J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX37_LEIMU

TriTrypDb:

LmxM.24.1910

Length:

120

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0001405	PAM complex, Tim23 associated import motor	4	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Expansion

Sequence features

E9AX37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX37

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0001671	ATPase activator activity	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	25	31	PF00089	0.550
CLV_PCSK_KEX2_1	88	90	PF00082	0.484
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.484
CLV_PCSK_SKI1_1	115	119	PF00082	0.328
CLV_PCSK_SKI1_1	39	43	PF00082	0.638
DEG_APCC_KENBOX_2	69	73	PF00400	0.445
DOC_PP4_FxxP_1	54	57	PF00568	0.451
DOC_PP4_FxxP_1	78	81	PF00568	0.491
DOC_USP7_UBL2_3	45	49	PF12436	0.599
DOC_WW_Pin1_4	101	106	PF00397	0.362
DOC_WW_Pin1_4	53	58	PF00397	0.380
LIG_14-3-3_CanoR_1	39	47	PF00244	0.583
LIG_eIF4E_1	61	67	PF01652	0.392
LIG_FHA_1	102	108	PF00498	0.514
LIG_FHA_2	57	63	PF00498	0.454
LIG_LIR_Apic_2	51	57	PF02991	0.464
LIG_LIR_Gen_1	62	69	PF02991	0.412
LIG_LIR_Nem_3	59	64	PF02991	0.402
LIG_Pex14_2	50	54	PF04695	0.474
LIG_SH2_CRK	64	68	PF00017	0.428
LIG_SH2_STAP1	17	21	PF00017	0.477
LIG_SH2_STAP1	61	65	PF00017	0.480
LIG_SH2_STAT3	52	55	PF00017	0.448
LIG_SH2_STAT5	106	109	PF00017	0.398
LIG_SH3_4	45	52	PF00018	0.453
LIG_TRAF2_1	82	85	PF00917	0.385
MOD_CK1_1	56	62	PF00069	0.423
MOD_CK1_1	99	105	PF00069	0.459
MOD_CK2_1	56	62	PF00069	0.350
MOD_GlcNHglycan	100	104	PF01048	0.461
MOD_GlcNHglycan	29	32	PF01048	0.498
MOD_GlcNHglycan	42	45	PF01048	0.449
MOD_N-GLC_1	35	40	PF02516	0.572
MOD_NEK2_1	16	21	PF00069	0.276
MOD_NEK2_1	40	45	PF00069	0.568
MOD_PKA_2	27	33	PF00069	0.554
MOD_Plk_1	35	41	PF00069	0.556
MOD_ProDKin_1	101	107	PF00069	0.357
MOD_ProDKin_1	53	59	PF00069	0.375
TRG_DiLeu_BaEn_1	62	67	PF01217	0.324
TRG_ENDOCYTIC_2	47	50	PF00928	0.522
TRG_ENDOCYTIC_2	64	67	PF00928	0.437
TRG_ENDOCYTIC_2	90	93	PF00928	0.361
TRG_NLS_MonoExtC_3	86	91	PF00514	0.480
TRG_NLS_MonoExtN_4	87	92	PF00514	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II15	Leptomonas seymouri	67%	100%
A0A0S4IZD1	Bodo saltans	44%	100%
A0A1X0NXI1	Trypanosomatidae	48%	99%
A0A3Q8IC73	Leishmania donovani	95%	99%
A0A422NWS9	Trypanosoma rangeli	46%	99%
A4HDQ3	Leishmania braziliensis	83%	100%
A4I0Z9	Leishmania infantum	95%	99%
C9ZWB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4QAD9	Leishmania major	91%	100%
Q54QN1	Dictyostelium discoideum	35%	100%
Q6CNW2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	74%
Q6FPU1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	33%	78%
Q759D2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	76%