Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX21_LEIMU

TriTrypDb:

LmxM.24.1760

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AX21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.659
CLV_NRD_NRD_1	100	102	PF00675	0.602
CLV_NRD_NRD_1	28	30	PF00675	0.647
CLV_PCSK_KEX2_1	100	102	PF00082	0.628
CLV_PCSK_KEX2_1	139	141	PF00082	0.534
CLV_PCSK_KEX2_1	27	29	PF00082	0.644
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.534
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.644
CLV_PCSK_SKI1_1	106	110	PF00082	0.503
CLV_PCSK_SKI1_1	211	215	PF00082	0.565
CLV_PCSK_SKI1_1	228	232	PF00082	0.658
DEG_SPOP_SBC_1	129	133	PF00917	0.525
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.595
DOC_MAPK_FxFP_2	67	70	PF00069	0.489
DOC_MAPK_MEF2A_6	253	261	PF00069	0.561
DOC_PP4_FxxP_1	67	70	PF00568	0.489
DOC_USP7_MATH_1	147	151	PF00917	0.777
DOC_USP7_MATH_1	160	164	PF00917	0.556
DOC_USP7_MATH_1	207	211	PF00917	0.540
DOC_USP7_MATH_1	226	230	PF00917	0.557
DOC_USP7_MATH_1	74	78	PF00917	0.766
DOC_USP7_MATH_1	82	86	PF00917	0.724
DOC_WW_Pin1_4	40	45	PF00397	0.492
DOC_WW_Pin1_4	62	67	PF00397	0.672
DOC_WW_Pin1_4	68	73	PF00397	0.705
LIG_14-3-3_CanoR_1	193	197	PF00244	0.439
LIG_14-3-3_CanoR_1	64	70	PF00244	0.510
LIG_Clathr_ClatBox_1	51	55	PF01394	0.594
LIG_deltaCOP1_diTrp_1	196	206	PF00928	0.676
LIG_FHA_1	129	135	PF00498	0.599
LIG_FHA_1	260	266	PF00498	0.596
LIG_FHA_2	162	168	PF00498	0.649
LIG_FHA_2	229	235	PF00498	0.623
LIG_LIR_Apic_2	65	70	PF02991	0.486
LIG_MYND_1	88	92	PF01753	0.696
LIG_SH3_3	121	127	PF00018	0.524
LIG_SH3_3	85	91	PF00018	0.789
LIG_SUMO_SIM_anti_2	131	138	PF11976	0.484
LIG_WRC_WIRS_1	5	10	PF05994	0.487
MOD_CK1_1	65	71	PF00069	0.762
MOD_CK1_1	77	83	PF00069	0.614
MOD_GlcNHglycan	140	143	PF01048	0.538
MOD_GlcNHglycan	158	161	PF01048	0.724
MOD_GlcNHglycan	183	186	PF01048	0.486
MOD_GlcNHglycan	265	268	PF01048	0.586
MOD_GlcNHglycan	80	83	PF01048	0.692
MOD_GlcNHglycan	84	87	PF01048	0.642
MOD_GSK3_1	156	163	PF00069	0.627
MOD_GSK3_1	259	266	PF00069	0.569
MOD_GSK3_1	55	62	PF00069	0.568
MOD_GSK3_1	74	81	PF00069	0.651
MOD_GSK3_1	82	89	PF00069	0.691
MOD_N-GLC_1	17	22	PF02516	0.295
MOD_N-GLC_2	9	11	PF02516	0.427
MOD_NEK2_1	112	117	PF00069	0.571
MOD_NEK2_1	171	176	PF00069	0.546
MOD_NEK2_1	181	186	PF00069	0.517
MOD_NEK2_1	60	65	PF00069	0.686
MOD_PIKK_1	241	247	PF00454	0.665
MOD_PKA_1	100	106	PF00069	0.533
MOD_PKA_2	100	106	PF00069	0.668
MOD_PKA_2	192	198	PF00069	0.518
MOD_Plk_1	17	23	PF00069	0.298
MOD_Plk_1	171	177	PF00069	0.549
MOD_Plk_4	130	136	PF00069	0.465
MOD_Plk_4	218	224	PF00069	0.516
MOD_Plk_4	260	266	PF00069	0.645
MOD_ProDKin_1	40	46	PF00069	0.492
MOD_ProDKin_1	62	68	PF00069	0.675
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.703
TRG_ER_diArg_1	100	102	PF00400	0.628
TRG_NLS_MonoExtC_3	26	32	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV6	Leptomonas seymouri	49%	96%
A0A3S7WYI4	Leishmania donovani	89%	100%
A4HDN6	Leishmania braziliensis	75%	100%
A4HDN7	Leishmania braziliensis	72%	100%
E9AH83	Leishmania infantum	89%	100%
Q4QAF5	Leishmania major	91%	100%