Hypothetical predicted multi-pass transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted multi-pass transmembrane protein

Species:

Leishmania mexicana

UniProt:

E9AX30_LEIMU

TriTrypDb:

LmxM.24.1850

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AX30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.606
CLV_NRD_NRD_1	126	128	PF00675	0.637
CLV_NRD_NRD_1	143	145	PF00675	0.744
CLV_NRD_NRD_1	221	223	PF00675	0.775
CLV_NRD_NRD_1	305	307	PF00675	0.723
CLV_NRD_NRD_1	319	321	PF00675	0.599
CLV_NRD_NRD_1	391	393	PF00675	0.488
CLV_PCSK_FUR_1	219	223	PF00082	0.757
CLV_PCSK_KEX2_1	143	145	PF00082	0.744
CLV_PCSK_KEX2_1	219	221	PF00082	0.789
CLV_PCSK_KEX2_1	305	307	PF00082	0.723
CLV_PCSK_KEX2_1	351	353	PF00082	0.690
CLV_PCSK_KEX2_1	409	411	PF00082	0.425
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.565
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.425
CLV_PCSK_SKI1_1	176	180	PF00082	0.760
DEG_SPOP_SBC_1	104	108	PF00917	0.490
DEG_SPOP_SBC_1	212	216	PF00917	0.482
DEG_SPOP_SBC_1	399	403	PF00917	0.587
DOC_CKS1_1	67	72	PF01111	0.504
DOC_MAPK_gen_1	305	314	PF00069	0.548
DOC_MAPK_MEF2A_6	305	314	PF00069	0.548
DOC_PP1_RVXF_1	385	392	PF00149	0.687
DOC_PP2B_LxvP_1	102	105	PF13499	0.535
DOC_PP4_FxxP_1	100	103	PF00568	0.476
DOC_USP7_MATH_1	105	109	PF00917	0.470
DOC_USP7_MATH_1	19	23	PF00917	0.599
DOC_USP7_MATH_1	236	240	PF00917	0.625
DOC_USP7_MATH_1	242	246	PF00917	0.578
DOC_USP7_MATH_1	255	259	PF00917	0.419
DOC_USP7_MATH_1	304	308	PF00917	0.570
DOC_USP7_MATH_1	326	330	PF00917	0.472
DOC_USP7_MATH_1	360	364	PF00917	0.520
DOC_USP7_MATH_1	91	95	PF00917	0.551
DOC_WW_Pin1_4	192	197	PF00397	0.477
DOC_WW_Pin1_4	230	235	PF00397	0.597
DOC_WW_Pin1_4	66	71	PF00397	0.491
LIG_14-3-3_CanoR_1	250	260	PF00244	0.573
LIG_14-3-3_CanoR_1	361	365	PF00244	0.510
LIG_BRCT_BRCA1_1	96	100	PF00533	0.495
LIG_FHA_1	213	219	PF00498	0.570
LIG_FHA_1	260	266	PF00498	0.516
LIG_FHA_1	383	389	PF00498	0.674
LIG_FHA_1	48	54	PF00498	0.502
LIG_FHA_2	291	297	PF00498	0.548
LIG_GBD_Chelix_1	23	31	PF00786	0.738
LIG_LIR_Apic_2	97	103	PF02991	0.511
LIG_LIR_Gen_1	343	354	PF02991	0.506
LIG_LIR_Gen_1	376	386	PF02991	0.513
LIG_LIR_Nem_3	185	191	PF02991	0.509
LIG_LIR_Nem_3	376	382	PF02991	0.437
LIG_NRBOX	26	32	PF00104	0.683
LIG_NRBOX	51	57	PF00104	0.538
LIG_Pex14_1	370	374	PF04695	0.436
LIG_Pex14_2	364	368	PF04695	0.478
LIG_REV1ctd_RIR_1	185	194	PF16727	0.493
LIG_REV1ctd_RIR_1	362	370	PF16727	0.472
LIG_RPA_C_Fungi	382	394	PF08784	0.610
LIG_SH2_CRK	379	383	PF00017	0.389
LIG_SH2_SRC	120	123	PF00017	0.542
LIG_SH2_STAP1	346	350	PF00017	0.702
LIG_SH2_STAP1	379	383	PF00017	0.436
LIG_SH2_STAT5	297	300	PF00017	0.761
LIG_SH3_3	190	196	PF00018	0.578
LIG_SH3_3	228	234	PF00018	0.763
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.599
LIG_SUMO_SIM_anti_2	50	57	PF11976	0.683
LIG_SUMO_SIM_par_1	44	51	PF11976	0.611
LIG_TRAF2_1	115	118	PF00917	0.820
LIG_TRAF2_1	158	161	PF00917	0.674
LIG_TRAF2_1	282	285	PF00917	0.827
LIG_TRAF2_1	41	44	PF00917	0.576
LIG_TRFH_1	100	104	PF08558	0.659
MOD_CDK_SPK_2	230	235	PF00069	0.763
MOD_CK1_1	130	136	PF00069	0.590
MOD_CK1_1	395	401	PF00069	0.708
MOD_CK1_1	66	72	PF00069	0.624
MOD_CK1_1	94	100	PF00069	0.638
MOD_CK2_1	155	161	PF00069	0.651
MOD_CK2_1	201	207	PF00069	0.751
MOD_CK2_1	242	248	PF00069	0.767
MOD_CK2_1	290	296	PF00069	0.740
MOD_GlcNHglycan	129	132	PF01048	0.695
MOD_GlcNHglycan	19	22	PF01048	0.655
MOD_GlcNHglycan	240	243	PF01048	0.732
MOD_GlcNHglycan	244	247	PF01048	0.709
MOD_GlcNHglycan	253	256	PF01048	0.629
MOD_GlcNHglycan	257	260	PF01048	0.539
MOD_GlcNHglycan	269	272	PF01048	0.556
MOD_GlcNHglycan	277	281	PF01048	0.555
MOD_GlcNHglycan	324	327	PF01048	0.702
MOD_GlcNHglycan	397	400	PF01048	0.630
MOD_GlcNHglycan	93	96	PF01048	0.731
MOD_GSK3_1	123	130	PF00069	0.695
MOD_GSK3_1	230	237	PF00069	0.849
MOD_GSK3_1	238	245	PF00069	0.752
MOD_GSK3_1	251	258	PF00069	0.648
MOD_GSK3_1	272	279	PF00069	0.686
MOD_GSK3_1	322	329	PF00069	0.525
MOD_GSK3_1	395	402	PF00069	0.588
MOD_GSK3_1	94	101	PF00069	0.607
MOD_NEK2_1	138	143	PF00069	0.735
MOD_NEK2_1	150	155	PF00069	0.515
MOD_NEK2_1	267	272	PF00069	0.725
MOD_NEK2_1	373	378	PF00069	0.513
MOD_NEK2_1	382	387	PF00069	0.364
MOD_NEK2_1	48	53	PF00069	0.712
MOD_NEK2_1	98	103	PF00069	0.628
MOD_NEK2_2	360	365	PF00069	0.652
MOD_PIKK_1	105	111	PF00454	0.479
MOD_PIKK_1	136	142	PF00454	0.747
MOD_PIKK_1	326	332	PF00454	0.484
MOD_PIKK_1	392	398	PF00454	0.645
MOD_PIKK_1	86	92	PF00454	0.758
MOD_PKA_1	127	133	PF00069	0.532
MOD_PKA_1	392	398	PF00069	0.621
MOD_PKA_2	304	310	PF00069	0.660
MOD_PKA_2	319	325	PF00069	0.675
MOD_PKA_2	360	366	PF00069	0.588
MOD_Plk_1	290	296	PF00069	0.740
MOD_Plk_2-3	201	207	PF00069	0.673
MOD_Plk_4	19	25	PF00069	0.600
MOD_Plk_4	360	366	PF00069	0.626
MOD_Plk_4	48	54	PF00069	0.618
MOD_Plk_4	94	100	PF00069	0.616
MOD_ProDKin_1	192	198	PF00069	0.600
MOD_ProDKin_1	230	236	PF00069	0.762
MOD_ProDKin_1	66	72	PF00069	0.609
MOD_SUMO_for_1	115	118	PF00179	0.545
MOD_SUMO_rev_2	186	196	PF00179	0.521
TRG_ENDOCYTIC_2	346	349	PF00928	0.706
TRG_ENDOCYTIC_2	379	382	PF00928	0.390
TRG_ER_diArg_1	218	221	PF00400	0.748
TRG_ER_diLys_1	408	411	PF00400	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P420	Leptomonas seymouri	36%	98%
A0A3S7WYI6	Leishmania donovani	84%	100%
A4HDP6	Leishmania braziliensis	66%	98%
E9AH92	Leishmania infantum	84%	100%
Q4QAE6	Leishmania major	87%	100%