SKI1_1	251	255	PF00082	0.591
CLV_PCSK_SKI1_1	334	338	PF00082	0.588
CLV_PCSK_SKI1_1	457	461	PF00082	0.585
CLV_Separin_Metazoa	472	476	PF03568	0.584
DEG_SPOP_SBC_1	309	313	PF00917	0.435
DEG_SPOP_SBC_1	83	87	PF00917	0.798
DEG_SPOP_SBC_1	94	98	PF00917	0.574
DOC_CKS1_1	399	404	PF01111	0.689
DOC_CKS1_1	6	11	PF01111	0.786
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.542
DOC_MAPK_MEF2A_6	334	341	PF00069	0.447
DOC_MAPK_NFAT4_5	334	342	PF00069	0.502
DOC_PP1_RVXF_1	441	447	PF00149	0.601
DOC_PP4_FxxP_1	342	345	PF00568	0.533
DOC_USP7_MATH_1	309	313	PF00917	0.667
DOC_USP7_MATH_1	365	369	PF00917	0.654
DOC_USP7_MATH_1	84	88	PF00917	0.715
DOC_USP7_MATH_1	94	98	PF00917	0.559
DOC_USP7_UBL2_3	162	166	PF12436	0.718
DOC_WW_Pin1_4	14	19	PF00397	0.772
DOC_WW_Pin1_4	30	35	PF00397	0.686
DOC_WW_Pin1_4	318	323	PF00397	0.657
DOC_WW_Pin1_4	398	403	PF00397	0.713
DOC_WW_Pin1_4	44	49	PF00397	0.696
DOC_WW_Pin1_4	5	10	PF00397	0.758
LIG_14-3-3_CanoR_1	240	248	PF00244	0.570
LIG_14-3-3_CanoR_1	364	374	PF00244	0.470
LIG_14-3-3_CanoR_1	508	516	PF00244	0.615
LIG_Actin_WH2_2	134	151	PF00022	0.644
LIG_Actin_WH2_2	203	219	PF00022	0.470
LIG_APCC_ABBA_1	339	344	PF00400	0.534
LIG_BIR_II_1	1	5	PF00653	0.748
LIG_Clathr_ClatBox_1	323	327	PF01394	0.651
LIG_Clathr_ClatBox_1	347	351	PF01394	0.567
LIG_deltaCOP1_diTrp_1	340	350	PF00928	0.504
LIG_FHA_1	140	146	PF00498	0.607
LIG_FHA_1	250	256	PF00498	0.584
LIG_FHA_1	265	271	PF00498	0.334
LIG_FHA_1	36	42	PF00498	0.785
LIG_FHA_1	399	405	PF00498	0.684
LIG_FHA_1	58	64	PF00498	0.702
LIG_FHA_1	96	102	PF00498	0.602
LIG_FHA_2	108	114	PF00498	0.596
LIG_FHA_2	404	410	PF00498	0.570
LIG_LIR_Apic_2	340	345	PF02991	0.509
LIG_LIR_Nem_3	340	346	PF02991	0.480
LIG_SH2_SRC	470	473	PF00017	0.558
LIG_SH2_SRC	496	499	PF00017	0.609
LIG_SH2_STAP1	470	474	PF00017	0.552
LIG_SH2_STAT5	126	129	PF00017	0.535
LIG_SH2_STAT5	479	482	PF00017	0.553
LIG_SH3_3	3	9	PF00018	0.780
LIG_SH3_3	371	377	PF00018	0.715
LIG_SH3_3	396	402	PF00018	0.658
LIG_SH3_3	45	51	PF00018	0.707
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.545
LIG_SUMO_SIM_par_1	269	274	PF11976	0.549
LIG_SUMO_SIM_par_1	35	42	PF11976	0.730
LIG_TRAF2_1	177	180	PF00917	0.675
LIG_TRAF2_1	34	37	PF00917	0.761
LIG_TRAF2_1	369	372	PF00917	0.723
LIG_UBA3_1	480	485	PF00899	0.559
MOD_CDK_SPK_2	14	19	PF00069	0.755
MOD_CDK_SPxxK_3	14	21	PF00069	0.790
MOD_CK1_1	239	245	PF00069	0.531
MOD_CK1_1	29	35	PF00069	0.692
MOD_CK1_1	318	324	PF00069	0.682
MOD_CK1_1	509	515	PF00069	0.606
MOD_CK1_1	86	92	PF00069	0.745
MOD_CK2_1	30	36	PF00069	0.760
MOD_CK2_1	434	440	PF00069	0.443
MOD_GlcNHglycan	10	13	PF01048	0.805
MOD_GlcNHglycan	154	157	PF01048	0.652
MOD_GlcNHglycan	170	173	PF01048	0.673
MOD_GlcNHglycan	20	24	PF01048	0.705
MOD_GlcNHglycan	3	6	PF01048	0.753
MOD_GlcNHglycan	306	309	PF01048	0.644
MOD_GlcNHglycan	359	362	PF01048	0.612
MOD_GlcNHglycan	367	370	PF01048	0.672
MOD_GlcNHglycan	86	89	PF01048	0.763
MOD_GSK3_1	1	8	PF00069	0.713
MOD_GSK3_1	122	129	PF00069	0.549
MOD_GSK3_1	152	159	PF00069	0.634
MOD_GSK3_1	19	26	PF00069	0.595
MOD_GSK3_1	247	254	PF00069	0.515
MOD_GSK3_1	304	311	PF00069	0.433
MOD_GSK3_1	502	509	PF00069	0.603
MOD_GSK3_1	57	64	PF00069	0.573
MOD_GSK3_1	82	89	PF00069	0.699
MOD_N-GLC_1	57	62	PF02516	0.792
MOD_NEK2_1	1	6	PF00069	0.749
MOD_NEK2_1	141	146	PF00069	0.573
MOD_NEK2_1	187	192	PF00069	0.649
MOD_NEK2_1	357	362	PF00069	0.609
MOD_PIKK_1	126	132	PF00454	0.596
MOD_PIKK_1	198	204	PF00454	0.482
MOD_PIKK_1	310	316	PF00454	0.732
MOD_PIKK_1	434	440	PF00454	0.356
MOD_PIKK_1	509	515	PF00454	0.669
MOD_PIKK_1	76	82	PF00454	0.723
MOD_PKA_2	239	245	PF00069	0.582
MOD_PKA_2	434	440	PF00069	0.431
MOD_PKA_2	452	458	PF00069	0.457
MOD_PKA_2	509	515	PF00069	0.585
MOD_Plk_1	19	25	PF00069	0.739
MOD_Plk_1	35	41	PF00069	0.625
MOD_Plk_2-3	61	67	PF00069	0.721
MOD_Plk_4	295	301	PF00069	0.621
MOD_Plk_4	352	358	PF00069	0.565
MOD_ProDKin_1	14	20	PF00069	0.771
MOD_ProDKin_1	30	36	PF00069	0.687
MOD_ProDKin_1	318	324	PF00069	0.651
MOD_ProDKin_1	398	404	PF00069	0.709
MOD_ProDKin_1	44	50	PF00069	0.692
MOD_ProDKin_1	5	11	PF00069	0.760
MOD_SUMO_for_1	177	180	PF00179	0.609
MOD_SUMO_for_1	484	487	PF00179	0.550
TRG_DiLeu_BaEn_2	441	447	PF01217	0.601
TRG_DiLeu_BaEn_4	243	249	PF01217	0.549
TRG_DiLeu_BaEn_4	418	424	PF01217	0.555
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.532
TRG_ENDOCYTIC_2	470	473	PF00928	0.533
TRG_ER_diArg_1	117	120	PF00400	0.545
TRG_ER_diArg_1	281	283	PF00400	0.513
TRG_ER_diArg_1	423	426	PF00400	0.570
TRG_ER_diArg_1	433	436	PF00400	0.526
TRG_ER_diArg_1	452	454	PF00400	0.342
TRG_ER_diArg_1	508	511	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P7	Leptomonas seymouri	57%	95%
A0A0S4J1F8	Bodo saltans	26%	95%
A0A1X0NW49	Trypanosomatidae	34%	100%
A0A3Q8IMW3	Leishmania donovani	93%	100%
A0A422NWS4	Trypanosoma rangeli	34%	100%
A4HDQ4	Leishmania braziliensis	85%	100%
A4I100	Leishmania infantum	93%	100%
C9ZWA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QAD8	Leishmania major	92%	100%