Inhibitor of cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inhibitor of cysteine peptidase

Species:

Leishmania mexicana

UniProt:

E9AX22_LEIMU

TriTrypDb:

LmxM.24.1770

Length:

113

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX22

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002020	protease binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	6	10	PF00656	0.537
CLV_NRD_NRD_1	80	82	PF00675	0.355
CLV_PCSK_KEX2_1	82	84	PF00082	0.229
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.229
CLV_PCSK_SKI1_1	44	48	PF00082	0.520
DEG_Nend_Nbox_1	1	3	PF02207	0.430
DEG_SCF_FBW7_1	60	65	PF00400	0.229
DOC_MAPK_gen_1	81	90	PF00069	0.393
DOC_MAPK_MEF2A_6	105	112	PF00069	0.373
DOC_MAPK_NFAT4_5	105	113	PF00069	0.362
DOC_MAPK_RevD_3	68	82	PF00069	0.229
DOC_PP1_RVXF_1	36	42	PF00149	0.289
DOC_USP7_MATH_1	60	64	PF00917	0.326
DOC_USP7_UBL2_3	8	12	PF12436	0.528
DOC_WW_Pin1_4	56	61	PF00397	0.405
DOC_WW_Pin1_4	62	67	PF00397	0.353
LIG_14-3-3_CanoR_1	105	109	PF00244	0.429
LIG_14-3-3_CanoR_1	83	89	PF00244	0.325
LIG_FHA_1	105	111	PF00498	0.375
LIG_FHA_1	19	25	PF00498	0.423
LIG_FHA_1	63	69	PF00498	0.371
LIG_FHA_1	85	91	PF00498	0.430
LIG_LIR_Apic_2	89	95	PF02991	0.291
LIG_LIR_Nem_3	93	99	PF02991	0.344
LIG_SH2_CRK	92	96	PF00017	0.429
LIG_SH2_NCK_1	92	96	PF00017	0.377
LIG_SH2_PTP2	74	77	PF00017	0.229
LIG_SH2_STAP1	106	110	PF00017	0.362
LIG_SH2_STAT5	106	109	PF00017	0.362
LIG_SH2_STAT5	58	61	PF00017	0.394
LIG_SH2_STAT5	74	77	PF00017	0.362
LIG_SH2_STAT5	92	95	PF00017	0.277
LIG_SUMO_SIM_anti_2	48	56	PF11976	0.301
LIG_SUMO_SIM_anti_2	87	93	PF11976	0.307
LIG_SUMO_SIM_par_1	3	9	PF11976	0.585
LIG_UBA3_1	1	8	PF00899	0.368
MOD_GSK3_1	56	63	PF00069	0.430
MOD_NEK2_1	90	95	PF00069	0.363
MOD_PKA_2	104	110	PF00069	0.429
MOD_Plk_2-3	45	51	PF00069	0.410
MOD_ProDKin_1	56	62	PF00069	0.405
MOD_SUMO_for_1	99	102	PF00179	0.301
TRG_ENDOCYTIC_2	74	77	PF00928	0.362
TRG_ER_diArg_1	80	83	PF00400	0.229
TRG_NLS_MonoExtN_4	79	85	PF00514	0.229

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSR0	Leptomonas seymouri	48%	100%
A0A1X0NX79	Trypanosomatidae	31%	98%
A0A3Q8IC64	Leishmania donovani	75%	97%
A0A3R7MAP9	Trypanosoma rangeli	34%	100%
A4HDN8	Leishmania braziliensis	55%	100%
C9ZWC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	93%
E9AH84	Leishmania infantum	75%	97%
Q868G9	Leishmania major	67%	100%
Q966X9	Trypanosoma cruzi	34%	100%