Putative short chain dehydrogenase/reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase/reductase, putative

Species:

Leishmania mexicana

UniProt:

E9AX26_LEIMU

TriTrypDb:

LmxM.24.1810

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 28
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	16
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AX26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX26

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004312	fatty acid synthase activity	5	3
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	3
GO:0016491	oxidoreductase activity	2	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	3
GO:0016740	transferase activity	2	3
GO:0016746	acyltransferase activity	3	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	183	189	PF00089	0.259
CLV_NRD_NRD_1	301	303	PF00675	0.587
CLV_NRD_NRD_1	308	310	PF00675	0.536
CLV_NRD_NRD_1	75	77	PF00675	0.366
CLV_PCSK_KEX2_1	159	161	PF00082	0.266
CLV_PCSK_KEX2_1	308	310	PF00082	0.547
CLV_PCSK_KEX2_1	75	77	PF00082	0.393
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.284
CLV_PCSK_PC7_1	155	161	PF00082	0.258
CLV_PCSK_SKI1_1	181	185	PF00082	0.215
CLV_PCSK_SKI1_1	279	283	PF00082	0.523
CLV_PCSK_SKI1_1	81	85	PF00082	0.356
DEG_Nend_Nbox_1	1	3	PF02207	0.656
DOC_MAPK_HePTP_8	183	195	PF00069	0.392
DOC_MAPK_MEF2A_6	186	195	PF00069	0.435
DOC_PP4_FxxP_1	197	200	PF00568	0.485
DOC_USP7_MATH_1	133	137	PF00917	0.480
DOC_USP7_MATH_1	161	165	PF00917	0.491
DOC_USP7_MATH_1	273	277	PF00917	0.486
DOC_USP7_MATH_1	280	284	PF00917	0.607
DOC_USP7_MATH_1	319	323	PF00917	0.769
DOC_USP7_MATH_1	334	338	PF00917	0.589
DOC_USP7_UBL2_3	434	438	PF12436	0.361
DOC_WW_Pin1_4	116	121	PF00397	0.586
DOC_WW_Pin1_4	242	247	PF00397	0.549
DOC_WW_Pin1_4	345	350	PF00397	0.516
DOC_WW_Pin1_4	357	362	PF00397	0.537
LIG_14-3-3_CanoR_1	18	22	PF00244	0.606
LIG_14-3-3_CanoR_1	3	8	PF00244	0.638
LIG_14-3-3_CanoR_1	341	349	PF00244	0.480
LIG_BRCT_BRCA1_1	358	362	PF00533	0.612
LIG_CSL_BTD_1	243	246	PF09270	0.555
LIG_eIF4E_1	370	376	PF01652	0.282
LIG_FHA_1	18	24	PF00498	0.578
LIG_FHA_1	202	208	PF00498	0.451
LIG_FHA_1	27	33	PF00498	0.448
LIG_FHA_1	331	337	PF00498	0.692
LIG_FHA_1	78	84	PF00498	0.598
LIG_FHA_1	92	98	PF00498	0.460
LIG_FHA_2	377	383	PF00498	0.317
LIG_HCF-1_HBM_1	11	14	PF13415	0.560
LIG_LIR_Apic_2	276	280	PF02991	0.648
LIG_LIR_Gen_1	149	157	PF02991	0.465
LIG_LIR_Gen_1	20	28	PF02991	0.568
LIG_LIR_Gen_1	363	374	PF02991	0.404
LIG_LIR_Nem_3	149	154	PF02991	0.440
LIG_LIR_Nem_3	363	369	PF02991	0.361
LIG_Pex14_2	362	366	PF04695	0.442
LIG_PTB_Apo_2	395	402	PF02174	0.289
LIG_PTB_Phospho_1	395	401	PF10480	0.291
LIG_RPA_C_Fungi	64	76	PF08784	0.476
LIG_SH2_GRB2like	402	405	PF00017	0.331
LIG_SH2_PTP2	373	376	PF00017	0.474
LIG_SH2_SRC	371	374	PF00017	0.225
LIG_SH2_SRC	407	410	PF00017	0.452
LIG_SH2_STAP1	312	316	PF00017	0.671
LIG_SH2_STAT5	128	131	PF00017	0.278
LIG_SH2_STAT5	157	160	PF00017	0.358
LIG_SH2_STAT5	182	185	PF00017	0.208
LIG_SH2_STAT5	201	204	PF00017	0.358
LIG_SH2_STAT5	220	223	PF00017	0.316
LIG_SH2_STAT5	237	240	PF00017	0.382
LIG_SH2_STAT5	368	371	PF00017	0.282
LIG_SH2_STAT5	373	376	PF00017	0.259
LIG_SH2_STAT5	41	44	PF00017	0.368
LIG_SH3_3	240	246	PF00018	0.495
LIG_SH3_3	47	53	PF00018	0.418
LIG_SUMO_SIM_anti_2	111	116	PF11976	0.360
LIG_SUMO_SIM_par_1	333	339	PF11976	0.364
LIG_TYR_ITIM	369	374	PF00017	0.340
MOD_CDK_SPK_2	242	247	PF00069	0.445
MOD_CK1_1	283	289	PF00069	0.550
MOD_CK1_1	307	313	PF00069	0.622
MOD_CK1_1	322	328	PF00069	0.694
MOD_CK2_1	3	9	PF00069	0.543
MOD_CK2_1	322	328	PF00069	0.473
MOD_CK2_1	376	382	PF00069	0.384
MOD_Cter_Amidation	300	303	PF01082	0.482
MOD_Cter_Amidation	73	76	PF01082	0.506
MOD_GlcNHglycan	135	138	PF01048	0.341
MOD_GlcNHglycan	238	241	PF01048	0.499
MOD_GlcNHglycan	26	29	PF01048	0.583
MOD_GlcNHglycan	309	312	PF01048	0.650
MOD_GlcNHglycan	324	327	PF01048	0.599
MOD_GlcNHglycan	362	365	PF01048	0.400
MOD_GlcNHglycan	94	97	PF01048	0.316
MOD_GSK3_1	280	287	PF00069	0.638
MOD_GSK3_1	330	337	PF00069	0.460
MOD_GSK3_1	356	363	PF00069	0.420
MOD_GSK3_1	41	48	PF00069	0.415
MOD_GSK3_1	77	84	PF00069	0.507
MOD_GSK3_1	88	95	PF00069	0.284
MOD_N-GLC_2	389	391	PF02516	0.307
MOD_N-GLC_2	77	79	PF02516	0.325
MOD_NEK2_1	24	29	PF00069	0.487
MOD_NEK2_1	356	361	PF00069	0.413
MOD_NEK2_1	362	367	PF00069	0.295
MOD_NEK2_1	412	417	PF00069	0.518
MOD_NEK2_1	60	65	PF00069	0.325
MOD_PIKK_1	319	325	PF00454	0.693
MOD_PIKK_1	381	387	PF00454	0.298
MOD_PKA_2	161	167	PF00069	0.360
MOD_PKA_2	17	23	PF00069	0.500
MOD_PKA_2	24	30	PF00069	0.427
MOD_PKA_2	287	293	PF00069	0.671
MOD_PKA_2	296	302	PF00069	0.727
MOD_PKA_2	307	313	PF00069	0.666
MOD_PKA_2	340	346	PF00069	0.355
MOD_PKA_2	77	83	PF00069	0.453
MOD_Plk_1	110	116	PF00069	0.305
MOD_Plk_4	233	239	PF00069	0.438
MOD_Plk_4	3	9	PF00069	0.534
MOD_Plk_4	362	368	PF00069	0.386
MOD_Plk_4	383	389	PF00069	0.306
MOD_Plk_4	60	66	PF00069	0.303
MOD_ProDKin_1	116	122	PF00069	0.480
MOD_ProDKin_1	242	248	PF00069	0.427
MOD_ProDKin_1	345	351	PF00069	0.390
MOD_ProDKin_1	357	363	PF00069	0.409
MOD_SUMO_for_1	437	440	PF00179	0.482
TRG_ENDOCYTIC_2	371	374	PF00928	0.365
TRG_ER_diArg_1	75	78	PF00400	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S7	Leptomonas seymouri	33%	86%
A0A0N1HZ81	Leptomonas seymouri	70%	79%
A0A0S4IWT0	Bodo saltans	33%	94%
A0A0S4IZG2	Bodo saltans	36%	97%
A0A0S4J1I6	Bodo saltans	44%	100%
A0A1X0NVT8	Trypanosomatidae	34%	88%
A0A1X0NVV6	Trypanosomatidae	50%	86%
A0A3Q8ID46	Leishmania donovani	35%	87%
A0A3R7K071	Trypanosoma rangeli	53%	91%
A0A3S5H7D5	Leishmania donovani	95%	100%
A0A3S7X986	Leishmania donovani	24%	91%
A0A422N2B6	Trypanosoma rangeli	33%	92%
A4HDP2	Leishmania braziliensis	87%	100%
A4HDP3	Leishmania braziliensis	33%	97%
A4HMN7	Leishmania braziliensis	27%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	93%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	88%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AF41	Leishmania major	22%	100%
E9AH88	Leishmania infantum	95%	88%
E9AH89	Leishmania infantum	34%	87%
E9AHV8	Leishmania infantum	24%	91%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	87%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	91%
Q4QAE9	Leishmania major	33%	100%
Q4QAF0	Leishmania major	94%	100%
V5BAF4	Trypanosoma cruzi	33%	92%
V5BNY6	Trypanosoma cruzi	28%	100%