Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AX15_LEIMU

TriTrypDb:

LmxM.24.1700

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AX15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	90	94	PF00656	0.733
CLV_NRD_NRD_1	129	131	PF00675	0.429
CLV_NRD_NRD_1	145	147	PF00675	0.398
CLV_NRD_NRD_1	174	176	PF00675	0.540
CLV_NRD_NRD_1	225	227	PF00675	0.572
CLV_NRD_NRD_1	442	444	PF00675	0.414
CLV_PCSK_FUR_1	127	131	PF00082	0.394
CLV_PCSK_FUR_1	143	147	PF00082	0.361
CLV_PCSK_KEX2_1	126	128	PF00082	0.401
CLV_PCSK_KEX2_1	129	131	PF00082	0.398
CLV_PCSK_KEX2_1	145	147	PF00082	0.475
CLV_PCSK_KEX2_1	174	176	PF00082	0.547
CLV_PCSK_KEX2_1	225	227	PF00082	0.505
CLV_PCSK_KEX2_1	442	444	PF00082	0.415
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.397
CLV_PCSK_SKI1_1	256	260	PF00082	0.467
CLV_PCSK_SKI1_1	356	360	PF00082	0.323
DOC_CYCLIN_yCln2_LP_2	241	247	PF00134	0.624
DOC_MAPK_MEF2A_6	290	297	PF00069	0.512
DOC_MAPK_MEF2A_6	303	312	PF00069	0.503
DOC_PP2B_LxvP_1	102	105	PF13499	0.573
DOC_PP2B_LxvP_1	241	244	PF13499	0.697
DOC_USP7_MATH_1	182	186	PF00917	0.741
DOC_USP7_MATH_1	4	8	PF00917	0.773
DOC_USP7_MATH_1	96	100	PF00917	0.672
DOC_USP7_UBL2_3	5	9	PF12436	0.620
DOC_WW_Pin1_4	148	153	PF00397	0.633
DOC_WW_Pin1_4	199	204	PF00397	0.785
DOC_WW_Pin1_4	32	37	PF00397	0.680
DOC_WW_Pin1_4	92	97	PF00397	0.619
LIG_14-3-3_CanoR_1	177	182	PF00244	0.759
LIG_14-3-3_CanoR_1	211	218	PF00244	0.634
LIG_14-3-3_CanoR_1	235	241	PF00244	0.730
LIG_14-3-3_CanoR_1	356	362	PF00244	0.578
LIG_14-3-3_CanoR_1	369	378	PF00244	0.576
LIG_14-3-3_CanoR_1	459	469	PF00244	0.686
LIG_14-3-3_CanoR_1	64	72	PF00244	0.706
LIG_Actin_WH2_2	301	318	PF00022	0.544
LIG_AP2alpha_2	275	277	PF02296	0.553
LIG_APCC_ABBA_1	274	279	PF00400	0.564
LIG_CaM_IQ_9	119	135	PF13499	0.638
LIG_FHA_1	212	218	PF00498	0.678
LIG_FHA_1	429	435	PF00498	0.606
LIG_FHA_2	88	94	PF00498	0.674
LIG_FHA_2	96	102	PF00498	0.595
LIG_LIR_Apic_2	360	364	PF02991	0.595
LIG_LIR_Gen_1	242	252	PF02991	0.684
LIG_LIR_Gen_1	329	335	PF02991	0.297
LIG_LIR_Gen_1	53	59	PF02991	0.677
LIG_LIR_Nem_3	242	248	PF02991	0.603
LIG_LIR_Nem_3	270	274	PF02991	0.559
LIG_LIR_Nem_3	329	334	PF02991	0.297
LIG_LIR_Nem_3	53	58	PF02991	0.631
LIG_Pex14_1	108	112	PF04695	0.588
LIG_Pex14_1	357	361	PF04695	0.484
LIG_Pex14_2	344	348	PF04695	0.258
LIG_RPA_C_Fungi	428	440	PF08784	0.546
LIG_SH2_CRK	33	37	PF00017	0.588
LIG_SH2_CRK	361	365	PF00017	0.477
LIG_SH2_NCK_1	33	37	PF00017	0.579
LIG_SH2_NCK_1	361	365	PF00017	0.439
LIG_SH2_STAP1	444	448	PF00017	0.497
LIG_SH2_STAP1	462	466	PF00017	0.464
LIG_SH2_STAP1	55	59	PF00017	0.547
LIG_SH2_STAP1	67	71	PF00017	0.542
LIG_SH2_STAT5	147	150	PF00017	0.609
LIG_SH2_STAT5	33	36	PF00017	0.634
LIG_SH2_STAT5	361	364	PF00017	0.454
LIG_SH2_STAT5	376	379	PF00017	0.272
LIG_SH2_STAT5	462	465	PF00017	0.603
LIG_SH2_STAT5	467	470	PF00017	0.587
LIG_SH2_STAT5	57	60	PF00017	0.594
LIG_SH3_5	267	271	PF00018	0.544
LIG_SUMO_SIM_par_1	425	431	PF11976	0.459
LIG_TRAF2_1	121	124	PF00917	0.511
LIG_TRFH_1	148	152	PF08558	0.546
LIG_TRFH_1	272	276	PF08558	0.512
LIG_TRFH_1	361	365	PF08558	0.442
LIG_TYR_ITIM	269	274	PF00017	0.520
LIG_UBA3_1	354	359	PF00899	0.478
MOD_CK1_1	18	24	PF00069	0.643
MOD_CK1_1	251	257	PF00069	0.527
MOD_CK1_1	280	286	PF00069	0.403
MOD_CK1_1	460	466	PF00069	0.514
MOD_CK1_1	66	72	PF00069	0.669
MOD_CK1_1	95	101	PF00069	0.569
MOD_CK2_1	158	164	PF00069	0.625
MOD_CK2_1	182	188	PF00069	0.658
MOD_CK2_1	4	10	PF00069	0.604
MOD_CK2_1	50	56	PF00069	0.628
MOD_CK2_1	95	101	PF00069	0.530
MOD_GlcNHglycan	279	282	PF01048	0.531
MOD_GlcNHglycan	317	320	PF01048	0.318
MOD_GlcNHglycan	382	385	PF01048	0.322
MOD_GlcNHglycan	406	409	PF01048	0.297
MOD_GlcNHglycan	464	467	PF01048	0.533
MOD_GlcNHglycan	47	50	PF01048	0.540
MOD_GSK3_1	158	165	PF00069	0.513
MOD_GSK3_1	326	333	PF00069	0.367
MOD_GSK3_1	457	464	PF00069	0.576
MOD_GSK3_1	63	70	PF00069	0.699
MOD_GSK3_1	92	99	PF00069	0.535
MOD_N-GLC_1	211	216	PF02516	0.606
MOD_N-GLC_1	326	331	PF02516	0.313
MOD_N-GLC_1	339	344	PF02516	0.331
MOD_N-GLC_1	395	400	PF02516	0.462
MOD_NEK2_1	15	20	PF00069	0.708
MOD_NEK2_1	176	181	PF00069	0.601
MOD_NEK2_1	277	282	PF00069	0.425
MOD_NEK2_1	315	320	PF00069	0.334
MOD_NEK2_1	326	331	PF00069	0.318
MOD_NEK2_1	378	383	PF00069	0.287
MOD_NEK2_1	395	400	PF00069	0.354
MOD_NEK2_1	404	409	PF00069	0.240
MOD_NEK2_1	434	439	PF00069	0.396
MOD_NEK2_1	50	55	PF00069	0.659
MOD_NEK2_2	339	344	PF00069	0.341
MOD_NEK2_2	4	9	PF00069	0.615
MOD_PKA_2	176	182	PF00069	0.719
MOD_PKA_2	224	230	PF00069	0.757
MOD_PKA_2	234	240	PF00069	0.647
MOD_PKA_2	370	376	PF00069	0.381
MOD_PKA_2	63	69	PF00069	0.675
MOD_PKB_1	175	183	PF00069	0.608
MOD_PKB_1	369	377	PF00069	0.267
MOD_Plk_1	15	21	PF00069	0.538
MOD_Plk_1	326	332	PF00069	0.279
MOD_Plk_1	339	345	PF00069	0.279
MOD_Plk_4	107	113	PF00069	0.523
MOD_Plk_4	15	21	PF00069	0.663
MOD_Plk_4	280	286	PF00069	0.403
MOD_Plk_4	321	327	PF00069	0.283
MOD_Plk_4	330	336	PF00069	0.311
MOD_Plk_4	339	345	PF00069	0.283
MOD_Plk_4	67	73	PF00069	0.611
MOD_ProDKin_1	148	154	PF00069	0.539
MOD_ProDKin_1	199	205	PF00069	0.756
MOD_ProDKin_1	32	38	PF00069	0.610
MOD_ProDKin_1	92	98	PF00069	0.523
TRG_ENDOCYTIC_2	147	150	PF00928	0.609
TRG_ENDOCYTIC_2	271	274	PF00928	0.520
TRG_ENDOCYTIC_2	444	447	PF00928	0.502
TRG_ENDOCYTIC_2	55	58	PF00928	0.653
TRG_ER_diArg_1	127	130	PF00400	0.539
TRG_ER_diArg_1	143	146	PF00400	0.482
TRG_ER_diArg_1	166	169	PF00400	0.507
TRG_ER_diArg_1	174	177	PF00400	0.503
TRG_ER_diArg_1	265	268	PF00400	0.552
TRG_ER_diArg_1	441	443	PF00400	0.515
TRG_NLS_Bipartite_1	113	130	PF00514	0.517
TRG_NLS_MonoExtC_3	125	130	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U8	Leptomonas seymouri	64%	99%
A0A0S4JPE5	Bodo saltans	41%	100%
A0A1X0NW21	Trypanosomatidae	52%	100%
A0A3S7WYL2	Leishmania donovani	93%	100%
A4HDN0	Leishmania braziliensis	83%	100%
C9ZWD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AH77	Leishmania infantum	93%	100%
Q4QAG1	Leishmania major	93%	100%
V5DBL9	Trypanosoma cruzi	46%	100%