Ssl1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ssl1-like, putative

Species:

Leishmania mexicana

UniProt:

E9AX13_LEIMU

TriTrypDb:

LmxM.24.1680

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005667	transcription regulator complex	2	1
GO:0005675	transcription factor TFIIH holo complex	4	1
GO:0032806	carboxy-terminal domain protein kinase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0090575	RNA polymerase II transcription regulator complex	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AX13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AX13

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006259	DNA metabolic process	4	3
GO:0006281	DNA repair	5	3
GO:0006289	nucleotide-excision repair	6	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0006950	response to stress	2	3
GO:0006974	DNA damage response	4	3
GO:0008152	metabolic process	1	3
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	3
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0033554	cellular response to stress	3	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3
GO:0046483	heterocycle metabolic process	3	3
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	3
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051716	cellular response to stimulus	2	3
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	3
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.354
CLV_C14_Caspase3-7	384	388	PF00656	0.401
CLV_C14_Caspase3-7	9	13	PF00656	0.388
CLV_NRD_NRD_1	218	220	PF00675	0.601
CLV_NRD_NRD_1	228	230	PF00675	0.721
CLV_NRD_NRD_1	235	237	PF00675	0.769
CLV_PCSK_FUR_1	219	223	PF00082	0.700
CLV_PCSK_FUR_1	231	235	PF00082	0.712
CLV_PCSK_KEX2_1	221	223	PF00082	0.674
CLV_PCSK_KEX2_1	228	230	PF00082	0.709
CLV_PCSK_KEX2_1	233	235	PF00082	0.678
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.671
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.683
CLV_PCSK_PC7_1	229	235	PF00082	0.691
CLV_PCSK_SKI1_1	3	7	PF00082	0.304
CLV_PCSK_SKI1_1	307	311	PF00082	0.308
CLV_PCSK_SKI1_1	77	81	PF00082	0.278
DEG_APCC_DBOX_1	28	36	PF00400	0.364
DEG_Nend_Nbox_1	1	3	PF02207	0.385
DEG_SCF_FBW7_1	40	47	PF00400	0.388
DOC_CDC14_PxL_1	310	318	PF14671	0.408
DOC_CYCLIN_RxL_1	304	312	PF00134	0.300
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.258
DOC_CYCLIN_yCln2_LP_2	326	329	PF00134	0.502
DOC_MAPK_gen_1	220	232	PF00069	0.499
DOC_PP2B_LxvP_1	297	300	PF13499	0.393
DOC_PP2B_LxvP_1	326	329	PF13499	0.416
DOC_PP4_MxPP_1	28	31	PF00568	0.388
DOC_USP7_MATH_1	115	119	PF00917	0.613
DOC_USP7_MATH_1	13	17	PF00917	0.302
DOC_USP7_MATH_1	278	282	PF00917	0.574
DOC_USP7_MATH_1	375	379	PF00917	0.682
DOC_USP7_MATH_1	396	400	PF00917	0.517
DOC_USP7_MATH_1	44	48	PF00917	0.259
DOC_WW_Pin1_4	274	279	PF00397	0.431
DOC_WW_Pin1_4	337	342	PF00397	0.513
DOC_WW_Pin1_4	371	376	PF00397	0.534
DOC_WW_Pin1_4	40	45	PF00397	0.336
LIG_14-3-3_CanoR_1	167	171	PF00244	0.264
LIG_14-3-3_CanoR_1	350	354	PF00244	0.232
LIG_14-3-3_CanoR_1	95	104	PF00244	0.243
LIG_Actin_WH2_2	18	36	PF00022	0.388
LIG_BRCT_BRCA1_1	281	285	PF00533	0.476
LIG_EH1_1	154	162	PF00400	0.236
LIG_eIF4E_1	20	26	PF01652	0.243
LIG_FHA_1	141	147	PF00498	0.327
LIG_FHA_1	2	8	PF00498	0.290
LIG_FHA_1	354	360	PF00498	0.392
LIG_FHA_1	410	416	PF00498	0.454
LIG_FHA_2	145	151	PF00498	0.275
LIG_LIR_Gen_1	152	163	PF02991	0.311
LIG_LIR_Nem_3	152	158	PF02991	0.286
LIG_LIR_Nem_3	190	195	PF02991	0.307
LIG_MYND_1	255	259	PF01753	0.535
LIG_SH2_CRK	192	196	PF00017	0.307
LIG_SH2_SRC	265	268	PF00017	0.461
LIG_SH2_SRC	39	42	PF00017	0.277
LIG_SH2_STAP1	197	201	PF00017	0.370
LIG_SH2_STAP1	317	321	PF00017	0.482
LIG_SH2_STAT5	192	195	PF00017	0.294
LIG_SH2_STAT5	20	23	PF00017	0.245
LIG_SH2_STAT5	24	27	PF00017	0.259
LIG_SH2_STAT5	265	268	PF00017	0.345
LIG_SH2_STAT5	286	289	PF00017	0.314
LIG_SH2_STAT5	39	42	PF00017	0.433
LIG_SUMO_SIM_anti_2	145	150	PF11976	0.248
LIG_SUMO_SIM_anti_2	169	175	PF11976	0.427
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.287
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.388
LIG_SUMO_SIM_par_1	138	143	PF11976	0.271
LIG_SUMO_SIM_par_1	3	9	PF11976	0.305
LIG_SUMO_SIM_par_1	70	76	PF11976	0.388
LIG_TYR_ITIM	195	200	PF00017	0.388
LIG_WRC_WIRS_1	317	322	PF05994	0.399
MOD_CK1_1	169	175	PF00069	0.264
MOD_CK1_1	281	287	PF00069	0.589
MOD_CK1_1	322	328	PF00069	0.464
MOD_CK1_1	378	384	PF00069	0.587
MOD_Cter_Amidation	226	229	PF01082	0.626
MOD_GlcNHglycan	132	135	PF01048	0.446
MOD_GlcNHglycan	272	275	PF01048	0.598
MOD_GlcNHglycan	311	314	PF01048	0.349
MOD_GlcNHglycan	378	381	PF01048	0.635
MOD_GlcNHglycan	394	397	PF01048	0.310
MOD_GlcNHglycan	84	87	PF01048	0.294
MOD_GSK3_1	111	118	PF00069	0.578
MOD_GSK3_1	140	147	PF00069	0.284
MOD_GSK3_1	162	169	PF00069	0.264
MOD_GSK3_1	266	273	PF00069	0.576
MOD_GSK3_1	274	281	PF00069	0.636
MOD_GSK3_1	295	302	PF00069	0.332
MOD_GSK3_1	315	322	PF00069	0.208
MOD_GSK3_1	337	344	PF00069	0.521
MOD_GSK3_1	349	356	PF00069	0.361
MOD_GSK3_1	371	378	PF00069	0.675
MOD_GSK3_1	392	399	PF00069	0.413
MOD_GSK3_1	40	47	PF00069	0.347
MOD_GSK3_1	82	89	PF00069	0.388
MOD_N-GLC_1	14	19	PF02516	0.243
MOD_N-GLC_1	86	91	PF02516	0.324
MOD_N-GLC_2	403	405	PF02516	0.388
MOD_NEK2_1	1	6	PF00069	0.330
MOD_NEK2_1	110	115	PF00069	0.602
MOD_NEK2_1	142	147	PF00069	0.248
MOD_NEK2_1	266	271	PF00069	0.285
MOD_NEK2_1	309	314	PF00069	0.354
MOD_NEK2_1	315	320	PF00069	0.340
MOD_NEK2_1	353	358	PF00069	0.444
MOD_NEK2_1	364	369	PF00069	0.655
MOD_NEK2_2	162	167	PF00069	0.388
MOD_OFUCOSY	351	358	PF10250	0.223
MOD_PIKK_1	132	138	PF00454	0.388
MOD_PK_1	117	123	PF00069	0.490
MOD_PKA_1	116	122	PF00069	0.686
MOD_PKA_2	166	172	PF00069	0.389
MOD_PKA_2	349	355	PF00069	0.242
MOD_Plk_1	266	272	PF00069	0.301
MOD_Plk_1	86	92	PF00069	0.242
MOD_Plk_2-3	181	187	PF00069	0.264
MOD_Plk_4	144	150	PF00069	0.243
MOD_Plk_4	169	175	PF00069	0.370
MOD_Plk_4	187	193	PF00069	0.260
MOD_Plk_4	316	322	PF00069	0.342
MOD_Plk_4	381	387	PF00069	0.617
MOD_ProDKin_1	274	280	PF00069	0.427
MOD_ProDKin_1	337	343	PF00069	0.511
MOD_ProDKin_1	371	377	PF00069	0.533
MOD_ProDKin_1	40	46	PF00069	0.336
TRG_DiLeu_BaEn_2	75	81	PF01217	0.258
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.271
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.365
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.336
TRG_ENDOCYTIC_2	192	195	PF00928	0.255
TRG_ENDOCYTIC_2	197	200	PF00928	0.227
TRG_ENDOCYTIC_2	317	320	PF00928	0.405
TRG_ER_diArg_1	228	231	PF00400	0.659
TRG_ER_diArg_1	234	236	PF00400	0.583
TRG_NLS_MonoCore_2	218	223	PF00514	0.523
TRG_NLS_MonoExtN_4	219	224	PF00514	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8I5	Leptomonas seymouri	62%	93%
A0A0S4JM00	Bodo saltans	33%	100%
A0A1X0NX76	Trypanosomatidae	39%	100%
A0A3S7WYH8	Leishmania donovani	87%	95%
A0A422MXM9	Trypanosoma rangeli	42%	100%
A0JN27	Rattus norvegicus	24%	100%
A4HDM8	Leishmania braziliensis	77%	98%
C9ZWD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AH75	Leishmania infantum	87%	95%
Q13888	Homo sapiens	24%	100%
Q2TBV5	Bos taurus	24%	100%
Q4QAG3	Leishmania major	87%	100%
Q6P1K8	Homo sapiens	24%	100%
Q9JIB4	Mus musculus	23%	100%
V5BAZ0	Trypanosoma cruzi	41%	100%