Protein prenyltransferase alpha subunit repeat-containing protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX36_LEIMU

TriTrypDb:

LmxM.24.1905

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX36

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0018342	protein prenylation	4	3
GO:0019538	protein metabolic process	3	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:0097354	prenylation	3	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004659	prenyltransferase activity	4	3
GO:0008318	protein prenyltransferase activity	3	3
GO:0016740	transferase activity	2	4
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.668
CLV_NRD_NRD_1	151	153	PF00675	0.416
CLV_NRD_NRD_1	253	255	PF00675	0.375
CLV_NRD_NRD_1	313	315	PF00675	0.538
CLV_NRD_NRD_1	338	340	PF00675	0.735
CLV_NRD_NRD_1	79	81	PF00675	0.538
CLV_PCSK_KEX2_1	150	152	PF00082	0.403
CLV_PCSK_KEX2_1	253	255	PF00082	0.377
CLV_PCSK_KEX2_1	338	340	PF00082	0.735
CLV_PCSK_KEX2_1	79	81	PF00082	0.545
CLV_PCSK_SKI1_1	122	126	PF00082	0.573
CLV_PCSK_SKI1_1	364	368	PF00082	0.505
CLV_PCSK_SKI1_1	39	43	PF00082	0.494
CLV_PCSK_SKI1_1	86	90	PF00082	0.449
DEG_APCC_DBOX_1	121	129	PF00400	0.587
DEG_Nend_UBRbox_2	1	3	PF02207	0.581
DEG_ODPH_VHL_1	367	378	PF01847	0.541
DEG_SPOP_SBC_1	64	68	PF00917	0.556
DOC_CKS1_1	30	35	PF01111	0.443
DOC_CYCLIN_RxL_1	170	182	PF00134	0.225
DOC_CYCLIN_yCln2_LP_2	442	448	PF00134	0.666
DOC_MAPK_MEF2A_6	176	185	PF00069	0.421
DOC_PP1_RVXF_1	251	258	PF00149	0.405
DOC_USP7_MATH_1	262	266	PF00917	0.579
DOC_USP7_MATH_1	410	414	PF00917	0.516
DOC_USP7_MATH_1	461	465	PF00917	0.519
DOC_USP7_MATH_1	48	52	PF00917	0.578
DOC_WW_Pin1_4	107	112	PF00397	0.700
DOC_WW_Pin1_4	114	119	PF00397	0.541
DOC_WW_Pin1_4	29	34	PF00397	0.442
DOC_WW_Pin1_4	406	411	PF00397	0.582
DOC_WW_Pin1_4	441	446	PF00397	0.638
LIG_14-3-3_CanoR_1	122	132	PF00244	0.483
LIG_14-3-3_CanoR_1	198	204	PF00244	0.371
LIG_14-3-3_CanoR_1	425	431	PF00244	0.443
LIG_Actin_WH2_2	142	157	PF00022	0.468
LIG_Actin_WH2_2	410	427	PF00022	0.562
LIG_APCC_ABBA_1	383	388	PF00400	0.319
LIG_CaM_IQ_9	376	391	PF13499	0.543
LIG_Clathr_ClatBox_1	178	182	PF01394	0.205
LIG_EH1_1	172	180	PF00400	0.224
LIG_eIF4E_1	430	436	PF01652	0.533
LIG_FHA_1	102	108	PF00498	0.648
LIG_FHA_1	155	161	PF00498	0.288
LIG_FHA_1	297	303	PF00498	0.442
LIG_FHA_2	11	17	PF00498	0.475
LIG_FHA_2	377	383	PF00498	0.476
LIG_FHA_2	427	433	PF00498	0.376
LIG_FXI_DFP_1	70	74	PF00024	0.504
LIG_LIR_Gen_1	144	154	PF02991	0.536
LIG_LIR_Gen_1	182	191	PF02991	0.232
LIG_LIR_Gen_1	2	12	PF02991	0.543
LIG_LIR_Gen_1	299	306	PF02991	0.380
LIG_LIR_Gen_1	428	436	PF02991	0.400
LIG_LIR_Gen_1	459	470	PF02991	0.467
LIG_LIR_Gen_1	67	77	PF02991	0.521
LIG_LIR_Nem_3	144	149	PF02991	0.538
LIG_LIR_Nem_3	182	187	PF02991	0.504
LIG_LIR_Nem_3	2	8	PF02991	0.556
LIG_LIR_Nem_3	299	304	PF02991	0.385
LIG_LIR_Nem_3	428	433	PF02991	0.475
LIG_LIR_Nem_3	459	465	PF02991	0.493
LIG_LIR_Nem_3	67	73	PF02991	0.545
LIG_NRBOX	301	307	PF00104	0.424
LIG_NRBOX	473	479	PF00104	0.491
LIG_Pex14_1	426	430	PF04695	0.524
LIG_Pex14_2	449	453	PF04695	0.375
LIG_Pex14_2	89	93	PF04695	0.548
LIG_RPA_C_Fungi	75	87	PF08784	0.461
LIG_SH2_CRK	208	212	PF00017	0.270
LIG_SH2_CRK	252	256	PF00017	0.465
LIG_SH2_CRK	5	9	PF00017	0.556
LIG_SH2_NCK_1	5	9	PF00017	0.556
LIG_SH2_PTP2	430	433	PF00017	0.537
LIG_SH2_STAP1	5	9	PF00017	0.556
LIG_SH2_STAT3	470	473	PF00017	0.442
LIG_SH2_STAT5	26	29	PF00017	0.548
LIG_SH2_STAT5	301	304	PF00017	0.395
LIG_SH2_STAT5	430	433	PF00017	0.481
LIG_SH2_STAT5	5	8	PF00017	0.553
LIG_SH2_STAT5	70	73	PF00017	0.267
LIG_SH3_3	30	36	PF00018	0.586
LIG_SUMO_SIM_anti_2	177	182	PF11976	0.276
LIG_SUMO_SIM_par_1	177	182	PF11976	0.246
LIG_SUMO_SIM_par_1	413	419	PF11976	0.564
LIG_UBA3_1	183	192	PF00899	0.489
LIG_WRC_WIRS_1	90	95	PF05994	0.545
MOD_CK1_1	110	116	PF00069	0.650
MOD_CK1_1	29	35	PF00069	0.511
MOD_CK1_1	296	302	PF00069	0.431
MOD_CK1_1	3	9	PF00069	0.526
MOD_CK1_1	413	419	PF00069	0.546
MOD_CK1_1	444	450	PF00069	0.594
MOD_CK1_1	454	460	PF00069	0.522
MOD_CK2_1	190	196	PF00069	0.454
MOD_CK2_1	376	382	PF00069	0.413
MOD_CK2_1	426	432	PF00069	0.467
MOD_CK2_1	479	485	PF00069	0.378
MOD_GlcNHglycan	166	169	PF01048	0.529
MOD_GlcNHglycan	2	5	PF01048	0.486
MOD_GlcNHglycan	262	265	PF01048	0.475
MOD_GlcNHglycan	295	299	PF01048	0.376
MOD_GlcNHglycan	320	323	PF01048	0.510
MOD_GlcNHglycan	339	342	PF01048	0.725
MOD_GlcNHglycan	353	356	PF01048	0.589
MOD_GlcNHglycan	364	367	PF01048	0.327
MOD_GlcNHglycan	418	421	PF01048	0.578
MOD_GlcNHglycan	446	449	PF01048	0.567
MOD_GlcNHglycan	455	459	PF01048	0.427
MOD_GSK3_1	110	117	PF00069	0.685
MOD_GSK3_1	154	161	PF00069	0.386
MOD_GSK3_1	293	300	PF00069	0.423
MOD_GSK3_1	406	413	PF00069	0.500
MOD_GSK3_1	453	460	PF00069	0.494
MOD_GSK3_1	461	468	PF00069	0.375
MOD_GSK3_1	64	71	PF00069	0.551
MOD_N-GLC_1	465	470	PF02516	0.532
MOD_N-GLC_1	479	484	PF02516	0.415
MOD_N-GLC_2	204	206	PF02516	0.443
MOD_NEK2_1	154	159	PF00069	0.423
MOD_NEK2_1	183	188	PF00069	0.480
MOD_NEK2_1	260	265	PF00069	0.351
MOD_NEK2_1	337	342	PF00069	0.687
MOD_NEK2_1	371	376	PF00069	0.415
MOD_NEK2_1	42	47	PF00069	0.571
MOD_NEK2_1	465	470	PF00069	0.484
MOD_NEK2_1	478	483	PF00069	0.518
MOD_OFUCOSY	56	62	PF10250	0.381
MOD_PIKK_1	376	382	PF00454	0.448
MOD_PIKK_1	42	48	PF00454	0.515
MOD_PKA_2	154	160	PF00069	0.467
MOD_PKA_2	337	343	PF00069	0.681
MOD_PKA_2	478	484	PF00069	0.644
MOD_Plk_1	316	322	PF00069	0.646
MOD_Plk_1	410	416	PF00069	0.477
MOD_Plk_1	465	471	PF00069	0.509
MOD_Plk_1	58	64	PF00069	0.471
MOD_Plk_2-3	10	16	PF00069	0.255
MOD_Plk_4	128	134	PF00069	0.432
MOD_Plk_4	190	196	PF00069	0.441
MOD_Plk_4	297	303	PF00069	0.394
MOD_Plk_4	3	9	PF00069	0.557
MOD_Plk_4	410	416	PF00069	0.660
MOD_Plk_4	426	432	PF00069	0.348
MOD_Plk_4	473	479	PF00069	0.508
MOD_ProDKin_1	107	113	PF00069	0.693
MOD_ProDKin_1	114	120	PF00069	0.525
MOD_ProDKin_1	29	35	PF00069	0.438
MOD_ProDKin_1	406	412	PF00069	0.590
MOD_ProDKin_1	441	447	PF00069	0.632
MOD_SUMO_rev_2	156	165	PF00179	0.607
TRG_ENDOCYTIC_2	208	211	PF00928	0.270
TRG_ENDOCYTIC_2	252	255	PF00928	0.502
TRG_ENDOCYTIC_2	301	304	PF00928	0.395
TRG_ENDOCYTIC_2	430	433	PF00928	0.490
TRG_ENDOCYTIC_2	5	8	PF00928	0.553
TRG_ENDOCYTIC_2	70	73	PF00928	0.267
TRG_ER_diArg_1	149	152	PF00400	0.426
TRG_ER_diArg_1	252	254	PF00400	0.366
TRG_ER_diArg_1	337	339	PF00400	0.735
TRG_ER_diArg_1	79	81	PF00400	0.535
TRG_NES_CRM1_1	169	182	PF08389	0.512
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTJ1	Leptomonas seymouri	41%	100%
A0A0S4JLJ0	Bodo saltans	26%	100%
A0A1X0NWB3	Trypanosomatidae	25%	100%
A0A3Q8IF02	Leishmania donovani	84%	100%
A0A422NWV9	Trypanosoma rangeli	30%	100%
A4HDQ2	Leishmania braziliensis	72%	100%
A4I0Z8	Leishmania infantum	85%	100%
C9ZWB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QAE0	Leishmania major	82%	100%