Putative lysophospholipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lysophospholipase, putative

Species:

Leishmania mexicana

UniProt:

E9AX29_LEIMU

TriTrypDb:

LmxM.24.1840

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX29

Function

Biological processes
Term	Name	Level	Count
GO:0002084	protein depalmitoylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0019538	protein metabolic process	3	1
GO:0030163	protein catabolic process	4	1
GO:0035601	protein deacylation	5	1
GO:0036211	protein modification process	4	1
GO:0042157	lipoprotein metabolic process	4	1
GO:0042159	lipoprotein catabolic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0098732	macromolecule deacylation	5	1
GO:0098734	macromolecule depalmitoylation	6	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016787	hydrolase activity	2	13
GO:0004620	phospholipase activity	5	5
GO:0004622	lysophospholipase activity	5	5
GO:0008474	palmitoyl-(protein) hydrolase activity	3	1
GO:0016298	lipase activity	4	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016790	thiolester hydrolase activity	4	1
GO:0052689	carboxylic ester hydrolase activity	4	5
GO:0098599	palmitoyl hydrolase activity	3	1
GO:0102545	phosphatidyl phospholipase B activity	5	5
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	91	93	PF00675	0.365
CLV_PCSK_KEX2_1	91	93	PF00082	0.365
CLV_PCSK_SKI1_1	106	110	PF00082	0.335
CLV_Separin_Metazoa	88	92	PF03568	0.445
DOC_CDC14_PxL_1	90	98	PF14671	0.445
DOC_MAPK_DCC_7	240	249	PF00069	0.445
DOC_MAPK_gen_1	91	99	PF00069	0.365
DOC_MAPK_MEF2A_6	221	228	PF00069	0.394
DOC_MAPK_MEF2A_6	91	98	PF00069	0.358
DOC_PP4_FxxP_1	98	101	PF00568	0.295
DOC_USP7_MATH_1	104	108	PF00917	0.429
DOC_USP7_MATH_1	192	196	PF00917	0.331
DOC_USP7_UBL2_3	232	236	PF12436	0.293
DOC_WW_Pin1_4	158	163	PF00397	0.153
DOC_WW_Pin1_4	43	48	PF00397	0.447
LIG_14-3-3_CanoR_1	141	147	PF00244	0.445
LIG_FHA_1	181	187	PF00498	0.343
LIG_FHA_1	200	206	PF00498	0.343
LIG_FHA_1	232	238	PF00498	0.445
LIG_FHA_1	265	271	PF00498	0.367
LIG_FHA_1	47	53	PF00498	0.434
LIG_FHA_1	64	70	PF00498	0.330
LIG_FHA_2	54	60	PF00498	0.511
LIG_LIR_Nem_3	248	252	PF02991	0.413
LIG_PDZ_Class_3	273	278	PF00595	0.500
LIG_PTAP_UEV_1	100	105	PF05743	0.325
LIG_SH2_CRK	54	58	PF00017	0.393
LIG_SH2_STAT5	146	149	PF00017	0.296
LIG_SH2_STAT5	197	200	PF00017	0.296
LIG_SH3_1	221	227	PF00018	0.424
LIG_SH3_2	101	106	PF14604	0.343
LIG_SH3_3	221	227	PF00018	0.424
LIG_SH3_3	98	104	PF00018	0.325
LIG_TYR_ITIM	52	57	PF00017	0.408
LIG_UBA3_1	57	63	PF00899	0.482
LIG_WRC_WIRS_1	266	271	PF05994	0.365
MOD_CDC14_SPxK_1	161	164	PF00782	0.153
MOD_CDK_SPxK_1	158	164	PF00069	0.153
MOD_CK1_1	168	174	PF00069	0.399
MOD_CK1_1	177	183	PF00069	0.381
MOD_CK1_1	268	274	PF00069	0.424
MOD_CK2_1	245	251	PF00069	0.442
MOD_CK2_1	53	59	PF00069	0.524
MOD_GlcNHglycan	131	134	PF01048	0.297
MOD_GlcNHglycan	167	170	PF01048	0.396
MOD_GlcNHglycan	194	197	PF01048	0.321
MOD_GlcNHglycan	228	231	PF01048	0.424
MOD_GlcNHglycan	77	80	PF01048	0.312
MOD_GSK3_1	102	109	PF00069	0.391
MOD_GSK3_1	136	143	PF00069	0.372
MOD_GSK3_1	264	271	PF00069	0.367
MOD_GSK3_1	42	49	PF00069	0.414
MOD_GSK3_1	63	70	PF00069	0.314
MOD_NEK2_1	254	259	PF00069	0.286
MOD_NEK2_1	75	80	PF00069	0.296
MOD_PIKK_1	168	174	PF00454	0.332
MOD_PIKK_1	231	237	PF00454	0.339
MOD_PKA_2	140	146	PF00069	0.445
MOD_PKA_2	42	48	PF00069	0.405
MOD_Plk_1	135	141	PF00069	0.369
MOD_Plk_1	254	260	PF00069	0.367
MOD_Plk_1	264	270	PF00069	0.241
MOD_Plk_4	265	271	PF00069	0.387
MOD_Plk_4	53	59	PF00069	0.541
MOD_ProDKin_1	158	164	PF00069	0.153
MOD_ProDKin_1	43	49	PF00069	0.445
MOD_SUMO_for_1	13	16	PF00179	0.376
TRG_DiLeu_BaEn_4	15	21	PF01217	0.456
TRG_ENDOCYTIC_2	120	123	PF00928	0.445
TRG_ENDOCYTIC_2	167	170	PF00928	0.325
TRG_ENDOCYTIC_2	54	57	PF00928	0.386
TRG_ER_diArg_1	90	92	PF00400	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M9	Leptomonas seymouri	73%	100%
A0A0S4IM79	Bodo saltans	39%	73%
A0A0S4IVW5	Bodo saltans	32%	89%
A0A0S4J016	Bodo saltans	43%	77%
A0A1X0NWA4	Trypanosomatidae	58%	100%
A0A3R7LLR7	Trypanosoma rangeli	60%	99%
A0A3S7WYH3	Leishmania donovani	96%	100%
A4HDP5	Leishmania braziliensis	87%	100%
C9ZWB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	99%
E9AH91	Leishmania infantum	96%	100%
O75608	Homo sapiens	30%	100%
O77821	Oryctolagus cuniculus	30%	100%
O95372	Homo sapiens	32%	100%
P0CL94	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	33%	100%
P0CL95	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	33%	100%
P70470	Rattus norvegicus	30%	100%
P97823	Mus musculus	30%	100%
Q0J969	Oryza sativa subsp. japonica	32%	100%
Q12354	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q3MHR0	Bos taurus	32%	100%
Q3UFF7	Mus musculus	27%	100%
Q4I8Q4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	34%	100%
Q4PID3	Ustilago maydis (strain 521 / FGSC 9021)	37%	100%
Q4QAE7	Leishmania major	95%	100%
Q4WCX7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	34%	100%
Q51758	Pseudomonas fluorescens	33%	100%
Q53547	Pseudomonas fluorescens	34%	100%
Q54T49	Dictyostelium discoideum	34%	100%
Q55FK4	Dictyostelium discoideum	30%	100%
Q5AGD1	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	100%
Q5ASI2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	35%	100%
Q5R8C2	Pongo abelii	27%	100%
Q5RBR7	Pongo abelii	30%	100%
Q6BSS8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	31%	100%
Q6CGL4	Yarrowia lipolytica (strain CLIB 122 / E 150)	31%	100%
Q6CJK6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	36%	100%
Q6FW75	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	100%
Q750X7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	100%
Q7XR62	Oryza sativa subsp. japonica	27%	100%
Q84WK4	Arabidopsis thaliana	28%	100%
Q8GYK2	Arabidopsis thaliana	30%	100%
Q9HFJ5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
Q9QYL8	Rattus norvegicus	32%	100%
Q9WTL7	Mus musculus	32%	100%
V5AV05	Trypanosoma cruzi	59%	99%