Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX28_LEIMU

TriTrypDb:

LmxM.24.1830

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AX28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.642
CLV_NRD_NRD_1	166	168	PF00675	0.584
CLV_NRD_NRD_1	225	227	PF00675	0.620
CLV_PCSK_KEX2_1	145	147	PF00082	0.607
CLV_PCSK_KEX2_1	225	227	PF00082	0.643
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.638
CLV_PCSK_SKI1_1	145	149	PF00082	0.607
CLV_PCSK_SKI1_1	62	66	PF00082	0.648
DEG_APCC_KENBOX_2	200	204	PF00400	0.649
DEG_Nend_UBRbox_1	1	4	PF02207	0.669
DEG_SCF_FBW7_2	83	88	PF00400	0.559
DOC_MAPK_gen_1	120	129	PF00069	0.561
DOC_MAPK_gen_1	145	154	PF00069	0.648
DOC_MAPK_MEF2A_6	120	129	PF00069	0.599
DOC_PP2B_LxvP_1	83	86	PF13499	0.539
DOC_PP4_FxxP_1	89	92	PF00568	0.567
DOC_USP7_MATH_2	130	136	PF00917	0.638
DOC_WW_Pin1_4	1	6	PF00397	0.656
DOC_WW_Pin1_4	49	54	PF00397	0.708
DOC_WW_Pin1_4	81	86	PF00397	0.551
LIG_14-3-3_CanoR_1	112	118	PF00244	0.478
LIG_14-3-3_CanoR_1	7	15	PF00244	0.665
LIG_deltaCOP1_diTrp_1	88	95	PF00928	0.599
LIG_EVH1_2	85	89	PF00568	0.565
LIG_FHA_1	14	20	PF00498	0.672
LIG_FHA_1	65	71	PF00498	0.588
LIG_FHA_2	63	69	PF00498	0.573
LIG_LIR_Apic_2	88	92	PF02991	0.585
LIG_PTB_Apo_2	155	162	PF02174	0.690
LIG_PTB_Phospho_1	155	161	PF10480	0.697
LIG_SH2_GRB2like	151	154	PF00017	0.592
LIG_SH2_PTP2	151	154	PF00017	0.649
LIG_SH2_STAP1	123	127	PF00017	0.596
LIG_SH2_STAP1	46	50	PF00017	0.614
LIG_SH2_STAT3	175	178	PF00017	0.588
LIG_SH2_STAT3	46	49	PF00017	0.557
LIG_SH2_STAT5	151	154	PF00017	0.649
LIG_SH2_STAT5	161	164	PF00017	0.621
LIG_SH2_STAT5	189	192	PF00017	0.611
LIG_SH3_3	124	130	PF00018	0.714
LIG_TRAF2_1	116	119	PF00917	0.521
LIG_TRAF2_1	99	102	PF00917	0.587
MOD_CDK_SPxK_1	1	7	PF00069	0.655
MOD_CDK_SPxxK_3	49	56	PF00069	0.718
MOD_CK2_1	113	119	PF00069	0.498
MOD_CK2_1	62	68	PF00069	0.559
MOD_GlcNHglycan	22	25	PF01048	0.617
MOD_GlcNHglycan	8	11	PF01048	0.684
MOD_N-GLC_1	211	216	PF02516	0.605
MOD_NEK2_1	13	18	PF00069	0.477
MOD_NEK2_1	20	25	PF00069	0.561
MOD_NEK2_1	6	11	PF00069	0.634
MOD_PKA_2	178	184	PF00069	0.629
MOD_PKA_2	6	12	PF00069	0.695
MOD_Plk_1	118	124	PF00069	0.558
MOD_Plk_1	171	177	PF00069	0.593
MOD_Plk_4	14	20	PF00069	0.650
MOD_ProDKin_1	1	7	PF00069	0.655
MOD_ProDKin_1	49	55	PF00069	0.712
MOD_ProDKin_1	81	87	PF00069	0.559
MOD_SUMO_rev_2	116	121	PF00179	0.507
TRG_ENDOCYTIC_2	151	154	PF00928	0.592
TRG_ENDOCYTIC_2	27	30	PF00928	0.556
TRG_ER_diArg_1	164	167	PF00400	0.594
TRG_ER_diArg_1	225	227	PF00400	0.643
TRG_NLS_MonoExtN_4	142	149	PF00514	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P367	Leptomonas seymouri	84%	85%
A0A0S4J5N9	Bodo saltans	60%	100%
A0A1X0NVV7	Trypanosomatidae	77%	100%
A0A3Q8ICY8	Leishmania donovani	98%	100%
A4HDP4	Leishmania braziliensis	98%	100%
C9ZWB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AH90	Leishmania infantum	98%	100%
Q4QAE8	Leishmania major	99%	100%