SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AX20_LEIMU

TriTrypDb:

LmxM.24.1750

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX20

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.604
CLV_C14_Caspase3-7	373	377	PF00656	0.481
CLV_C14_Caspase3-7	579	583	PF00656	0.641
CLV_C14_Caspase3-7	92	96	PF00656	0.494
CLV_NRD_NRD_1	123	125	PF00675	0.727
CLV_NRD_NRD_1	386	388	PF00675	0.518
CLV_NRD_NRD_1	712	714	PF00675	0.451
CLV_PCSK_KEX2_1	123	125	PF00082	0.740
CLV_PCSK_KEX2_1	296	298	PF00082	0.633
CLV_PCSK_KEX2_1	386	388	PF00082	0.518
CLV_PCSK_KEX2_1	711	713	PF00082	0.427
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.611
CLV_PCSK_SKI1_1	248	252	PF00082	0.497
CLV_PCSK_SKI1_1	297	301	PF00082	0.578
CLV_PCSK_SKI1_1	459	463	PF00082	0.417
CLV_PCSK_SKI1_1	527	531	PF00082	0.555
CLV_PCSK_SKI1_1	713	717	PF00082	0.524
DEG_APCC_DBOX_1	296	304	PF00400	0.510
DEG_APCC_DBOX_1	390	398	PF00400	0.439
DEG_APCC_DBOX_1	435	443	PF00400	0.563
DEG_COP1_1	406	415	PF00400	0.316
DEG_Nend_Nbox_1	1	3	PF02207	0.474
DOC_ANK_TNKS_1	574	581	PF00023	0.503
DOC_CKS1_1	281	286	PF01111	0.684
DOC_CYCLIN_RxL_1	398	409	PF00134	0.555
DOC_MAPK_gen_1	386	394	PF00069	0.459
DOC_MAPK_MEF2A_6	391	399	PF00069	0.406
DOC_PP1_RVXF_1	399	406	PF00149	0.517
DOC_PP1_RVXF_1	420	427	PF00149	0.496
DOC_PP1_RVXF_1	58	64	PF00149	0.509
DOC_PP4_FxxP_1	281	284	PF00568	0.619
DOC_USP7_MATH_1	197	201	PF00917	0.624
DOC_USP7_MATH_1	216	220	PF00917	0.521
DOC_USP7_MATH_1	246	250	PF00917	0.648
DOC_USP7_MATH_1	341	345	PF00917	0.506
DOC_USP7_MATH_1	377	381	PF00917	0.538
DOC_USP7_MATH_1	411	415	PF00917	0.630
DOC_USP7_MATH_1	514	518	PF00917	0.660
DOC_USP7_MATH_1	578	582	PF00917	0.650
DOC_USP7_MATH_1	602	606	PF00917	0.612
DOC_USP7_MATH_2	80	86	PF00917	0.691
DOC_USP7_UBL2_3	94	98	PF12436	0.708
DOC_WW_Pin1_4	118	123	PF00397	0.708
DOC_WW_Pin1_4	198	203	PF00397	0.776
DOC_WW_Pin1_4	207	212	PF00397	0.574
DOC_WW_Pin1_4	214	219	PF00397	0.541
DOC_WW_Pin1_4	259	264	PF00397	0.748
DOC_WW_Pin1_4	280	285	PF00397	0.634
DOC_WW_Pin1_4	4	9	PF00397	0.649
DOC_WW_Pin1_4	496	501	PF00397	0.678
DOC_WW_Pin1_4	510	515	PF00397	0.624
DOC_WW_Pin1_4	561	566	PF00397	0.532
DOC_WW_Pin1_4	632	637	PF00397	0.544
LIG_14-3-3_CanoR_1	131	138	PF00244	0.593
LIG_14-3-3_CanoR_1	191	197	PF00244	0.673
LIG_14-3-3_CanoR_1	248	257	PF00244	0.748
LIG_14-3-3_CanoR_1	264	273	PF00244	0.648
LIG_14-3-3_CanoR_1	404	408	PF00244	0.499
LIG_14-3-3_CanoR_1	463	467	PF00244	0.397
LIG_14-3-3_CanoR_1	74	80	PF00244	0.437
LIG_Actin_WH2_1	391	406	PF00022	0.441
LIG_Actin_WH2_2	388	406	PF00022	0.509
LIG_Actin_WH2_2	447	465	PF00022	0.524
LIG_BIR_III_4	582	586	PF00653	0.743
LIG_BRCT_BRCA1_1	30	34	PF00533	0.608
LIG_BRCT_BRCA1_1	537	541	PF00533	0.469
LIG_CSL_BTD_1	497	500	PF09270	0.560
LIG_FAT_LD_1	182	190	PF03623	0.640
LIG_FHA_1	128	134	PF00498	0.770
LIG_FHA_1	218	224	PF00498	0.666
LIG_FHA_1	286	292	PF00498	0.679
LIG_FHA_1	480	486	PF00498	0.443
LIG_FHA_1	521	527	PF00498	0.625
LIG_FHA_1	528	534	PF00498	0.535
LIG_FHA_1	584	590	PF00498	0.552
LIG_FHA_1	668	674	PF00498	0.390
LIG_FHA_1	689	695	PF00498	0.508
LIG_FHA_2	150	156	PF00498	0.620
LIG_FHA_2	203	209	PF00498	0.577
LIG_FHA_2	250	256	PF00498	0.771
LIG_FHA_2	266	272	PF00498	0.589
LIG_FHA_2	371	377	PF00498	0.473
LIG_FHA_2	517	523	PF00498	0.647
LIG_FHA_2	97	103	PF00498	0.699
LIG_GBD_Chelix_1	395	403	PF00786	0.405
LIG_HP1_1	341	345	PF01393	0.487
LIG_LIR_Gen_1	219	229	PF02991	0.665
LIG_LIR_Gen_1	465	474	PF02991	0.466
LIG_LIR_Gen_1	479	486	PF02991	0.564
LIG_LIR_Gen_1	691	699	PF02991	0.575
LIG_LIR_Nem_3	106	111	PF02991	0.698
LIG_LIR_Nem_3	219	224	PF02991	0.661
LIG_LIR_Nem_3	465	469	PF02991	0.380
LIG_LIR_Nem_3	470	475	PF02991	0.377
LIG_LIR_Nem_3	479	484	PF02991	0.442
LIG_LIR_Nem_3	610	616	PF02991	0.562
LIG_LIR_Nem_3	687	693	PF02991	0.510
LIG_NRBOX	181	187	PF00104	0.627
LIG_NRBOX	393	399	PF00104	0.476
LIG_PCNA_yPIPBox_3	339	347	PF02747	0.504
LIG_PDZ_Class_2	740	745	PF00595	0.643
LIG_PTAP_UEV_1	412	417	PF05743	0.362
LIG_PTB_Apo_2	660	667	PF02174	0.548
LIG_Rb_LxCxE_1	470	492	PF01857	0.465
LIG_SH2_CRK	108	112	PF00017	0.698
LIG_SH2_CRK	481	485	PF00017	0.435
LIG_SH2_CRK	625	629	PF00017	0.390
LIG_SH2_NCK_1	625	629	PF00017	0.390
LIG_SH2_NCK_1	650	654	PF00017	0.501
LIG_SH2_PTP2	693	696	PF00017	0.420
LIG_SH2_SRC	446	449	PF00017	0.544
LIG_SH2_STAP1	481	485	PF00017	0.435
LIG_SH2_STAT5	266	269	PF00017	0.619
LIG_SH2_STAT5	280	283	PF00017	0.558
LIG_SH2_STAT5	481	484	PF00017	0.514
LIG_SH2_STAT5	546	549	PF00017	0.405
LIG_SH2_STAT5	560	563	PF00017	0.489
LIG_SH2_STAT5	567	570	PF00017	0.548
LIG_SH2_STAT5	693	696	PF00017	0.425
LIG_SH2_STAT5	714	717	PF00017	0.466
LIG_SH3_3	410	416	PF00018	0.526
LIG_SH3_3	501	507	PF00018	0.602
LIG_SH3_3	559	565	PF00018	0.505
LIG_SH3_CIN85_PxpxPR_1	500	505	PF14604	0.433
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.532
LIG_SUMO_SIM_anti_2	604	610	PF11976	0.675
LIG_TRAF2_1	153	156	PF00917	0.597
LIG_TRAF2_2	54	59	PF00917	0.445
LIG_TYR_ITSM	689	696	PF00017	0.557
LIG_UBA3_1	394	401	PF00899	0.482
LIG_UBA3_1	608	614	PF00899	0.600
LIG_WRC_WIRS_1	354	359	PF05994	0.476
MOD_CDC14_SPxK_1	121	124	PF00782	0.590
MOD_CDK_SPK_2	118	123	PF00069	0.708
MOD_CDK_SPK_2	198	203	PF00069	0.718
MOD_CDK_SPK_2	259	264	PF00069	0.748
MOD_CDK_SPxK_1	118	124	PF00069	0.594
MOD_CDK_SPxxK_3	118	125	PF00069	0.712
MOD_CDK_SPxxK_3	498	505	PF00069	0.507
MOD_CK1_1	132	138	PF00069	0.783
MOD_CK1_1	142	148	PF00069	0.646
MOD_CK1_1	19	25	PF00069	0.624
MOD_CK1_1	198	204	PF00069	0.715
MOD_CK1_1	249	255	PF00069	0.691
MOD_CK1_1	29	35	PF00069	0.566
MOD_CK1_1	380	386	PF00069	0.503
MOD_CK1_1	4	10	PF00069	0.655
MOD_CK1_1	434	440	PF00069	0.482
MOD_CK1_1	489	495	PF00069	0.634
MOD_CK1_1	496	502	PF00069	0.736
MOD_CK1_1	517	523	PF00069	0.605
MOD_CK2_1	149	155	PF00069	0.639
MOD_CK2_1	190	196	PF00069	0.765
MOD_CK2_1	216	222	PF00069	0.502
MOD_CK2_1	249	255	PF00069	0.705
MOD_CK2_1	287	293	PF00069	0.637
MOD_CK2_1	434	440	PF00069	0.560
MOD_CK2_1	442	448	PF00069	0.479
MOD_CK2_1	516	522	PF00069	0.656
MOD_CK2_1	96	102	PF00069	0.699
MOD_CMANNOS	570	573	PF00535	0.594
MOD_Cter_Amidation	294	297	PF01082	0.664
MOD_GlcNHglycan	147	150	PF01048	0.626
MOD_GlcNHglycan	196	200	PF01048	0.672
MOD_GlcNHglycan	323	326	PF01048	0.615
MOD_GlcNHglycan	336	339	PF01048	0.409
MOD_GlcNHglycan	408	411	PF01048	0.530
MOD_GlcNHglycan	413	416	PF01048	0.512
MOD_GlcNHglycan	454	457	PF01048	0.365
MOD_GlcNHglycan	489	492	PF01048	0.619
MOD_GlcNHglycan	516	519	PF01048	0.653
MOD_GlcNHglycan	91	94	PF01048	0.709
MOD_GSK3_1	127	134	PF00069	0.739
MOD_GSK3_1	145	152	PF00069	0.573
MOD_GSK3_1	16	23	PF00069	0.727
MOD_GSK3_1	198	205	PF00069	0.745
MOD_GSK3_1	210	217	PF00069	0.503
MOD_GSK3_1	255	262	PF00069	0.641
MOD_GSK3_1	26	33	PF00069	0.609
MOD_GSK3_1	330	337	PF00069	0.673
MOD_GSK3_1	376	383	PF00069	0.517
MOD_GSK3_1	427	434	PF00069	0.362
MOD_GSK3_1	487	494	PF00069	0.622
MOD_GSK3_1	510	517	PF00069	0.634
MOD_GSK3_1	561	568	PF00069	0.509
MOD_GSK3_1	583	590	PF00069	0.639
MOD_GSK3_1	638	645	PF00069	0.581
MOD_N-GLC_1	118	123	PF02516	0.629
MOD_N-GLC_1	656	661	PF02516	0.301
MOD_N-GLC_2	663	665	PF02516	0.239
MOD_N-GLC_2	77	79	PF02516	0.660
MOD_NEK2_1	1	6	PF00069	0.757
MOD_NEK2_1	16	21	PF00069	0.595
MOD_NEK2_1	298	303	PF00069	0.692
MOD_NEK2_1	330	335	PF00069	0.675
MOD_NEK2_1	403	408	PF00069	0.480
MOD_NEK2_1	427	432	PF00069	0.479
MOD_NEK2_1	442	447	PF00069	0.575
MOD_NEK2_1	462	467	PF00069	0.269
MOD_NEK2_1	615	620	PF00069	0.619
MOD_NEK2_1	642	647	PF00069	0.590
MOD_NEK2_1	656	661	PF00069	0.521
MOD_NEK2_1	689	694	PF00069	0.583
MOD_NEK2_1	69	74	PF00069	0.470
MOD_NEK2_1	75	80	PF00069	0.575
MOD_NEK2_2	246	251	PF00069	0.501
MOD_NEK2_2	377	382	PF00069	0.543
MOD_PIKK_1	20	26	PF00454	0.477
MOD_PIKK_1	210	216	PF00454	0.596
MOD_PIKK_1	520	526	PF00454	0.322
MOD_PKA_2	142	148	PF00069	0.729
MOD_PKA_2	190	196	PF00069	0.731
MOD_PKA_2	20	26	PF00069	0.679
MOD_PKA_2	202	208	PF00069	0.498
MOD_PKA_2	403	409	PF00069	0.471
MOD_PKA_2	462	468	PF00069	0.382
MOD_Plk_1	177	183	PF00069	0.502
MOD_Plk_1	241	247	PF00069	0.590
MOD_Plk_1	427	433	PF00069	0.437
MOD_Plk_1	479	485	PF00069	0.435
MOD_Plk_1	656	662	PF00069	0.476
MOD_Plk_2-3	190	196	PF00069	0.685
MOD_Plk_2-3	287	293	PF00069	0.637
MOD_Plk_4	287	293	PF00069	0.658
MOD_Plk_4	341	347	PF00069	0.465
MOD_Plk_4	467	473	PF00069	0.450
MOD_Plk_4	565	571	PF00069	0.524
MOD_Plk_4	602	608	PF00069	0.686
MOD_Plk_4	64	70	PF00069	0.532
MOD_Plk_4	673	679	PF00069	0.544
MOD_Plk_4	689	695	PF00069	0.426
MOD_ProDKin_1	118	124	PF00069	0.711
MOD_ProDKin_1	198	204	PF00069	0.779
MOD_ProDKin_1	207	213	PF00069	0.573
MOD_ProDKin_1	214	220	PF00069	0.541
MOD_ProDKin_1	259	265	PF00069	0.747
MOD_ProDKin_1	280	286	PF00069	0.633
MOD_ProDKin_1	4	10	PF00069	0.649
MOD_ProDKin_1	496	502	PF00069	0.673
MOD_ProDKin_1	510	516	PF00069	0.635
MOD_ProDKin_1	561	567	PF00069	0.534
MOD_ProDKin_1	632	638	PF00069	0.544
MOD_SUMO_for_1	153	156	PF00179	0.476
MOD_SUMO_rev_2	290	298	PF00179	0.627
TRG_DiLeu_BaEn_1	287	292	PF01217	0.611
TRG_DiLeu_BaEn_1	390	395	PF01217	0.436
TRG_DiLeu_BaEn_1	457	462	PF01217	0.547
TRG_DiLeu_BaEn_3	293	299	PF01217	0.703
TRG_DiLeu_BaEn_4	177	183	PF01217	0.556
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.689
TRG_ENDOCYTIC_2	108	111	PF00928	0.696
TRG_ENDOCYTIC_2	481	484	PF00928	0.549
TRG_ENDOCYTIC_2	546	549	PF00928	0.470
TRG_ENDOCYTIC_2	613	616	PF00928	0.570
TRG_ENDOCYTIC_2	625	628	PF00928	0.408
TRG_ENDOCYTIC_2	693	696	PF00928	0.454
TRG_ER_diArg_1	122	124	PF00400	0.589
TRG_ER_diArg_1	435	438	PF00400	0.509
TRG_ER_diArg_1	711	713	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I099	Leptomonas seymouri	42%	100%
A0A3S7WYH5	Leishmania donovani	86%	100%
A4HDN5	Leishmania braziliensis	75%	100%
C9ZWC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AH82	Leishmania infantum	86%	100%
Q4QAF6	Leishmania major	86%	99%
V5CZP8	Trypanosoma cruzi	30%	100%