RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9AX24_LEIMU

TriTrypDb:

LmxM.24.1790

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX24

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	134	138	PF00082	0.312
CLV_PCSK_SKI1_1	228	232	PF00082	0.472
CLV_PCSK_SKI1_1	261	265	PF00082	0.431
DEG_Nend_UBRbox_2	1	3	PF02207	0.582
DOC_CKS1_1	85	90	PF01111	0.679
DOC_MAPK_MEF2A_6	206	214	PF00069	0.529
DOC_PP4_FxxP_1	224	227	PF00568	0.441
DOC_USP7_MATH_1	113	117	PF00917	0.616
DOC_USP7_MATH_1	234	238	PF00917	0.462
DOC_WW_Pin1_4	118	123	PF00397	0.654
DOC_WW_Pin1_4	148	153	PF00397	0.470
DOC_WW_Pin1_4	214	219	PF00397	0.525
DOC_WW_Pin1_4	79	84	PF00397	0.684
LIG_14-3-3_CanoR_1	245	250	PF00244	0.539
LIG_BRCT_BRCA1_1	216	220	PF00533	0.562
LIG_BRCT_BRCA1_1	73	77	PF00533	0.691
LIG_CtBP_PxDLS_1	152	156	PF00389	0.475
LIG_EH_1	74	78	PF12763	0.690
LIG_FHA_1	119	125	PF00498	0.614
LIG_FHA_1	174	180	PF00498	0.470
LIG_FHA_1	207	213	PF00498	0.475
LIG_FHA_1	214	220	PF00498	0.454
LIG_FHA_2	148	154	PF00498	0.483
LIG_LIR_Gen_1	182	192	PF02991	0.475
LIG_LIR_Nem_3	182	187	PF02991	0.475
LIG_PAM2_1	75	87	PF00658	0.683
LIG_Pex14_1	260	264	PF04695	0.430
LIG_Pex14_2	220	224	PF04695	0.442
LIG_RPA_C_Fungi	6	18	PF08784	0.575
LIG_SH2_STAT3	93	96	PF00017	0.664
LIG_SH2_STAT5	184	187	PF00017	0.352
LIG_SH2_STAT5	190	193	PF00017	0.352
LIG_SH2_STAT5	221	224	PF00017	0.469
LIG_SH3_3	47	53	PF00018	0.636
LIG_SH3_3	63	69	PF00018	0.717
LIG_SH3_3	70	76	PF00018	0.684
LIG_SH3_3	80	86	PF00018	0.613
LIG_TRAF2_1	151	154	PF00917	0.312
LIG_TRAF2_1	237	240	PF00917	0.531
LIG_WRC_WIRS_1	124	129	PF05994	0.573
MOD_CK1_1	128	134	PF00069	0.461
MOD_CK1_1	3	9	PF00069	0.590
MOD_CK2_1	147	153	PF00069	0.326
MOD_CK2_1	234	240	PF00069	0.501
MOD_GlcNHglycan	4	8	PF01048	0.634
MOD_GSK3_1	114	121	PF00069	0.682
MOD_GSK3_1	128	135	PF00069	0.450
MOD_GSK3_1	142	149	PF00069	0.348
MOD_N-GLC_1	166	171	PF02516	0.312
MOD_N-GLC_1	79	84	PF02516	0.684
MOD_NEK2_1	166	171	PF00069	0.314
MOD_NEK2_1	179	184	PF00069	0.379
MOD_NEK2_1	205	210	PF00069	0.339
MOD_NEK2_1	222	227	PF00069	0.598
MOD_NEK2_1	229	234	PF00069	0.517
MOD_NEK2_1	45	50	PF00069	0.698
MOD_NEK2_1	61	66	PF00069	0.646
MOD_PIKK_1	61	67	PF00454	0.641
MOD_PIKK_1	91	97	PF00454	0.646
MOD_PK_1	245	251	PF00069	0.452
MOD_PKA_2	142	148	PF00069	0.340
MOD_PKA_2	173	179	PF00069	0.312
MOD_PKB_1	245	253	PF00069	0.450
MOD_Plk_1	166	172	PF00069	0.312
MOD_Plk_1	188	194	PF00069	0.414
MOD_Plk_4	166	172	PF00069	0.341
MOD_Plk_4	206	212	PF00069	0.335
MOD_Plk_4	38	44	PF00069	0.626
MOD_ProDKin_1	118	124	PF00069	0.654
MOD_ProDKin_1	148	154	PF00069	0.305
MOD_ProDKin_1	214	220	PF00069	0.530
MOD_ProDKin_1	79	85	PF00069	0.684
MOD_SUMO_rev_2	173	182	PF00179	0.312
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.410
TRG_ENDOCYTIC_2	184	187	PF00928	0.312
TRG_ENDOCYTIC_2	190	193	PF00928	0.322
TRG_ENDOCYTIC_2	221	224	PF00928	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IMV3	Leishmania donovani	86%	100%
A0A3R7NAM0	Trypanosoma rangeli	51%	100%
A4HDP0	Leishmania braziliensis	77%	100%
E9AH86	Leishmania infantum	86%	100%
Q4QAF2	Leishmania major	89%	99%