Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative

Species:

Leishmania mexicana

UniProt:

E9AX35_LEIMU

TriTrypDb:

LmxM.24.1900

Length:

827

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	7
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AX35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX35

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0010992	ubiquitin recycling	3	1
GO:0019538	protein metabolic process	3	1
GO:0019725	cellular homeostasis	2	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0042592	homeostatic process	3	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.396
CLV_C14_Caspase3-7	755	759	PF00656	0.494
CLV_NRD_NRD_1	376	378	PF00675	0.396
CLV_PCSK_KEX2_1	375	377	PF00082	0.581
CLV_PCSK_KEX2_1	465	467	PF00082	0.244
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.244
CLV_PCSK_SKI1_1	164	168	PF00082	0.294
CLV_PCSK_SKI1_1	284	288	PF00082	0.364
CLV_PCSK_SKI1_1	348	352	PF00082	0.613
CLV_PCSK_SKI1_1	448	452	PF00082	0.269
CLV_PCSK_SKI1_1	608	612	PF00082	0.303
CLV_PCSK_SKI1_1	692	696	PF00082	0.355
CLV_PCSK_SKI1_1	707	711	PF00082	0.212
CLV_PCSK_SKI1_1	715	719	PF00082	0.294
CLV_PCSK_SKI1_1	770	774	PF00082	0.273
DEG_APCC_DBOX_1	762	770	PF00400	0.494
DEG_Nend_UBRbox_4	1	3	PF02207	0.552
DEG_SPOP_SBC_1	350	354	PF00917	0.549
DOC_CDC14_PxL_1	496	504	PF14671	0.594
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	535	541	PF00134	0.482
DOC_MAPK_FxFP_2	599	602	PF00069	0.354
DOC_MAPK_gen_1	388	398	PF00069	0.458
DOC_MAPK_MEF2A_6	391	398	PF00069	0.457
DOC_MAPK_RevD_3	362	377	PF00069	0.487
DOC_PP2B_LxvP_1	450	453	PF13499	0.494
DOC_PP4_FxxP_1	599	602	PF00568	0.354
DOC_USP7_MATH_1	216	220	PF00917	0.479
DOC_USP7_MATH_1	339	343	PF00917	0.426
DOC_USP7_MATH_1	350	354	PF00917	0.557
DOC_USP7_MATH_1	356	360	PF00917	0.595
DOC_USP7_MATH_1	476	480	PF00917	0.507
DOC_USP7_MATH_1	508	512	PF00917	0.665
DOC_USP7_MATH_1	576	580	PF00917	0.566
DOC_USP7_MATH_1	583	587	PF00917	0.523
DOC_USP7_MATH_1	98	102	PF00917	0.516
DOC_USP7_MATH_2	529	535	PF00917	0.574
DOC_USP7_UBL2_3	429	433	PF12436	0.412
DOC_WW_Pin1_4	120	125	PF00397	0.499
DOC_WW_Pin1_4	22	27	PF00397	0.383
DOC_WW_Pin1_4	255	260	PF00397	0.558
DOC_WW_Pin1_4	489	494	PF00397	0.494
DOC_WW_Pin1_4	523	528	PF00397	0.594
DOC_WW_Pin1_4	572	577	PF00397	0.434
DOC_WW_Pin1_4	695	700	PF00397	0.472
DOC_WW_Pin1_4	720	725	PF00397	0.514
DOC_WW_Pin1_4	756	761	PF00397	0.513
DOC_WW_Pin1_4	774	779	PF00397	0.494
DOC_WW_Pin1_4	793	798	PF00397	0.397
LIG_14-3-3_CanoR_1	13	22	PF00244	0.448
LIG_14-3-3_CanoR_1	600	610	PF00244	0.479
LIG_14-3-3_CanoR_1	653	659	PF00244	0.555
LIG_14-3-3_CanoR_1	707	714	PF00244	0.479
LIG_14-3-3_CanoR_1	715	720	PF00244	0.414
LIG_14-3-3_CanoR_1	746	754	PF00244	0.363
LIG_14-3-3_CanoR_1	767	773	PF00244	0.494
LIG_Actin_WH2_1	784	802	PF00022	0.494
LIG_Actin_WH2_2	785	802	PF00022	0.583
LIG_BRCT_BRCA1_1	218	222	PF00533	0.479
LIG_BRCT_BRCA1_1	29	33	PF00533	0.305
LIG_BRCT_BRCA1_1	365	369	PF00533	0.487
LIG_Clathr_ClatBox_1	751	755	PF01394	0.479
LIG_CtBP_PxDLS_1	493	497	PF00389	0.523
LIG_deltaCOP1_diTrp_1	143	151	PF00928	0.340
LIG_FHA_1	176	182	PF00498	0.494
LIG_FHA_1	198	204	PF00498	0.276
LIG_FHA_1	228	234	PF00498	0.427
LIG_FHA_1	270	276	PF00498	0.500
LIG_FHA_1	285	291	PF00498	0.378
LIG_FHA_1	314	320	PF00498	0.494
LIG_FHA_1	342	348	PF00498	0.465
LIG_FHA_1	368	374	PF00498	0.479
LIG_FHA_1	38	44	PF00498	0.438
LIG_FHA_1	530	536	PF00498	0.605
LIG_FHA_1	602	608	PF00498	0.479
LIG_FHA_1	61	67	PF00498	0.456
LIG_FHA_1	610	616	PF00498	0.496
LIG_FHA_1	689	695	PF00498	0.487
LIG_FHA_1	708	714	PF00498	0.415
LIG_FHA_1	716	722	PF00498	0.514
LIG_FHA_1	794	800	PF00498	0.560
LIG_FHA_2	127	133	PF00498	0.447
LIG_FHA_2	264	270	PF00498	0.479
LIG_FHA_2	50	56	PF00498	0.341
LIG_FHA_2	669	675	PF00498	0.441
LIG_LIR_Gen_1	436	445	PF02991	0.455
LIG_LIR_Gen_1	590	599	PF02991	0.453
LIG_LIR_Nem_3	436	440	PF02991	0.455
LIG_LIR_Nem_3	590	595	PF02991	0.453
LIG_LIR_Nem_3	63	68	PF02991	0.452
LIG_LIR_Nem_3	657	662	PF02991	0.510
LIG_NRBOX	768	774	PF00104	0.494
LIG_PCNA_PIPBox_1	480	489	PF02747	0.494
LIG_Pex14_1	320	324	PF04695	0.442
LIG_SH2_CRK	437	441	PF00017	0.456
LIG_SH2_CRK	592	596	PF00017	0.452
LIG_SH2_STAP1	162	166	PF00017	0.444
LIG_SH2_STAP1	253	257	PF00017	0.431
LIG_SH2_STAP1	437	441	PF00017	0.452
LIG_SH2_STAT3	432	435	PF00017	0.479
LIG_SH2_STAT5	265	268	PF00017	0.522
LIG_SH2_STAT5	397	400	PF00017	0.503
LIG_SH2_STAT5	419	422	PF00017	0.462
LIG_SH2_STAT5	439	442	PF00017	0.337
LIG_SH2_STAT5	68	71	PF00017	0.479
LIG_SH3_3	23	29	PF00018	0.445
LIG_SH3_3	408	414	PF00018	0.412
LIG_SH3_3	612	618	PF00018	0.479
LIG_SH3_3	636	642	PF00018	0.507
LIG_SH3_3	664	670	PF00018	0.435
LIG_SH3_3	775	781	PF00018	0.470
LIG_SH3_3	818	824	PF00018	0.494
LIG_SUMO_SIM_anti_2	74	79	PF11976	0.539
LIG_SUMO_SIM_par_1	146	152	PF11976	0.392
LIG_SUMO_SIM_par_1	717	723	PF11976	0.479
LIG_TRAF2_1	479	482	PF00917	0.494
LIG_TRAF2_2	158	163	PF00917	0.444
LIG_WRC_WIRS_1	545	550	PF05994	0.298
MOD_CDK_SPxxK_3	756	763	PF00069	0.384
MOD_CDK_SPxxK_3	793	800	PF00069	0.400
MOD_CK1_1	126	132	PF00069	0.499
MOD_CK1_1	235	241	PF00069	0.529
MOD_CK1_1	310	316	PF00069	0.365
MOD_CK1_1	341	347	PF00069	0.562
MOD_CK1_1	49	55	PF00069	0.556
MOD_CK1_1	520	526	PF00069	0.635
MOD_CK1_1	579	585	PF00069	0.381
MOD_CK1_1	686	692	PF00069	0.469
MOD_CK1_1	727	733	PF00069	0.352
MOD_CK1_1	765	771	PF00069	0.373
MOD_CK1_1	776	782	PF00069	0.284
MOD_CK1_1	793	799	PF00069	0.517
MOD_CK2_1	126	132	PF00069	0.442
MOD_CK2_1	263	269	PF00069	0.264
MOD_CK2_1	456	462	PF00069	0.358
MOD_CK2_1	476	482	PF00069	0.137
MOD_CK2_1	641	647	PF00069	0.318
MOD_CK2_1	668	674	PF00069	0.308
MOD_CK2_1	98	104	PF00069	0.460
MOD_GlcNHglycan	111	114	PF01048	0.398
MOD_GlcNHglycan	140	143	PF01048	0.413
MOD_GlcNHglycan	154	157	PF01048	0.322
MOD_GlcNHglycan	182	185	PF01048	0.268
MOD_GlcNHglycan	204	207	PF01048	0.227
MOD_GlcNHglycan	223	226	PF01048	0.201
MOD_GlcNHglycan	278	281	PF01048	0.445
MOD_GlcNHglycan	28	32	PF01048	0.431
MOD_GlcNHglycan	309	312	PF01048	0.398
MOD_GlcNHglycan	353	356	PF01048	0.537
MOD_GlcNHglycan	358	361	PF01048	0.547
MOD_GlcNHglycan	48	51	PF01048	0.607
MOD_GlcNHglycan	510	513	PF01048	0.613
MOD_GlcNHglycan	519	522	PF01048	0.655
MOD_GlcNHglycan	580	584	PF01048	0.381
MOD_GlcNHglycan	585	588	PF01048	0.385
MOD_GlcNHglycan	643	646	PF01048	0.383
MOD_GlcNHglycan	732	735	PF01048	0.441
MOD_GlcNHglycan	747	750	PF01048	0.365
MOD_GlcNHglycan	99	103	PF01048	0.555
MOD_GSK3_1	173	180	PF00069	0.317
MOD_GSK3_1	182	189	PF00069	0.240
MOD_GSK3_1	217	224	PF00069	0.300
MOD_GSK3_1	247	254	PF00069	0.332
MOD_GSK3_1	255	262	PF00069	0.279
MOD_GSK3_1	265	272	PF00069	0.163
MOD_GSK3_1	27	34	PF00069	0.439
MOD_GSK3_1	296	303	PF00069	0.312
MOD_GSK3_1	335	342	PF00069	0.444
MOD_GSK3_1	351	358	PF00069	0.594
MOD_GSK3_1	363	370	PF00069	0.553
MOD_GSK3_1	37	44	PF00069	0.343
MOD_GSK3_1	502	509	PF00069	0.683
MOD_GSK3_1	552	559	PF00069	0.304
MOD_GSK3_1	572	579	PF00069	0.392
MOD_GSK3_1	583	590	PF00069	0.400
MOD_GSK3_1	623	630	PF00069	0.371
MOD_GSK3_1	682	689	PF00069	0.440
MOD_GSK3_1	720	727	PF00069	0.400
MOD_GSK3_1	768	775	PF00069	0.253
MOD_GSK3_1	79	86	PF00069	0.393
MOD_GSK3_1	791	798	PF00069	0.440
MOD_N-GLC_1	176	181	PF02516	0.337
MOD_N-GLC_1	576	581	PF02516	0.450
MOD_N-GLC_1	715	720	PF02516	0.360
MOD_N-GLC_1	756	761	PF02516	0.358
MOD_N-GLC_2	227	229	PF02516	0.358
MOD_NEK2_1	175	180	PF00069	0.358
MOD_NEK2_1	21	26	PF00069	0.416
MOD_NEK2_1	251	256	PF00069	0.329
MOD_NEK2_1	502	507	PF00069	0.633
MOD_NEK2_1	544	549	PF00069	0.509
MOD_NEK2_1	631	636	PF00069	0.223
MOD_NEK2_1	654	659	PF00069	0.380
MOD_NEK2_1	683	688	PF00069	0.399
MOD_NEK2_1	772	777	PF00069	0.287
MOD_NEK2_2	186	191	PF00069	0.274
MOD_NEK2_2	587	592	PF00069	0.287
MOD_PIKK_1	339	345	PF00454	0.477
MOD_PIKK_1	476	482	PF00454	0.274
MOD_PIKK_1	562	568	PF00454	0.442
MOD_PIKK_1	623	629	PF00454	0.253
MOD_PK_1	232	238	PF00069	0.274
MOD_PKA_1	376	382	PF00069	0.390
MOD_PKA_2	276	282	PF00069	0.413
MOD_PKA_2	376	382	PF00069	0.452
MOD_PKA_2	745	751	PF00069	0.179
MOD_PKA_2	762	768	PF00069	0.314
MOD_Plk_1	176	182	PF00069	0.300
MOD_Plk_1	186	192	PF00069	0.226
MOD_Plk_1	217	223	PF00069	0.300
MOD_Plk_1	227	233	PF00069	0.225
MOD_Plk_1	238	244	PF00069	0.298
MOD_Plk_1	269	275	PF00069	0.264
MOD_Plk_1	313	319	PF00069	0.358
MOD_Plk_1	494	500	PF00069	0.604
MOD_Plk_1	562	568	PF00069	0.333
MOD_Plk_1	715	721	PF00069	0.358
MOD_Plk_1	724	730	PF00069	0.358
MOD_Plk_1	98	104	PF00069	0.460
MOD_Plk_4	177	183	PF00069	0.259
MOD_Plk_4	247	253	PF00069	0.298
MOD_Plk_4	456	462	PF00069	0.435
MOD_Plk_4	531	537	PF00069	0.598
MOD_Plk_4	55	61	PF00069	0.343
MOD_Plk_4	556	562	PF00069	0.333
MOD_Plk_4	587	593	PF00069	0.339
MOD_Plk_4	627	633	PF00069	0.393
MOD_Plk_4	654	660	PF00069	0.337
MOD_ProDKin_1	120	126	PF00069	0.499
MOD_ProDKin_1	22	28	PF00069	0.387
MOD_ProDKin_1	255	261	PF00069	0.447
MOD_ProDKin_1	489	495	PF00069	0.358
MOD_ProDKin_1	523	529	PF00069	0.594
MOD_ProDKin_1	572	578	PF00069	0.273
MOD_ProDKin_1	695	701	PF00069	0.326
MOD_ProDKin_1	720	726	PF00069	0.386
MOD_ProDKin_1	756	762	PF00069	0.384
MOD_ProDKin_1	774	780	PF00069	0.358
MOD_ProDKin_1	793	799	PF00069	0.393
MOD_SUMO_rev_2	278	286	PF00179	0.423
MOD_SUMO_rev_2	341	350	PF00179	0.495
TRG_DiLeu_BaEn_1	531	536	PF01217	0.606
TRG_DiLeu_BaEn_3	481	487	PF01217	0.298
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.405
TRG_ENDOCYTIC_2	324	327	PF00928	0.512
TRG_ENDOCYTIC_2	437	440	PF00928	0.303
TRG_ENDOCYTIC_2	592	595	PF00928	0.298
TRG_ENDOCYTIC_2	68	71	PF00928	0.337
TRG_ER_diArg_1	375	377	PF00400	0.401
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAR3	Leptomonas seymouri	61%	100%
A0A0S4J046	Bodo saltans	37%	100%
A0A3Q8IC13	Leishmania donovani	93%	100%
A0A3R7L9T6	Trypanosoma rangeli	37%	94%
A4HDQ1	Leishmania braziliensis	87%	99%
A4I0Z7	Leishmania infantum	93%	100%
O94289	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P27612	Mus musculus	27%	100%
P54319	Rattus norvegicus	27%	100%
Q4QAE1	Leishmania major	93%	100%
Q6GM65	Xenopus laevis	27%	100%
Q9Y263	Homo sapiens	26%	100%