GCV_T domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate-binding protein YgfZ, putative

Species:

Leishmania mexicana

UniProt:

E9AX19_LEIMU

TriTrypDb:

LmxM.24.1740

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005759	mitochondrial matrix	5	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

E9AX19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX19

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0022607	cellular component assembly	4	1
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0044237	cellular metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005542	folic acid binding	3	1
GO:0019842	vitamin binding	3	1
GO:0031406	carboxylic acid binding	4	1
GO:0033218	amide binding	2	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0043177	organic acid binding	3	1
GO:0072341	modified amino acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0004047	aminomethyltransferase activity	5	1
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.461
CLV_NRD_NRD_1	208	210	PF00675	0.504
CLV_NRD_NRD_1	282	284	PF00675	0.412
CLV_NRD_NRD_1	377	379	PF00675	0.517
CLV_NRD_NRD_1	96	98	PF00675	0.243
CLV_PCSK_KEX2_1	14	16	PF00082	0.461
CLV_PCSK_KEX2_1	208	210	PF00082	0.467
CLV_PCSK_KEX2_1	284	286	PF00082	0.369
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.369
CLV_PCSK_PC7_1	10	16	PF00082	0.477
CLV_PCSK_SKI1_1	14	18	PF00082	0.417
CLV_PCSK_SKI1_1	379	383	PF00082	0.497
DOC_ANK_TNKS_1	232	239	PF00023	0.489
DOC_CYCLIN_RxL_1	243	251	PF00134	0.411
DOC_MAPK_DCC_7	352	362	PF00069	0.538
DOC_MAPK_gen_1	283	291	PF00069	0.377
DOC_MAPK_gen_1	95	102	PF00069	0.452
DOC_MAPK_MEF2A_6	107	114	PF00069	0.347
DOC_MAPK_MEF2A_6	283	291	PF00069	0.393
DOC_PP1_RVXF_1	256	263	PF00149	0.384
DOC_PP2B_LxvP_1	167	170	PF13499	0.575
DOC_PP4_FxxP_1	155	158	PF00568	0.416
DOC_USP7_MATH_1	122	126	PF00917	0.678
DOC_USP7_MATH_1	134	138	PF00917	0.731
DOC_USP7_MATH_1	176	180	PF00917	0.733
DOC_USP7_MATH_1	183	187	PF00917	0.653
DOC_USP7_MATH_1	41	45	PF00917	0.450
DOC_USP7_UBL2_3	379	383	PF12436	0.467
DOC_USP7_UBL2_3	95	99	PF12436	0.511
DOC_WW_Pin1_4	169	174	PF00397	0.688
DOC_WW_Pin1_4	192	197	PF00397	0.706
DOC_WW_Pin1_4	198	203	PF00397	0.685
DOC_WW_Pin1_4	219	224	PF00397	0.523
DOC_WW_Pin1_4	363	368	PF00397	0.582
LIG_14-3-3_CanoR_1	135	140	PF00244	0.696
LIG_14-3-3_CanoR_1	283	288	PF00244	0.384
LIG_Actin_WH2_2	333	350	PF00022	0.414
LIG_BRCT_BRCA1_1	246	250	PF00533	0.433
LIG_Dynein_DLC8_1	350	356	PF01221	0.267
LIG_EVH1_2	202	206	PF00568	0.422
LIG_FHA_1	225	231	PF00498	0.515
LIG_FHA_1	284	290	PF00498	0.381
LIG_FHA_1	31	37	PF00498	0.470
LIG_FHA_1	311	317	PF00498	0.602
LIG_FHA_1	352	358	PF00498	0.537
LIG_FHA_1	51	57	PF00498	0.462
LIG_FHA_2	144	150	PF00498	0.606
LIG_FHA_2	301	307	PF00498	0.561
LIG_LIR_Apic_2	152	158	PF02991	0.436
LIG_LIR_Apic_2	215	219	PF02991	0.555
LIG_LIR_Gen_1	224	231	PF02991	0.447
LIG_LIR_LC3C_4	108	111	PF02991	0.513
LIG_LIR_Nem_3	161	167	PF02991	0.453
LIG_LIR_Nem_3	224	229	PF02991	0.403
LIG_LIR_Nem_3	44	49	PF02991	0.451
LIG_MYND_1	165	169	PF01753	0.405
LIG_SH2_CRK	226	230	PF00017	0.528
LIG_SH2_STAP1	226	230	PF00017	0.438
LIG_SH2_STAT3	267	270	PF00017	0.369
LIG_SH2_STAT5	226	229	PF00017	0.453
LIG_SH2_STAT5	267	270	PF00017	0.369
LIG_SH2_STAT5	349	352	PF00017	0.423
LIG_SH2_STAT5	51	54	PF00017	0.511
LIG_SH3_3	162	168	PF00018	0.579
LIG_SH3_3	197	203	PF00018	0.674
LIG_SH3_3	293	299	PF00018	0.597
LIG_SH3_3	315	321	PF00018	0.535
LIG_SUMO_SIM_anti_2	108	113	PF11976	0.477
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.425
LIG_SUMO_SIM_par_1	110	117	PF11976	0.422
LIG_SUMO_SIM_par_1	312	320	PF11976	0.552
LIG_SUMO_SIM_par_1	75	81	PF11976	0.494
LIG_TRAF2_1	146	149	PF00917	0.677
LIG_UBA3_1	344	352	PF00899	0.494
LIG_UBA3_1	87	95	PF00899	0.481
MOD_CDK_SPxK_1	363	369	PF00069	0.286
MOD_CK1_1	125	131	PF00069	0.735
MOD_CK1_1	137	143	PF00069	0.649
MOD_CK1_1	171	177	PF00069	0.715
MOD_CK2_1	143	149	PF00069	0.634
MOD_CK2_1	322	328	PF00069	0.430
MOD_GlcNHglycan	116	121	PF01048	0.536
MOD_GlcNHglycan	124	127	PF01048	0.696
MOD_GlcNHglycan	129	132	PF01048	0.745
MOD_GlcNHglycan	185	188	PF01048	0.601
MOD_GlcNHglycan	192	195	PF01048	0.723
MOD_GlcNHglycan	324	327	PF01048	0.552
MOD_GlcNHglycan	81	85	PF01048	0.300
MOD_GSK3_1	134	141	PF00069	0.655
MOD_GSK3_1	225	232	PF00069	0.467
MOD_GSK3_1	279	286	PF00069	0.411
MOD_GSK3_1	363	370	PF00069	0.551
MOD_N-GLC_1	244	249	PF02516	0.548
MOD_NEK2_1	229	234	PF00069	0.411
MOD_NEK2_1	279	284	PF00069	0.435
MOD_NEK2_1	322	327	PF00069	0.510
MOD_NEK2_1	50	55	PF00069	0.444
MOD_NEK2_2	41	46	PF00069	0.511
MOD_PIKK_1	351	357	PF00454	0.271
MOD_PK_1	135	141	PF00069	0.731
MOD_PKA_1	283	289	PF00069	0.376
MOD_PKA_2	134	140	PF00069	0.663
MOD_PKA_2	143	149	PF00069	0.640
MOD_PKA_2	19	25	PF00069	0.505
MOD_Plk_1	244	250	PF00069	0.517
MOD_Plk_4	225	231	PF00069	0.446
MOD_Plk_4	41	47	PF00069	0.451
MOD_ProDKin_1	169	175	PF00069	0.689
MOD_ProDKin_1	192	198	PF00069	0.704
MOD_ProDKin_1	219	225	PF00069	0.515
MOD_ProDKin_1	363	369	PF00069	0.578
MOD_SUMO_rev_2	374	384	PF00179	0.436
MOD_SUMO_rev_2	89	96	PF00179	0.537
TRG_DiLeu_BaEn_1	380	385	PF01217	0.516
TRG_ENDOCYTIC_2	226	229	PF00928	0.383
TRG_ENDOCYTIC_2	46	49	PF00928	0.511
TRG_ER_diArg_1	14	16	PF00400	0.461
TRG_ER_diArg_1	17	20	PF00400	0.537
TRG_ER_diArg_1	207	209	PF00400	0.413
TRG_ER_diArg_1	345	348	PF00400	0.386
TRG_NLS_MonoExtC_3	96	101	PF00514	0.432
TRG_NLS_MonoExtN_4	95	102	PF00514	0.475
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM11	Leptomonas seymouri	62%	88%
A0A0S4JL83	Bodo saltans	38%	100%
A0A1X0NVS6	Trypanosomatidae	43%	100%
A0A3Q8IEZ2	Leishmania donovani	90%	99%
A0A3R7K245	Trypanosoma rangeli	47%	100%
A4HDN4	Leishmania braziliensis	78%	99%
A4R8F9	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	27%	100%
B8JMH0	Danio rerio	29%	100%
C9ZWC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AH81	Leishmania infantum	90%	100%
Q2H6N9	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	30%	89%
Q4P7A4	Ustilago maydis (strain 521 / FGSC 9021)	26%	97%
Q4QAF7	Leishmania major	84%	94%
Q54NS1	Dictyostelium discoideum	26%	95%
Q5T440	Homo sapiens	29%	100%
Q6C8Y7	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	81%
Q7RYZ1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	89%
Q8CAK1	Mus musculus	30%	100%
Q8L733	Arabidopsis thaliana	25%	99%
V5AJ90	Trypanosoma cruzi	47%	100%