Cyclin 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cyclin 10

Gene product:

cyclin 10

Species:

Leishmania mexicana

UniProt:

E9AX34_LEIMU

TriTrypDb:

LmxM.24.1890

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX34

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	7
GO:0001932	regulation of protein phosphorylation	7	7
GO:0019220	regulation of phosphate metabolic process	6	7
GO:0019222	regulation of metabolic process	3	7
GO:0031323	regulation of cellular metabolic process	4	7
GO:0031399	regulation of protein modification process	6	7
GO:0042325	regulation of phosphorylation	7	7
GO:0043549	regulation of kinase activity	5	7
GO:0045859	regulation of protein kinase activity	6	7
GO:0050789	regulation of biological process	2	7
GO:0050790	regulation of catalytic activity	3	7
GO:0050794	regulation of cellular process	3	7
GO:0051171	regulation of nitrogen compound metabolic process	4	7
GO:0051174	regulation of phosphorus metabolic process	5	7
GO:0051246	regulation of protein metabolic process	5	7
GO:0051338	regulation of transferase activity	4	7
GO:0051726	regulation of cell cycle	4	7
GO:0060255	regulation of macromolecule metabolic process	4	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7
GO:0071900	regulation of protein serine/threonine kinase activity	7	7
GO:0080090	regulation of primary metabolic process	4	7
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0019899	enzyme binding	3	7
GO:0019900	kinase binding	4	7
GO:0019901	protein kinase binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	364	366	PF00675	0.586
CLV_NRD_NRD_1	430	432	PF00675	0.589
CLV_NRD_NRD_1	609	611	PF00675	0.611
CLV_PCSK_FUR_1	362	366	PF00082	0.583
CLV_PCSK_KEX2_1	212	214	PF00082	0.304
CLV_PCSK_KEX2_1	364	366	PF00082	0.586
CLV_PCSK_KEX2_1	430	432	PF00082	0.588
CLV_PCSK_KEX2_1	609	611	PF00082	0.611
CLV_PCSK_KEX2_1	92	94	PF00082	0.542
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.304
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.529
CLV_PCSK_PC7_1	605	611	PF00082	0.601
CLV_PCSK_SKI1_1	184	188	PF00082	0.205
CLV_PCSK_SKI1_1	213	217	PF00082	0.304
CLV_PCSK_SKI1_1	251	255	PF00082	0.440
CLV_PCSK_SKI1_1	350	354	PF00082	0.593
CLV_PCSK_SKI1_1	392	396	PF00082	0.609
CLV_PCSK_SKI1_1	584	588	PF00082	0.654
CLV_PCSK_SKI1_1	609	613	PF00082	0.612
CLV_Separin_Metazoa	131	135	PF03568	0.587
DEG_Nend_UBRbox_3	1	3	PF02207	0.454
DEG_SCF_FBW7_1	334	340	PF00400	0.636
DEG_SCF_FBW7_1	79	85	PF00400	0.619
DEG_SPOP_SBC_1	41	45	PF00917	0.549
DEG_SPOP_SBC_1	542	546	PF00917	0.531
DOC_CKS1_1	334	339	PF01111	0.634
DOC_CKS1_1	79	84	PF01111	0.600
DOC_CYCLIN_yClb1_LxF_4	285	291	PF00134	0.304
DOC_CYCLIN_yClb1_LxF_4	297	302	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.369
DOC_MAPK_gen_1	630	640	PF00069	0.623
DOC_MAPK_MEF2A_6	200	207	PF00069	0.304
DOC_PP1_RVXF_1	297	303	PF00149	0.447
DOC_PP2B_LxvP_1	520	523	PF13499	0.654
DOC_PP2B_LxvP_1	647	650	PF13499	0.654
DOC_PP2B_PxIxI_1	202	208	PF00149	0.304
DOC_PP4_FxxP_1	114	117	PF00568	0.353
DOC_SPAK_OSR1_1	113	117	PF12202	0.370
DOC_USP7_MATH_1	141	145	PF00917	0.615
DOC_USP7_MATH_1	147	151	PF00917	0.611
DOC_USP7_MATH_1	164	168	PF00917	0.642
DOC_USP7_MATH_1	35	39	PF00917	0.545
DOC_USP7_MATH_1	379	383	PF00917	0.622
DOC_USP7_MATH_1	386	390	PF00917	0.566
DOC_USP7_MATH_1	397	401	PF00917	0.521
DOC_USP7_MATH_1	40	44	PF00917	0.503
DOC_USP7_MATH_1	425	429	PF00917	0.667
DOC_USP7_MATH_1	527	531	PF00917	0.643
DOC_USP7_MATH_1	543	547	PF00917	0.497
DOC_USP7_MATH_1	579	583	PF00917	0.559
DOC_USP7_MATH_1	66	70	PF00917	0.553
DOC_USP7_MATH_1	82	86	PF00917	0.481
DOC_USP7_MATH_2	337	343	PF00917	0.690
DOC_USP7_UBL2_3	212	216	PF12436	0.304
DOC_WW_Pin1_4	12	17	PF00397	0.729
DOC_WW_Pin1_4	142	147	PF00397	0.571
DOC_WW_Pin1_4	160	165	PF00397	0.690
DOC_WW_Pin1_4	168	173	PF00397	0.248
DOC_WW_Pin1_4	186	191	PF00397	0.369
DOC_WW_Pin1_4	218	223	PF00397	0.304
DOC_WW_Pin1_4	333	338	PF00397	0.627
DOC_WW_Pin1_4	382	387	PF00397	0.627
DOC_WW_Pin1_4	436	441	PF00397	0.606
DOC_WW_Pin1_4	452	457	PF00397	0.605
DOC_WW_Pin1_4	493	498	PF00397	0.657
DOC_WW_Pin1_4	54	59	PF00397	0.630
DOC_WW_Pin1_4	563	568	PF00397	0.598
DOC_WW_Pin1_4	603	608	PF00397	0.595
DOC_WW_Pin1_4	78	83	PF00397	0.572
LIG_14-3-3_CanoR_1	403	408	PF00244	0.674
LIG_14-3-3_CanoR_1	516	521	PF00244	0.646
LIG_14-3-3_CanoR_1	584	593	PF00244	0.778
LIG_14-3-3_CanoR_1	627	637	PF00244	0.648
LIG_BIR_III_4	532	536	PF00653	0.629
LIG_Clathr_ClatBox_1	504	508	PF01394	0.648
LIG_EH1_1	289	297	PF00400	0.419
LIG_eIF4E_1	247	253	PF01652	0.437
LIG_EVH1_1	64	68	PF00568	0.513
LIG_EVH1_1	647	651	PF00568	0.655
LIG_FAT_LD_1	288	296	PF03623	0.412
LIG_FHA_1	149	155	PF00498	0.509
LIG_FHA_1	197	203	PF00498	0.304
LIG_FHA_1	264	270	PF00498	0.304
LIG_FHA_1	407	413	PF00498	0.676
LIG_FHA_1	479	485	PF00498	0.660
LIG_FHA_1	500	506	PF00498	0.643
LIG_FHA_1	543	549	PF00498	0.553
LIG_FHA_1	551	557	PF00498	0.595
LIG_FHA_1	59	65	PF00498	0.619
LIG_FHA_1	79	85	PF00498	0.619
LIG_FHA_2	156	162	PF00498	0.597
LIG_FHA_2	279	285	PF00498	0.304
LIG_FHA_2	304	310	PF00498	0.442
LIG_FHA_2	330	336	PF00498	0.661
LIG_FHA_2	338	344	PF00498	0.594
LIG_FHA_2	494	500	PF00498	0.646
LIG_FHA_2	68	74	PF00498	0.616
LIG_Integrin_RGD_1	510	512	PF01839	0.613
LIG_LIR_Apic_2	111	117	PF02991	0.373
LIG_LIR_Apic_2	218	222	PF02991	0.304
LIG_LIR_Apic_2	308	313	PF02991	0.475
LIG_LIR_Gen_1	273	280	PF02991	0.315
LIG_LIR_Gen_1	287	296	PF02991	0.454
LIG_LIR_Nem_3	111	115	PF02991	0.417
LIG_LIR_Nem_3	273	277	PF02991	0.315
LIG_LIR_Nem_3	287	293	PF02991	0.405
LIG_LIR_Nem_3	305	310	PF02991	0.416
LIG_LYPXL_S_1	238	242	PF13949	0.203
LIG_LYPXL_yS_3	239	242	PF13949	0.203
LIG_MYND_1	62	66	PF01753	0.598
LIG_NRBOX	231	237	PF00104	0.304
LIG_Pex14_2	114	118	PF04695	0.417
LIG_PTB_Apo_2	268	275	PF02174	0.352
LIG_PTB_Apo_2	295	302	PF02174	0.399
LIG_PTB_Phospho_1	295	301	PF10480	0.372
LIG_SH2_CRK	112	116	PF00017	0.371
LIG_SH2_CRK	217	221	PF00017	0.403
LIG_SH2_CRK	310	314	PF00017	0.394
LIG_SH2_GRB2like	563	566	PF00017	0.486
LIG_SH2_PTP2	219	222	PF00017	0.326
LIG_SH2_SRC	563	566	PF00017	0.486
LIG_SH2_STAP1	374	378	PF00017	0.584
LIG_SH2_STAT5	210	213	PF00017	0.346
LIG_SH2_STAT5	217	220	PF00017	0.343
LIG_SH2_STAT5	231	234	PF00017	0.352
LIG_SH2_STAT5	301	304	PF00017	0.387
LIG_SH2_STAT5	310	313	PF00017	0.379
LIG_SH3_3	140	146	PF00018	0.617
LIG_SH3_3	345	351	PF00018	0.609
LIG_SH3_3	390	396	PF00018	0.634
LIG_SH3_3	437	443	PF00018	0.598
LIG_SH3_3	59	65	PF00018	0.567
LIG_SH3_3	645	651	PF00018	0.604
LIG_SH3_3	76	82	PF00018	0.598
LIG_SUMO_SIM_par_1	502	509	PF11976	0.631
LIG_TRAF2_1	506	509	PF00917	0.628
LIG_TRAF2_1	70	73	PF00917	0.439
LIG_TRFH_1	78	82	PF08558	0.516
LIG_TYR_ITIM	215	220	PF00017	0.304
LIG_WW_2	65	68	PF00397	0.528
MOD_CDC14_SPxK_1	385	388	PF00782	0.593
MOD_CDK_SPK_2	160	165	PF00069	0.654
MOD_CDK_SPxK_1	382	388	PF00069	0.592
MOD_CDK_SPxK_1	603	609	PF00069	0.598
MOD_CDK_SPxxK_3	603	610	PF00069	0.600
MOD_CK1_1	11	17	PF00069	0.643
MOD_CK1_1	145	151	PF00069	0.624
MOD_CK1_1	303	309	PF00069	0.379
MOD_CK1_1	363	369	PF00069	0.645
MOD_CK1_1	377	383	PF00069	0.774
MOD_CK1_1	398	404	PF00069	0.727
MOD_CK1_1	406	412	PF00069	0.633
MOD_CK1_1	424	430	PF00069	0.759
MOD_CK1_1	544	550	PF00069	0.624
MOD_CK1_1	57	63	PF00069	0.525
MOD_CK1_1	603	609	PF00069	0.592
MOD_CK1_1	613	619	PF00069	0.588
MOD_CK1_1	628	634	PF00069	0.554
MOD_CK1_1	91	97	PF00069	0.510
MOD_CK2_1	155	161	PF00069	0.632
MOD_CK2_1	195	201	PF00069	0.304
MOD_CK2_1	303	309	PF00069	0.564
MOD_CK2_1	329	335	PF00069	0.652
MOD_CK2_1	367	373	PF00069	0.587
MOD_CK2_1	66	72	PF00069	0.626
MOD_GlcNHglycan	17	20	PF01048	0.662
MOD_GlcNHglycan	179	182	PF01048	0.277
MOD_GlcNHglycan	37	40	PF01048	0.489
MOD_GlcNHglycan	381	384	PF01048	0.585
MOD_GlcNHglycan	388	391	PF01048	0.601
MOD_GlcNHglycan	397	400	PF01048	0.608
MOD_GlcNHglycan	423	426	PF01048	0.723
MOD_GlcNHglycan	427	430	PF01048	0.728
MOD_GlcNHglycan	44	47	PF01048	0.611
MOD_GlcNHglycan	464	467	PF01048	0.626
MOD_GlcNHglycan	469	472	PF01048	0.603
MOD_GlcNHglycan	499	502	PF01048	0.812
MOD_GlcNHglycan	520	523	PF01048	0.701
MOD_GlcNHglycan	588	591	PF01048	0.705
MOD_GlcNHglycan	627	630	PF01048	0.703
MOD_GlcNHglycan	632	636	PF01048	0.787
MOD_GlcNHglycan	93	96	PF01048	0.590
MOD_GSK3_1	141	148	PF00069	0.567
MOD_GSK3_1	160	167	PF00069	0.697
MOD_GSK3_1	170	177	PF00069	0.236
MOD_GSK3_1	254	261	PF00069	0.304
MOD_GSK3_1	319	326	PF00069	0.564
MOD_GSK3_1	329	336	PF00069	0.602
MOD_GSK3_1	356	363	PF00069	0.618
MOD_GSK3_1	382	389	PF00069	0.795
MOD_GSK3_1	397	404	PF00069	0.608
MOD_GSK3_1	417	424	PF00069	0.622
MOD_GSK3_1	480	487	PF00069	0.609
MOD_GSK3_1	493	500	PF00069	0.544
MOD_GSK3_1	514	521	PF00069	0.665
MOD_GSK3_1	527	534	PF00069	0.577
MOD_GSK3_1	54	61	PF00069	0.527
MOD_GSK3_1	571	578	PF00069	0.753
MOD_GSK3_1	594	601	PF00069	0.648
MOD_GSK3_1	7	14	PF00069	0.662
MOD_GSK3_1	78	85	PF00069	0.604
MOD_N-GLC_1	168	173	PF02516	0.432
MOD_N-GLC_1	41	46	PF02516	0.557
MOD_N-GLC_1	575	580	PF02516	0.527
MOD_N-GLC_1	8	13	PF02516	0.588
MOD_N-GLC_1	98	103	PF02516	0.492
MOD_N-GLC_2	568	570	PF02516	0.610
MOD_NEK2_1	252	257	PF00069	0.331
MOD_NEK2_1	434	439	PF00069	0.626
MOD_NEK2_1	598	603	PF00069	0.695
MOD_NEK2_2	203	208	PF00069	0.304
MOD_NEK2_2	579	584	PF00069	0.483
MOD_NEK2_2	8	13	PF00069	0.599
MOD_PIKK_1	367	373	PF00454	0.587
MOD_PIKK_1	377	383	PF00454	0.586
MOD_PK_1	364	370	PF00069	0.584
MOD_PK_1	403	409	PF00069	0.667
MOD_PK_1	514	520	PF00069	0.602
MOD_PKA_1	364	370	PF00069	0.585
MOD_PKA_2	164	170	PF00069	0.647
MOD_PKA_2	303	309	PF00069	0.444
MOD_PKA_2	363	369	PF00069	0.594
MOD_PKA_2	535	541	PF00069	0.790
MOD_PKA_2	88	94	PF00069	0.553
MOD_PKB_1	362	370	PF00069	0.583
MOD_PKB_1	514	522	PF00069	0.663
MOD_Plk_1	123	129	PF00069	0.356
MOD_Plk_1	272	278	PF00069	0.304
MOD_Plk_1	372	378	PF00069	0.585
MOD_Plk_1	8	14	PF00069	0.626
MOD_Plk_2-3	284	290	PF00069	0.205
MOD_Plk_4	215	221	PF00069	0.326
MOD_Plk_4	364	370	PF00069	0.564
MOD_Plk_4	480	486	PF00069	0.616
MOD_Plk_4	499	505	PF00069	0.506
MOD_Plk_4	51	57	PF00069	0.584
MOD_Plk_4	544	550	PF00069	0.472
MOD_Plk_4	594	600	PF00069	0.648
MOD_Plk_4	633	639	PF00069	0.623
MOD_ProDKin_1	12	18	PF00069	0.728
MOD_ProDKin_1	142	148	PF00069	0.575
MOD_ProDKin_1	160	166	PF00069	0.690
MOD_ProDKin_1	168	174	PF00069	0.248
MOD_ProDKin_1	186	192	PF00069	0.369
MOD_ProDKin_1	218	224	PF00069	0.304
MOD_ProDKin_1	333	339	PF00069	0.632
MOD_ProDKin_1	382	388	PF00069	0.630
MOD_ProDKin_1	436	442	PF00069	0.606
MOD_ProDKin_1	452	458	PF00069	0.607
MOD_ProDKin_1	493	499	PF00069	0.660
MOD_ProDKin_1	54	60	PF00069	0.628
MOD_ProDKin_1	563	569	PF00069	0.600
MOD_ProDKin_1	603	609	PF00069	0.598
MOD_ProDKin_1	78	84	PF00069	0.578
TRG_DiLeu_BaEn_1	111	116	PF01217	0.502
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.338
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.570
TRG_ENDOCYTIC_2	112	115	PF00928	0.378
TRG_ENDOCYTIC_2	217	220	PF00928	0.383
TRG_ENDOCYTIC_2	239	242	PF00928	0.272
TRG_ENDOCYTIC_2	247	250	PF00928	0.343
TRG_ER_diArg_1	362	365	PF00400	0.585
TRG_NES_CRM1_1	283	294	PF08389	0.335
TRG_Pf-PMV_PEXEL_1	312	317	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K2	Leptomonas seymouri	52%	94%
A0A3Q8IG93	Leishmania donovani	93%	100%
A4HDQ0	Leishmania braziliensis	78%	100%
A4I0Z6	Leishmania infantum	93%	100%
Q4QAE2	Leishmania major	91%	100%