RRM_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX31_LEIMU

TriTrypDb:

LmxM.24.1860

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.666
CLV_NRD_NRD_1	285	287	PF00675	0.687
CLV_NRD_NRD_1	302	304	PF00675	0.550
CLV_NRD_NRD_1	354	356	PF00675	0.721
CLV_PCSK_KEX2_1	20	22	PF00082	0.677
CLV_PCSK_KEX2_1	284	286	PF00082	0.686
CLV_PCSK_KEX2_1	302	304	PF00082	0.542
CLV_PCSK_KEX2_1	354	356	PF00082	0.721
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.628
CLV_PCSK_SKI1_1	328	332	PF00082	0.590
CLV_PCSK_SKI1_1	462	466	PF00082	0.346
DEG_APCC_DBOX_1	461	469	PF00400	0.524
DOC_CKS1_1	105	110	PF01111	0.734
DOC_CKS1_1	153	158	PF01111	0.669
DOC_CYCLIN_yCln2_LP_2	332	338	PF00134	0.638
DOC_CYCLIN_yCln2_LP_2	87	90	PF00134	0.525
DOC_MAPK_gen_1	445	453	PF00069	0.499
DOC_PP1_RVXF_1	398	404	PF00149	0.545
DOC_PP2B_LxvP_1	15	18	PF13499	0.654
DOC_PP2B_LxvP_1	87	90	PF13499	0.658
DOC_USP7_MATH_1	135	139	PF00917	0.565
DOC_USP7_MATH_1	185	189	PF00917	0.472
DOC_USP7_MATH_1	199	203	PF00917	0.718
DOC_USP7_MATH_1	226	230	PF00917	0.541
DOC_USP7_MATH_1	234	238	PF00917	0.717
DOC_USP7_MATH_1	275	279	PF00917	0.779
DOC_USP7_MATH_1	280	284	PF00917	0.722
DOC_USP7_MATH_1	312	316	PF00917	0.597
DOC_USP7_MATH_1	356	360	PF00917	0.796
DOC_USP7_MATH_1	372	376	PF00917	0.615
DOC_USP7_MATH_1	377	381	PF00917	0.628
DOC_USP7_MATH_1	415	419	PF00917	0.511
DOC_USP7_MATH_1	478	482	PF00917	0.317
DOC_USP7_MATH_2	295	301	PF00917	0.688
DOC_WW_Pin1_4	104	109	PF00397	0.691
DOC_WW_Pin1_4	152	157	PF00397	0.715
DOC_WW_Pin1_4	19	24	PF00397	0.648
DOC_WW_Pin1_4	217	222	PF00397	0.722
DOC_WW_Pin1_4	291	296	PF00397	0.696
DOC_WW_Pin1_4	319	324	PF00397	0.658
DOC_WW_Pin1_4	331	336	PF00397	0.568
DOC_WW_Pin1_4	42	47	PF00397	0.692
DOC_WW_Pin1_4	48	53	PF00397	0.670
DOC_WW_Pin1_4	498	503	PF00397	0.552
LIG_14-3-3_CanoR_1	109	118	PF00244	0.622
LIG_14-3-3_CanoR_1	231	239	PF00244	0.677
LIG_14-3-3_CanoR_1	285	291	PF00244	0.720
LIG_14-3-3_CanoR_1	321	327	PF00244	0.505
LIG_14-3-3_CanoR_1	38	42	PF00244	0.620
LIG_14-3-3_CterR_2	516	520	PF00244	0.663
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BRCT_BRCA1_1	123	127	PF00533	0.638
LIG_EH1_1	490	498	PF00400	0.396
LIG_eIF4E_1	326	332	PF01652	0.518
LIG_EVH1_1	15	19	PF00568	0.654
LIG_FHA_1	160	166	PF00498	0.757
LIG_FHA_1	366	372	PF00498	0.634
LIG_FHA_1	423	429	PF00498	0.661
LIG_FHA_1	499	505	PF00498	0.673
LIG_FHA_2	114	120	PF00498	0.713
LIG_FHA_2	179	185	PF00498	0.558
LIG_FHA_2	28	34	PF00498	0.673
LIG_FHA_2	381	387	PF00498	0.517
LIG_FHA_2	49	55	PF00498	0.702
LIG_LIR_Gen_1	490	497	PF02991	0.616
LIG_LIR_Nem_3	375	381	PF02991	0.645
LIG_LIR_Nem_3	444	450	PF02991	0.461
LIG_LIR_Nem_3	490	494	PF02991	0.607
LIG_SH2_CRK	153	157	PF00017	0.649
LIG_SH2_CRK	26	30	PF00017	0.658
LIG_SH2_CRK	447	451	PF00017	0.445
LIG_SH2_NCK_1	153	157	PF00017	0.649
LIG_SH2_NCK_1	26	30	PF00017	0.538
LIG_SH2_NCK_1	326	330	PF00017	0.519
LIG_SH2_STAT3	346	349	PF00017	0.593
LIG_SH3_1	13	19	PF00018	0.592
LIG_SH3_2	16	21	PF14604	0.662
LIG_SH3_3	102	108	PF00018	0.692
LIG_SH3_3	13	19	PF00018	0.635
LIG_SH3_3	211	217	PF00018	0.673
LIG_SH3_3	269	275	PF00018	0.692
LIG_SH3_3	334	340	PF00018	0.556
LIG_SH3_3	426	432	PF00018	0.664
LIG_SH3_3	499	505	PF00018	0.612
LIG_SUMO_SIM_par_1	367	375	PF11976	0.633
LIG_TRAF2_1	458	461	PF00917	0.404
LIG_TRAF2_1	464	467	PF00917	0.384
LIG_UBA3_1	450	459	PF00899	0.399
LIG_WW_1	23	26	PF00397	0.652
LIG_WW_3	22	26	PF00397	0.681
MOD_CDC14_SPxK_1	45	48	PF00782	0.685
MOD_CDK_SPK_2	104	109	PF00069	0.676
MOD_CDK_SPK_2	48	53	PF00069	0.671
MOD_CDK_SPxK_1	19	25	PF00069	0.634
MOD_CDK_SPxK_1	42	48	PF00069	0.682
MOD_CK1_1	112	118	PF00069	0.678
MOD_CK1_1	125	131	PF00069	0.542
MOD_CK1_1	171	177	PF00069	0.751
MOD_CK1_1	202	208	PF00069	0.716
MOD_CK1_1	229	235	PF00069	0.612
MOD_CK1_1	237	243	PF00069	0.651
MOD_CK1_1	245	251	PF00069	0.604
MOD_CK1_1	27	33	PF00069	0.697
MOD_CK1_1	296	302	PF00069	0.712
MOD_CK1_1	307	313	PF00069	0.623
MOD_CK1_1	322	328	PF00069	0.520
MOD_CK1_1	365	371	PF00069	0.656
MOD_CK1_1	380	386	PF00069	0.528
MOD_CK1_1	413	419	PF00069	0.648
MOD_CK1_1	81	87	PF00069	0.571
MOD_CK2_1	113	119	PF00069	0.721
MOD_CK2_1	178	184	PF00069	0.567
MOD_CK2_1	185	191	PF00069	0.486
MOD_CK2_1	27	33	PF00069	0.656
MOD_CK2_1	286	292	PF00069	0.770
MOD_CK2_1	470	476	PF00069	0.473
MOD_GlcNHglycan	132	135	PF01048	0.674
MOD_GlcNHglycan	136	140	PF01048	0.643
MOD_GlcNHglycan	187	190	PF01048	0.447
MOD_GlcNHglycan	228	231	PF01048	0.817
MOD_GlcNHglycan	247	250	PF01048	0.652
MOD_GlcNHglycan	251	254	PF01048	0.689
MOD_GlcNHglycan	277	280	PF01048	0.761
MOD_GlcNHglycan	306	309	PF01048	0.706
MOD_GlcNHglycan	412	416	PF01048	0.673
MOD_GlcNHglycan	472	475	PF01048	0.471
MOD_GlcNHglycan	480	483	PF01048	0.364
MOD_GSK3_1	109	116	PF00069	0.708
MOD_GSK3_1	121	128	PF00069	0.683
MOD_GSK3_1	130	137	PF00069	0.587
MOD_GSK3_1	167	174	PF00069	0.756
MOD_GSK3_1	199	206	PF00069	0.712
MOD_GSK3_1	225	232	PF00069	0.796
MOD_GSK3_1	245	252	PF00069	0.549
MOD_GSK3_1	25	32	PF00069	0.698
MOD_GSK3_1	275	282	PF00069	0.768
MOD_GSK3_1	293	300	PF00069	0.641
MOD_GSK3_1	340	347	PF00069	0.587
MOD_GSK3_1	377	384	PF00069	0.688
MOD_GSK3_1	411	418	PF00069	0.622
MOD_GSK3_1	42	49	PF00069	0.597
MOD_GSK3_1	88	95	PF00069	0.680
MOD_LATS_1	291	297	PF00433	0.689
MOD_N-GLC_1	159	164	PF02516	0.695
MOD_N-GLC_1	178	183	PF02516	0.599
MOD_N-GLC_1	242	247	PF02516	0.609
MOD_NEK2_1	1	6	PF00069	0.644
MOD_NEK2_1	159	164	PF00069	0.756
MOD_NEK2_1	178	183	PF00069	0.566
MOD_NEK2_1	468	473	PF00069	0.432
MOD_NEK2_1	496	501	PF00069	0.549
MOD_NEK2_1	92	97	PF00069	0.623
MOD_NEK2_2	377	382	PF00069	0.651
MOD_PIKK_1	109	115	PF00454	0.688
MOD_PIKK_1	232	238	PF00454	0.687
MOD_PIKK_1	344	350	PF00454	0.644
MOD_PIKK_1	362	368	PF00454	0.642
MOD_PIKK_1	65	71	PF00454	0.715
MOD_PKA_1	354	360	PF00069	0.630
MOD_PKA_2	174	180	PF00069	0.617
MOD_PKA_2	199	205	PF00069	0.594
MOD_PKA_2	230	236	PF00069	0.677
MOD_PKA_2	24	30	PF00069	0.693
MOD_PKA_2	354	360	PF00069	0.799
MOD_PKA_2	37	43	PF00069	0.537
MOD_PKA_2	381	387	PF00069	0.699
MOD_PKA_2	410	416	PF00069	0.584
MOD_PKA_2	509	515	PF00069	0.551
MOD_PKB_1	284	292	PF00069	0.629
MOD_PKB_1	409	417	PF00069	0.628
MOD_Plk_1	296	302	PF00069	0.687
MOD_Plk_2-3	168	174	PF00069	0.672
MOD_Plk_2-3	509	515	PF00069	0.539
MOD_ProDKin_1	104	110	PF00069	0.691
MOD_ProDKin_1	152	158	PF00069	0.716
MOD_ProDKin_1	19	25	PF00069	0.653
MOD_ProDKin_1	217	223	PF00069	0.723
MOD_ProDKin_1	291	297	PF00069	0.698
MOD_ProDKin_1	319	325	PF00069	0.655
MOD_ProDKin_1	331	337	PF00069	0.567
MOD_ProDKin_1	42	48	PF00069	0.694
MOD_ProDKin_1	498	504	PF00069	0.556
MOD_SUMO_for_1	458	461	PF00179	0.428
MOD_SUMO_rev_2	81	87	PF00179	0.714
TRG_DiLeu_BaEn_1	423	428	PF01217	0.661
TRG_DiLeu_BaEn_1	492	497	PF01217	0.403
TRG_DiLeu_BaEn_2	398	404	PF01217	0.545
TRG_DiLeu_BaEn_4	460	466	PF01217	0.395
TRG_DiLeu_BaLyEn_6	502	507	PF01217	0.636
TRG_ENDOCYTIC_2	26	29	PF00928	0.658
TRG_ENDOCYTIC_2	447	450	PF00928	0.613
TRG_ER_diArg_1	284	286	PF00400	0.686
TRG_ER_diArg_1	301	303	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID03	Leishmania donovani	83%	97%
A4HDP7	Leishmania braziliensis	50%	99%
A4I0Z3	Leishmania infantum	83%	97%
Q4QAE5	Leishmania major	80%	100%